Training Grant in Cardiac and Vascular Cell Biology

Summary

Principal Investigator: Steven A Fisher
Abstract: This Training Program provides a high-quality interdisciplinary training experience for pre- and postdoctoral trainees in cardiovascular physiology and pathophysiology. Training includes molecular, cell and systems biology, with an emphasis on translational science. Our goal is to provide trainees with comprehensive, multi-faceted training in cardiac and vascular cell biology, imbued with a strong appreciation of the disease relevance of their research. Our 32 faculty mentors are from 13 basic and clinical departments and divisions in the School of Medicine (SOM), School of Nursing (SON) and Medical Biotechnology Center (MBC) of the University of Maryland Biotechnology Institute (UMBI). All senior faculty mentors are NIH-funded;our talented new junior faculty, are, themselves, closely mentored provide the next wave of mentors for the Training Program The Program brings together selected, motivated students and postdoctoral fellows. Training opportunities are broad and include: molecular determinants of cardiovascular function, structure and function studies of cardiac and vascular signaling pathways, including protein trafficking. In this renewal there is increased focus, on genetics of cardiovascular diseases, analysis of the function of individual cardiac and vascular cells, as well as the biomechanical properties of whole tissues and intact organs. With reorganization of graduate studies at the School of Medicine (SOM) under the umbrella Graduate Program in Life Sciences (GPILS), quality and number of TGE predoctoral applicants continues to increase. Institutional support for graduate education is outstanding, with an annual investment over $2M. GPILS also takes the lead in mentoring postdoctoral fellows (e.g. career seminars, grant writing workshops). The coursework for pre-doctoral trainees consists of an 8 credit Core Curriculum, interdisciplinary courses in muscle biology, molecular biology and functional genomics. Topics in Molecular Medicine, a newly plaimed course on cardiac pathophysiology, and a hands on course on cardiovascular fiinction. The Program provides the framework for a cross-discipline, interactive community of pre- and postdoctoral trainees. Postdoctoral fellows take two cardiovascular intensive courses for credit and join with predoctoral trainees in regular meetings to present work-in-progress, provide feedback on the program, attend and present at weekly lunch time research forums, a weekly journal clubs and Annual Research Retreat. A new Program Director, and new Steering Committee, and an External Advisory Committee (EAC) closely track progress of the trainees and the success of the overall Program. Trainees completing this program will be prepared to bring to bear a range of experimental approaches on basic questions in normal cardiac and vascular cell biology, on the underlying mechanisms responsible for cardiac and vascular pathologies, and on their possible cure and prevention. RELEVANCE (See instructions):
Funding Period: 2003-04-01 - 2014-07-31
more information: NIH RePORT

Top Publications

  1. pmc Smooth muscle contractile diversity in the control of regional circulations
    John J Reho
    Division of Cardiology, School of Medicine, University of Maryland, Baltimore, Maryland
    Am J Physiol Heart Circ Physiol 306:H163-72. 2014
  2. pmc Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development
    Maureen O Shanks
    Department of Physiology, University of Maryland Baltimore, Baltimore, Maryland, United States of America
    PLoS ONE 7:e46316. 2012
  3. pmc Microtubules underlie dysfunction in duchenne muscular dystrophy
    Ramzi J Khairallah
    Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Sci Signal 5:ra56. 2012
  4. pmc High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects
    Tatiana F Galvao
    Division of Cardiology, Department of Medicine, University of Maryland Baltimore, 21201, USA
    Cardiovasc Res 93:24-32. 2012
  5. pmc Dietary fat and heart failure: moving from lipotoxicity to lipoprotection
    William C Stanley
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Circ Res 110:764-76. 2012
  6. pmc Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets
    Peter A Hecker
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Physiol Endocrinol Metab 303:E959-72. 2012
  7. pmc Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids
    William C Stanley
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Curr Opin Clin Nutr Metab Care 15:122-6. 2012
  8. pmc Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers
    Tova Neustadt Schachter
    Dept of Biochemistry and Molecular Biology, Univ of Maryland School of Medicine, 108 North Greene St, Baltimore MD 21201 1503, USA
    Am J Physiol Cell Physiol 303:C977-90. 2012
  9. pmc SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner
    P Richard Grimm
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:37673-90. 2012
  10. pmc High-sugar intake does not exacerbate metabolic abnormalities or cardiac dysfunction in genetic cardiomyopathy
    Peter A Hecker
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, Maryland, USA
    Nutrition 28:520-6. 2012

