MULTIDISCIPLINARY PRE-DOCTORAL TRAINING IN INTEGRATIVE CARDIOVASCULAR BIOLOGY
Principal Investigator: David M Pollock
Abstract: Description (provided by applicant): This application is a competing renewal of a multidisciplinary pre-doctoral training grant in integrative cardiovascular biology at the Medical College of Georgia (MCG). The long-term objective of this program is to train pre-doctoral Ph.D. and M.D./Ph.D. students for independent research careers in integrative cardiovascular biology, utilizing molecular, genetic, cellular, tissue/organ, whole animal and human experimental approaches. This program involves the expertise of 28 faculty in the Departments of Cell Biology &Anatomy, Medicine, Pathology, Pediatrics, Pharmacology &Toxicology, Physiology, Surgery. A majority of these faculty also have appointments or affiliations with the Georgia Prevention Institute, the Institute for Molecular Medicine and Genetics, and the Vascular Biology Center on the MCG campus. The faculty preceptors of the program represent an outstanding group of established integrative cardiac and vascular biologists whose research interests cover five related cardiovascular areas: 1) vascular cell signaling, 2) control of vascular tone, 3) cardiac development, 4) endothelial dysfunction, and 5) prevention of cardiovascular disease. This training grant will be administered through the Vascular Biology Center in the School of Medicine. The program is directed by Dr. David M. Pollock, Program Director and Dr. Jennifer S. Pollock, Program Co- Director, both established investigators. An Internal Advisory Committee of experienced leaders of the graduate program at the Medical College of Georgia will supervise the program. Trainees will be Ph.D. or M.D./Ph.D. graduate students currently enrolled full-time in the Biomedical Sciences Ph.D. program in the Medical College of Georgia School of Graduate Studies. Students will be selected based on their expressed interest in integrative cardiovascular biology and their previous academic performance and research experience. All trainees will be required to participate in didactic training activities, which consist of the first year core curriculum and passing the first qualifying exam;advanced course electives such as Cardiovascular Physiology &Pharmacology and Frontiers in Vascular Biology;courses in Scientific Communications and Research Ethics, and Biostatistics;attendance in one or more departmental seminar series;the cardiovascular journal club;and the annual Graduate Research Day activities. Upon completion of the program, students will be ready to pursue post-doctoral training at premier laboratories as they begin their careers as independent investigators in cardiovascular sciences.
Funding Period: 2004-04-01 - 2014-09-30
more information: NIH RePORT
- PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKGJason O Burnette
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
Exp Eye Res 83:1359-65. 2006..Further, we propose PKG-dependent stimulation of BKCa channel activity as a new potential therapeutic target to combat decreased retinal blood flow seen in some disease states (e.g., diabetic retinopathy)...
- Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone ratsChristine S Rigsby
Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
Microvasc Res 73:198-205. 2007..Therefore, we hypothesized that chronic spironolactone treatment would improve cerebral artery structure in the SHRSP...
- Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker ratJessica M Osmond
Department of Physiology, Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB3212A, Augusta, GA 30912, USA
Hypertension 53:381-6. 2009..These cerebrovascular changes correlate with the development of hypertension and suggest that the increased blood pressure may be the major determinant for stroke risk in obese individuals...
- TNF-alpha knockout mice have increased corpora cavernosa relaxationFernando S Carneiro
Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, SP, Brazil
J Sex Med 6:115-25. 2009..Tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine, suppresses endothelial nitric oxide synthase (eNOS) expression...
- Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathwayAlia Shatanawi
Dept of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, GA 30912, USA
Am J Physiol Cell Physiol 300:C1181-92. 2011..These results indicate that ANG II increases endothelial arginase activity/expression through Gα12/13 G proteins coupled to AT(1) receptors and subsequent activation of RhoA/ROCK/p38 MAPK pathways leading to endothelial dysfunction...
- Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or raceVanessa Bundy
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
J Pediatr Endocrinol Metab 24:119-24. 2011..To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships...
- Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lambSaurabh Aggarwal
Pulmonary Disease Program, Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA
Trends Cardiovasc Med 20:238-46. 2010....
- Astrocyte regulation of cerebral vascular toneJessica A Filosa
Georgia Regents University, Augusta, Georgia
Am J Physiol Heart Circ Physiol 305:H609-19. 2013..Finally, we discuss current advances in the technical tools available to study NVC mechanisms in the brain as it relates to the participation of astrocytes. ..
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