Dental Caries Traits: The Genetic Contribution
Principal Investigator: Walter A Bretz
Abstract: DESCRIPTION: A variety of factors, including microbial, genetic, immunological, behavioral and environmental, may interact to contribute to dental caries development. One feature that has hampered better understanding of caries etiology and natural history is the inability within most studies to date, to account for a variety of potential effect modifiers. These include poor characterization of the study participants' exposure to fluoridated water, other sources of topical fluoride, utilization of professional dental care, and other factors that may alter disease development and progression. In response to these deficiencies, the National Institutes of Health has recently commissioned a Consensus Development Conference on the Diagnosis and Management of Dental Caries throughout. Some of the key recommendations from this conference to be addressed by this application include: 1) early identification of populations at risk for developing dental caries such as young children; 2) longitudinal studies on the natural progression of dental caries; 3) research on emerging techniques for the diagnosis of dental caries; and 4) genetic studies and characterization of genetic markers for dental caries. To date, our investigative team has assembled a cohort of 322 twin pairs (644 individuals) 18 months to 7 years of age and of low socioeconomic status residing in the city of Montes Claros, State of Minas Gerais, Brazil. A large proportion of these children are caries active and without access to professional dental care and thus far their caries has remained untreated. In addition, they have no access to fluoridated water or professionally administered topical fluorides. The primary goal of this proposal is to determine, in cross-sectional and prospective data, the relative contribution of genetic and environmental factors to individual variation in liability to early dental caries, including its phenotypic stability and change. To enable this research, we will thoroughly characterize structural changes in enamel from pre-cavitated lesions to surface collapse. In this investigation we propose to study dental caries traits in young twins with the following specific aims: Specific Aim 1- to recruit and examine 500 twin pairs, in the age range of 18 months to 7 years; Specific Aim 2- to characterize dental caries phenotypic expression by detailing its onset and progression; Specific Aim 3- to determine the relative role of heredity and environment in phenotypic variation related to the onset and progression of dental caries. To our knowledge, this study will be the first to examine the genetic and environmental composition of variation in caries development, employing a comprehensive set of clinical measurements. The results obtained in this study, by identifying the most heritable traits, will inform research that will employ molecular genetic analyses for dental caries surface-specific traits in the same twin sample.
Funding Period: 2004-09-24 - 2009-06-30
more information: NIH RePORT
- The dental plaque microbiome in health and diseaseScott N Peterson
J Craig Venter Institute, Rockville, Maryland, United States of America
PLoS ONE 8:e58487. 2013..A comparison of this data to other published studies indicate significant heterogeneity in study outcomes and suggest that novel approaches may be required to further define the signatures of dental caries onset and progression...
- Environmental and genetic contributions to indicators of oral malodor in twinsWalter A Bretz
New York University College of Dentistry, 345 East 24th Street, Room 1005, New York, NY 10010, USA
Twin Res Hum Genet 14:568-72. 2011..Intraoral breath VSC values were primarily attributable to environmental factors, whereas exhaled breath VSC values were partially explained by genetic factors...
- Dental caries pathogenicity: a genomic and metagenomic perspectiveScott N Peterson
The J Craig Venter Institute, Rockville, MD 20886, USA
Int Dent J 61:11-22. 2011....
- Inheritance of occlusal topography: a twin studyC Y Su
Dept Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Eur Arch Paediatr Dent 9:19-24. 2008..This was to determine the relative contribution of genetic factors on the morphology of occlusal surfaces of mandibular primary first molars by employing the twin study model...
- Resemblance of tongue anatomy in twinsAndrew I Spielman
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, United States of America
Twin Res Hum Genet 14:277-82. 2011..This study should help identify baseline and control data in future behavioral studies of taste, which has a genetic basis...
- Heritability of oral microbial species in caries-active and caries-free twinsPatricia M Corby
New York University College of Dentistry, New York, NY 10010, USA
Twin Res Hum Genet 10:821-8. 2007..It appears that genetic and/or familial factors significantly contribute to the colonization of oral beneficial species in twins...
- Microbial acid production (Clinpro Cario L-Pop) and dental caries in infants and childrenW A Bretz
New York University, College of Dentistry, New York, NY 10010, USA
Quintessence Int 38:e213-7. 2007..The purpose of this study was to evaluate the diagnostic utility of the Clinpro Cario-L-Pop test as it relates to dental caries rates and severity in infants and children...
- Heritability estimates for dental caries and sucrose sweetness preferenceWalter A Bretz
College of Dentistry, New York University, 345 East 24th St, New York, NY 10010, USA
Arch Oral Biol 51:1156-60. 2006..The aim of this study was to determine heritability estimates for dental caries traits and sucrose sweetness preference...
- Using biometrics for participant identification in a research study: a case reportPatricia M Corby
Division of Pediatric and Developmental Dental Sciences, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
J Am Med Inform Assoc 13:233-5. 2006..This case report provides insights that may serve as useful hints for those responsible for planning system implementation that involves participants' authentication that would require a more secure form of identification...
- Microbial risk indicators of early childhood cariesP M Corby
University of Pittsburgh, School of Dental Medicine, Division of Pediatric and Developmental Dental Sciences, 3501 Terrace St, Room 386, Pittsburgh, PA 15261, USA
J Clin Microbiol 43:5753-9. 2005..which exhibited an inverse relationship to beneficial bacterial species, such as Streptococcus parasanguinis, Abiotrophia defectiva, Streptococcus mitis, Streptococcus oralis, and Streptococcus sanguinis...
- Longitudinal analysis of heritability for dental caries traitsW A Bretz
School of Dental Medicine, Division of Pediatric and Developmental Dental Sciences, University of Pittsburgh, 3501 Terrace St, Room 380, Pittsburgh, PA 15261, USA
J Dent Res 84:1047-51. 2005..4-56.2). These findings are consistent with a significant genetic contribution to dental caries progression and severity in both emerging primary and permanent dentitions...
- Dental caries and microbial acid production in twinsW A Bretz
School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
Caries Res 39:168-72. 2005..To determine the relative contribution of genetic and environmental stimuli on dental caries traits and microbial acid production in a twin model...