OPTIMIZED 3D SPIN-ECHO MR IMAGING OF THE CNS

Summary

Principal Investigator: John Mugler
Abstract: DESCRIPTION (Adapted from Applicant's Abstract): The primary objective of this work is to create routinely useful techniques for spin-echo based, three dimensional, single-slab magnetic resonance imaging (MRI) of the human central nervous system (CNS) in clinically reasonable times. The comprehensive, high-resolution coverage accomplished with these new three-dimensional methods will provide more complete descriptions of pathological components of CNS diseases, higher probabilities of detecting focal abnormalities, and more accurate, quantitative evaluations of the extent of lesions. This work seeks to continue to advance the state of the art for high-resolution MRI of the CNS by building upon the progress achieved with three-dimensional single-slab techniques for imaging the brain during the first phase of this project. The current objectives include improving the temporal resolution for whole brain imaging, developing and evaluating three-dimensional single-slab techniques with other clinically-useful contrast behaviors, and extending the applications of these techniques beyond the brain to other territories of the CNS. Specifically, the research aims to: (1) substantially increase the spatial/temporal resolution of the new pulse sequence architectures, (2) extend the range of their contrast behaviors by adding fluid-attenuated inversion-recovery (FLAIR) contrast and robust separation of fat and water signals, (3)incorporate spatial selectivity to permit efficient, high-resolution imaging of the optic nerves and cervical spine, (4) implement the pulse sequences on an MR imager in a research setting and optimize their design, and (5) demonstrate in a clinical setting that the new techniques yield improved resolution with image contrast and artifacts at least comparable to current two-dimensional spin-echo-based techniques.
Funding Period: 1996-05-01 - 2005-08-31
more information: NIH RePORT

Top Publications

  1. ncbi Long-interval T2-weighted subtraction magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials
    Bastiaan Moraal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 67:667-75. 2010
  2. pmc Subtraction MR images in a multiple sclerosis multicenter clinical trial setting
    Bastiaan Moraal
    Departments of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Radiology 250:506-14. 2009
  3. ncbi Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis
    Bastiaan Moraal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Eur Radiol 18:2311-20. 2008
  4. pmc A rhesus monkey reference label atlas for template driven segmentation
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    J Med Primatol 37:250-60. 2008
  5. ncbi Segmentation of subtraction images for the measurement of lesion change in multiple sclerosis
    Y Duan
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    AJNR Am J Neuroradiol 29:340-6. 2008
  6. ncbi MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability
    D S Meier
    Department of Radiology, Center for Neurological Imaging, Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    AJNR Am J Neuroradiol 28:1956-63. 2007
  7. ncbi Time-series modeling of multiple sclerosis disease activity: a promising window on disease progression and repair potential?
    Dominik S Meier
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 4:485-98. 2007
  8. pmc An MRI study of age-related white and gray matter volume changes in the rhesus monkey
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, United States
    Neurobiol Aging 29:1563-75. 2008
  9. ncbi Magnetic resonance imaging of iron deposition in neurological disorders
    Steven D Brass
    Center for Neurological Imaging, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Top Magn Reson Imaging 17:31-40. 2006
  10. ncbi Human gray matter: feasibility of single-slab 3D double inversion-recovery high-spatial-resolution MR imaging
    Petra J W Pouwels
    MS Research Center, Department of Physics and Medical Technology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 241:873-9. 2006

