ISGS: The Ischemic Stroke Genetics Study

Summary

Principal Investigator: JAMES MESCHIA
Abstract: Stroke is the third leading cause of death in industrialized countries and the leading cause of disability in adults. Epidemiological and twins studies strongly support an inherited component to stroke risk. The broad long-term objective of this application is to clarify the molecular basis for inherited ischemic stroke risk. The application focuses on thrombosis genes because of overwhelming evidence for the etiologic relevance of thrombosis in acute ischemic stroke that comes from clinical prevention and treatment trials and emergent angiography studies. The specific aims of this application are: (1) to collect DNA and create immortalized cell lines from patients with recent ischemic stroke and from healthy control subjects and (2) to test for associations between ischemic stroke and candidate thrombosis genes. The candidate genes to be tested are the beta fibrinogen gene and genes that code for components of 3 platelet glycoprotein receptors GPIIb/IIIa, GPIb, and GPla. These genes were selected based on previous studies demonstrating associations between variations in these genes and ischemic stroke, either overall or in subgroup analyses. Four hundred and fifty [450] patients with recent CTIMR-confirmed ischemic stroke will be recruited from inpatient services at 5 US clinical centers over 3 years. Four hundred and fifty [450] controls will be enrolled concurrently. Matching criteria will be age, sex, and race (African-American versus non-African-American). The prospective design of this application permits rigorous exploration of whether there is heterogeneity in genetic risk factors among common ischemic stroke subtypes that are defined clinically. Patients will have dual subtyping by certified study neurologists using standardized classification systems: the Trial of ORG 10172 Acute Stroke Treatment (TOAST) system and the Oxfordshire Community Stroke Project system. This application has been designed to permit valid pooled analyses with SWISS, an ongoing affected sibling pair study supported by the NINDS (ROI NS39987). The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria.
Funding Period: 2002-07-15 - 2009-05-31
more information: NIH RePORT

Top Publications

  1. pmc Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies
    Rainer Malik
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom S B, H S M Laboratory of Neurogenetics M A N and Laboratory of Epidemiology and Population Sciences L J L, National Institute on Aging, National Institutes of Health, Bethesda, MD Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H and Center for Translational Neuroscience and Mental Health Research C L, University of Newcastle, Callaghan, NSW, Australia Center for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, New Lambton, NSW, Australia E G H Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA W J D, J R Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Y C C, B D M Department of Veterans Affairs and Veterans Affairs Medical Center, Baltimore Geriatric Research, Education, and Clinical Center GRECC, Baltimore, MD Y C C, B D M Department of Epidemiology C A I V, B F J V, Baltimore
    Stroke 45:394-402. 2014
  2. pmc Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke
    M G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, FL 32224, USA
    Eur J Neurol 20:300-8. 2013
  3. pmc Ischemic stroke is associated with the ABO locus: the EuroCLOT study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, United Kingdom
    Ann Neurol 73:16-31. 2013
  4. pmc Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy
    Nadine Norton
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Circ Cardiovasc Genet 6:144-53. 2013
  5. pmc Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals
    Tauseef A Khan
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 42:475-92. 2013
  6. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
  7. pmc Genome-wide analysis of blood pressure variability and ischemic stroke
    Sunaina Yadav
    From the Imperial College Cerebrovascular Research Unit ICCRU S Y, I C, M S K, N H, M P, P E R, P S and International Centre for Circulatory Health P S, Imperial College London, London, United Kingdom Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H, M M, J A, School of Nursing and Midwifery J M M, and School of Biomedical Sciences and Pharmacy R J S, University of Newcastle, Newcastle, New South Wales, Australia Hunter Medical Research Institute, Newcastle, New South Wales, Australia E G H, J M M, M M, R J S, J A Institute for Stroke and Dementia Research ISD, Medical Centre, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany R M, M D Munich Cluster for Systems Neurology SyNergy, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, Germany
    Stroke 44:2703-9. 2013
  8. pmc Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes
    James F Meschia
    From the Mayo Clinic Jacksonville, FL J F M University of Alabama at Birmingham D K A, L A M Mayo Clinic Rochester, MN R D B Massachusetts General Hospital, Boston, MA H A, J R, O W University of British Columbia, Vancouver, British Columbia, Canada O R B University of Maryland School of Medicine and Veterans Administration Medical Center, Baltimore, MD J W C, P F M, B D M, A R S, S J K University Medical Center Utrecht, Utrecht, The Netherlands P I W d B Brigham and Women s Hospital, Harvard Medical School, Boston, MA P I W d B Broad Institute of Harvard, MIT, Cambridge, MA P I W d B Klinikum der Universität München, Ludwig Maximilians University, Munich, Germany M D Johns Hopkins University, Baltimore, MD K F D University of Texas Health Science Center at Houston M F Saint Francis Medical Center, Lynwood, CA R P G NINDS Neurogenetics Cluster, Bethesda, MD K G IMIM Hospital Universitari del Mar, Barcelona, Spain J J C University of Florida, College of Pharmacy, Gainesville, FL J A J Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Germany
    Stroke 44:2694-702. 2013
  9. pmc NOTCH3 variants and risk of ischemic stroke
    Owen A Ross
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 8:e75035. 2013
  10. pmc Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    Martin Dichgans
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany M D, R Malik Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Institut für Medizinische Biometrie und Statistik I R K, and Institut für integrative und experimentelle Genomik J E, Universitat zu Lubeck, Lubeck, Germany Universitätsklinikum Schleswig Holstein, Campus Lubeck, Germany I R K Department of Neurology and Center for Human Genetic Research J R, and Cardiology Division C J O D, Massachusetts General Hospital, Boston Harvard Medical School, Boston, MA J R Program in Medical and Population Genetics J R, and Program in Medical and Population Genetics S K, Broad Institute of Harvard and MIT, Cambridge, MA Clinical Trial Service Unit and Epidemiological Studies Unit R C, J C H, Wellcome Trust Centre for Human Genetics H W, M Farrall, Department of Cardiovascular Medicine M Farrall, and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience P M R, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom deCODE Genetics, Reykjavik, Iceland S G, G T, U T
    Stroke 45:24-36. 2014

