Burden of Malaria in Pregnancy in India

Summary

Principal Investigator: DAVIDSON HOWES HAMER
Abstract: [unreadable] DESCRIPTION (provided by applicant): Malaria is one of the gravest threats to the health of pregnant women and their unborn babies. Malaria in pregnancy (MIP) is associated with an increased risk of fetal death, prematurity, intrauterine growth retardation (IUGR), low birth weight (LBW), and maternal anemia. In recent years, malaria has reemerged as a public health problem in India, with 1.5-2 million documented cases reported annually by India's National Malaria Control Programme, though these figures probably substantially underestimate the true burden of disease. The development and implementation of effective policies for the prevention and control of MIP in India has been hampered by a lack of detailed information on malaria-associated morbidity during pregnancy and the impact of malaria on birth outcomes. To address these issues, we are proposing a study to be conducted in two districts of Chhattisgarh state, India, one with stable malaria transmission and one with unstable transmission. We aim to establish the impact of MIP on maternal anemia, birth outcomes (LBW, IUGR, and stillbirths), and the relative contributions of Plasmodium falciparum and P. vivaxto malaria-associated morbidity. In addition, we will assess the current availability of MIP interventions, such as chloroquine prophylaxis and insecticide treated bednets, and patient/clinic level factors that influence the utilization of such interventions. This project will be a collaborative effort between scientists at Boston University's Center for International Health and Development, the National Malaria Research Center in Jabalbur, India, and the Malaria Branch of the Centers for Disease Control and Prevention in Atlanta. This project will serve to strenghten the collaborative relationship of these institutions while enhancing the capacity of Indian researchers to design, implement, and analyze data from applied research studies. The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. [unreadable] [unreadable] [unreadable]
Funding Period: 2006-09-20 - 2009-08-31
more information: NIH RePORT

Top Publications

  1. pmc Malaria prevalence among pregnant women in two districts with differing endemicity in Chhattisgarh, India
    Neeru Singh
    Regional Medical Research Centre for Tribals, Jabalpur, Madhya Pradesh, India
    Malar J 11:274. 2012
  2. pmc Impact of biomass fuels on pregnancy outcomes in central East India
    Blair J Wylie
    Division of Maternal Fetal Medicine, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, USA
    Environ Health 13:1. 2014
  3. pmc Decline in temperature and humidity increases the occurrence of influenza in cold climate
    Kari Jaakkola
    Institute of Health Sciences, University of Oulu, P, O, Box 5000, FI 90014 Oulu, Finland
    Environ Health 13:22. 2014
  4. pmc Availability and utilization of malaria prevention strategies in pregnancy in eastern India
    Blair J Wylie
    Center for Global Health and Development, Boston University School of Public Health, Boston, MA, USA
    BMC Public Health 10:557. 2010

Scientific Experts

  • Blair J Wylie
  • Kari Jaakkola
  • Neeru Singh
  • Annika Saukkoriipi
  • Jari Jokelainen
  • Tiina M Ikäheimo
  • Jouni Jk Jaakkola
  • Esa Rönkkö
  • Olli Vainio
  • Raija Juvonen
  • Jaana Kauppila
  • Thedi Ziegler
  • V Udhayakumar
  • Mobassir Hussain
  • Lora Sabin
  • Chander Shekhar
  • Davidson H Hamer
  • Yeboah A Kojo
  • Meghna Desai
  • Mrigendra P Singh

Detail Information

Publications4

  1. pmc Malaria prevalence among pregnant women in two districts with differing endemicity in Chhattisgarh, India
    Neeru Singh
    Regional Medical Research Centre for Tribals, Jabalpur, Madhya Pradesh, India
    Malar J 11:274. 2012
    ....
  2. pmc Impact of biomass fuels on pregnancy outcomes in central East India
    Blair J Wylie
    Division of Maternal Fetal Medicine, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, USA
    Environ Health 13:1. 2014
    ..Our objective was to evaluate effects of exposure to biomass smoke on birth weight, preterm birth and stillbirth...
  3. pmc Decline in temperature and humidity increases the occurrence of influenza in cold climate
    Kari Jaakkola
    Institute of Health Sciences, University of Oulu, P, O, Box 5000, FI 90014 Oulu, Finland
    Environ Health 13:22. 2014
    ..We examined the relations between the level and decrease of temperature, humidity and the risk of influenza A and B virus infections in a subarctic climate...
  4. pmc Availability and utilization of malaria prevention strategies in pregnancy in eastern India
    Blair J Wylie
    Center for Global Health and Development, Boston University School of Public Health, Boston, MA, USA
    BMC Public Health 10:557. 2010
    ..It is not known whether prevention and treatment strategies for malaria in pregnancy (case management, insecticide-treated bednets, intermittent preventive therapy) are widely utilized in India...