Detail Information

Publications41

  1. pmc Smooth muscle contractile diversity in the control of regional circulations
    John J Reho
    Division of Cardiology, School of Medicine, University of Maryland, Baltimore, Maryland
    Am J Physiol Heart Circ Physiol 306:H163-72. 2014
    ..We consider how these unique properties may allow for selective drug targeting of regional circulations for therapeutic benefit and point out gaps in our knowledge and areas in need of further investigation. ..
  2. pmc Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development
    Maureen O Shanks
    Department of Physiology, University of Maryland Baltimore, Baltimore, Maryland, United States of America
    PLoS ONE 7:e46316. 2012
    ..We also show high levels of Chd8 mRNA in RNA extracted from post-natal rat hearts. These data add Chd8 to the short list of known nuclear AKAPs, and implicate a function for Chd8 in post-natal rat cardiac development...
  3. pmc Microtubules underlie dysfunction in duchenne muscular dystrophy
    Ramzi J Khairallah
    Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Sci Signal 5:ra56. 2012
    ..Together, these data show that microtubules are the proximate element responsible for the dysfunction in Ca(2+) and ROS signaling in DMD and could be effective therapeutic targets for intervention...
  4. pmc High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects
    Tatiana F Galvao
    Division of Cardiology, Department of Medicine, University of Maryland Baltimore, 21201, USA
    Cardiovasc Res 93:24-32. 2012
    ..Here, we compared a standard low-fat diet to high-fat diets enriched with either saturated fat (palmitate and stearate) or PUFA (linoleic and ╬▒-linolenic acids) in hamsters with genetic cardiomyopathy...
  5. pmc Dietary fat and heart failure: moving from lipotoxicity to lipoprotection
    William C Stanley
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Circ Res 110:764-76. 2012
    ..Additional clinical and animals studies are needed to determine the optimal diet in terms of saturated, monounsaturated, and n-6 polyunsaturated fatty acids intake for this vulnerable patient population...
  6. pmc Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets
    Peter A Hecker
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Physiol Endocrinol Metab 303:E959-72. 2012
    ..On the other hand, it modestly suppressed indexes of glucose flux into nonoxidative pathways in myocardium, suggesting potential protective effects...
  7. pmc Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids
    William C Stanley
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Curr Opin Clin Nutr Metab Care 15:122-6. 2012
    ..In the present review, we examine the novel effects of n-3 PUFA on mitochondria, with an emphasis on cardiac mitochondrial phospholipids...
  8. pmc Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers
    Tova Neustadt Schachter
    Dept of Biochemistry and Molecular Biology, Univ of Maryland School of Medicine, 108 North Greene St, Baltimore MD 21201 1503, USA
    Am J Physiol Cell Physiol 303:C977-90. 2012
    ..Our approach allows quantitative kinetic characterization of Foxo1 and Foxo3A nuclear-cytoplasmic movements in living muscle fibers under various experimental conditions...
  9. pmc SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner
    P Richard Grimm
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:37673-90. 2012
    ..As a result of the dependent nature of OSR1 on SPAK in the DCT, NCC is unable to be activated. Consequently, SPAK(-/-) mice are highly sensitive to dietary salt restriction, displaying prolonged negative sodium balance and hypotension...
  10. pmc High-sugar intake does not exacerbate metabolic abnormalities or cardiac dysfunction in genetic cardiomyopathy
    Peter A Hecker
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, Maryland, USA
    Nutrition 28:520-6. 2012
    ..Conversely, G6PD also facilitates ROS scavenging using the glutathione pathway. We hypothesized that a high-sugar intake would increase flux through G6PD to increase myocardial NADPH and ROS and accelerate cardiac dysfunction and death...
  11. pmc Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival
    Tatiana F Galvao
    Division of Cardiology, Department of Medicine, University of Maryland, 20 Penn St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 304:H12-21. 2013
    ..This suggest that greater susceptibility to MPT is not a contributor to cardiac pathology and poor survival in heart failure...
  12. pmc Mathematical modeling reveals modulation of both nuclear influx and efflux of Foxo1 by the IGF-I/PI3K/Akt pathway in skeletal muscle fibers
    Robert J Wimmer
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland and
    Am J Physiol Cell Physiol 306:C570-84. 2014
    ..New media change experiments show that cultured fibers release IGF-I-like factors, which maintain low nuclear Foxo1 in the medium. This study demonstrates the power of quantitative modeling of observed nuclear fluxes. ..
  13. pmc Regional imbalanced activation of the calcineurin/BAD apoptotic pathway and the PI3K/Akt survival pathway after myocardial infarction
    Tieluo Li
    Departments of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Int J Cardiol 166:158-65. 2013
    ..The purpose of this study was to investigate the role of a survival pathway (PI3K/Akt) and an apoptosis pathway (calcineurin/BAD) in the remodeling after MI in a large animal model...
  14. pmc Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny
    Caitlin D Castro
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, USA
    Eur J Immunol 43:3061-75. 2013
    ....
  15. pmc Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics
    L M Yerges-Armstrong
    Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Pharmacol Ther 94:525-32. 2013
    ..Combining metabolomics and genomics allowed for more comprehensive interrogation of mechanisms of variation in aspirin response--an important step toward personalized treatment approaches for cardiovascular disease...
  16. pmc Elevated nuclear Foxo1 suppresses excitability of skeletal muscle fibers
    Erick O Hernández-Ochoa
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland
    Am J Physiol Cell Physiol 305:C643-53. 2013
    ..We conclude that increased nuclear activity of Foxo1 prevents the normal muscle responses to electrical stimulation and that this indicates a novel capability of Foxo1 to disable the functional activity of skeletal muscle. ..
  17. pmc X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch
    Benjamin L Prosser
    Department of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Room 340, 725 W Lombard Street, Baltimore, MD 21201, USA
    Cardiovasc Res 98:307-14. 2013
    ..Thus, the objective of this study was (i) to characterize X-ROS signalling during stretch-shortening cycles and (ii) to evaluate how the amplitude (pre-load) and frequency (heart rate) of cell stretch affects X-ROS and Ca(2+) signalling...
  18. ncbi Glucose 6-phosphate dehydrogenase deficiency increases redox stress and moderately accelerates the development of heart failure
    Peter A Hecker
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Circ Heart Fail 6:118-26. 2013
    ..Therefore, G6PD deficiency might prevent heart failure by decreasing NADPH and reactive oxygen species production...