Scientific Experts

Detail Information

Publications17

  1. ncbi Long-interval T2-weighted subtraction magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials
    Bastiaan Moraal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 67:667-75. 2010
    ....
  2. pmc Subtraction MR images in a multiple sclerosis multicenter clinical trial setting
    Bastiaan Moraal
    Departments of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Radiology 250:506-14. 2009
    ....
  3. ncbi Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis
    Bastiaan Moraal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Eur Radiol 18:2311-20. 2008
    ..A selection of single-slab 3D contrasts, for example, 3D-FLAIR and 3D-DIR, could replace 2D sequences in the radiological practice...
  4. pmc A rhesus monkey reference label atlas for template driven segmentation
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    J Med Primatol 37:250-60. 2008
    ..To analyze these legacy data for regional volume changes, we have created a reference label atlas for the Template Driven Segmentation (TDS) algorithm...
  5. ncbi Segmentation of subtraction images for the measurement of lesion change in multiple sclerosis
    Y Duan
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    AJNR Am J Neuroradiol 29:340-6. 2008
    ....
  6. ncbi MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability
    D S Meier
    Department of Radiology, Center for Neurological Imaging, Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    AJNR Am J Neuroradiol 28:1956-63. 2007
    ..With the use of time-series modeling of MR imaging intensity, our study relates the short-term dynamics of new T2 lesion formation to those of contrast enhancement and markers of long-term progression of disease...
  7. ncbi Time-series modeling of multiple sclerosis disease activity: a promising window on disease progression and repair potential?
    Dominik S Meier
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 4:485-98. 2007
    ....
  8. pmc An MRI study of age-related white and gray matter volume changes in the rhesus monkey
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, United States
    Neurobiol Aging 29:1563-75. 2008
    ..We found that none of the cognitive measures were related to ROI volume changes in our sample size of monkeys...
  9. ncbi Magnetic resonance imaging of iron deposition in neurological disorders
    Steven D Brass
    Center for Neurological Imaging, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Top Magn Reson Imaging 17:31-40. 2006
    ..The potential role of iron deposition and its assessment by MRI provides exciting potential applications to the diagnosis, longitudinal monitoring, and therapeutic development for disorders of the brain...
  10. ncbi Human gray matter: feasibility of single-slab 3D double inversion-recovery high-spatial-resolution MR imaging
    Petra J W Pouwels
    MS Research Center, Department of Physics and Medical Technology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 241:873-9. 2006
    ..These GM images with high spatial resolution are suitable to identify cortical pathologic conditions and can potentially be used for segmentation purposes to determine cortical thickness or volume...
  11. ncbi MRI time series modeling of MS lesion development
    Dominik S Meier
    Center for Neurological Imaging, Brigham and Women s Hospital, 221 Longwood Avenue, RF 396, Boston, MA 02115, USA
    Neuroimage 32:531-7. 2006
    ..Concentric patterns of dynamic properties within a lesion were observed, consistent with concentric histological appearance of resulting MS plaques...
  12. ncbi Automated segmentation of multiple sclerosis lesion subtypes with multichannel MRI
    Ying Wu
    Center for Neurological Imaging, Departments of Radiology and Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue RF394A, Boston, MA 02115, USA
    Neuroimage 32:1205-15. 2006
    ..To automatically segment multiple sclerosis (MS) lesions into three subtypes (i.e., enhancing lesions, T1 "black holes", T2 hyperintense lesions)...
  13. ncbi Can MRI reveal phenotypes of multiple sclerosis?
    Charles R G Guttmann
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Magn Reson Imaging 24:475-81. 2006
    ..In conjunction with clinical, immunological, serological and genetic information, clusters of MS patients with distinct clinical prognosis and diverse response profiles to available and future treatments may be identified...
  14. ncbi Detection of lesions in multiple sclerosis by 2D FLAIR and single-slab 3D FLAIR sequences at 3.0 T: initial results
    Andrea Bink
    Department of Neuroradiology, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt Main, Germany
    Eur Radiol 16:1104-10. 2006
    ..0 T for detection of lesions in patients with MS. With the 3D FLAIR sequence significantly higher CNRs were achieved and significantly more lesions in patients with MS were detected...
  15. ncbi Multiple sclerosis medical image analysis and information management
    Lifeng Liu
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 15:103S-117S. 2005
    ..The authors' system can be extended to general applications in clinical trials and to routine processing for image-based clinical research...
  16. ncbi Magnetic resonance imaging of the body trunk using a single-slab, 3-dimensional, T2-weighted turbo-spin-echo sequence with high sampling efficiency (SPACE) for high spatial resolution imaging: initial clinical experiences
    Matthias Philipp Lichy
    Department of Diagnostic Radiology, University of Tubingen, Tubingen, Germany
    Invest Radiol 40:754-60. 2005
    ..The authors conducted a clinical evaluation of single-slab, 3-dimensional, T2-weighted turbo-spin-echo (TSE) with high sampling efficiency (SPACE) for high isotropic body imaging with large field-of-view (FoV)...
  17. ncbi Efficient multi-modal dense field non-rigid registration: alignment of histological and section images
    Aloys du Bois d'Aische
    Communications and Remote Sensing Laboratory, Universite Catholique de Louvain, B 1348 Louvain la Neuve, Belgium
    Med Image Anal 9:538-46. 2005
    ..A further acceleration in speed without cost of accuracy is achieved by using an adaptive mesh refinement strategy...