Scientific Experts

  • JAMES MESCHIA
  • Natalia S Rost
  • Min Zhuo
  • Bradford B Worrall
  • Mar Matarin
  • Stephen S Rich
  • Thomas G Brott
  • Robert D Brown
  • Braxton D Mitchell
  • Pankaj Sharma
  • Martin Dichgans
  • Yu Ching Cheng
  • Jonathan Rosand
  • Owen A Ross
  • Hugh S Markus
  • Steve Bevan
  • Rainer Malik
  • Elizabeth G Holliday
  • Michael A Nalls
  • Luigi Ferrucci
  • Andreas Gschwendtner
  • Andrew Singleton
  • Peter M Rothwell
  • Christopher Levi
  • Myriam Fornage
  • Joshua C Bis
  • Cathie Sudlow
  • Sudha Seshadri
  • M Arfan Ikram
  • W Mark Brown
  • Giorgio B Boncoraglio
  • Eugenio A Parati
  • Sruti Rayaprolu
  • L Douglas Case
  • John Attia
  • Rodney J Scott
  • Sunaina Yadav
  • Zbigniew K Wszolek
  • Karen L Furie
  • Christopher D Anderson
  • John W Cole
  • John Hardy
  • O A Ross
  • Andrew B Singleton
  • John A Hardy
  • Scott L Silliman
  • Bruce M Psaty
  • Robert Clarke
  • Martin Farrall
  • Gudmar Thorleifsson
  • Kari Stefansson
  • Solveig Gretarsdottir
  • Unnur Thorsteinsdottir
  • Frances M K Williams
  • M G Heckman
  • Tauseef A Khan
  • Nadine Norton
  • Jane M Maguire
  • BRADFORD WORRALL
  • Michael Nalls
  • Wei Min Chen
  • Ronald C Petersen
  • Debbie A Lawlor
  • Juan P Casas
  • Ian R Mackenzie
  • Kay Tee Khaw
  • Ryan J Uitti
  • Rosa Rademakers
  • Philippa J Talmud
  • Shah Ebrahim
  • Bruce L Miller
  • Jackie Cooper
  • Catherine Lomen-Hoerth
  • Eileen H Bigio
  • Bradley F Boeve
  • Alexandra I Soto-Ortolaza
  • Steve E Humphries
  • Jaroslav A Hubacek
  • David S Knopman
  • George Davey Smith
  • Charles L White
  • Kimmo J Hatanpaa
  • Zoltan Szolnoki
  • Elizabeth Finger
  • Steven G Younkin
  • Carol Lippa
  • Andrew Kertesz
  • Neill R Graff-Radford
  • Matt Baker
  • Aroon D Hingorani

