Diabetes: Implant Integration, Success, and Benefit

Summary

Principal Investigator: Thomas Oates
Abstract: One of the more subtle complications of diabetes mellitus is a decrease in the patient's quality of life due to tooth loss and compromised function. While implant therapy has shown promise in patients with well- managed diabetes, questions remain as to the influence of this systemic condition on dental implant therapy. In fact, it may be those patients with inadequate glycemic control that have the most to gain by improvements in dietary control through implant therapy. Purpose: Our long-term goal is to develop the scientific rationale for the development of patient-specific, therapeutic protocols for implant care in diabetic patients. This study seeks to address the following aims: 1) Determine the impact of type 2 diabetes and glycemic control on dental implant integration, complications, and success both before and after functional loading. 2) Identify the impact of type 2 diabetes and glycemic control on oral health-related quality of life associated with the addition of implant-support to mandibular complete dentures. Methods: A parallel design, prospective study will assess dental implant integration, success, complications, oral health-related quality of life and satisfaction for edentulous patients with conventional dentures, and through 1 to 3.5 years after converting the denture to a 2-implant supported mandibular overdenture. Patients will be recruited (45 subjects/group) from well-controlled (HbA1c<8.0%) or poorly-controlled (HbA1c 8.1-12%) type 2 diabetic patients, and non-diabetic, healthy control subjects. All patients (n=135) will be recruited from the San Antonio/south Texas area. This study looks to capitalize on the high prevalence of diabetes. in this area. Outcomes: Assessments include implant failures (removal or non-restored), clinical complications, resonance frequency analysis (RFA) as a measure of implant integration, oral health-related quality of life, satisfaction, and diet. Implications: This proposal challenges existing paradigms regarding the utilization of dental implant therapy for diabetic patients lacking good glycemic control by examining the specific relationship between glycemic control and implant therapy. It explores the potential for implant therapy to provide important functional, nutritional, and quality of life benefits to diabetes patients with poorer glycemic control. Ultimately, this information will contribute to the establishment of evidence-based guidelines for the assessment and application of dental implant therapy for patients with diabetes.
Funding Period: ----------------2006 - ---------------2011-
more information: NIH RePORT

Top Publications

  1. pmc A critical review of diabetes, glycemic control, and dental implant therapy
    Thomas W Oates
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Clin Oral Implants Res 24:117-27. 2013
  2. pmc Using an existing denture to design a radiographic template for a two-implant mandibular overdenture
    Guy Huynh-Ba
    Department of Periodontics, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Prosthet Dent 109:53-6. 2013
  3. pmc A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4
    Leandro F S Bastos
    Núcleo de Neurociências NNC, Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Bloco A4, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, Brazil
    Neurosci Lett 543:157-62. 2013
  4. pmc Glycemic control and implant stabilization in type 2 diabetes mellitus
    T W Oates
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Dent Res 88:367-71. 2009
  5. pmc Diabetes and oral disease: implications for health professionals
    David A Albert
    Columbia University College of Dental Medicine, New York, New York 10032, USA
    Ann N Y Acad Sci 1255:1-15. 2012

Scientific Experts

  • David A Albert
  • Thomas Oates
  • Guy Huynh-Ba
  • Leandro F S Bastos
  • Renes R Machado
  • Márcio M Coelho
  • Bruno C S Ferreira
  • Marcio F D Moraes
  • Steven F Maier
  • Rossimiriam P de Freitas
  • Yingning Zhang
  • Yasuo Konishi
  • Peggy Alexander
  • Adriana Vargas
  • Suwatchai Jarussophon
  • Matthew J Vierra
  • Adriana M Godin
  • Linda R Watkins
  • Bernd L Fiebich

Detail Information

Publications5

  1. pmc A critical review of diabetes, glycemic control, and dental implant therapy
    Thomas W Oates
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Clin Oral Implants Res 24:117-27. 2013
    ....
  2. pmc Using an existing denture to design a radiographic template for a two-implant mandibular overdenture
    Guy Huynh-Ba
    Department of Periodontics, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Prosthet Dent 109:53-6. 2013
    ..This allows prosthetically driven treatment planning and the surgical placement of 2 implants to support the existing mandibular denture...
  3. pmc A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4
    Leandro F S Bastos
    Núcleo de Neurociências NNC, Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Bloco A4, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, Brazil
    Neurosci Lett 543:157-62. 2013
    ..This study supports the evaluation of the potential usefulness of PMIN in the management of neuropathic pain, as its lack of antibacterial and Ca(2+) chelating activities might confer greater safety over conventional tetracyclines...
  4. pmc Glycemic control and implant stabilization in type 2 diabetes mellitus
    T W Oates
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Dent Res 88:367-71. 2009
    ..This study demonstrates alterations in implant stability consistent with impaired implant integration for persons with type 2 diabetes mellitus in direct relation to hyperglycemic conditions...
  5. pmc Diabetes and oral disease: implications for health professionals
    David A Albert
    Columbia University College of Dental Medicine, New York, New York 10032, USA
    Ann N Y Acad Sci 1255:1-15. 2012
    ..This report summarizes the scientific presentations of the event...