COLLABORATIVE DEPRESSION STUDY

Summary

Principal Investigator: Martin Keller
Abstract: The Collaborative Depression Study (CDS) has advanced the long-term prospective study of mood disorders. This revised application seeks to extend the prospective annual follow-up of the CDS probands to at least 27 years for all subjects. Renewed funding will permit us to better address the general aim of describing the long-term course of moderate to severe major mood disorders in ways not previously possible and to further investigate the general hypothesis that many individuals with moderate to severe mood disorders will develop a lifelong illness. Since no similar data set exists to collect information of this nature, the next 5 years of continued data collection are essential to gaining a complete perspective of the lifetime course of mood disorders, particularly as many more of our subjects pass the age of 65 when the effects of aging on the course of mood disorders can be better assessed. The specific aims are to provide long-term, prospective, data that will help investigators to study: (1) the patterns and predictors of course of illness and psychosocial outcome in mood disorders; (2) morbidity, mortality and suicide associated with mood disorders; (3) somatic treatment as a mediating variable of outcome in mood disorders; (4) the longitudinal course of syndromal and sub-syndromal affective symptoms in subjects with unipolar and bipolar depressive disorders; and (5) mood disorders and aging.
Funding Period: 1977-07-01 - 2010-01-31
more information: NIH RePORT

Top Publications

  1. ncbi The distinct temperament profiles of bipolar I, bipolar II and unipolar patients
    Hagop S Akiskal
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, Rockville, MD, USA
    J Affect Disord 92:19-33. 2006
  2. pmc Subthreshold hypomanic symptoms in progression from unipolar major depression to bipolar disorder
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, 52242, USA jess fi
    Am J Psychiatry 168:40-8. 2011
  3. pmc Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, USA
    Am J Psychiatry 169:285-91. 2012
  4. pmc Recovery and subsequent recurrence in patients with recurrent major depressive disorder
    Boadie W Dunlop
    Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30322, USA
    J Psychiatr Res 46:708-15. 2012
  5. pmc Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, USA
    J Affect Disord 138:440-8. 2012
  6. pmc Effects of anxiety on the long-term course of depressive disorders
    William Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins, Iowa City, IA 52242, USA
    Br J Psychiatry 200:210-5. 2012
  7. pmc Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, W278GH Iowa City, IA 52242, USA
    Bipolar Disord 14:664-71. 2012
  8. pmc Dysfunctional attitudes as a moderator of pharmacotherapy and psychotherapy for chronic depression
    Stewart A Shankman
    Department of Psychology, University of Illinois at Chicago, IL 60607, USA
    J Psychiatr Res 47:113-21. 2013
  9. pmc Recovery from multiple episodes of bipolar I depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Clin Psychiatry 74:e205-11. 2013
  10. pmc Antidepressants and risks of suicide and suicide attempts: a 27-year observational study
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    J Clin Psychiatry 72:580-6. 2011

