Effects of family smoking history in never-smokers
Principal Investigator: Ovide Pomerleau
Abstract: Individual differences in initial sensitivity to nicotine may play a significant role in determining whether or not a person becomes a smoker. In people with high susceptibility, the initial response to nicotine seems to include not only aversive effects but also reinforcing consequences such as pleasurable effects and temporary improvements in affect or performance, and further exposure leads to rapid development of tolerance to aversive effects and sensitization of positive effects, resulting in nicotine dependence. The concentration of people with high susceptibility among those who continue to smoke may explain the difficulty encountered in reducing the prevalence of smoking much below 25 percent over the past decade. To manage this important public health problem more effectively, there is a pressing need to identify the individual behavioral and biological characteristics that set the stage for nicotine reinforcement as well as those factors that interfere with it. The proposed research involves comparisons of sensitivity to nicotine in people who have a positive or a negative family smoking history; never smokers have been chosen for study, rather than current or former smokers, in order to avoid the influence of extensive nicotine exposure on tolerance and sensitization. The approach is comparable to that which has been employed to study the children of alcoholics and other drug abusers. Over a five-year period, the responses of men and women with positive or negative family histories will be investigated, employing both within-subject and between group comparisons. The reinforcement potential of nicotine will be explored by determining reactivity to nicotine administration via nasal spray; subjective, physiological, cognitive, and neuroendocrine response systems will be examined to provide a multi-dimensional assessment. Determination of differences in initial reactivity to nicotine along with identification of baseline characteristics that may contribute to nicotine reinforcement, such as personality variables, psychiatric cofactors, and environmental factors, should increase the understanding of the conditions that promote or protect against smoking behavior, providing the basis for more effective prevention programs and more efficient treatment interventions.
Funding Period: 2002-09-01 - 2008-05-31
more information: NIH RePORT
- Differences in accuracy of offspring assessment based on parental smoking statusCynthia S Pomerleau
Nicotine Research Laboratory, Department of Psychiatry, University of Michigan, 475 Market Place, Ste L, Ann Arbor, MI 48108, USA
Addict Behav 30:437-41. 2005..Overall, these results support the utility of proxy reports of parental smoking phenotype by adult informants when self-report is unavailable...
- Never-smokers with a positive family smoking history are more likely to be overweight or obese than never-smokers with a negative family smoking historyCynthia S Pomerleau
University of Michigan, Department of Psychiatry, USA
Eat Behav 10:49-51. 2009..Further research in larger samples, using more complex statistical models, will be needed to disentangle these issues and identify causal pathways...
- Substance use, trait measures, and subjective response to nicotine in never-smokers stratified on parental smoking history and sexOvide F Pomerleau
Department of Psychiatry, University of Michigan Medical School, Rachel Upjohn Building, Room 2137, Ann Arbor, MI 48105, USA
Nicotine Tob Res 11:1055-66. 2009..Male and female never-smokers stratified on parental history of smoking were tested for possible differences in susceptibility to the hedonic effects of nicotine...