NEUROIMAGING OF HIV AND COMORBID DISORDERS

Summary

Principal Investigator: Lance Bauer
Abstract: DESCRIPTION (Adapted From The Applicants Abstract): The neuroimaging study proposed presently differs from many of the extant studies of the neurophysiological effects of HIV/AIDS in several substantive areas. For example, the proposed study will not focus exclusively on thc subset of HIV/AIDS patients with profound dementia in the terminal stages of disease. Secondly, it will also not focus exclusively upon verifying a neurological or neuropsychological staging system which is subjective and has unknown specificity and reliability. Thirdly, the proposed study will not exclude HIV/AIDS patients who are female or possess comorbid psychiatric disorders. The focus of the proposed study will instead be directed toward the quantitative assessment of degrees of impairment in a broader sample of HIV/AIDS patients using objective and reliable neurophysiological tools. For this purpose, we will recruit 120 HIV-1 seropositive and 120 HIV-1 seronegative subjects. All of the subjects will undergo identical procedures which will include structured medical and psychological evaluations. An attempt will be made to match the groups on several neurophysiologically relevant background variables (i.e., depression level, drug use history, gender, and age). The dependent measures will include several quantitative electroencephalographic measures, sensory evoked potential latencies and amplitudes, and topographic analyses of endogenous event-related potentials. Additional dependent measures will include objective and quantitative measures of balance, tremor, and eye movements. The overall goal of the study will be to construct a multivariate model in which one can test the role of various risk factors (e.g., antisocial personality disorder), comorbid disorders (e.g., mood disorder; cocaine, alcohol, or heroin dependence), and markers of disease severity (e.g., CDC clinical stages A, B, or C; viral load, CD4+ count, TNF-alpha) in either mediating, amplifying, or adding to the degree of neurophysiological impairment. In addition, cerebrospinal measures of cytokine and beta-chemokine activity will be gathered for the purpose of examining their correlation with neurophysiological functioning in the subset of HIV/AIDS patients who consent to a lumbar puncture. A secondary study will evaluate the same measures listed above among 45 HIV/AIDS patients before and 3 months after the initiation of a standard antiviral medication regimen as compared to 45 unmedicated HIV/AIDS patients (because of medication intolerance or noncompliance) who are also tested twice. An analysis of change scores across groups will permit a formal test of the effects of antiviral treatment on neurophysiological status.
Funding Period: 1999-09-30 - 2006-05-31
more information: NIH RePORT

Top Publications

  1. pmc Sensorimotor dysfunction in HIV/AIDS: effects of antiretroviral treatment and comorbid psychiatric disorders
    Lance O Bauer
    Departments of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    AIDS 19:495-502. 2005
  2. pmc A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART
    L O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Drug Alcohol Depend 127:45-52. 2013
  3. pmc An obese body mass increases the adverse effects of HIV/AIDS on balance and gait
    Lance O Bauer
    University of Connecticut School of Medicine, 263 Farmington Ave, MC 2103, Farmington, CT 06030 2103, USA
    Phys Ther 91:1063-71. 2011
  4. pmc Interactive effects of HIV/AIDS, body mass, and substance abuse on the frontal brain: a P300 study
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Psychiatry Res 185:232-7. 2011
  5. pmc Pathological gamblers discount probabilistic rewards less steeply than matched controls
    Gregory J Madden
    Department of Applied Behavioral Science, University of Kansas, Lawrence, KS 66045, USA
    Exp Clin Psychopharmacol 17:283-90. 2009
  6. pmc Psychiatric and neurophysiological predictors of obesity in HIV/AIDS
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 0603 2103, USA
    Psychophysiology 45:1055-63. 2008
  7. pmc A family history of psychopathology modifies the decrement in cognitive control among patients with HIV/AIDS
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Brain Cogn 67:103-14. 2008
  8. pmc The effects of HIV on P300 are moderated by familial risk for substance dependence: implications for a theory of brain reserve
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Drug Alcohol Depend 94:92-100. 2008
  9. pmc Predictors of decision-making on the Iowa Gambling Task: independent effects of lifetime history of substance use disorders and performance on the Trail Making Test
    Danielle Barry
    Department of Psychiatry MC 3944, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Brain Cogn 66:243-52. 2008
  10. ncbi ASPD blunts the effects of HIV and antiretroviral treatment on event-related brain potentials
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Neuropsychobiology 53:17-25. 2006