Detail Information

Publications21

  1. ncbi The distinct temperament profiles of bipolar I, bipolar II and unipolar patients
    Hagop S Akiskal
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, Rockville, MD, USA
    J Affect Disord 92:19-33. 2006
    ....
  2. pmc Subthreshold hypomanic symptoms in progression from unipolar major depression to bipolar disorder
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, 52242, USA jess fi
    Am J Psychiatry 168:40-8. 2011
    ..The authors assessed whether subthreshold hypomanic symptoms in patients with major depression predicted new-onset mania or hypomania...
  3. pmc Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, USA
    Am J Psychiatry 169:285-91. 2012
    ..The present study examines the hypothesis that the three antiepileptics approved for bipolar disorder (carbamazepine, lamotrigine, and valproate) are associated with an elevated risk of suicide attempts and suicides...
  4. pmc Recovery and subsequent recurrence in patients with recurrent major depressive disorder
    Boadie W Dunlop
    Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30322, USA
    J Psychiatr Res 46:708-15. 2012
    ..We conclude that protection against recurrence derives from the degree and duration of recovery, particularly for patients maintained on antidepressant medication...
  5. pmc Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, USA
    J Affect Disord 138:440-8. 2012
    ..This paper examines the prevalence and clinical characteristics of MDEs with subsyndromal manic symptoms. The specific effects of overt irritability and psychomotor agitation are examined...
  6. pmc Effects of anxiety on the long-term course of depressive disorders
    William Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins, Iowa City, IA 52242, USA
    Br J Psychiatry 200:210-5. 2012
    ..Important questions remain as to which anxiety features are important to outcome and how sustained their prognostic effects are over time...
  7. pmc Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, W278GH Iowa City, IA 52242, USA
    Bipolar Disord 14:664-71. 2012
    ..In a well-defined sample, we sought to determine which clinical variables, some of potential nosological relevance, influence subsequent course following prospectively observed initial episodes of hypomania or mania (H/M)...
  8. pmc Dysfunctional attitudes as a moderator of pharmacotherapy and psychotherapy for chronic depression
    Stewart A Shankman
    Department of Psychology, University of Illinois at Chicago, IL 60607, USA
    J Psychiatr Res 47:113-21. 2013
    ..Individuals with chronic depression exhibit heterogeneous responses to treatment. Important individual differences may therefore exist within this particularly difficult to treat population that act as moderators of treatment response...
  9. pmc Recovery from multiple episodes of bipolar I depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Clin Psychiatry 74:e205-11. 2013
    ..To describe the duration of bipolar I major and minor depressive episodes and factors associated with time to recovery...
  10. pmc Antidepressants and risks of suicide and suicide attempts: a 27-year observational study
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    J Clin Psychiatry 72:580-6. 2011
    ..The objective of this study was to examine the association of antidepressants with suicide attempts and with suicide deaths...
  11. pmc Longitudinal course of bipolar I disorder: duration of mood episodes
    David A Solomon
    UpToDate, Inc, Waltham, Massachusetts, USA
    Arch Gen Psychiatry 67:339-47. 2010
    ..The phenomenology of bipolar I disorder affects treatment and prognosis...
  12. pmc Do risk factors for suicidal behavior differ by affective disorder polarity?
    J G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Psychol Med 39:763-71. 2009
    ..The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort...
  13. ncbi The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
    ..Affectively ill individuals were recruited into the Collaborative Depression Study and followed prospectively for up to 15 years...
  14. ncbi Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder
    Martin Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    Biol Psychiatry 59:216-23. 2006
    ..An early clinical trial suggested that the substance P (neurokinin(1) receptor) antagonist, aprepitant, might provide a unique mechanism of antidepressant activity. Phase III trials were conducted to confirm these findings...
  15. ncbi Distinguishing bipolar major depression from unipolar major depression with the screening assessment of depression-polarity (SAD-P)
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    J Clin Psychiatry 67:434-42. 2006
    ..The goal of this study was to develop and validate a brief instrument to screen for bipolar disorder in patients actively ill with major depression...
  16. ncbi Long-term treatment of patients with recurrent unipolar major depression: evidence to clinical practice
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    CNS Spectr 11:4-5. 2006
  17. ncbi Preventing recurrent depression: long-term treatment for major depressive disorder
    Pierre Blier
    Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Canada
    J Clin Psychiatry 68:e06. 2007
    ..Maintenance therapy considerations for clinicians include assessing treatment guidelines, addressing nonadherent patients, and measuring medication treatment response...
  18. pmc Predicting recovery from episodes of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02903 4970, United States
    J Affect Disord 107:285-91. 2008
    ..This study examined psychosocial functioning as a predictor of recovery from episodes of unipolar major depression...
  19. pmc Manic/hypomanic symptom burden and cardiovascular mortality in bipolar disorder
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Psychosom Med 71:598-606. 2009
    ..To compare the risk for cardiovascular mortality between bipolar I and bipolar II subtypes and determine correlates of cardiovascular mortality. Bipolar disorder conveys an increased risk of cardiovascular mortality...
  20. pmc Empirical typology of bipolar I mood episodes
    David A Solomon
    Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence, Rhode Island 02903 4970, USA
    Br J Psychiatry 195:525-30. 2009
    ..Much remains unknown about the phenomenology of bipolar I disorder...
  21. pmc Age of onset and the prospectively observed course of illness in bipolar disorder
    William Coryell
    Department of Psychiatry, University of Iowa, Carver College of Medicine, 500 Newton Road, Iowa City, IA 52231 1190, United States
    J Affect Disord 146:34-8. 2013
    ..To test the validity of age-of-onset grouping in bipolar disorder through the use of prospectively observed time in mood episodes...