Detail Information

Publications36

  1. pmc Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies
    Rainer Malik
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom S B, H S M Laboratory of Neurogenetics M A N and Laboratory of Epidemiology and Population Sciences L J L, National Institute on Aging, National Institutes of Health, Bethesda, MD Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H and Center for Translational Neuroscience and Mental Health Research C L, University of Newcastle, Callaghan, NSW, Australia Center for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, New Lambton, NSW, Australia E G H Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA W J D, J R Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Y C C, B D M Department of Veterans Affairs and Veterans Affairs Medical Center, Baltimore Geriatric Research, Education, and Clinical Center GRECC, Baltimore, MD Y C C, B D M Department of Epidemiology C A I V, B F J V, Baltimore
    Stroke 45:394-402. 2014
    ..We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts...
  2. pmc Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke
    M G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, FL 32224, USA
    Eur J Neurol 20:300-8. 2013
    ..This study evaluated whether genetic risk factors for CAD and MI also affect susceptibility to ischaemic stroke in Caucasians and African Americans...
  3. pmc Ischemic stroke is associated with the ABO locus: the EuroCLOT study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, United Kingdom
    Ann Neurol 73:16-31. 2013
    ..We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype...
  4. pmc Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy
    Nadine Norton
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Circ Cardiovasc Genet 6:144-53. 2013
    ..However, the lack of segregation of all identified TTN truncating variants illustrates the challenge of determining variant pathogenicity even with full exome sequencing...
  5. pmc Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals
    Tauseef A Khan
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 42:475-92. 2013
    ..We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk...
  6. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
    ..With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders...
  7. pmc Genome-wide analysis of blood pressure variability and ischemic stroke
    Sunaina Yadav
    From the Imperial College Cerebrovascular Research Unit ICCRU S Y, I C, M S K, N H, M P, P E R, P S and International Centre for Circulatory Health P S, Imperial College London, London, United Kingdom Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H, M M, J A, School of Nursing and Midwifery J M M, and School of Biomedical Sciences and Pharmacy R J S, University of Newcastle, Newcastle, New South Wales, Australia Hunter Medical Research Institute, Newcastle, New South Wales, Australia E G H, J M M, M M, R J S, J A Institute for Stroke and Dementia Research ISD, Medical Centre, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany R M, M D Munich Cluster for Systems Neurology SyNergy, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, Germany
    Stroke 44:2703-9. 2013
    ..We sought to determine whether such variability has genetic causes and whether genetic variants associated with BP variability are also associated with ischemic stroke...
  8. pmc Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes
    James F Meschia
    From the Mayo Clinic Jacksonville, FL J F M University of Alabama at Birmingham D K A, L A M Mayo Clinic Rochester, MN R D B Massachusetts General Hospital, Boston, MA H A, J R, O W University of British Columbia, Vancouver, British Columbia, Canada O R B University of Maryland School of Medicine and Veterans Administration Medical Center, Baltimore, MD J W C, P F M, B D M, A R S, S J K University Medical Center Utrecht, Utrecht, The Netherlands P I W d B Brigham and Women s Hospital, Harvard Medical School, Boston, MA P I W d B Broad Institute of Harvard, MIT, Cambridge, MA P I W d B Klinikum der Universität München, Ludwig Maximilians University, Munich, Germany M D Johns Hopkins University, Baltimore, MD K F D University of Texas Health Science Center at Houston M F Saint Francis Medical Center, Lynwood, CA R P G NINDS Neurogenetics Cluster, Bethesda, MD K G IMIM Hospital Universitari del Mar, Barcelona, Spain J J C University of Florida, College of Pharmacy, Gainesville, FL J A J Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Germany
    Stroke 44:2694-702. 2013
    ..The National Institute of Neurological Disorders and Stroke SiGN (Stroke Genetics Network) contributes substantially to meta-analyses that focus on specific subtypes of stroke...
  9. pmc NOTCH3 variants and risk of ischemic stroke
    Owen A Ross
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 8:e75035. 2013
    ..The role of other exonic NOTCH3 variation not involving cysteine residues and mutations in exons 25-33 in ischemic stroke remains unresolved...
  10. pmc Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    Martin Dichgans
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany M D, R Malik Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Institut für Medizinische Biometrie und Statistik I R K, and Institut für integrative und experimentelle Genomik J E, Universitat zu Lubeck, Lubeck, Germany Universitätsklinikum Schleswig Holstein, Campus Lubeck, Germany I R K Department of Neurology and Center for Human Genetic Research J R, and Cardiology Division C J O D, Massachusetts General Hospital, Boston Harvard Medical School, Boston, MA J R Program in Medical and Population Genetics J R, and Program in Medical and Population Genetics S K, Broad Institute of Harvard and MIT, Cambridge, MA Clinical Trial Service Unit and Epidemiological Studies Unit R C, J C H, Wellcome Trust Centre for Human Genetics H W, M Farrall, Department of Cardiovascular Medicine M Farrall, and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience P M R, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom deCODE Genetics, Reykjavik, Iceland S G, G T, U T
    Stroke 45:24-36. 2014
    ..Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases...
  11. pmc White matter hyperintensity volume is increased in small vessel stroke subtypes
