High Resolution EEG Source Imaging: Validation Study

Summary

Principal Investigator: Bin He
Abstract: The long-term goal of this proposed research project is to establish a high-resolution noninvasive functional imaging technology, which promises to have great potential in clinical applications guiding presurgical planning in epileptic and tumor patients, who will undergo cortical resections. The specific goal of the proposed research project is to validate a high-resolution cortical imaging technique (CIT), which promises to reconstruct electrocorticogram (ECoG) from noninvasive scalp electrical recordings and patients' magnetic resonance imaging (MRI), in patients undergoing neurosurgical procedures in a clinical setting. To accomplish this goal, the following specific aims will be addressed: (1) Evaluation and Optimization of CIT by Computer Simulations: We will systematically evaluate the performance of the CIT through a series of numerical experiments, and optimize parameters of importance and numerical strategies for the cortical imaging procedures. (2) Validation of CIT from Intracranial Recordings during Somatosensory Stimulation in Patients: We will undertake the first, to our knowledge, full-scale study to validate the CIT in 50 epilepsy patients undergoing surgical evaluation. We will test the hypothesis that the CIT will be able to noninvasively identify and localize the central sulcus separating the sensory and motor cortex in the SEP paradigm. (3) Validation of CIT from Intracranial Recordings during Epileptic Seizures in Patients: We will directly test the clinical applicability of CIT to noninvasively identify cortical regions displaying epileptic activity, through intra- and extra-cranial recordings in 50 epilepsy patients undergoing surgical evaluation. We will test the hypothesis that the CIT will be able to noninvasively and reliably reconstruct site of seizure onset and locations of inter-ictal spikes, and significant characteristics of spatial maps of ECoG. Determining the location of the epileptogenic foci is of crucial significance for the successful surgical treatment of intractable epilepsy. The established clinical practice is to use ECoG recordings obtained by subdural electrode arrays, which represents risks and expenses to the patients and healthcare. The present application addresses the practical problem of developing noninvasive means of reconstructing ECoG from scalp EEG recordings and MRIs of the patients. The studies addressed in this application may establish CIT as a clinically useful tool aiding neurosurgical planning in epilepsy patients.
Funding Period: 2002-07-15 - 2008-04-30
more information: NIH RePORT

Top Publications

  1. pmc Multimodal functional neuroimaging: integrating functional MRI and EEG/MEG
    Bin He
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Rev Biomed Eng 1:23-40. 2008
  2. pmc Sparse cortical current density imaging in motor potentials induced by finger movement
    Lei Ding
    School of Electrical and Computer Engineering, University of Oklahoma, OK, USA
    J Neural Eng 8:036008. 2011
  3. pmc Cortical potential imaging of somatosensory evoked potentials by means of the boundary element method in pediatric epilepsy patients
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, 7 105 NHH, 312 Church Street, Minneapolis, MN 55455, USA
    Brain Topogr 23:333-43. 2011
  4. pmc Noninvasive cortical imaging of epileptiform activities from interictal spikes in pediatric patients
    Yuan Lai
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 54:244-52. 2011
  5. ncbi Spatio-temporal source localization and Granger causality in ictal source analysis
    L Ding
    Univ of Minnesota, Twin Cities, MN, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3670-1. 2006
  6. ncbi A high resolution EEG study of dynamic brain activity during video game play
    C Sheikholeslami
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:2489-91. 2007
  7. ncbi An adaptive directed transfer function approach for detecting dynamic causal interactions
    Christopher Wilke
    Department of Biomedical Engineering, University of Minnesota, 7 105 NHH, 312 Church Street SE, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:4949-52. 2007
  8. pmc fMRI-EEG integrated cortical source imaging by use of time-variant spatial constraints
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, 7 105 Hasselmo Hall, 312 Church Street, Minneapolis, MN 55455, USA
    Neuroimage 39:1198-214. 2008
  9. ncbi Three-dimensional ventricular activation imaging by means of equivalent current source modeling and estimation
    Z Liu
    Dept of Biomed Eng, Minnesota Univ, Minneapolis, MN, USA
    Conf Proc IEEE Eng Med Biol Soc 1:4524-7. 2006
