Modifiable lifestyle-related factors and triple negative breast cancer prognosis


Principal Investigator: SARAH JEAN NECHUTA
Abstract: DESCRIPTION (provided by applicant): Triple negative breast cancers (TNBCs) are defined as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) negative. TNBCs, accounting for about 11-20% of invasive breast cancers, are more aggressive, have a poorer prognosis, and have few targeted treatment options, compared with hormone-sensitive breast cancers. A growing body of literature suggests post- diagnosis, lifestyle-related factors may impact overall breast cancer prognosis. However, little is known about the role of modifiable lifestyle-related factors in TNBC prognosis. To date, no prospective cohort study has investigated lifestyle-related factors that have been implicated in breast cancer prognosis overall, specifically in the prognosis of TNBC. This effort has not been feasible in the past due primarily to the need for data on post- diagnosis lifestyle factors and breast cancer outcomes in a large population of women with TNBC. The proposed study will overcome these limitations by using the resources of the After Breast Cancer Pooling Project (ABCPP), a collaborative project that includes four prospective cohorts of breast cancer survivors, for which we have successfully pooled and harmonized data on clinical characteristics and lifestyle factors. With the addition of two more ongoing cohort studies, we anticipate a total of approximately 1,550 women diagnosed with invasive TNBC recruited from the United States, the United Kingdom, and Shanghai, China. Our overall hypothesis is that the associations of lifestyle-related factors with breast cancer recurrence and mortality may differ for women with TNBC, as compared to women with ER+ breast cancer, depending on the underlying biological mechanisms for each lifestyle factor-breast cancer outcome association. To investigate this hypothesis, we propose to evaluate the associations of post-diagnosis body mass index, weight change, post-diagnosis recreational physical activity, and select dietary factors suggested to be associated with breast cancer prognosis overall (i.e., soy food intake, vegetable intake, alcohol consumption, and tea consumption) with recurrence, breast cancer-specific mortality, and total mortality among women (1) with TNBC and (2) with ER+ breast cancer. The proposed collaborative study, which will pool the resources of six prospective cohorts of breast cancer survivors, will be the first study that is sufficiently powered to investigate the effect of modifible lifestyle-related factors on TNBC prognosis. The findings of our study will lead to public health recommendations and guidelines appropriate for breast cancer survivors with TNBC, information critically needed, with the ultimate goal of reducing morbidity and mortality among breast cancer survivors. This study, building upon an existing collaborative pooling project and experienced research team, is cost-effective. Further, the proposed project will help sustain collaborative research efforts to promote future pooled analyses in the ABCPP.
Funding Period: 2013-04-01 - 2015-03-31
more information: NIH RePORT

Detail Information

Research Grants30

  1. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
    ..This application is innovative and timely in bridging basic mechanisms, preclinical models, and human studies of epigenetics and diet. ..
  2. COBRE Center for Central Nervous System Function
    Jerome N Sanes; Fiscal Year: 2013
    ..The COBRE Center will leverage the administrative resources available through the Brown Institute for Brain Science to ensure efficient operation and coordinate with other brain science research activities at Brown. ..
  3. Molecular Profiles and Lifestyle Factors in Breast Cancer Prognosis
    Bette J Caan; Fiscal Year: 2013
    ..This population-based cohort is uniquely positioned to address several important gaps in our knowledge about cancer survivorship. ..
    Victor J Hruby; Fiscal Year: 2013
  5. The CYGNET Study: Enviromental and Genetic Determinants of Maturation of Girls
    Lawrence H Kushi; Fiscal Year: 2013
    ..57 comparing high and low quartiles of a continuous variable such as biomarker levels. The investigators anticipate continuing our collaborations with similar studies in Cincinnati and New York. ..
  6. Penn TREC Survivor Center
    Kathryn H Schmitz; Fiscal Year: 2013
    ..abstract_text> ..
  7. Vaccine Immunotoxin and Radioimmunotherapy of Primary and Metastatic CNS Tumors
    Darell D Bigner; Fiscal Year: 2013
    ..abstract_text> ..
    Graham A Colditz; Fiscal Year: 2013
    ..To address these aims, we propose four research projects and five cores that form a cohesive, transdisciplinary center focused on research, training/career development, and dissemination. ..
    Meir Stampfer; Fiscal Year: 2013
    ..abstract_text> ..
  10. Harvard Transdisciplinary Research in Energetics and Cancer Center
    Frank B Hu; Fiscal Year: 2013
    ..By leveraging multiple areas of expertise and different resources within and across TREC centers, we can help further build a unique national resource of energetics and cancer knowledge. ..
  11. Bridging Research, Innovation, Training &Education Solutions for Minority Health
    Vickie M Mays; Fiscal Year: 2013
    ..abstract_text> ..