Scientific Experts

Detail Information

Publications10

  1. pmc Sensorimotor dysfunction in HIV/AIDS: effects of antiretroviral treatment and comorbid psychiatric disorders
    Lance O Bauer
    Departments of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    AIDS 19:495-502. 2005
    ..Objective evidence of these problems has rarely been reported, however. Furthermore, the extent to which balance and gait are influenced by antiretroviral medications or comorbid psychiatric disorders has rarely been examined...
  2. pmc A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART
    L O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Drug Alcohol Depend 127:45-52. 2013
    ..This investigation responds to that call by examining a host factor, a family history of substance dependence, often overlooked in cognitive and neuroimaging studies of HIV/AIDS...
  3. pmc An obese body mass increases the adverse effects of HIV/AIDS on balance and gait
    Lance O Bauer
    University of Connecticut School of Medicine, 263 Farmington Ave, MC 2103, Farmington, CT 06030 2103, USA
    Phys Ther 91:1063-71. 2011
    ..The extent to which these problems are exacerbated by either frailty or obesity has not been examined. Objective The purpose of this study was to compare participants who differed in body mass and the presence or absence of HIV/AIDS...
  4. pmc Interactive effects of HIV/AIDS, body mass, and substance abuse on the frontal brain: a P300 study
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Psychiatry Res 185:232-7. 2011
    ..Substance abuse, likewise, interacts with HIV/AIDS but may impair frontal brain function via a different mechanism...
  5. pmc Pathological gamblers discount probabilistic rewards less steeply than matched controls
    Gregory J Madden
    Department of Applied Behavioral Science, University of Kansas, Lawrence, KS 66045, USA
    Exp Clin Psychopharmacol 17:283-90. 2009
    ..The nature of the relation between probability discounting and severity of problem gambling is deserving of further study...
  6. pmc Psychiatric and neurophysiological predictors of obesity in HIV/AIDS
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 0603 2103, USA
    Psychophysiology 45:1055-63. 2008
    ..This relationship was mediated through premature response preparation (anterior scalp CNV amplitude) and its hypothesized association with impatience/impulsivity...
  7. pmc A family history of psychopathology modifies the decrement in cognitive control among patients with HIV/AIDS
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Brain Cogn 67:103-14. 2008
    ..The effects of familial risk on this slow potential are sufficiently robust as to attenuate the effects of HIV/AIDS on the probable generators of the response: the anterior cingulate and prefrontal cortex...
  8. pmc The effects of HIV on P300 are moderated by familial risk for substance dependence: implications for a theory of brain reserve
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Drug Alcohol Depend 94:92-100. 2008
    ..In addition, it tested the convergent validity of 2 operational definitions of premorbid reserve: verbal IQ (VIQ) and a family history (FH) of substance abuse or dependence...
  9. pmc Predictors of decision-making on the Iowa Gambling Task: independent effects of lifetime history of substance use disorders and performance on the Trail Making Test
    Danielle Barry
    Department of Psychiatry MC 3944, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Brain Cogn 66:243-52. 2008
    ..A lifetime SUD diagnosis was associated with performance on the IGT after controlling for covariates, and Trail Making Test performance was associated with IGT performance in both SUD and control participants...
  10. ncbi ASPD blunts the effects of HIV and antiretroviral treatment on event-related brain potentials
    Lance O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Neuropsychobiology 53:17-25. 2006
    ..The diminished response to treatment is more likely related to a pre-existing neurophysiological decrement localized to the same brain regions where HIV/AIDS and antiretroviral treatment exert their maximal effect...