Pilot Study of an Internet-based Cognitive Stimulation Program in AIDS

Summary

Principal Investigator: James Becker
Abstract: [unreadable] DESCRIPTION (provided by applicant): The neurocognitive manifestations of HIV/AIDS have long been recognized as important for the management, survival, and quality of life of affected patients and their families. Following the advent of Highly active anti-retroviral therapy (HAART) the incidence of HIV-associated dementia (HAD) has fallen, but the prevalence of the milder forms of HIV-related cognitive disorders has risen. This is important because alterations in cognitive function can have significant impact on work and social activities, mood, and perceived quality of life. To date, pharmacological management of HIV-associated cognitive disorders - apart from HAART - have met with limited success (e.g., Peptide T, Ritalin). Therefore, it appears reasonable to ask whether the use of non-pharmacological tools might help alleviate or ameliorate the symptoms of the milder forms of cognitive impairment, and thus improve mood and activities of daily living. The purpose of this application is to request funds to allow us to complete a feasibility/pilot study of the merits of using an internet-based cognitive stimulation program (CSP) to improve the cognitive functions and quality of life of individuals with HIV/AIDS, and, secondarily, to detect such changes using a computerized assessment tool designed for use in a health care practitioner's office (Computer-Based Assessment of Mild Cognitive Impairment (CAMCI)). [unreadable] [unreadable] There has been little success in treating the cognitive (thinking) problems associated with HIV/AIDS using medications. The purpose of this study is to determine whether an internet-based cognitive "stimulation" program might help HIV-infected individuals think more clearly. If this is true, then it means that people with mild forms of cognitive impairment may be able to help themselves to get better. [unreadable] [unreadable] [unreadable] [unreadable]
Funding Period: 2007-09-27 - 2010-08-31
more information: NIH RePORT

Top Publications

  1. pmc Age, Alzheimer disease, and brain structure
    C A Raji
    Departments of Pathology, School of Medicine and Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Neurology 73:1899-905. 2009
  2. pmc Concurrent validity of a computer-based cognitive screening tool for use in adults with HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA
    AIDS Patient Care STDS 25:351-7. 2011
  3. pmc A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Disabil Rehabil 34:1848-52. 2012

Detail Information

Publications3

  1. pmc Age, Alzheimer disease, and brain structure
    C A Raji
    Departments of Pathology, School of Medicine and Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Neurology 73:1899-905. 2009
    ..Lack of clear understanding remains on the overlapping atrophy patterns of aging and early Alzheimer disease (AD) pathology in gray matter (GM) of the brain in vivo...
  2. pmc Concurrent validity of a computer-based cognitive screening tool for use in adults with HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA
    AIDS Patient Care STDS 25:351-7. 2011
    ..A larger trial to obtain risk-group appropriate normative data will be necessary to make the instrument useful in both clinical practice and research (e.g., clinical trials)...
  3. pmc A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Disabil Rehabil 34:1848-52. 2012
    ..We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease...