HIV Prevention and Adherence Intervention for HIV Positives and Partners in India

Summary

Principal Investigator: CARL A contact LATKIN
Abstract: DESCRIPTION (provided by applicant): This is a resubmission of "HIV Prevention and Adherence Intervention for HIV Positives and Partners in India" (R01 MH083589). Alcohol abusers in India have high rates of HIV, low access and adherence to antiretroviral therapies (ART), and low rates of condom use. The proposed five-year study is a RCT of network-focused integrated behavioral HIV prevention, HIV medical care, and ART adherence in Chennai, India. The study sample will comprise sexually active PLHAs (n=400), their spouses (n=400), and a family member who provides HIV support (n=400). The PLHAs will be treatment naive patients, have a history of alcohol abuse or dependence, enrolled in the Global Fund program, and initiating ART. Data collection will include sexual risk behaviors, CD4 count, viral load, clinic medical records, ART adherence, social networks and other clinical and psychosocial assessments. Participants will be assessed at baseline, 3-, 6-, 12- and 18- months follow-up. Half of the PLHAs and their spouses and family supporters will be randomly assigned to the culturally tailored 8-session intervention condition, and the other participants to the enhanced standard-of-care control condition. The intervention will include individual, dyad, and family network-focused skills training sessions. Spouses and supporters in both conditions will be offered VCT and free HIV treatment as indicated. The study represents a progression of the decade long collaboration among researchers and clinicians at YRG CARE;Johns Hopkins University (JHU) Bloomberg School of Public Health;and JHU School of Medicine. The study builds on the team's extensive prior social network-oriented HIV intervention research targeting substance users, and expertise on the role of social networks, social support and informal HIV caregiving in HIV prevention and treatment. The study is highly feasible given the Indian government's recent roll-out of free ART, our recent establishment of a community-based HIV treatment and prevention clinic in Chennai, and our prior study findings on the importance of network members for HIV treatment support and prevention. PUBLIC HEALTH RELEVANCE: This proposal has high public relevance due to the low rates of HIV medication adherence found in many impoverished communities domestically and internationally.
Funding Period: ----------------2009 - ---------------2014-
more information: NIH RePORT

Top Publications

  1. pmc The relationship between social network factors, HIV, and Hepatitis C among injection drug users in Chennai, India
    Carl Latkin
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Drug Alcohol Depend 117:50-4. 2011
  2. pmc Understanding subtypes of inner-city drug users with a latent class approach
    S J Kuramoto
    Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, MD, USA
    Drug Alcohol Depend 118:237-43. 2011

Scientific Experts

Detail Information

Publications2

  1. pmc The relationship between social network factors, HIV, and Hepatitis C among injection drug users in Chennai, India
    Carl Latkin
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Drug Alcohol Depend 117:50-4. 2011
    ..The purpose of this study was to examine whether social network factors predict HIV and Hepatitis C (HCV) serostatus after controlling for individual-level factors at baseline among a cohort of male injection drug users in Chennai, India...
  2. pmc Understanding subtypes of inner-city drug users with a latent class approach
    S J Kuramoto
    Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, MD, USA
    Drug Alcohol Depend 118:237-43. 2011
    ..We empirically identified subtypes of inner-city users of heroin and cocaine based on type of drug used and route of administration...