  10. ncbi Evaluation of cortical imaging techniques based on somatosensory evoked potentials
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, 312 Church Street, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1000-1. 2006

Scientific Experts

  • Lei Ding
  • Zhongming Liu
  • J Hori
  • Nanyin Zhang
  • Qingyu Ma
  • Xiaotong Zhang
  • L Astolfi
  • Nuo Gao
  • Bin He
  • Xiaoxiao Bai
  • Wim van Drongelen
  • Christopher Wilke
  • Yuan Lai
  • Yingchun Zhang
  • B He
  • Chang Hwan Im
  • Baharan Kamousi
  • C Wilke
  • Kurt Hecox
  • Vernon L Towle
  • Kun Wang
  • Wei Chen
  • Yuan Xu
  • Han Yuan
  • Michael Kohrman
  • Arvind Gururajan
  • Shanan Zhu
  • Xu Li
  • N Yamawaki
  • C Sheikholeslami
  • Z S Li
  • W van Drongelen
  • Jing Li
  • Eric J He
  • Chenguang Liu
  • Nobuyuki Yamawaki
  • Lei Qin
  • Y Lai
  • Ying Ni
  • Michael Korhman
  • M Kohrman
  • Kelvin O Lim
  • Bryon A Mueller
  • Alexander Doud
  • H Yuan
  • L Hue
  • S A Zhu
  • E J He
  • L Yang
  • David Frim
  • Ali Nasiri Amini
  • X Bai
  • David M Frim
  • Steven M Pogwizd
  • K E Hecox
  • V L Towle
  • D M Frim

Detail Information

Publications65

  1. pmc Multimodal functional neuroimaging: integrating functional MRI and EEG/MEG
    Bin He
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Rev Biomed Eng 1:23-40. 2008
    ..Finally, we summarize important remaining issues and perspectives concerning multimodal functional neuroimaging, including brain connectivity imaging...
  2. pmc Sparse cortical current density imaging in motor potentials induced by finger movement
    Lei Ding
    School of Electrical and Computer Engineering, University of Oklahoma, OK, USA
    J Neural Eng 8:036008. 2011
    ....
  3. pmc Cortical potential imaging of somatosensory evoked potentials by means of the boundary element method in pediatric epilepsy patients
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, 7 105 NHH, 312 Church Street, Minneapolis, MN 55455, USA
    Brain Topogr 23:333-43. 2011
    ..These also suggest that the CPI method may provide a promising means of estimating the cortical potential and noninvasive localizing the central sulcus to aid surgical planning for pediatric patients...
  4. pmc Noninvasive cortical imaging of epileptiform activities from interictal spikes in pediatric patients
    Yuan Lai
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 54:244-52. 2011
    ..Confirmation of our results may have a significant impact on the process of presurgical planning in pediatric patients with intractable epilepsy by dramatically reducing or potentially eliminating the use of intracranial recording...
  5. ncbi Spatio-temporal source localization and Granger causality in ictal source analysis
    L Ding
    Univ of Minnesota, Twin Cities, MN, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3670-1. 2006
    ..It is found that the primary ictal source is within the visible lesion, which gave the consistent presurgical evaluation as MRI for this patient...
  6. ncbi A high resolution EEG study of dynamic brain activity during video game play
    C Sheikholeslami
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:2489-91. 2007
    ..These experimental results indicate the high resolution EEG provides a useful quantitative analysis tool for studying dynamic brain activity...
  7. ncbi An adaptive directed transfer function approach for detecting dynamic causal interactions
    Christopher Wilke
    Department of Biomedical Engineering, University of Minnesota, 7 105 NHH, 312 Church Street SE, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:4949-52. 2007
    ....
  8. pmc fMRI-EEG integrated cortical source imaging by use of time-variant spatial constraints
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, 7 105 Hasselmo Hall, 312 Church Street, Minneapolis, MN 55455, USA
    Neuroimage 39:1198-214. 2008
    ....
  9. ncbi Three-dimensional ventricular activation imaging by means of equivalent current source modeling and estimation
    Z Liu
    Dept of Biomed Eng, Minnesota Univ, Minneapolis, MN, USA
    Conf Proc IEEE Eng Med Biol Soc 1:4524-7. 2006
    ..90, relative error of 0.19, and the origin of ventricular excitation can be localized with an average localization error of 5.5 mm for 12 different pacing sites distributed throughout the ventricles...
  10. ncbi Evaluation of cortical imaging techniques based on somatosensory evoked potentials
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, 312 Church Street, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1000-1. 2006
    ..The present results suggest that L(1)-norm methods gave the most accurate results in terms of cortical current density imaging of brain responses invoked by somatosensory stimulation...
