Post-trial HIV Vaccines: Receptivity, Risk & Disparities

Summary

Principal Investigator: WILLIAM EMERY CUNNINGHAM
Abstract: [unreadable] DESCRIPTION (provided by applicant): As 40,000 persons contract HIV each year in the U.S., developing and disseminating effective HIV vaccines is a primary scientific and public health objective. This proposal seeks funding to conduct research on populations at risk to facilitate optimal future post-trial dissemination of HIV vaccines and maximize the vaccines' potential to help control the HIV epidemic. The specific aims are: 1) To examine consumer acceptability of HIV vaccines and intentions to change HIV risk behaviors, and how acceptability and intentions vary with attributes of the hypothetical vaccines (e.g., efficacy, side effects, cost, etc.); 2) To examine how post-trial HIV vaccine acceptability and risk behavior intentions, and their relationship to vaccine attributes, vary with sociodemographic characteristics, HIV vaccine knowledge, and barriers to and motivators for vaccine uptake; and 3) To examine the direct and indirect effects on HIV vaccine acceptability and risk behavior intentions of a broad range of independent variables derived from theory: sociodemographic characteristics, past health care experiences, past HIV risk behaviors, past HIV testing behaviors, past vaccine uptake, HIV vaccine knowledge, barriers, and motivators, using structural equation modeling. To address these aims, we will conduct a survey of a representative, probability sample of 1200 demographically diverse persons attending three types of venues in Los Angeles: Sexually Transmitted Disease Clinics, Needle Exchange Programs, and Latino Community Health and HIV Prevention Clinics. We will assess the acceptability of post-trial HIV vaccines and intentions to change risk behaviors using conjoint analysis, a technique increasingly used in health research. Hypothetical HIV vaccines with different levels of seven dichotomous attributes (efficacy, side effects, duration of protection, number of doses, route, number of subtypes, cost) are presented to elicit vaccine preferences and intentions regarding vaccine uptake and changes in risk behavior. Intentions will be compared across respondents' characteristics, e.g., whether Latinos' distrust of government mediates their lower acceptability of HIV vaccines. Results of this analysis will enable us to develop empirical, consumer-based social marketing and public health education strategies tailored to target populations, and will help guide public health agencies toward optimal dissemination of future HIV vaccines. [unreadable] [unreadable] [unreadable]
Funding Period: 2004-09-29 - 2009-03-31
more information: NIH RePORT

Top Publications

  1. pmc Endorsement of compulsory HIV vaccination policy among populations at high risk of HIV exposure (LA VOICES)
    Peter A Newman
    Factor Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street West, Toronto, Ontario, Canada, M5S 1 V4
    Prev Sci 15:428-35. 2014
  2. pmc Use of conjoint analysis to assess HIV vaccine acceptability: feasibility of an innovation in the assessment of consumer health-care preferences
    S J Lee
    University of California Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Center for Community Health, Los Angeles, CA, USA
    Int J STD AIDS 23:235-41. 2012
  3. pmc "Once Bitten, Twice Shy": participant perspectives in the aftermath of an early HIV vaccine trial termination
    P A Newman
    University of Toronto, Factor Inwentash Faculty of Social Work, Centre for Applied Social Research, 246 Bloor Street West, Toronto, Ontario, Canada
    Vaccine 29:451-8. 2011
  4. pmc The impact of acculturation on utilization of HIV prevention services and access to care among an at-risk Hispanic population
    Janni J Kinsler
    Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Health Care Poor Underserved 20:996-1011. 2009
  5. pmc Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES)
    Peter A Newman
    Centre for Applied Social Research, Factor Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street West, Toronto, Ontario, Canada
    Health Serv Res 44:2167-79. 2009
  6. pmc What can HIV vaccine trials teach us about future HIV vaccine dissemination?
    Peter A Newman
    University of Toronto, Centre for Applied Social Research, Faculty of Social Work, 246 Bloor Street West, Toronto, Ontario, Canada M5S 1A1
    Vaccine 26:2528-36. 2008
  7. pmc Experiences of social stigma and implications for healthcare among a diverse population of HIV positive adults
    Jennifer N Sayles
    Division of General Internal Medicine, University of California, Los Angeles, CA, USA
    J Urban Health 84:814-28. 2007
  8. ncbi The effect of perceived stigma from a health care provider on access to care among a low-income HIV-positive population
    Janni J Kinsler
    Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    AIDS Patient Care STDS 21:584-92. 2007
  9. pmc The association between life chaos, health care use, and health status among HIV-infected persons
    Mitchell D Wong
    UCLA Division of General Internal Medicine and Health Services Research, University of California, 911 Broxton Avenue, Suite 101, Los Angeles, CA 90024, USA
    J Gen Intern Med 22:1286-91. 2007
  10. ncbi Factors associated with engaging socially marginalized HIV-positive persons in primary care
    Maureen H Rumptz
    Program Design and Evaluation Services, Multnomah County Health Department, Portland, Oregon 97232, USA
    AIDS Patient Care STDS 21:S30-9. 2007

