Central Auditory System Plasticity in Implanted Children

Summary

Principal Investigator: Anu Sharma
Abstract: DESCRIPTION: (Adapted from applicant's abstract): The long-term objective of this research is to study the development, deterioration, and plasticity of auditory pathways mediating human communication. Specifically, our aim is to examine the development of the central auditory system as reflected by latencies of P1 and Ni cortical auditory evoked potentials in normal-hearing children and in congenitally deaf children after they are fitted with a cochlear implant. Three projects are proposed. The goal of the first project is to provide a comprehensive account of the development of P1 and Ni latencies in normal-hearing children. These data will serve as a baseline against which to compare the performance of cochlear implant recipients. In the second project we will examine whether, and to what extent, pediatric cochlear implant recipients show a delay in the development of P1 and NI latencies. The goal is to determine the age after which cochlear implantation would be in a physiologically degenerate auditory system, or conversely, the age before which implantation would be in a relatively 'normal' auditory system. The third project is a longitudinal assessment of the development of P1 and NI latencies in pediatric implant users. The goal is to determine the time period over which plasticity remains a property of the central auditory pathways. Overall, our experiments are designed to assess the consequences on the developing central auditory system of initiating electrical stimulation at different ages. The results of these experiments could provide an estimate of the upper age limit for implantation into a highly plastic and/or relatively non-degenerate auditory system.
Funding Period: 2001-06-01 - 2008-05-31
more information: NIH RePORT

Top Publications

  1. pmc Cortical reorganization in children with cochlear implants
    Phillip M Gilley
    Department of Speech, Language, and Hearing Science, University of Colorado at Boulder, 2501 Kittredge Loop Rd, 409 UCB, Boulder, CO 80309 0409, USA
    Brain Res 1239:56-65. 2008
  2. pmc The influence of a sensitive period for auditory-visual integration in children with cochlear implants
    Phillip M Gilley
    Department of Speech, Language, and Hearing Science, University of Colorado at Boulder, Boulder, CO 80309 0409, USA
    Restor Neurol Neurosci 28:207-18. 2010
  3. ncbi The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants
    Anu Sharma
    Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    Hear Res 203:134-43. 2005
  4. ncbi P1 latency as a biomarker for central auditory development in children with hearing impairment
    Anu Sharma
    Behavioral and Brian Sciences, Callier Advanced Hearing Research Center, University of Texas at Dallas 75235, USA
    J Am Acad Audiol 16:564-73. 2005
  5. ncbi Minimization of cochlear implant stimulus artifact in cortical auditory evoked potentials
    Phillip M Gilley
    School of Behavioral and Brain Sciences, Callier Advanced Hearing Research Center, The University of Texas at Dallas, 1966 Inwood Road, 75235, USA
    Clin Neurophysiol 117:1772-82. 2006
  6. ncbi Abnormalities in central auditory maturation in children with language-based learning problems
    Phillip M Gilley
    The University of Texas at Dallas, School of Behavioral and Brain Sciences, Callier Advanced Hearing Research Center, 1966 Inwood Rd, Dallas, TX 75206, USA
    Clin Neurophysiol 117:1949-56. 2006
  7. ncbi Central auditory development in children with bilateral cochlear implants
    Paul W Bauer
    Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas 75230, USA
    Arch Otolaryngol Head Neck Surg 132:1133-6. 2006
  8. pmc Central auditory development: evidence from CAEP measurements in children fit with cochlear implants
    Michael F Dorman
    Department of Speech and Hearing Science, Arizona State University, AZ, USA
    J Commun Disord 40:284-94. 2007
  9. pmc The representation of voice onset time in the cortical auditory evoked potentials of young children
    Katrina Agung King
    Callier Advanced Hearing Research Center, Department of Brain and Behavioral Sciences, University of Texas at Dallas, TX, USA
    Clin Neurophysiol 119:2855-61. 2008

Scientific Experts

Detail Information

Publications9

  1. pmc Cortical reorganization in children with cochlear implants
    Phillip M Gilley
    Department of Speech, Language, and Hearing Science, University of Colorado at Boulder, 2501 Kittredge Loop Rd, 409 UCB, Boulder, CO 80309 0409, USA
    Brain Res 1239:56-65. 2008
    ..Reorganization of central auditory pathways is limited by the age at which implantation occurs, and may help explain the benefits and limitations of implantation in congenitally deaf children...
  2. pmc The influence of a sensitive period for auditory-visual integration in children with cochlear implants
    Phillip M Gilley
    Department of Speech, Language, and Hearing Science, University of Colorado at Boulder, Boulder, CO 80309 0409, USA
    Restor Neurol Neurosci 28:207-18. 2010
    ..Our goal was to investigate the effects of reorganization in a task that examines performance during multisensory integration...
  3. ncbi The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants
    Anu Sharma
    Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    Hear Res 203:134-43. 2005
    ..Our results are consistent with animal models of central auditory development after implantation and confirm the presence of a relatively brief sensitive period for central auditory development in young children...
  4. ncbi P1 latency as a biomarker for central auditory development in children with hearing impairment
    Anu Sharma
    Behavioral and Brian Sciences, Callier Advanced Hearing Research Center, University of Texas at Dallas 75235, USA
    J Am Acad Audiol 16:564-73. 2005
    ..Using the same marker, clinicians will also be able to monitor the maturation of central auditory pathways once electrical stimulation is initiated...
  5. ncbi Minimization of cochlear implant stimulus artifact in cortical auditory evoked potentials
    Phillip M Gilley
    School of Behavioral and Brain Sciences, Callier Advanced Hearing Research Center, The University of Texas at Dallas, 1966 Inwood Road, 75235, USA
    Clin Neurophysiol 117:1772-82. 2006
    ..To compare two methods of minimizing cochlear implant artifact in cortical auditory evoked potential (CAEP) recordings...
  6. ncbi Abnormalities in central auditory maturation in children with language-based learning problems
    Phillip M Gilley
    The University of Texas at Dallas, School of Behavioral and Brain Sciences, Callier Advanced Hearing Research Center, 1966 Inwood Rd, Dallas, TX 75206, USA
    Clin Neurophysiol 117:1949-56. 2006
    ..To examine maturation of the central auditory pathways in children with language-based learning problems (LP)...
  7. ncbi Central auditory development in children with bilateral cochlear implants
    Paul W Bauer
    Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas 75230, USA
    Arch Otolaryngol Head Neck Surg 132:1133-6. 2006
    ..To examine the time course of maturation of P1 latencies in infant sequential and simultaneous bilateral cochlear implant recipients...
  8. pmc Central auditory development: evidence from CAEP measurements in children fit with cochlear implants
    Michael F Dorman
    Department of Speech and Hearing Science, Arizona State University, AZ, USA
    J Commun Disord 40:284-94. 2007
    ....
  9. pmc The representation of voice onset time in the cortical auditory evoked potentials of young children
    Katrina Agung King
    Callier Advanced Hearing Research Center, Department of Brain and Behavioral Sciences, University of Texas at Dallas, TX, USA
    Clin Neurophysiol 119:2855-61. 2008
    ..In adults, a 'double-on' N1 response is often considered a cortical marker of VOT representation...