  11. ncbi A new multimodal imaging strategy for integrating fMRI with EEG
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA
    Conf Proc IEEE Eng Med Biol Soc 1:859-62. 2006
    ..The proposed Twomey approach may make an important contribution to the multimodal neuroimaging integrating fMRI with EEG...
  12. ncbi Cortical potential imaging of movement-related potentials using parametric Wiener filter in realistic-shaped head model
    Junichi Hori
    Dept of Biocybern, Niigata Univ
    Conf Proc IEEE Eng Med Biol Soc 1:3662-5. 2006
    ..The proposed methods demonstrated that the contralateral premotor cortex was preponderantly activated In relation to movement performance...
  13. pmc Sparse source imaging in electroencephalography with accurate field modeling
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Hum Brain Mapp 29:1053-67. 2008
    ..The SEP source imaging results indicate that SSI has the best accuracy in the prediction of subdural potential field as validated by direct subdural recordings. The new SSI algorithm is also applicable to MEG source imaging...
  14. ncbi Effects of holes on EEG forward solutions using a realistic geometry head model
    Jing Li
    College of Electrical Engineering, Zhejiang University, Hangzhou 310027, People s Republic of China
    J Neural Eng 4:197-204. 2007
    ..The effect of a hole on the EEG is much larger than upon the ECoG...
  15. ncbi Noninvasive study of neurovascular coupling during graded neuronal suppression
    Nanyin Zhang
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 28:280-90. 2008
    ..This study extends the range of the neurovascular coupling relationship from graded neuronal excitation conditions to graded neuronal suppression conditions...
  16. pmc Magnetoacoustic tomography with magnetic induction: a rigorous theory
    Qingyu Ma
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455 USA
    IEEE Trans Biomed Eng 55:813-6. 2008
    ....
  17. ncbi Noninvasive imaging of bioimpedance distribution by means of current reconstruction magnetic resonance electrical impedance tomography
    Nuo Gao
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 55:1530-8. 2008
    ..The present MREIT method may have potential applications to breast cancer imaging and imaging of other organs...
  18. pmc Three-dimensional brain current source reconstruction from intra-cranial ECoG recordings
    Yingchun Zhang
    University of Minnesota, Department of Biomedical Engineering, Minneapolis, MN 55455, USA
    Neuroimage 42:683-95. 2008
    ..The present promising results indicate the feasibility and applicability of the developed ECoG-CDR method of estimating brain sources from intracranial electrical recordings, with detailed forward modeling using FEM...
  19. pmc Identification of epileptogenic foci from causal analysis of ECoG interictal spike activity
    C Wilke
    University of Minnesota, Department of Biomedical Engineering, Minneapolis, MN 55455, USA
    Clin Neurophysiol 120:1449-56. 2009
    ..We hypothesize that causal analysis of the functional brain networks during interictal spikes are correlated with the clinically-defined epileptogenic zone...
  20. pmc Three-dimensional imaging of complex neural activation in humans from EEG
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 56:1980-8. 2009
    ....
  21. pmc Mapping the bilateral visual integration by EEG and fMRI
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 46:989-97. 2009
    ....
  22. pmc Estimation of effective and functional cortical connectivity from neuroelectric and hemodynamic recordings
    Laura Astolfi
    Department of Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
    IEEE Trans Neural Syst Rehabil Eng 17:224-33. 2009
    ..Differences in cortical connectivity were noted between the patterns estimated with the use of multimodal integration and those estimated by using only the neuroelectric data...
  23. pmc Three-dimensional source imaging from simultaneously recorded ERP and BOLD-fMRI
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Neural Syst Rehabil Eng 17:101-6. 2009
    ..The present results demonstrate the merits of high-resolution spatiotemporal functional neuroimaging by integrating the simultaneously recorded fMRI and EEG data...
  24. ncbi Quantitatively Interpreting fMRI signal
    Nanyin Zhang
    Center for Magnetic Resonance Research, The Department of Radiology, The University of Minnesota Twin Cities, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:4415-8. 2008
    ....
  25. ncbi Functional neuroimaging of dynamic brain activation
    Bin He
    Department of Biomedical Engineering, University of Minnesota, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:3355. 2008
    ..Brain activation is distributed in 3-dimensional brain and evolves in time. This paper reviews our recent work on developing high resolution spatio-temporal functional neuroimaging methods...