    N S Rost
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Massachusetts General Hospital, 175 Cambridge St, Suite 300, Boston, MA 02114, USA
    Neurology 75:1670-7. 2010
    ..Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant...
  12. pmc Ataxin-2 repeat-length variation and neurodegeneration
    Owen A Ross
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Hum Mol Genet 20:3207-12. 2011
    ....
  13. pmc Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
    Michael V Holmes
    Research Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 378:584-94. 2011
    ..We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials...
  14. pmc Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 6:e23161. 2011
    ..We present a meta-analysis of genome-wide association scans (GWAS) from 3 cohorts to identify the contribution of common variants to ischemic stroke risk...
  15. pmc Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?
    Yu Ching Cheng
    Department of Medicine, University of Maryland School of Medicine, 660 W Redwood St, Howard Hall, Room 492, Baltimore, MD 21201, USA
    Stroke 43:980-6. 2012
    ..To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently associated with MI or CAD through genome-wide association studies were associated with IS...
  16. pmc Common mitochondrial sequence variants in ischemic stroke
    Christopher D Anderson
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, USA
    Ann Neurol 69:471-80. 2011
    ..We investigated whether common mitochondrial genetic variants influence risk of sporadic ischemic stroke and, in patients with stroke, the volume of white matter hyperintensity (WMHV)...
  17. ncbi Ischemic stroke as a complex genetic disorder
    James F Meschia
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Semin Neurol 26:49-56. 2006
    ..Family history studies suggest that some subphenotypes like cardioembolic stroke may be less heritable than others...
  18. pmc PDE4D and stroke: a real advance or a case of the Emperor's new clothes?
    Bradford B Worrall
    Stroke 37:1955-7. 2006
  19. pmc Family history of stroke and severity of neurologic deficit after stroke
    J F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurology 67:1396-402. 2006
    ..A family history of stroke is an independent risk factor for stroke...
  20. pmc IL1RN VNTR polymorphism in ischemic stroke: analysis in 3 populations
    Bradford B Worrall
    Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA
    Stroke 38:1189-96. 2007
    ..The purpose of this study was to confirm our earlier finding of an association between allele 2 of a variable number tandem repeat of the IL-1 receptor antagonist gene (IL1RN) and cerebrovascular disease...
  21. pmc A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
    Mar Matarin
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 6:414-20. 2007
    ..We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same...
  22. pmc Association of integrin alpha2 gene variants with ischemic stroke
    Mar Matarin
    Neurogenetics Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 28:81-9. 2008
    ..These results provide additional support for a role for platelet receptor genes in the pathogenesis of ischemic stroke of diverse subtypes...
  23. ncbi Advancing stroke therapeutics through genetic understanding
    O A Ross
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Curr Drug Targets 8:850-9. 2007
    ..Identifying possible genetic determinants of outcome will also open new avenues of research into stroke therapeutics beyond thrombolysis...
  24. ncbi A synaptic model for pain: long-term potentiation in the anterior cingulate cortex
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Cells 23:259-71. 2007
    ..Understanding signaling pathways related to ACC LTP may help us to identify novel drug target for various mental disorders...
  25. pmc Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic stroke
    Kevin M Barrett
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:34-9. 2007
    ..The purpose of the study was to assess whether there were sex differences in stroke severity, infarct characteristics, symptoms, or the symptoms-deficit relationship at the time of acute stroke presentation...
  26. pmc Sex differences in stroke evaluations in the Ischemic Stroke Genetics Study
    Thabele M Leslie-Mazwi
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:187-93. 2007
    ..Sex differences in stroke evaluation could lead to sex differences in the validity of diagnosing ischemic stroke subtypes. This study assessed sex differences in the Ischemic Stroke Genetics Study (ISGS)...
  27. pmc Impact of restricting enrollment in stroke genetics research to adults able to provide informed consent
    Donna T Chen
    Department of Public Health Sciences, University of Virginia Center for Biomedical Ethics, University of Virginia, Charlottesville, VA, USA
    Stroke 39:831-7. 2008
    ..The purpose of this study was to assess differences in stroke cohort characteristics between those who provided informed consent and those whose enrollment was authorized by surrogate decision makers...
  28. pmc Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21
    Mar Matarin
    Stroke 39:1586-9. 2008
    ..Given that stroke is a common complication after myocardial infarction, we investigated if the same SNPs were associated with ischemic stroke in our population...
  29. pmc Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke
    Andreas Gschwendtner
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistrasse 15, Munich, Germany
    Ann Neurol 65:531-9. 2009
    ..3. Stroke, in particular, ischemic stroke caused by atherosclerotic disease, shares common mechanisms with myocardial infarction. We investigated whether the 9p21 region contributes to ischemic stroke risk...
  30. pmc Prestroke physical activity and early functional status after stroke
    N Stroud
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Neurol Neurosurg Psychiatry 80:1019-22. 2009
    ..The effect of exercise on stroke severity and stroke outcomes is less clear. This study aimed to assess that effect...
  31. pmc Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 58:351-61. 2005
    ..There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations...