Cardiovascular Research Training Program (CRTP)

Summary

Principal Investigator: MUKESH KUMAR JAIN
Abstract: DESCRIPTION (provided by applicant): The goal of this Cardiovascular Research Training Program (CRTP) is to provide outstanding training in basic cardiovascular research to promising predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 27 trainers and 9 junior trainers from 6 basic science and 4 clinical affiliate programs at Case Western Reserve University. The recruited faculty is known for excellence in research, ample NIH funding, and robust research space. The training focuses on relating the basic approaches of molecular and cellular biology, physiology, biophysics, biomedical engineering, and imaging to mechanistic questions and problems pertinent to the cardiovascular system in health and disease, with particular emphasis on (a) Vascular development, inflammation, and thrombosis (b) Cardiac hypertrophy, failure, and regeneration, (c) Cardiac Electrophysiology and arrhythmias, (d) Metabolism and redox regulation, (e) Signal transduction and gene expression , and (f) Cardiovascular imaging. Predoctoral training is accomplished through enrollment of students who have already matriculated in PhD programs in Biomedical Engineering, Cell Biology, Molecular Medicine, Nutrition, Pharmacology, and Physiology &Biophysics, and who have selected a thesis advisor from among the participating trainers. The basic coursework and guided training in research skills provided by these departmental programs is supplemented and enhanced by CRTP-specific components. These include completion of a required graduate course in Cardiovascular Physiology, an exciting Immersion Experience in Cardiovascular Healthcare, participation in the weekly seminar series, monthly journal club, and annual research retreat organized by the recently established Case Cardiovascular Research Institute (CVRI), and mentoring by a CRTP faculty committee that includes senior trainers and junior non-trainer faculty who are developing independent programs in cutting-edge areas of cardiovascular research. Postdoctoral trainees, who are appointed via their recruitment to CRTP trainer labs, also participate in the Cardiovascular Healthcare Immersion, CVRI seminars/retreats/journal club, and the mentoring process. This application seeks 6 positions for years 1-2 (3 for predoctoral trainees and 3 postdoctoral trainees) and 8 positions for years 3-5 (4 predoctoral and 4 postdoctoral trainees).
Funding Period: 2010-09-20 - 2015-08-31
more information: NIH RePORT

Top Publications

  1. pmc Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG
    Adrienne T Dennis
    Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Biol Chem 286:34413-25. 2011
  2. pmc Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus
    Michael A Bruckman
    Department of Biomedical Engineering, Department of Radiology, Department of Materials Science and Engineering, and Department of Macromolecular Engineering, Case Western Reserve University Schools of Medicine and Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States
    Nano Lett 14:1551-8. 2014
  3. pmc Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and -spheres in mice
    Michael A Bruckman
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Virology 449:163-73. 2014
  4. pmc Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism
    Domenick A Prosdocimo
    From the Case Cardiovascular Research Institute and Harrington Heart and Vascular Institute
    J Biol Chem 289:5914-24. 2014
  5. ncbi Chemical modification of the inner and outer surfaces of Tobacco Mosaic Virus (TMV)
    Michael A Bruckman
    Departments of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 1108:173-85. 2014
  6. pmc KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance
    Dae Young Jung
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e77851. 2013
  7. pmc Engineering Gd-loaded nanoparticles to enhance MRI sensitivity via T(1) shortening
    Michael A Bruckman
    Department of Biomedical Engineering, Case Western Reserve University, Schools of Medicine and Engineering, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Nanotechnology 24:462001. 2013
  8. pmc BET bromodomains mediate transcriptional pause release in heart failure
    Priti Anand
    Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, and Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell 154:569-82. 2013
  9. pmc Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation
    Saptarsi M Haldar
    Harrington Heart and Vascular Institute and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 109:6739-44. 2012
  10. pmc Molecular determinants of pentamidine-induced hERG trafficking inhibition
    Adrienne T Dennis
    Rammelkamp Center for Education and Research, MetroHealth Campus, Cleveland, OH 44109, USA
    Mol Pharmacol 81:198-209. 2012

Research Grants

Detail Information

Publications11

  1. pmc Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG
    Adrienne T Dennis
    Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Biol Chem 286:34413-25. 2011
    ....
  2. pmc Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus
    Michael A Bruckman
    Department of Biomedical Engineering, Department of Radiology, Department of Materials Science and Engineering, and Department of Macromolecular Engineering, Case Western Reserve University Schools of Medicine and Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States
    Nano Lett 14:1551-8. 2014
    ....
  3. pmc Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and -spheres in mice
    Michael A Bruckman
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Virology 449:163-73. 2014
    ..Further, blood biocompatibility was supported, as none of the formulations induced clotting or hemolysis. This work lays the foundation for further application and tailoring of TMV for biomedical applications. ..
  4. pmc Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism
    Domenick A Prosdocimo
    From the Case Cardiovascular Research Institute and Harrington Heart and Vascular Institute
    J Biol Chem 289:5914-24. 2014
    ..This study establishes KLF15 as a key regulator of myocardial lipid utilization and is the first to implicate the KLF transcription factor family in cardiac metabolism. ..
  5. ncbi Chemical modification of the inner and outer surfaces of Tobacco Mosaic Virus (TMV)
    Michael A Bruckman
    Departments of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 1108:173-85. 2014
    ..We describe methods to isolate TMV from its tobacco plant host for spatially controlled interior and exterior chemical modification and to characterize the resulting TMV hybrid materials. ..
  6. pmc KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance
    Dae Young Jung
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e77851. 2013
    ..This study establishes KLF15 as an important molecular link between ER stress and insulin action. ..
  7. pmc Engineering Gd-loaded nanoparticles to enhance MRI sensitivity via T(1) shortening
    Michael A Bruckman
    Department of Biomedical Engineering, Case Western Reserve University, Schools of Medicine and Engineering, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Nanotechnology 24:462001. 2013
    ..Different engineering strategies and nanoparticle platforms will be compared in terms of their manufacturability, biocompatibility properties, and their overall potential to make an impact in clinical MR imaging. ..
  8. pmc BET bromodomains mediate transcriptional pause release in heart failure
    Priti Anand
    Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, and Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell 154:569-82. 2013
    ..This study implicates epigenetic readers as essential effectors of transcriptional pause release during HF pathogenesis and identifies BET coactivator proteins as therapeutic targets in the heart. ..
  9. pmc Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation
    Saptarsi M Haldar
    Harrington Heart and Vascular Institute and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 109:6739-44. 2012
    ....
  10. pmc Molecular determinants of pentamidine-induced hERG trafficking inhibition
    Adrienne T Dennis
    Rammelkamp Center for Education and Research, MetroHealth Campus, Cleveland, OH 44109, USA
    Mol Pharmacol 81:198-209. 2012
    ..We propose that pentamidine is the founding member of a novel pharmacological entity whose members act as small molecule antichaperones...
  11. pmc Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis
    M M Mumaw
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA
    J Thromb Haemost 12:1331-41. 2014
    ..To date, many therapies have been developed targeting proteins that mediate this process to prevent unwanted activation. However, the current standard of care for acute coronary syndromes still has limitations, including bleeding risk...

Research Grants30