Detail Information

Publications15

  1. pmc Endorsement of compulsory HIV vaccination policy among populations at high risk of HIV exposure (LA VOICES)
    Peter A Newman
    Factor Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street West, Toronto, Ontario, Canada, M5S 1 V4
    Prev Sci 15:428-35. 2014
    ....
  2. pmc Use of conjoint analysis to assess HIV vaccine acceptability: feasibility of an innovation in the assessment of consumer health-care preferences
    S J Lee
    University of California Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Center for Community Health, Los Angeles, CA, USA
    Int J STD AIDS 23:235-41. 2012
    ..Conjoint analysis provided insights into universal and population-specific preferences among diverse end users of future HIV vaccines, with implications for evidence-informed targeting of dissemination efforts to optimize vaccine uptake...
  3. pmc "Once Bitten, Twice Shy": participant perspectives in the aftermath of an early HIV vaccine trial termination
    P A Newman
    University of Toronto, Factor Inwentash Faculty of Social Work, Centre for Applied Social Research, 246 Bloor Street West, Toronto, Ontario, Canada
    Vaccine 29:451-8. 2011
    ..Future HIV vaccine trials may benefit from increased emphasis on: (1) communication mechanisms among participants, investigators and trial sponsors, and (2) post-trial dissemination of information and psychosocial support...
  4. pmc The impact of acculturation on utilization of HIV prevention services and access to care among an at-risk Hispanic population
    Janni J Kinsler
    Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Health Care Poor Underserved 20:996-1011. 2009
    ..The purpose of this study was to evaluate the relationship of acculturation with HIV and hepatitis C testing, and access to care among Hispanics at risk for HIV...
  5. pmc Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES)
    Peter A Newman
    Centre for Applied Social Research, Factor Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street West, Toronto, Ontario, Canada
    Health Serv Res 44:2167-79. 2009
    ..To assess HIV vaccine acceptability among high-risk adults in Los Angeles...
  6. pmc What can HIV vaccine trials teach us about future HIV vaccine dissemination?
    Peter A Newman
    University of Toronto, Centre for Applied Social Research, Faculty of Social Work, 246 Bloor Street West, Toronto, Ontario, Canada M5S 1A1
    Vaccine 26:2528-36. 2008
    ....
  7. pmc Experiences of social stigma and implications for healthcare among a diverse population of HIV positive adults
    Jennifer N Sayles
    Division of General Internal Medicine, University of California, Los Angeles, CA, USA
    J Urban Health 84:814-28. 2007
    ..We discuss implications of HIV-related stigma for the mental and physical health of HIV-positive women and men and suggestions for possible interventions to address stigma in the healthcare setting...
  8. ncbi The effect of perceived stigma from a health care provider on access to care among a low-income HIV-positive population
    Janni J Kinsler
    Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    AIDS Patient Care STDS 21:584-92. 2007
    ..Interventions are needed to reduce perceived stigma in the health care setting. Educational programs and modeling of nonstigmatizing behavior can teach health care providers to provide unbiased care...
  9. pmc The association between life chaos, health care use, and health status among HIV-infected persons
    Mitchell D Wong
    UCLA Division of General Internal Medicine and Health Services Research, University of California, 911 Broxton Avenue, Suite 101, Los Angeles, CA 90024, USA
    J Gen Intern Med 22:1286-91. 2007
    ..Whether having a stable and predictable lifestyle is associated with health care use and health status among HIV patients is unknown...
  10. ncbi Factors associated with engaging socially marginalized HIV-positive persons in primary care
    Maureen H Rumptz
    Program Design and Evaluation Services, Multnomah County Health Department, Portland, Oregon 97232, USA
    AIDS Patient Care STDS 21:S30-9. 2007
    ....
  11. ncbi Making the connection: the importance of engagement and retention in HIV medical care
    Carol Tobias
    Health and Disability Working Group, Boston University School of Public Health, Boston, Massachusetts 02210, USA
    AIDS Patient Care STDS 21:S3-8. 2007
    ..Interventions to engage and retain underserved populations living with HIV in medical care are essential to ensure access to medical care and to reduce disparities in health outcomes...
  12. pmc Willingness to participate in HIV vaccine trials: the impact of trial attributes
    Peter A Newman
    University of Toronto, Faculty of Social Work, Centre for Applied Social Research, Toronto, Ontario, Canada
    Prev Med 44:554-7. 2007
    ....
  13. ncbi Time trends in failure to return for HIV test results
    Janni J Kinsler
    Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Sex Transm Dis 34:397-400. 2007
    ..The purpose of this study was to examine time trends of failure to return for HIV test results among a mobile van population in Los Angeles...
  14. ncbi Health services utilization for people with HIV infection: comparison of a population targeted for outreach with the U.S. population in care
    William E Cunningham
    Division of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    Med Care 44:1038-47. 2006
    ..However, these hard-to-reach groups are important to study because they may be in greatest need of services...
  15. pmc HIV vaccine acceptability among communities at risk: the impact of vaccine characteristics
    Peter A Newman
    Centre for Applied Social Research, University of Toronto, Faculty of Social Work, 246 Bloor Street West, Toronto, Ont, Canada M5S 1A1
    Vaccine 24:2094-101. 2006
    ..Low acceptability of "partial efficacy" vaccines may present obstacles to future HIV vaccine dissemination. Educational and social marketing interventions may be necessary to ensure broad HIV vaccine uptake...