ACOUSTIC RESPONSES OF THE HUMAN COCHLEA AND MIDDLE EAR

Summary

Principal Investigator: DOUGLAS H contact KEEFE
Abstract: The primary goal of this application is to use a combination of acoustic and behavioral responses to test theories of auditory processing at the mechanical and behavioral levels. A subordinate goal is to relate acoustic responses measured non-invasively in the ear canal to cochlear and middle ear function. The first aim studies the relationships between middle ear and cochlear mechanics using a combination of experimental and theoretical approaches. Measurements of stimulus-frequency otoacoustic emission (SFOAE) and otoreflectance measurements will be used to predict hearing loss, an improved test of acoustic reflex function will be used to study middle-ear noise sources and no linearity, and time-domain models of middle-ear and cochlear energy transmission will be developed and evaluated based on experimental measurements performed in this application or reported in the literature. The second aim studies the effects of cochlear no linearity on spectral processing using SFOAE stimulus conditions similar to those used in behavioral experiments on simultaneous and non-simultaneous masking and suppression. Specifically, the experiments will address the extent to which SFOAE measurements of peripheral mechanics are able to noninvasive assess the strength of the medial olive-cochlear (MOC) efferent system on outer hair cell function, assess the level dependence of SFOAE fine structure, and account for the performance of normal-hearing listeners and listeners with sensor neural hearing loss in detecting tones in broadband and notched noise. The third aim studies the effects of cochlear no linearity on temporal processing using SFOAE stimulus conditions similar to those used in behavioral experiments on overshoot and amplitude modulation (AM). These experiments will assess the shifts in SFOAEs produced by activation of the MOC system in response to sounds with AM, and will test the extent to which SFOAE measurements can account for measurements of behavioral overshoot in normal listeners and subjects with auditory neuropathy. The results of the proposed experiments will provide useful data and modeling to improve our understanding of the auditory periphery in humans, and may improve our ability to diagnose the magnitude of hearing loss and improve our understanding of the impact of hearing loss on spectral and temporal resolution.
Funding Period: 1999-05-01 - 2010-02-28
more information: NIH RePORT

Top Publications

  1. pmc Simultaneous measurement of noise-activated middle-ear muscle reflex and stimulus frequency otoacoustic emissions
    Shawn S Goodman
    Center for Hearing Research, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Assoc Res Otolaryngol 7:125-39. 2006
  2. pmc Detecting high-frequency hearing loss with click-evoked otoacoustic emissions
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 129:245-61. 2011
  3. ncbi Ear-canal wideband acoustic transfer functions of adults and two- to nine-month-old infants
    Lynne A Werner
    Department of Speech and Hearing Sciences, University of Washington, Seattle, Washington 98105 6246, USA
    Ear Hear 31:587-98. 2010
  4. pmc Wideband acoustic-reflex test in a test battery to predict middle-ear dysfunction
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    Hear Res 263:52-65. 2010
  5. pmc Use of stimulus-frequency otoacoustic emissions to investigate efferent and cochlear contributions to temporal overshoot
    Douglas H Keefe
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 125:1595-604. 2009
  6. pmc High-frequency click-evoked otoacoustic emissions and behavioral thresholds in humans
    Shawn S Goodman
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 125:1014-32. 2009
  7. pmc Ear asymmetries in middle-ear, cochlear, and brainstem responses in human infants
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 123:1504-12. 2008
  8. pmc Two-tone suppression of stimulus frequency otoacoustic emissions
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 123:1479-94. 2008
  9. pmc Distortion product otoacoustic emission suppression tuning and acoustic admittance in human infants: birth through 6 months
    Carolina Abdala
    House Ear Institute, 2100 West Third Street, Children s Auditory Research and Evaluation Center, Los Angeles, California 90057, USA
    J Acoust Soc Am 121:3617-27. 2007
  10. pmc Theory of forward and reverse middle-ear transmission applied to otoacoustic emissions in infant and adult ears
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 121:978-93. 2007

