Research Training in Nuclear Molecular Imaging
Principal Investigator: Alan J Fischman
Abstract: DESCRIPTION (provided by applicant): The purpose of the program here proposed is to provide training experience in the techniques of nuclear/molecular imaging research as well as a working knowledge of related nuclear medical science to physicians who wish to become researchers in molecular imaging with radioisotopes. Physicians who are trained in these areas will be in the best position to define the future research directions in the field. The proposed program includes formal training in the fundamentals of nuclear medical science, advanced formal training in selected areas defined by the trainee's interests and goals and an extended research experience in the form of a mentored research project, or projects, that will span his/her tenure in the program. The proposed training program will be based in Harvard Medical School's Joint Program in Nuclear Medicine. This program encompasses Nuclear Medicine and related activities in six major Harvard teaching hospitals as well as the University itself. The joint program and its affiliates includes a nuclear medicine residency program as well as several NIH training programs for scientists as well as graduate students thereby giving trainees in the proposed program a large pool of peers with whom to share experience and knowledge. The program faculty consisting of 29 active researchers and practitioners is a unique resource for the training of physician-researchers. These faculty supervise a number of federally funded research programs in which trainees may participate. The training experience is expected to extend over two years. Three positions are requested during the first year with a total of six trainee slots requested during year 2 through year 5. The resources available to the proposed program through the Harvard Medical School Joint Program in Nuclear Medicine are unique in terms of faculty size, extent of research activities and teaching/ mentoring experience of the faculty.
Funding Period: 2003-09-16 - 2009-06-30
more information: NIH RePORT
- Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorderScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 61:330-6. 2007..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions...
- Inverted U wavesShawn A Gregory
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
Am J Med 119:746-7. 2006
- Comparison of sixty-four-slice multidetector computed tomographic coronary angiography to coronary angiography with intravascular ultrasound for the detection of transplant vasculopathyShawn A Gregory
Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 98:877-84. 2006..Further, MDCT measurements of lumen diameters correlated well with quantitative coronary angiography...
- A diffusion tensor imaging study of white matter in obsessive-compulsive disorderPaul A Cannistraro
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Depress Anxiety 24:440-6. 2007..This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance...
- Myocardial blood flow and oxygen consumption in patients with Friedreich's ataxia prior to the onset of cardiomyopathyShawn A Gregory
Departments of Medicine Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Coron Artery Dis 18:15-22. 2007....
- Analysis of cardiac dimensions, mass and function in heart transplant recipients using 64-slice multi-detector computed tomographyMaros Ferencik
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Heart Lung Transplant 26:478-84. 2007..The aim of this study was to compare 64-slice MDCT analysis of cardiac structure and function to 2-dimensional echocardiography in heart transplant recipients...
- A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorderKarleyton C Evans
Department of Psychiatry, Psychiatric Neuroscience Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Neuropsychopharmacology 34:390-8. 2009..Given the pharmacological profile of tiagabine, these findings suggest that its therapeutic effects in gSAD may be mediated by GABAergic modulation within the vmPFC...
- MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> MetJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 105:17573-8. 2008..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype...
- Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI studyKarleyton C Evans
Department of Psychiatry, Division of Neurotherapeutics, Massachusetts General Hospital East, 13th Street, Building 149, Suite 2625, Charlestown, MA 02129, USA
Neuroimage 47:961-71. 2009..We propose that the identified limbic/paralimbic-bulbar circuitry plays a significant role in cognitive and emotional modulation of spontaneous breathing...