MULTIDISCIPLINARY PRE-DOCTORAL TRAINING IN INTEGRATIVE CARDIOVASCULAR BIOLOGY

Summary

Principal Investigator: David M Pollock
Abstract: Description (provided by applicant): This application is a competing renewal of a multidisciplinary pre-doctoral training grant in integrative cardiovascular biology at the Medical College of Georgia (MCG). The long-term objective of this program is to train pre-doctoral Ph.D. and M.D./Ph.D. students for independent research careers in integrative cardiovascular biology, utilizing molecular, genetic, cellular, tissue/organ, whole animal and human experimental approaches. This program involves the expertise of 28 faculty in the Departments of Cell Biology &Anatomy, Medicine, Pathology, Pediatrics, Pharmacology &Toxicology, Physiology, Surgery. A majority of these faculty also have appointments or affiliations with the Georgia Prevention Institute, the Institute for Molecular Medicine and Genetics, and the Vascular Biology Center on the MCG campus. The faculty preceptors of the program represent an outstanding group of established integrative cardiac and vascular biologists whose research interests cover five related cardiovascular areas: 1) vascular cell signaling, 2) control of vascular tone, 3) cardiac development, 4) endothelial dysfunction, and 5) prevention of cardiovascular disease. This training grant will be administered through the Vascular Biology Center in the School of Medicine. The program is directed by Dr. David M. Pollock, Program Director and Dr. Jennifer S. Pollock, Program Co- Director, both established investigators. An Internal Advisory Committee of experienced leaders of the graduate program at the Medical College of Georgia will supervise the program. Trainees will be Ph.D. or M.D./Ph.D. graduate students currently enrolled full-time in the Biomedical Sciences Ph.D. program in the Medical College of Georgia School of Graduate Studies. Students will be selected based on their expressed interest in integrative cardiovascular biology and their previous academic performance and research experience. All trainees will be required to participate in didactic training activities, which consist of the first year core curriculum and passing the first qualifying exam;advanced course electives such as Cardiovascular Physiology &Pharmacology and Frontiers in Vascular Biology;courses in Scientific Communications and Research Ethics, and Biostatistics;attendance in one or more departmental seminar series;the cardiovascular journal club;and the annual Graduate Research Day activities. Upon completion of the program, students will be ready to pursue post-doctoral training at premier laboratories as they begin their careers as independent investigators in cardiovascular sciences.
Funding Period: 2004-04-01 - 2014-09-30
more information: NIH RePORT

Top Publications

  1. ncbi PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG
    Jason O Burnette
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Eye Res 83:1359-65. 2006
  2. pmc Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone rats
    Christine S Rigsby
    Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
    Microvasc Res 73:198-205. 2007
  3. pmc Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker rat
    Jessica M Osmond
    Department of Physiology, Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB3212A, Augusta, GA 30912, USA
    Hypertension 53:381-6. 2009
  4. pmc TNF-alpha knockout mice have increased corpora cavernosa relaxation
    Fernando S Carneiro
    Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, SP, Brazil
    J Sex Med 6:115-25. 2009
  5. pmc Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway
    Alia Shatanawi
    Dept of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Am J Physiol Cell Physiol 300:C1181-92. 2011
  6. pmc Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race
    Vanessa Bundy
    Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
    J Pediatr Endocrinol Metab 24:119-24. 2011
  7. pmc Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb
    Saurabh Aggarwal
    Pulmonary Disease Program, Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Trends Cardiovasc Med 20:238-46. 2010
  8. pmc Astrocyte regulation of cerebral vascular tone
    Jessica A Filosa
    Georgia Regents University, Augusta, Georgia
    Am J Physiol Heart Circ Physiol 305:H609-19. 2013

