METANALYSIS COGNITIVE NEUROIMAGING: METHODS VALIDATIONS

Summary

Principal Investigator: P T Fox
Abstract: The objective of this research proposal is to advance the use of quantitative metanalysis as a research method for human functional brain mapping. This will done by testing, refining and distributing strategies and software tools for metanalysis developed by the PI and colleagues at the University of Texas Health Science Center at San Antonio (UTHSCSA). Fox and colleagues have developed a new strategy for metanalytic modeling of the functional organization of the human brain-mapping literature, termed functional volumes models (FVM). FVM computes spatial probability profiles of the brain locations of mental operations. Fox and colleagues have also developed an electronic environment (BrainMap) for encoding, retrieval and visualization of the human brain mapping literature, as an aid to metanalysis. BrainMap includes a coding scheme (a hierarchical semantics) for the behaviors used and mental operations experimentally mapped, termed the Behavioral Coding Scheme (BCS). In the present proposal, the FVM metanalysis strategy (Aim 1) and the BCS (Aim 2) will be validated and refined in a collaboration between Fox and colleagues at UTHSCSA and the Washington University group of Raichle and Petersen. The FVM strategy will be validated by modeling 12, language-related brain areas using two, alternative strategies: original-data metanalysis and literature-based metanalysis (FVM). Original-data metanalysis will be made possible by accessing the extensive image-data archives of the participating groups. Modeling assumptions and results will be independently tested (Aim 1). The behavioral coding scheme will be validated by coding three, 30-paper samples from the brain-mapping literature and analyzing for comprehensivity, reproducibility, and accuracy (Aim 2). Validation of the BCS is a necessary precursor to investigator entry of data into BrainMap. General strategies and rules for metanalysis will be addressed at biannual workshops amongst grant personnel and invited consultants, including refinements of the FVM strategy, the BCS, and the BrainMap environment (Aim 3). BrainMap will be modified in an ongoing manner, to accommodate identified strategies, procedures, coding schemes and data produced by this project (Aim 3). Strategies and guidelines will also be presented to the community through publications and workshops at meetings of the brain mapping and informatics communities. As this approach to metanalysis is new and substantially different from prior forms of metanalysis, the field of informatics stands to benefit from the validation of a new analysis paradigm.
Funding Period: 2000-03-01 - 2004-02-29
more information: NIH RePORT

Top Publications

  1. ncbi Task demands modulate sustained and transient neural activity during visual-matching tasks
    E Darcy Burgund
    Department of Psychology, MS 25, Rice University, PO Box 1892, Houston, TX 77251, USA
    Neuroimage 25:511-9. 2005
  2. ncbi BrainMap taxonomy of experimental design: description and evaluation
    Peter T Fox
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Hum Brain Mapp 25:185-98. 2005
  3. ncbi ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:155-64. 2005
  4. ncbi Neuroanatomical correlates of phonological processing of Chinese characters and alphabetic words: a meta-analysis
    Li Hai Tan
    Cognitive Neuroscience Laboratory, Department of Linguistics, University of Hong Kong, Pokfulam Road, Hong Kong
    Hum Brain Mapp 25:83-91. 2005
  5. ncbi Meta-analyses of object naming: effect of baseline
    Cathy J Price
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, United Kingdom
    Hum Brain Mapp 25:70-82. 2005
  6. ncbi A comparison of label-based review and ALE meta-analysis in the Stroop task
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:6-21. 2005
  7. ncbi BrainMap: the social evolution of a human brain mapping database
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neuroinformatics 3:65-78. 2005
  8. ncbi The development of sustained and transient neural activity
    E Darcy Burgund
    Department of Psychology, MS 25, Rice University, PO Box 1892, Houston, TX 77251, USA
    Neuroimage 29:812-21. 2006

Scientific Experts

Detail Information

Publications8

  1. ncbi Task demands modulate sustained and transient neural activity during visual-matching tasks
    E Darcy Burgund
    Department of Psychology, MS 25, Rice University, PO Box 1892, Houston, TX 77251, USA
    Neuroimage 25:511-9. 2005
    ..In combination, results suggest that sustained and transient activities interact to produce the context-appropriate response during visual-matching tasks...
  2. ncbi BrainMap taxonomy of experimental design: description and evaluation
    Peter T Fox
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Hum Brain Mapp 25:185-98. 2005
    ..Authors made a total of 115 content-filter choices. Of these, 78 (68%) were Stage 1, Grade A filters; 16 (14%) were Stage 2, Grade A; and 21 (18%) were Stage 2, Grade C. No author-applied filter was absent from the taxonomy...
  3. ncbi ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:155-64. 2005
    ..We then give an example of how comparisons of this sort may lead to advanced designs in future meta-analytic research...
  4. ncbi Neuroanatomical correlates of phonological processing of Chinese characters and alphabetic words: a meta-analysis
    Li Hai Tan
    Cognitive Neuroscience Laboratory, Department of Linguistics, University of Hong Kong, Pokfulam Road, Hong Kong
    Hum Brain Mapp 25:83-91. 2005
    ..Language form, cognitive process, and learning strategy drive the development of functional neuroanatomy...
  5. ncbi Meta-analyses of object naming: effect of baseline
    Cathy J Price
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, United Kingdom
    Hum Brain Mapp 25:70-82. 2005
    ..These results therefore have implications for understanding the convergence of functional imaging and neuropsychological findings...
  6. ncbi A comparison of label-based review and ALE meta-analysis in the Stroop task
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:6-21. 2005
    ....
  7. ncbi BrainMap: the social evolution of a human brain mapping database
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neuroinformatics 3:65-78. 2005
    ..In this article, we discuss BrainMap's structure and utility, and relate its progress and development as a neuroinformatics tool...
  8. ncbi The development of sustained and transient neural activity
    E Darcy Burgund
    Department of Psychology, MS 25, Rice University, PO Box 1892, Houston, TX 77251, USA
    Neuroimage 29:812-21. 2006
    ..Moreover, these results underscore the value of separating sustained and transient signals in fMRI studies of development...