MENTAL DISORDERS AS RISK FACTORS FOR SUBSTANCE DISORDERS

Summary

Principal Investigator: R C Kessler
Abstract: DESCRIPTION: (Applicant's Abstract) This proposal seeks support for a ten-year follow-up of the 5877 people who participated in Parts I and II of the National Comorbidity Survey (NCS; Kessler et al., 1994), a nationally representative survey of people in the age range 15-54 in the U.S. household population designed to estimate the prevalences and correlates of DSM-III-R mental and substance disorders. The focus of the follow-up survey will be on the relationship between temporally primary mental disorders and the subsequent onset and course of substance disorders. Specifically, we aim to use information about mental disorders collected in the baseline survey to predict the subsequent onset of substance use and the onset and course of substance disorders over the intervening decade. We also aim to use causal modeling to evaluate the effects of mediators and modifiers of these associations. There are two specific aims. The first is to evaluate the two overarching hypotheses that guide the proposed research: that temporally primary mental disorders assessed at baseline predict the subsequent first onset and progression of substance use and substance disorders over the intervening decade; and that co-occurring mental disorders among baseline respondents with substance disorders are significant predictors of continuation over the intervening decade. The second specific aim is to carry out more refined analyses to elucidate the mechanisms involved in the associations documented under the first aim. A large number of potentially important mediators and modifiers will be considered here, with a particular interest in modifiable risk factors that could be intervention targets associated with mental disorders. All of the work under this second aim will separately consider the subsample of respondents with primary conduct disorder and the subsample of respondents without conduct disorder who have primary anxiety-mood disorders. The processes involved in the onset and course of secondary substance disorders are anticipated to be considerably different in these two subsamples, with substance disorders strongly related to a broader pattern of unconventionality and risk taking in the subsample with primary conduct disorder and to self- medication in the subsample with primary anxiety-mood disorders.
Funding Period: 1999-07-15 - 2006-06-30
more information: NIH RePORT

Top Publications

  1. pmc Socio-demographic risk factors for alcohol and drug dependence: the 10-year follow-up of the national comorbidity survey
    Joel Swendsen
    National Scientific Research Center CNRS 5231, Bordeaux, France
    Addiction 104:1346-55. 2009
  2. pmc The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Epidemiol Psichiatr Soc 18:23-33. 2009
  3. pmc School mental health resources and adolescent mental health service use
    Jennifer Greif Green
    School of Education, Boston University, Two Silber Way, Boston, MA 02215, USA
    J Am Acad Child Adolesc Psychiatry 52:501-10. 2013
  4. pmc Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey
    Joel Swendsen
    National Scientific Research Center, Bordeaux, France
    Addiction 105:1117-28. 2010
  5. pmc The effects of latent variables in the development of comorbidity among common mental disorders
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Depress Anxiety 28:29-39. 2011
  6. pmc Co-morbid major depression and generalized anxiety disorders in the National Comorbidity Survey follow-up
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 38:365-74. 2008
  7. pmc Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication
    L Degenhardt
    National Drug and Alcohol Research Centre, University of NSW, Sydney, NSW, Australia
    Psychol Med 39:157-67. 2009

Scientific Experts

Detail Information

Publications8

  1. pmc Socio-demographic risk factors for alcohol and drug dependence: the 10-year follow-up of the national comorbidity survey
    Joel Swendsen
    National Scientific Research Center CNRS 5231, Bordeaux, France
    Addiction 104:1346-55. 2009
    ..The present study examines prospective associations between socio-demographic variables and the subsequent onset of alcohol and drug dependence using data from the National Comorbidity Survey (NCS) and the NCS Follow-up survey (NCS-2)...
  2. pmc The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Epidemiol Psichiatr Soc 18:23-33. 2009
    ..The paper reviews recent findings from the WHO World Mental Health (WMH) surveys on the global burden of mental disorders...
  3. pmc School mental health resources and adolescent mental health service use
    Jennifer Greif Green
    School of Education, Boston University, Two Silber Way, Boston, MA 02215, USA
    J Am Acad Child Adolesc Psychiatry 52:501-10. 2013
    ..This article examines associations of school resources with past-year mental health service use among students with 12-month DSM-IV mental disorders...
  4. pmc Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey
    Joel Swendsen
    National Scientific Research Center, Bordeaux, France
    Addiction 105:1117-28. 2010
    ..This investigation examines the role of primary mental disorders as risk factors for the later onset of nicotine, alcohol and illicit drug use, abuse and dependence with abuse...
  5. pmc The effects of latent variables in the development of comorbidity among common mental disorders
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Depress Anxiety 28:29-39. 2011
    ....
  6. pmc Co-morbid major depression and generalized anxiety disorders in the National Comorbidity Survey follow-up
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 38:365-74. 2008
    ....
  7. pmc Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication
    L Degenhardt
    National Drug and Alcohol Research Centre, University of NSW, Sydney, NSW, Australia
    Psychol Med 39:157-67. 2009
    ..We have examined the role of pre-existing mental disorders and sociodemographics in explaining the predictive effects of violations using data from the US National Comorbidity Survey Replication (NCS-R)...