Research Grants

Detail Information

Publications8

  1. ncbi PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG
    Jason O Burnette
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Eye Res 83:1359-65. 2006
    ..Further, we propose PKG-dependent stimulation of BKCa channel activity as a new potential therapeutic target to combat decreased retinal blood flow seen in some disease states (e.g., diabetic retinopathy)...
  2. pmc Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone rats
    Christine S Rigsby
    Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
    Microvasc Res 73:198-205. 2007
    ..Therefore, we hypothesized that chronic spironolactone treatment would improve cerebral artery structure in the SHRSP...
  3. pmc Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker rat
    Jessica M Osmond
    Department of Physiology, Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB3212A, Augusta, GA 30912, USA
    Hypertension 53:381-6. 2009
    ..These cerebrovascular changes correlate with the development of hypertension and suggest that the increased blood pressure may be the major determinant for stroke risk in obese individuals...
  4. pmc TNF-alpha knockout mice have increased corpora cavernosa relaxation
    Fernando S Carneiro
    Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, SP, Brazil
    J Sex Med 6:115-25. 2009
    ..Tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine, suppresses endothelial nitric oxide synthase (eNOS) expression...
  5. pmc Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway
    Alia Shatanawi
    Dept of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Am J Physiol Cell Physiol 300:C1181-92. 2011
    ..These results indicate that ANG II increases endothelial arginase activity/expression through Gα12/13 G proteins coupled to AT(1) receptors and subsequent activation of RhoA/ROCK/p38 MAPK pathways leading to endothelial dysfunction...
  6. pmc Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race
    Vanessa Bundy
    Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
    J Pediatr Endocrinol Metab 24:119-24. 2011
    ..To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships...
  7. pmc Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb
    Saurabh Aggarwal
    Pulmonary Disease Program, Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Trends Cardiovasc Med 20:238-46. 2010
    ....
  8. pmc Astrocyte regulation of cerebral vascular tone
    Jessica A Filosa
    Georgia Regents University, Augusta, Georgia
    Am J Physiol Heart Circ Physiol 305:H609-19. 2013
    ..Finally, we discuss current advances in the technical tools available to study NVC mechanisms in the brain as it relates to the participation of astrocytes. ..

Research Grants30

  1. Center for Enviromental Health in Northern Manahattan
    Regina M Santella; Fiscal Year: 2013
    ..An Executive Committee helps the Director administer the program while two Advisory Committees provide additional guidance. ..
  2. Immune-Based Interventions Against Infectious Diseases
    Alan L Rothman; Fiscal Year: 2013
    ..3. Recruit promising junior investigators and provide mentoring by established NIH-funded researchers. 4. Support a multidisciplinary research program led by junior investigators in translational infectious diseases immunology. ..
  3. JHU-UMD Diabetes Research Center
    Fredric E Wondisford; Fiscal Year: 2013
    ..The Enrichment Program will facilitate the interaction within and between Johns Hopkins University and the University of Maryland. ..
  4. Endothelial Injury and Repair: CardioPulmonary Vascular Biology COBRE
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..abstract_text> ..
  5. Diabetes Research Center
    Jean E Schaffer; Fiscal Year: 2013
    ..Translating new knowledge in diabetes to improved treatment of patients with diabetes. ..
  6. Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors
    John K Hewitt; Fiscal Year: 2013
    ..This new knowledge will contribute to the development of intervention strategies to reduce the risk of drug abuse, STDs, and HIV/AIDS. CENTER CHARACTERISTICS ..
  7. Expanding Excellence in Developmental Biology in Oklahoma
    Linda F Thompson; Fiscal Year: 2013
    ..abstract_text> ..
  8. Cardiac Myosin Binding Protein-C: Structure, Function, and Regulation
    David M Warshaw; Fiscal Year: 2013
    ..abstract_text> ..
  9. CVD protection mechanisms involving ACE2/Ang-(1-7) axis
    Mohan K Raizada; Fiscal Year: 2013
    ..Finally, we believe that ACE2/Ang-(1-7) based concept will have an immediate impact not only in HD therapeutics, but will lead to the development of novel cardioprotective strategies in patients undergoing anthracyclin chemotherapy. ..