Neurology of Attention and Neglect-A Network Approach

Summary

Principal Investigator: MAREK MARSEL M MESULAM
Abstract: This is a competitive renewal application for a project addressing the neurological mechanisms of spatial attention. The proposed studies will use the methodology of functional magnetic resonance imaging (fMRI) and will be conducted on young volunteer subjects. Spatial attention is frequently impaired in patients with brain damage. The most common impairment of spatial attention is known as hemispatial neglect. This condition interferes with the ability to attend to the environment and severely disrupts a wide range of daily living activities ranging from reading to driving. Up to 82% of all patients with damage in the right side of the brain display some manifestation of this syndrome. More than 20 years ago, work on brain damaged patients led us to propose that spatial attention was normally controlled by a large-scale network of interconnected areas in the cingulate gyrus, frontal cortex, and posterior parietal cortex. During the past project period, we used fMRI methodology to establish the face validity and general outlines of this network. These experiments raised new questions and hypotheses related to the internal organization of the attentional network. Our goal during the next project period is to pursue these questions and hypotheses with the help of functional magnetic resonance imaging (fMRI). We have three broad goals, each containing multiple questions raised by experiments performed in the current project period. Our first goal is to delineate functional segregations within the parietal, frontal, and cingulate components of the attentional network. Our second goal is to determine the way in which the attentional network interacts with other networks related to motivation, eye movements, and working memory. Our third goal is to address the nature of hemispheric asymmetry in spatial attention. We designed 7 experiments and generated specific hypotheses in order to pursue these goals. The proposed experiments will address new questions on visual search and the relationship of spatial attention to reward and punishment. The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect.
Funding Period: 1993-09-29 - 2008-11-30
more information: NIH RePORT

Top Publications

  1. ncbi Anatomical physiology of spatial extinction
    Metehan Cicek
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cereb Cortex 17:2892-8. 2007
  2. ncbi Remapping attentional priorities: differential contribution of superior parietal lobule and intraparietal sulcus
    Pascal Molenberghs
    Cognitive Neurology Laboratory, Experimental Neurology Section, Katholieke Universiteit Leuven, Belgium
    Cereb Cortex 17:2703-12. 2007
  3. ncbi The cerebellum predicts the timing of perceptual events
    Jill X O'Reilly
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 28:2252-60. 2008
  4. pmc The spatial attention network interacts with limbic and monoaminergic systems to modulate motivation-induced attention shifts
    Aprajita Mohanty
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cereb Cortex 18:2604-13. 2008
  5. pmc Neural repetition suppression reflects fulfilled perceptual expectations
    Christopher Summerfield
    INSERM U742, Université Pierre et Marie Currie, 9 Quai St Bernard, 75005 Paris, France
    Nat Neurosci 11:1004-6. 2008
  6. ncbi Search for a threatening target triggers limbic guidance of spatial attention
    Aprajita Mohanty
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 29:10563-72. 2009
  7. pmc TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
    William D Hastings
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 39:2492-501. 2009

Detail Information

Publications7

  1. ncbi Anatomical physiology of spatial extinction
    Metehan Cicek
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cereb Cortex 17:2892-8. 2007
    ....
  2. ncbi Remapping attentional priorities: differential contribution of superior parietal lobule and intraparietal sulcus
    Pascal Molenberghs
    Cognitive Neurology Laboratory, Experimental Neurology Section, Katholieke Universiteit Leuven, Belgium
    Cereb Cortex 17:2703-12. 2007
    ..Collectively, these 2 areas allow posterior parietal cortex to dynamically encode extrapersonal events according to their spatial coordinates and valence...
  3. ncbi The cerebellum predicts the timing of perceptual events
    Jill X O'Reilly
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 28:2252-60. 2008
    ..Finally, in temporal-spatial prediction, functional connectivity was enhanced between the cerebellum and the putamen, a structure which has been proposed to supply the brain's metric of time, in the temporal-spatial prediction task...
  4. pmc The spatial attention network interacts with limbic and monoaminergic systems to modulate motivation-induced attention shifts
    Aprajita Mohanty
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cereb Cortex 18:2604-13. 2008
    ....
  5. pmc Neural repetition suppression reflects fulfilled perceptual expectations
    Christopher Summerfield
    INSERM U742, Université Pierre et Marie Currie, 9 Quai St Bernard, 75005 Paris, France
    Nat Neurosci 11:1004-6. 2008
    ..Our data suggest that repetition suppression reflects a relative reduction in top-down perceptual 'prediction error' when processing an expected, compared with an unexpected, stimulus...
  6. ncbi Search for a threatening target triggers limbic guidance of spatial attention
    Aprajita Mohanty
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 29:10563-72. 2009
    ....
  7. pmc TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
    William D Hastings
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 39:2492-501. 2009
    ..These results suggest that TIM-3 is a negative regulator of human T cells and regulates Th1 and Th17 cytokine secretion...