  26. pmc Cortical imaging of event-related (de)synchronization during online control of brain-computer interface using minimum-norm estimates in frequency domain
    Han Yuan
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Neural Syst Rehabil Eng 16:425-31. 2008
    ..Statistical source analysis revealed that maximum correlation with movement imagination is localized in sensorimotor cortex...
  27. pmc Estimation of time-varying connectivity patterns through the use of an adaptive directed transfer function
    Christopher Wilke
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 55:2557-64. 2008
    ..The present ADTF method was tested in real epileptiform ECoG data from an epilepsy patient, and the ADTF results are consistent with the clinical assessments performed by neurologists...
  28. pmc A new method to derive white matter conductivity from diffusion tensor MRI
    Kun Wang
    College of Electrical Engineering, Zhejiang University, Hangzhou, China
    IEEE Trans Biomed Eng 55:2481-6. 2008
    ..Therefore, it holds potential to provide a more accurate estimate of the WM anisotropic conductivity, and may have important applications to neuroscience research or clinical applications in neurology and neurophysiology...
  29. pmc Noninvasive imaging of head-brain conductivity profiles
    Xiaotong Zhang
    College of Electrical Engineering, Zhejiang University, Hangzhou 310027, China
    IEEE Eng Med Biol Mag 27:78-83. 2008
  30. ncbi Investigation on magnetoacoustic signal generation with magnetic induction and its application to electrical conductivity reconstruction
    Qingyu Ma
    Department of Biomedical Engineering, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, USA
    Phys Med Biol 52:5085-99. 2007
    ....
  31. ncbi Solving the ECG forward problem by means of a meshless finite element method
    Z S Li
    College of Electrical Engineering, Zhejiang University, Hangzhou, People s Republic of China
    Phys Med Biol 52:N287-96. 2007
    ..The present results suggest that the meshless FEM may provide an alternative for ECG forward solutions...
  32. ncbi Imaging functional brain connectivity patterns from high-resolution EEG and fMRI via graph theory
    L Astolfi
    Dipartimento Fisiologia Umana e Farmacologia, Universita La Sapienza, Rome, Italy
    Psychophysiology 44:880-93. 2007
    ..The present findings suggest that the methodology is able to identify differences in functional connectivity patterns elicited by different experimental tasks or conditions...
  33. pmc An enhanced time-frequency-spatial approach for motor imagery classification
    Nobuyuki Yamawaki
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Neural Syst Rehabil Eng 14:250-4. 2006
    ..The enhanced performance in terms of classification accuracy was found for the proposed approach, with a mean accuracy rate of 91.1% for two subjects studied...
  34. pmc Effects of fMRI-EEG mismatches in cortical current density estimation integrating fMRI and EEG: a simulation study
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, 7 105 BSBE, 312 Church Street, Minneapolis, MN 55455, USA
    Clin Neurophysiol 117:1610-22. 2006
    ....
  35. ncbi Comparison of different cortical connectivity estimators for high-resolution EEG recordings
    Laura Astolfi
    Dipartimento Informatica e Sistemistica, Universita La Sapienza, Rome, Italy
    Hum Brain Mapp 28:143-57. 2007
    ....
  36. pmc A new magnetic resonance electrical impedance tomography (MREIT) algorithm: the RSM-MREIT algorithm with applications to estimation of human head conductivity
    Nuo Gao
    College of Electrical Engineering, Zhejiang University, People s Republic of China
    Phys Med Biol 51:3067-83. 2006
    ....
  37. pmc Functional cortical source imaging from simultaneously recorded ERP and fMRI
    Chang Hwan Im
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci Methods 157:118-23. 2006
    ..The present results demonstrate that reliable cortical source images can be acquired during simultaneous fMRI scanning and they may be used for multimodal functional source imaging studies...
  38. pmc A cortical potential imaging study from simultaneous extra- and intracranial electrical recordings by means of the finite element method
    Yingchun Zhang
    University of Minnesota, Department of Biomedical Engineering, 7 105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USA
    Neuroimage 31:1513-24. 2006
    ..The FEM-based CPI technique provides a means of connecting the simultaneous recorded ECoG and the scalp EEG and promises to become an effective tool to evaluate and validate CPI techniques using clinic data...