  19. pmc Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease
    Peter A Hecker
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 304:H491-500. 2013
    ..Definitive clinical studies in large populations are needed to determine the effects of G6PD deficiency on the development of cardiovascular disease and subsequent outcomes...
  20. ncbi X-ROS signaling: rapid mechano-chemo transduction in heart
    Benjamin L Prosser
    Center for Biomedical Engineering and Technology BioMET, University of Maryland School of Medicine, Baltimore, MD 21209, USA
    Science 333:1440-5. 2011
    ..X-ROS signaling thus provides a mechanistic explanation for the mechanotransduction of Ca(2+) release in the heart and offers fresh therapeutic possibilities...
  21. pmc An extracellular matrix protein prevents cytokinesis failure and aneuploidy in the C. elegans germline
    Bruce E Vogel
    Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland at Baltimore, Baltimore, MD, USA
    Cell Cycle 10:1916-20. 2011
    ..elegans hemicentin mutant hermaphrodites...
  22. ncbi Role of adiponectin in the development of high fat diet-induced metabolic abnormalities in mice
    P A Hecker
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Horm Metab Res 43:100-5. 2011
    ....
  23. pmc The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Epidemiol 168:1016-23. 2008
    ..Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference...
  24. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    ..The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown...
  25. pmc TCF7L2 variants associate with CKD progression and renal function in population-based cohorts
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Nephrol 19:1989-99. 2008
    ..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...
  26. pmc Investigating parent of origin effects in studies of type 2 diabetes and obesity
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland, Baltimore, MD, USA
    Curr Diabetes Rev 4:329-39. 2008
    ..Through this paper, we hope emphasizes the potentially significant importance of POE in the etiology of T2DM and obesity...
  27. ncbi Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 56:3053-62. 2007
    ..We sought to identify type 2 diabetes susceptibility genes through a genome-wide association scan (GWAS) in the Amish...
  28. ncbi Lin-7 targets the Kir 2.3 channel on the basolateral membrane via a L27 domain interaction with CASK
    Christine Alewine
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 293:C1733-41. 2007
    ..Taken together, these data support a model whereby mLin-7 acts as a PDZ-to-L27 adapter, mediating indirect association of Kir 2.3 with a basolateral membrane scaffold and thereby stabilizing Kir 2.3 at the basolateral membrane...
  29. ncbi Early in vivo experience with the pediatric Jarvik 2000 heart
    Ahmet Kilic
    Department of Surgery, University of Maryland, Baltimore, MD 21201, USA
    ASAIO J 53:374-8. 2007
    ..Our initial animal in vivo experience with the pediatric Jarvik 2000 heart shows that a small axial flow pump can provide partial to nearly complete circulatory support with minimal adverse effects on blood components...
  30. pmc JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes
    Nicole D Glaser
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 291:H1183-92. 2006
    ..Thus these studies provide new evidence that signaling-induced mRNA instability is an important mechanism that underlies the changes in the pattern of gene expression evoked by stress-activated pathways in cardiac cells...
  31. pmc The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study
    Braxton D Mitchell
    Division of Endocrinology, Department of Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am Heart J 155:823-8. 2008
    ..Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactions...
  32. pmc The cardiac IP3 receptor: uncovering the role of "the other" calcium-release channel
    Thomas J Hund
    J Mol Cell Cardiol 45:159-61. 2008
  33. pmc Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure
    Donghui Ma
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cell 145:1102-15. 2011
    ..1 reveals a quality control step that couples protein conformation to Golgi export and provides molecular insight into how mutations in Kir2.1 arrest the channels at the Golgi...
  34. pmc Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction
    Mariah H Goodall
    Department of Biochemistry and Molecular Biology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:41686-700. 2010
    ..Taken together, these data reveal that localized PKD may play a role as a dynamic regulator of Ca(2+) sensitivity of contraction in cardiac myocytes...
  35. pmc Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat
    Yinghua Zhang
    Department of Physiology, University of Maryland, School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA
    J Mol Cell Cardiol 48:1050-9. 2010
    ..Our results suggest that the embryonic mammalian heart expresses a significant amount of alpha II-spectrin with a reduced avidity for beta-spectrin and the ability to promote myocyte growth...
  36. pmc COL4A1 is associated with arterial stiffness by genome-wide association scan
    Kirill V Tarasov
    Laboratory of Cardiovascular Science, Laboratory of Genetics, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:151-8. 2009
    ..Heritability and linkage studies have pointed toward a genetic component affecting PWV. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with PWV...
  37. ncbi Chronic hypoxia increases inducible NOS-derived nitric oxide in fetal guinea pig hearts
    Loren Thompson
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 65:188-92. 2009
    ..5x and decreased with L-NIL by 67 +/- 14%. Thus, up-regulation of iNOS-derived nitric oxide (NO) generation is an important mechanism by which fetal hearts respond to chronic hypoxic stress...
  38. pmc Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus
    Armina A Kazi
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biol Reprod 81:378-87. 2009
    ..In summary, the rapid E(2)-induced signaling events that lead to the expression of Vegfa observed previously using the whole uterus occur in LE cells and appear to be initiated via a membrane form of ESR1...
  39. pmc The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle
    Diana L Ford-Speelman
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 20:3905-17. 2009
    ..Our results suggest that obscurin's rhoGEF domain signals at least in part by inducing rhoA expression and activation, and altering the expression of downstream kinases in vitro and in vivo...
  40. pmc Inhibition of oxygen-induced hypoxia-inducible factor-1alpha degradation unmasks estradiol induction of vascular endothelial growth factor expression in ECC-1 cancer cells in vitro
    Kristin Happ Molitoris
    Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201 1559, USA
    Endocrinology 150:5405-14. 2009
    ..Through the induction of increased microvascular permeability and the consequent exudation of plasma growth factors, VEGF in turn may play an essential role in cancer cell proliferation in vivo...
  41. ncbi Strain-related regional alterations of calcium-handling proteins in myocardial remodeling
    Ahmet Kilic
    Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Thorac Cardiovasc Surg 132:900-8. 2006
    ....

