Longitudinal Course and Impact of Depression

Summary

Principal Investigator: J W Pettit
Abstract: [unreadable] DESCRIPTION (provided by applicant): We seek support to analyze existing data from the Oregon Adolescent Depression Project (OADP) to better understand the long-term course and outcome of major depressive disorder (MOD). The OADP is a multi-generational project that includes a study of prevalence and risk factors for adolescent psychopathology in a large community sample; a longitudinal follow-up of probands' diagnostic course and psychosocial outcomes through young adulthood; a family study of their 1st-degree relatives; and a longitudinal study of their children. We seek to extend prior work with this data set by addressing three broad issues that integrate these components using state of the art data analytic techniques. 1. Psychosocial Functioning and Depressive Symptoms: Growth. Predictors, and Outcomes. Little is known about distinct courses and outcomes of depressive symptoms and psychosocial functioning. We will identify distinct growth trajectories in and reciprocal relations between these areas through young adulthood, and examine prospective predictors and long-term outcomes of distinct trajectories. Identification of unique growth patterns, their risk factors, and their outcomes will have important screening, prevention, and treatment implications for reducing the long-term burden of depression. 2. MOD: Comorbidity. Growth, and Long-term Outcomes. MOD often co-occurs with other psychiatric disorders, particularly substance use disorders (SUDs) and anxiety disorders (ANX). Although MOD comorbidity is associated with elevated impairment in numerous domains, little is known about its etiology and long-term impact. We will examine MDD-SUD and MDD-ANX comorbidity models based upon patterns of risk and protective factors and long-term outcomes of pure and comorbid disorders. Identification of prospective predictors and long-term outcomes of comorbidity will improve nosology and inform screening and prevention strategies. 3. Intergenerational Outcomes: Transmission of Psvchopathology across Three Generations. Evidence indicates that MOD is familial, yet the circumstances under which and mechanisms by which MOD is transmitted across generations remain unknown. We will examine moderational and mediational models of transmission between grandparents, parents, and children, and examine the diagnostic specificity of intergenerational transmission of psychopathology. We will also examine risk and protective factor profiles according to familial MDD patterns. Uncovering the conditions, mechanisms of, and risk and protective factors for MDD transmission across generations will have important implications for identifying those at risk for the disorder and point to potential targets for intervention. [unreadable] [unreadable] [unreadable] [unreadable]
Funding Period: 2006-07-26 - 2010-05-31
more information: NIH RePORT

Top Publications

  1. pmc Influence of parental and grandparental major depressive disorder on behavior problems in early childhood: a three-generation study
    Thomas M Olino
    Department of Psychology, State University of New York at Stony Brook, NY 11794 2500, USA
    J Am Acad Child Adolesc Psychiatry 47:53-60. 2008
  2. pmc Is liability to recurrent major depressive disorder present before first episode onset in adolescence or acquired after the initial episode?
    Jeremy W Pettit
    Department of Psychology, Florida International University, Miami, FL 33199, USA
    J Abnorm Psychol 122:353-8. 2013
  3. pmc Attention-deficit/hyperactivity disorder in adolescence predicts onset of major depressive disorder through early adulthood
    Michael C Meinzer
    Florida International University, Miami, Florida 33199, USA
    Depress Anxiety 30:546-53. 2013
  4. pmc Co-morbidity between major depressive disorder and anxiety disorders: shared etiology or direct causation?
    A R Mathew
    University of Houston, Houston, TX, USA
    Psychol Med 41:2023-34. 2011
  5. pmc Developmental relations between perceived social support and depressive symptoms through emerging adulthood: blood is thicker than water
    Jeremy W Pettit
    Department of Psychology, Florida International University, FL, USA
    J Fam Psychol 25:127-36. 2011
  6. pmc Developmental relations between depressive symptoms, minor hassles, and major events from adolescence through age 30 years
    Jeremy W Pettit
    Department of Psychology, Florida International University, Miami, FL 33199, USA
    J Abnorm Psychol 119:811-24. 2010
  7. pmc Familial influence of substance use disorder on emotional disorder across three generations
    Adam M Leventhal
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Psychiatry Res 185:402-7. 2011
  8. pmc Effect of maternal depression on child behavior: a sensitive period?
    Daniel M Bagner
    Department of Psychology, Florida International University, 11200 S W 8th Street, Miami, FL 33199, USA
    J Am Acad Child Adolesc Psychiatry 49:699-707. 2010
  9. pmc Intergenerational transmission of internalizing problems: effects of parental and grandparental major depressive disorder on child behavior
    Jeremy W Pettit
    Department of Psychology, University of Houston, Houston, TX 77204 5022, USA
    J Clin Child Adolesc Psychol 37:640-50. 2008
  10. pmc The long-term course of depression: development of an empirical index and identification of early adult outcomes
    J W Pettit
    Department of Psychology, University of Houston, Houston, TX 77204 5022, USA
    Psychol Med 39:403-12. 2009