  39. pmc A wavelet-based time-frequency analysis approach for classification of motor imagery for brain-computer interface applications
    Lei Qin
    Department of Biomedical Engineering, University of Minnesota, 7 105 BSBE, 312 Church Street, Minneapolis, MN 55455, USA
    J Neural Eng 2:65-72. 2005
    ..The present method has been tested in nine human subjects and reached an averaged classification rate of 78%. The simplicity of the present technique suggests that it may provide an alternative method for EEG-based BCI applications...
  40. pmc Magnetoacoustic tomography with magnetic induction (MAT-MI)
    Yuan Xu
    Department of Biomedical Engineering, University of Minnesota, 7 105 BSBE, 312 Church Street, Minneapolis, MN 55455, USA
    Phys Med Biol 50:5175-87. 2005
    ..The promising pilot experimental results suggest the feasibility of the proposed MAT-MI approach...
  41. ncbi Noninvasive three-dimensional electrocardiographic imaging of ventricular activation sequence
    Xin Zhang
    Dept of Biomedical Engineering, Univ of Minnesota, 7 105 BSBE, 312 Church St, Minneapolis, MN 55455, USA
    Am J Physiol Heart Circ Physiol 289:H2724-32. 2005
    ..This new 3-D electrocardiographic imaging modality has the potential to guide catheter-based ablative interventions for the treatment of life-threatening cardiac arrhythmias...
  42. pmc On the estimation of the number of dipole sources in EEG source localization
    Xiaoxiao Bai
    Department of Biomedical Engineering University of Minnesota, 7 105 BSBE, 312 Church Street SE, Minneapolis, MN 55455, USA
    Clin Neurophysiol 116:2037-43. 2005
    ..The purpose of the present study was to determine the number of the equivalent dipole sources corresponding to the scalp EEG using the information criterion method based on the instantaneous-state modeling...
  43. ncbi Classification of motor imagery tasks for brain-computer interface applications by means of two equivalent dipoles analysis
    Baharan Kamousi
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Neural Syst Rehabil Eng 13:166-71. 2005
    ..In four human subjects, an averaged accuracy of classification of 80% was achieved. The present study suggests the merits and feasibility of applying EEG inverse solutions to BCI applications from noninvasive EEG recordings...
  44. ncbi Estimation of electrical conductivity distribution within the human head from magnetic flux density measurement
    Nuo Gao
    College of Electrical Engineering, Zhejiang University, Hangzhou 310027, People s Republic of China
    Phys Med Biol 50:2675-87. 2005
    ..The present promising results suggest the feasibility of estimating important conductivity values within the head from noninvasive magnetic flux density measurements...
  45. pmc Use of 3-D magnetic resonance electrical impedance tomography in detecting human cerebral stroke: a simulation study
    Nuo Gao
    School of Electrical Engineering, Zhejiang University, Hangzhou 310027, China
    J Zhejiang Univ Sci B 6:438-45. 2005
    ....
  46. ncbi Low resolution brain electromagnetic tomography in a realistic geometry head model: a simulation study
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Phys Med Biol 50:45-56. 2005
    ..The present simulation results suggest that the use of the RG head model reduces the localization error of LORETA, and that the RG head model based LORETA is desirable if high localization accuracy is needed...
  47. pmc 3D source localization of interictal spikes in epilepsy patients with MRI lesions
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, 7 105 BSBE, 312 Church Street, Minneapolis, MN 55455, USA
    Phys Med Biol 51:4047-62. 2006
    ..The present study may lead to the establishment of a high-resolution source localization technique from scalp-recorded EEGs for aiding presurgical planning in epilepsy patients...
  48. pmc Integration of EEG/MEG with MRI and fMRI
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, MN 5545, USA
    IEEE Eng Med Biol Mag 25:46-53. 2006
  49. pmc EEG source imaging: correlating source locations and extents with electrocorticography and surgical resections in epilepsy patients
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Neurophysiol 24:130-6. 2007
    ..The value of the proposed noninvasive technique for estimating epileptiform activity was supported by satisfactory surgery outcomes...
  50. ncbi Classification of motor imagery by means of cortical current density estimation and Von Neumann entropy
    Baharan Kamousi
    Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Neural Eng 4:17-25. 2007
    ....
  51. ncbi Cortical dipole imaging of movement-related potentials by means of parametric inverse filters incorporating with signal and noise covariance
    J Hori
    Department of Biocybernetics, Niigata University, 8050 Ikarashi 2, Niigata 950 2181, Japan
    Methods Inf Med 46:242-6. 2007
    ..We utilize cortical dipole source imaging to locate the possible generators of scalp-measured movement-related potentials (MRPs) in human...
