STATISTICAL METHODS FOR CORRELATED SUBSTANCE USE DATA

Summary

Principal Investigator: Heping Zhang
Abstract: DESCRIPTION (Applicant's abstract): In response to NIH announcement PA-98-03 1, we will develop and apply tree- and spline-based statistical methods for the analysis of irregularly structured correlated data on substance use. These statistical methods usually produce data-driven models, but we will study ways to incorporate them with existing theory in medical, behavioral, and social sciences. This new theory-embedded data-driven methodology will enhance our understanding of health-related problems. Specifically, we will address issues of: (a) estimating covariance structures for analyzing irregularly spaced longitudinal data and bridging adaptive splines models with classic effects models. (b) Exploring tree-based methods for discrete longitudinal/genetic data analyses; and, (c) developing frailty models and their combination with tree based technique for segregation analysis, particularly useful for genetic epidemiological studies of psychiatric disorders. The secondary goal of this project is to enrich existing statistical software from the previous work of the Principal Investigator. This free software has already been downloaded by many researchers. The emphasis of this second component is: (a) to simplify the user interface for data input and analysis output; (b) to improve the stability of the programs by performing thorough error-free " checking; and (c) to increase the portability of the software for different platforms. This software will provide a much needed data-mining tool for modeling complicated and correlated (e.g., longitudinal) data in medical, behavioral, and social sciences. In addition, we will apply the statistical methods to important data sets related to substance use and address a variety of problems including: (a) determining the effect of cocaine use by pregnant women on infant growth; (b) understanding the risk factors and the genetic epidemiology of substance use disorders, the impact of daily drug use on later employment, and the connection between drug use and income; (c) determining under what conditions our methods can lead to a deeper understanding of behavioral problems than more traditional analyses.
Funding Period: 2000-08-01 - 2005-07-31
more information: NIH RePORT

Top Publications

  1. pmc Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Genet 132:735-43. 2013
  2. pmc NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Drug Alcohol Depend 129:254-64. 2013
  3. pmc The familial aggregation of cannabis use disorders
    Kathleen R Merikangas
    Section on Developmental Genetic Epidemiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814 3720, USA
    Addiction 104:622-9. 2009
  4. ncbi Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia
    Robert T Malison
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Psychiatr Genet 16:245-9. 2006
  5. ncbi Familial and genetic susceptibility to major neonatal morbidities in preterm twins
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 117:1901-6. 2006
  6. pmc A statistical framework for the classification of tensor morphologies in diffusion tensor images
    Hongtu Zhu
    MRI Unit, Department of Psychiatry, Columbia University Medical Center, USA
    Magn Reson Imaging 24:569-82. 2006
  7. pmc Substance-abusing mothers and disruptions in child custody: an attachment perspective
    Nancy E Suchman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Subst Abuse Treat 30:197-204. 2006
  8. pmc Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data
    Xiaoyun Zhong
    Yale University School of Medicine, New Haven, Connecticut, USA
    BMC Genet 6:S31. 2005
  9. pmc A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking
    Yuanqing Ye
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    BMC Genet 6:S135. 2005
  10. pmc Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, CT 06520 8034, USA
    BMC Genet 6:S118. 2005

Scientific Experts

Detail Information

Publications14

  1. pmc Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Genet 132:735-43. 2013
    ..We concluded that common ADH variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans...
  2. pmc NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Drug Alcohol Depend 129:254-64. 2013
    ..We aimed to identify novel, functional, replicable and genome-wide significant risk regions specific for alcohol dependence using genome-wide association studies (GWASs)...
  3. pmc The familial aggregation of cannabis use disorders
    Kathleen R Merikangas
    Section on Developmental Genetic Epidemiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814 3720, USA
    Addiction 104:622-9. 2009
    ..The aim of this paper is to examine the familial aggregation of cannabis use disorders and other psychiatric conditions among first-degree relatives and spouses of probands with a cannabis use disorder...
  4. ncbi Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia
    Robert T Malison
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Psychiatr Genet 16:245-9. 2006
    ..These results do not support the involvement of genetic variation in these three circadian gene SNPs for influencing risks for either of these cocaine phenotypes...
  5. ncbi Familial and genetic susceptibility to major neonatal morbidities in preterm twins
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 117:1901-6. 2006
    ..Intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia remain significant causes of morbidity and mortality in preterm newborns...
  6. pmc A statistical framework for the classification of tensor morphologies in diffusion tensor images
    Hongtu Zhu
    MRI Unit, Department of Psychiatry, Columbia University Medical Center, USA
    Magn Reson Imaging 24:569-82. 2006
    ..We also show that the P values for test statistics are more sensitive tools for classifying tensor morphologies than are invariant measures of anisotropy alone...
  7. pmc Substance-abusing mothers and disruptions in child custody: an attachment perspective
    Nancy E Suchman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Subst Abuse Treat 30:197-204. 2006
    ..g., children nested within families). Findings are consistent with an attachment perspective on parenting suggesting that the internal psychological processes of a parent play a critical role in the continuity of parenting...
  8. pmc Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data
    Xiaoyun Zhong
    Yale University School of Medicine, New Haven, Connecticut, USA
    BMC Genet 6:S31. 2005
    ..We also compare the methods with mean identity-by-descent tests and transmission/disequilibrium tests that do not use age of onset information...
  9. pmc A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking
    Yuanqing Ye
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    BMC Genet 6:S135. 2005
    ..Our analysis also identified genes that were reported in other studies of alcoholism and identified new genes or single-nucleotide polymorphisms that can be useful candidates for future studies...
  10. pmc Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, CT 06520 8034, USA
    BMC Genet 6:S118. 2005
    ..Our multivariate linkage analysis found linkage evidence on two regions on chromosome 4: around marker GABRB1 at 51.4 cM and marker FABP2 at 116.8 cM (unadjusted p-value = 0.00006)...
  11. ncbi Comparison of single-nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3
    Marsha A Wilcox
    Genetics Program, Division of Graduate Medical Sciences, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Genet Epidemiol 29:S7-28. 2005
    ..5) Analyses with SNPs were computationally challenging, and identified areas where improvements in analysis tools will be necessary to make analysis practical for widespread use...
  12. pmc Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 6:50. 2005
    ....
  13. pmc Detection of genes for ordinal traits in nuclear families and a unified approach for association studies
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Genetics 172:693-9. 2006
    ..We further demonstrated the advantage of our test by revealing a significant association (P = 0.00067) between alcohol dependence and a SNP in the growth-associated protein 43...
  14. ncbi Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Genet Epidemiol 28:302-12. 2005
    ..The number of markers required is much lower than has been suggested in previous studies...