Detail Information

Publications11

  1. pmc Influence of parental and grandparental major depressive disorder on behavior problems in early childhood: a three-generation study
    Thomas M Olino
    Department of Psychology, State University of New York at Stony Brook, NY 11794 2500, USA
    J Am Acad Child Adolesc Psychiatry 47:53-60. 2008
    ..This aim of this study was to examine the influence of grandparental (G1) and parental (G2) major depressive disorder (MDD) and other forms of psychopathology on behavior problems in very young offspring (G3)...
  2. pmc Is liability to recurrent major depressive disorder present before first episode onset in adolescence or acquired after the initial episode?
    Jeremy W Pettit
    Department of Psychology, Florida International University, Miami, FL 33199, USA
    J Abnorm Psychol 122:353-8. 2013
    ..Liability to rMDD exists prior to MDD onset in the form of familial risk and less severe mood disturbances, whereas liability to rMDD in the form of elevated stress may develop following a first onset in adolescence...
  3. pmc Attention-deficit/hyperactivity disorder in adolescence predicts onset of major depressive disorder through early adulthood
    Michael C Meinzer
    Florida International University, Miami, Florida 33199, USA
    Depress Anxiety 30:546-53. 2013
    ..A secondary aim was to examine whether this relationship was robust after accounting for comorbid psychopathology and psychosocial impairment...
  4. pmc Co-morbidity between major depressive disorder and anxiety disorders: shared etiology or direct causation?
    A R Mathew
    University of Houston, Houston, TX, USA
    Psychol Med 41:2023-34. 2011
    ..The present study compared these etiological models of MDD-ANX co-morbidity in a large, prospective, non-clinical sample of adolescents tracked through age 30...
  5. pmc Developmental relations between perceived social support and depressive symptoms through emerging adulthood: blood is thicker than water
    Jeremy W Pettit
    Department of Psychology, Florida International University, FL, USA
    J Fam Psychol 25:127-36. 2011
    ..23, p < .05). Cross-domain predictive effects were not observed for perceived support from friends and depressive symptoms. Implications of the findings are discussed...
  6. pmc Developmental relations between depressive symptoms, minor hassles, and major events from adolescence through age 30 years
    Jeremy W Pettit
    Department of Psychology, Florida International University, Miami, FL 33199, USA
    J Abnorm Psychol 119:811-24. 2010
    ....
  7. pmc Familial influence of substance use disorder on emotional disorder across three generations
    Adam M Leventhal
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Psychiatry Res 185:402-7. 2011
    ..There was no evidence that the influence of G1 SUD on G3 EmD was transmitted via G2 EmD. These findings shed light on the multigenerational processes through which SUD influences EmD...
  8. pmc Effect of maternal depression on child behavior: a sensitive period?
    Daniel M Bagner
    Department of Psychology, Florida International University, 11200 S W 8th Street, Miami, FL 33199, USA
    J Am Acad Child Adolesc Psychiatry 49:699-707. 2010
    ..The purpose of this study was to examine the effect of maternal depression during the child's first year of life (i.e., sensitive period) on subsequent behavior problems...
  9. pmc Intergenerational transmission of internalizing problems: effects of parental and grandparental major depressive disorder on child behavior
    Jeremy W Pettit
    Department of Psychology, University of Houston, Houston, TX 77204 5022, USA
    J Clin Child Adolesc Psychol 37:640-50. 2008
    ..These effects were robust to statistical adjustments for status variables and parental relationship measures but not to adjustment for concurrent parental depressive symptoms...
  10. pmc The long-term course of depression: development of an empirical index and identification of early adult outcomes
    J W Pettit
    Department of Psychology, University of Houston, Houston, TX 77204 5022, USA
    Psychol Med 39:403-12. 2009
    ..The aims of this study were to derive an empirical index of MDD course, to examine its predictive validity, and to identify the adulthood outcomes associated with a chronic course...
  11. pmc Escalation to Major Depressive Disorder among adolescents with subthreshold depressive symptoms: evidence of distinct subgroups at risk
    Ryan M Hill
    Florida International University, United States Electronic address
    J Affect Disord 158:133-8. 2014
    ..This study used a longitudinal prospective design in a community sample of adolescents to identify combinations of risk factors that predicted escalation from SubD to MDD...