  52. ncbi Enhancement of classification accuracy of a time-frequency approach for an EEG-based brain-computer interface
    N Yamawaki
    Department of Biomedical Engineering, University of Minnesota, 7 105 NHH, 312 Church Street S E, Minneapolis, MN 55455, USA
    Methods Inf Med 46:155-9. 2007
    ..The aim of this paper is to develop a new algorithm to enhance the performance of EEG-based brain-computer interface (BCI)...
  53. pmc Evaluation of cortical current density imaging methods using intracranial electrocorticograms and functional MRI
    Xiaoxiao Bai
    University of Minnesota, Department of Biomedical Engineering, 7 105 NHH, 312 Church Street, Minneapolis, MN 55455, USA
    Neuroimage 35:598-608. 2007
    ..The aim of the present study was to evaluate source reconstruction techniques by means of the intracranial electrocorticograms (ECoGs) and functional MRI...
  54. ncbi Cortical activation mapping of epileptiform activity derived from interictal ECoG spikes
    Yuan Lai
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Epilepsia 48:305-14. 2007
    ..To develop and evaluate a new cortical activation mapping (CAM) method to obtain the neuronal activation sequences from the cortical potential distributions...
  55. ncbi Imaging electrical impedance from acoustic measurements by means of magnetoacoustic tomography with magnetic induction (MAT-MI)
    Xu Li
    Department of Biomedical Engineering, University of Minnesota, Minneapolis 55455, USA
    IEEE Trans Biomed Eng 54:323-30. 2007
    ..The feasibility of MAT-MI in providing high spatial resolution images containing impedance-related information has also been demonstrated in a phantom experiment...
  56. pmc Ictal source analysis: localization and imaging of causal interactions in humans
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, 7 105 NHH, 312 Church St SE, Minneapolis, MN 55455, USA
    Neuroimage 34:575-86. 2007
    ..Each step of the ictal source analysis is statistically evaluated in order to guarantee the confidence in the results...
  57. pmc Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortex
    Chang Hwan Im
    Department of Biomedical Engineering, University of Minnesota, 7 105 Hasselmo Hall, 312 Church St S E, Minneapolis, MN 55455, USA
    J Neurosci Methods 161:142-54. 2007
    ..The present results suggest that the spatial resolution of the EEG cortical source imaging can correctly discriminate cortical activation changes in V1 corresponding to less than 3 degrees visual field changes...
  58. ncbi Noninvasive reconstruction of three-dimensional ventricular activation sequence from the inverse solution of distributed equivalent current density
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA
    IEEE Trans Med Imaging 25:1307-18. 2006
    ....
  59. pmc Estimation of number of independent brain electric sources from the scalp EEGs
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 53:1883-92. 2006
    ..The present study suggests that the information criterion method may provide a useful means in estimating the number of independent brain electrical sources from EEG/MEG measurements...
  60. ncbi Three-dimensional myocardial activation imaging in a rabbit model
    Chenguang Liu
    University of Minnesota, Minneapolis 55455, USA
    IEEE Trans Biomed Eng 53:1813-20. 2006
    ..20 and the localization error was 5.1 mm. The present simulation and experimental results suggest the merits of the 3DECI imaging approach, and the validity of intracardiac mapping as a tool to evaluate the 3DECI...
  61. pmc Spatio-temporal EEG source localization using a three-dimensional subspace FINE approach in a realistic geometry inhomogeneous head model
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, Minneapolis 55414, USA
    IEEE Trans Biomed Eng 53:1732-9. 2006
    ..The present study suggests that FINE provides enhanced performance in localizing multiple closely spaced, and inter-correlated sources under low SNR, and may become an important alternative to brain source localization from EEG or MEG...
  62. ncbi Estimation of in vivo human brain-to-skull conductivity ratio from simultaneous extra- and intra-cranial electrical potential recordings
    Y Lai
    Department of Biomedical Engineering, University of Minnesota, 7 105 BSBE, 312 Church Street, Minneapolis, MN 55455, USA
    Clin Neurophysiol 116:456-65. 2005
    ..Simultaneous extra- and intra-cranial potential recordings induced by subdural current stimulation were analyzed to get the estimation...