Research Grants30

  1. Functional Implications of Caveolae-localized Myocardial sGC in Heart Failure
    EMILY JOY TSAI; Fiscal Year: 2013
    ....
  2. Colorado Hepatitis C Cooperative Research Center
    HUGO RAMON ROSEN; Fiscal Year: 2013
    ..These include clinical hepatology, cellular and molecular immunology, virology, cell biology, and systems biology. ..
  3. Multi-level analysis of iron metabolism and treatment of chronic kidney disease
    Paul L Fox; Fiscal Year: 2013
    ..Our goal is to investigate the mechanisms regulating iron homeostasis during of CKD, and devise regimens for personalized treatment that will improve health and minimize risk. ..
  4. Realistic models of gastrointestinal bioelectromagnetism
    Leo Cheng; Fiscal Year: 2013
    ....
  5. Endothelial Cell Phenotypes in Health and Disease
    William C Aird; Fiscal Year: 2013
    ..Core C ("Gene Targeting Core";William C. Aird, Core Leader) provides the necessary tools for targeting the Hprt locus and the loci of endogenous genes in ES cells and mice. ..
  6. Function and Integration of Stem Cell-derived Cardiac Tissue Patch
    Nenad Bursac; Fiscal Year: 2013
    ..The knowledge obtained in this project will allow us to pursue in the future engineering of a functional cardiac tissue patch made of human stem cells for potential clinical applications. ..
  7. COPPER HOMEOSTASIS IN MAMMALS
    Dennis J Thiele; Fiscal Year: 2013
    ....
  8. VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASE
    Devendra K Agrawal; Fiscal Year: 2013
    ....
  9. COBRE in Lipidomics and Pathobiology
    Besim Ogretmen; Fiscal Year: 2013
    ....
  10. SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES
    Roger R Markwald; Fiscal Year: 2013
    ..abstract_text> ..