Detail Information

Publications13

  1. pmc Simultaneous measurement of noise-activated middle-ear muscle reflex and stimulus frequency otoacoustic emissions
    Shawn S Goodman
    Center for Hearing Research, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Assoc Res Otolaryngol 7:125-39. 2006
    ..These results suggest caution in the interpretation of effects observed using ipsilaterally presented acoustic activators intended to excite the MOC reflex...
  2. pmc Detecting high-frequency hearing loss with click-evoked otoacoustic emissions
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 129:245-61. 2011
    ..3 ms. Results have potential clinical significance in predicting hearing status from at least 1 to 10 kHz using a single CEOAE response...
  3. ncbi Ear-canal wideband acoustic transfer functions of adults and two- to nine-month-old infants
    Lynne A Werner
    Department of Speech and Hearing Sciences, University of Washington, Seattle, Washington 98105 6246, USA
    Ear Hear 31:587-98. 2010
    ..Although these measures would be diagnostically useful in older infants, normative data on a large number of older infants are lacking. The goal of this study was to provide such normative data...
  4. pmc Wideband acoustic-reflex test in a test battery to predict middle-ear dysfunction
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    Hear Res 263:52-65. 2010
    ..Baseline clinical and WB ARTs were also compared in ipsilateral and contralateral measurements in adults...
  5. pmc Use of stimulus-frequency otoacoustic emissions to investigate efferent and cochlear contributions to temporal overshoot
    Douglas H Keefe
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 125:1595-604. 2009
    ....
  6. pmc High-frequency click-evoked otoacoustic emissions and behavioral thresholds in humans
    Shawn S Goodman
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 125:1014-32. 2009
    ..Envelope delays of both components were approximately invariant with level...
  7. pmc Ear asymmetries in middle-ear, cochlear, and brainstem responses in human infants
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 123:1504-12. 2008
    ..No left-ear dominance for DPOAE signal was observed. These results do not support a theory that ear asymmetries in cochlear processing mimic hemispheric brain specialization for auditory processing...
  8. pmc Two-tone suppression of stimulus frequency otoacoustic emissions
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 123:1479-94. 2008
    ..SFOAE suppression provides a noninvasive measure of the saturating nonlinearities associated with cochlear amplification on the basilar membrane...
  9. pmc Distortion product otoacoustic emission suppression tuning and acoustic admittance in human infants: birth through 6 months
    Carolina Abdala
    House Ear Institute, 2100 West Third Street, Children s Auditory Research and Evaluation Center, Los Angeles, California 90057, USA
    J Acoust Soc Am 121:3617-27. 2007
    ..Study of older infants and children is needed to fully define postnatal immaturity of human peripheral auditory function...
  10. pmc Theory of forward and reverse middle-ear transmission applied to otoacoustic emissions in infant and adult ears
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 121:978-93. 2007
    ..The forward middle-ear transmittance level was -16 dB less in infants, so that the conductive efficiency was poorer in infants than adults...
  11. ncbi Effects of middle-ear immaturity on distortion product otoacoustic emission suppression tuning in infant ears
    Carolina Abdala
    House Ear Institute, 2100 West Third Street, Children s Auditory Research and Evaluation Center, Los Angeles, California 90057, USA
    J Acoust Soc Am 120:3832-42. 2006
    ..Results show that once the immaturity was compensated for by providing infants with a relative increase in primary tone level, DPOAE suppression tuning at f2= 6000 Hz was similar in adults and infants...
  12. pmc Use of stimulus-frequency otoacoustic emission latency and level to investigate cochlear mechanics in human ears
    Kim S Schairer
    Center for Hearing Research, Boys Town National Research Hospital, 555 N 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 120:901-14. 2006
    ..Tuning estimates were constant above 1000 Hz, consistent with simultaneous masking data, but in contrast to previous estimates from SFOAEs...
  13. pmc Moments of click-evoked otoacoustic emissions in human ears: group delay and spread, instantaneous frequency and bandwidth
    Douglas H Keefe
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 132:3319-50. 2012
    ..CEOAE moments reveal clinically relevant information on cochlear tuning in ears with normal and impaired hearing...