Vevo 2100 Imaging System


Principal Investigator: Mark L Kahn
Abstract: DESCRIPTION (provided by applicant): This proposal is for a Visual Sonics Vevo 2100 Imaging system. This instrument will be housed in the Cardiovascular Physiology Core facility at the University of Pennsylvania Translational Research Center (TRC). This Cardiovascular Physiology Core was created 5 years ago in an effort to bring clinically relevant analysis of cardiovascular physiology to investigators using mouse genetic models to understand human cardiovascular disease. It is a highly specialized and utilized core facility that performs echocardiography and vascular ultrasonography on mice from the earliest stages of development (E10.5 in utero) to maturity. Manned by a fully trained human fetal echo cardiographer, the goal of this core is to apply the same type and level of physiologic analysis to mouse genetic models that is used daily in the assessment of patients with complex cardiovascular diseases. The size and breadth of cardiovascular investigation at Penn has made this core a highly used and essential service for the institution. Its tight focus and the hig level training and expertise of the core has resulted in many new cardiovascular discoveries in mice that are pertinent to human diseases and added value to many genetic models created by NIH-funded investigators at Penn. The Cardiovascular Physiology Core presently uses a first generation Visual Sonics machine that provides basic imaging but lacks color Doppler and linear array technology, technical features that are essential to identify the type of cardiovascular defects observed daily in the clinic in prenatal and postnatal mice. The goal of this proposal is to replace this machine with one capable of providing imaging and flow data on a level commensurate with that used in our analysis of human patients to fully investigate and exploit sophisticated mouse genetic models of cardiovascular disease at Penn.
Funding Period: 2013-06-20 - 2014-05-31
more information: NIH RePORT

Detail Information

Research Grants30

  1. Perinatal Nicotine and Auditory Evoked Potentials in Early Infancy
    Karen M Grewen; Fiscal Year: 2013
    ..We plan to use acquired findings to support an application for more detailed, longitudinal study. ..
    John E Hall; Fiscal Year: 2013
    ..End of Abstract) ..
  3. Center for Fetal Gene Transfer for Heart, Lung, and Blood Diseases
    Alice F Tarantal; Fiscal Year: 2013
    ..Lung, and Blood Diseases. ..
  4. Comparative Biology of Tissue Repair, Regeneration and Aging
    Kevin Strange; Fiscal Year: 2013
    ..The proposed COBRE will greatly enhance MDIBL's growth and development, which in turn will contribute to the continued growth and enhancement of the biomedical research infrastructure in Maine. ..
  5. IBD and Mucosal Inflammation, Immunology, and Microbiology of the GI Tract
    Eugene B Chang; Fiscal Year: 2013
    ..Through its cost-effective, enabling technologies and services, the DDRCC has been a major factor in the advancement of scholarship and discovery in IBD and digestive diseases at the University of Chicago. ..