Drug Abuse, Social Decision-Making, and Sex-Related Functional Brain Asymmetry

Summary

Principal Investigator: DANIEL T TRANEL
Abstract: This research application is in response to #RFA-DA-06-004. At the heart of drug and alcohol abuse is bad decision-making, especially in response to social influences. This decision-making defect is highly reminiscent of the social decision-making impairments that characterize neurological patients with damage to ventromedial prefrontal cortex (VMPC). The VMPC patients provide a neurological model of social decision- making gone awry. There is evidence at both preclinical and clinical levels that the VMPC is a key brain region in drug abuse, and we propose that VMPC dysfunction and defective social decision-making may characterize individuals who abuse and become addicted to drugs and alcohol. In this research application, we plan to conduct studies in neurological patients in order to flesh out the neurobiological underpinnings of social decision-making, taking advantage of the unique Iowa Patient Registry that contains neuropsychological and neuroanatomical data for thousands of patients. A particular focus is on gender differences. We have intriguing preliminary findings suggesting that there might be an important sex-related difference in the relationship between the VMPC and social decision-making: in men, the right VMPC might be critical, whereas in women, the left VMPC might be critical. The experiments will test three specific aims: (1) To determine whether there is sex-related functional asymmetry of the VMPC in regard to social decision- making, using tasks such as the Ultimatum Game, Trust Game, Iowa Gambling Task, and Ellsberg Tasks; (2) To extend the investigation of sex-related functional asymmetry to other brain structures known to be critical for social and affective processes related to decision-making, namely, the amygdala and the insular cortex;(3) To investigate developmental influences on the relationship between the VMPC and social- decision making and emotional processing, by studying patients who incurred VMPC damage early in life. The experiments will furnish important new information about the neurobiological underpinnings of social decision-making and emotional processing. The link with substance abuse is direct: the decision-making deficits in VMPC patients have striking similarities with those evident in drug and alcohol abusers and addicts ("myopia for the future"). Thus, our research could help pinpoint sources of neural dysfunction that contribute to bad decision-making of the type that characterizes drug and alcohol abuse. Public health relevance: This research will help us understand how various parts of the brain are important for social decision-making and emotional processing, whether there are gender differences in these brain- behavior relationships, and how these relationships develop. The research could help inform treatment and prevention of drug and alcohol abuse disorders, as well as social conduct disorders, personality disorders, and anxiety and mood disorders, all of which have high comorbidity with drug and alcohol abuse.
Funding Period: ----------------2006 - ---------------2011-
more information: NIH RePORT

Top Publications

  1. pmc Damage to insula abolishes cognitive distortions during simulated gambling
    Luke Clark
    Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Proc Natl Acad Sci U S A 111:6098-103. 2014
  2. pmc Behavioral patterns and lesion sites associated with impaired processing of lexical and conceptual knowledge of actions
    David Kemmerer
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, IA, USA
    Cortex 48:826-48. 2012
  3. ncbi Further lesion evidence for the neural basis of conceptual knowledge for persons and other concrete entities
    Daniel Tranel
    Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    J Neuropsychol 2:301-20. 2008
  4. pmc Preserved self-awareness following extensive bilateral brain damage to the insula, anterior cingulate, and medial prefrontal cortices
    Carissa L Philippi
    Division of Behavioral Neurology and Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e38413. 2012
  5. pmc Hemispheric side of damage influences sex-related differences in smoking cessation in neurological patients
    Natassia Gaznick
    a Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, Tranel Lab, University of Iowa, Iowa City, IA, USA
    J Clin Exp Neuropsychol 36:551-8. 2014
  6. ncbi Neurological and psychiatric aspects of emotion
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Handb Clin Neurol 106:53-74. 2012
  7. pmc Authoritarianism, religious fundamentalism, and the human prefrontal cortex
    Erik Asp
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, IA City, IA 52242, USA
    Neuropsychology 26:414-21. 2012
  8. pmc Anterior prefrontal cortex contributes to action selection through tracking of recent reward trends
    Christopher K Kovach
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 32:8434-42. 2012
  9. pmc Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex
    Jan Gläscher
    Division of Humanities and Social Sciences and Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 109:14681-6. 2012
  10. pmc Famous face identification in temporal lobe epilepsy: support for a multimodal integration model of semantic memory
    Daniel L Drane
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cortex 49:1648-67. 2013

Scientific Experts

Detail Information

Publications74

  1. pmc Damage to insula abolishes cognitive distortions during simulated gambling
    Luke Clark
    Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Proc Natl Acad Sci U S A 111:6098-103. 2014
    ..Interventions to reduce insula reactivity could show promise in the treatment of disordered gambling. ..
  2. pmc Behavioral patterns and lesion sites associated with impaired processing of lexical and conceptual knowledge of actions
    David Kemmerer
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, IA, USA
    Cortex 48:826-48. 2012
    ..Regarding theoretical implications, the study provides new support for the Embodied Cognition Framework, which maintains that conceptual knowledge is grounded in sensorimotor systems...
  3. ncbi Further lesion evidence for the neural basis of conceptual knowledge for persons and other concrete entities
    Daniel Tranel
    Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    J Neuropsychol 2:301-20. 2008
    ....
  4. pmc Preserved self-awareness following extensive bilateral brain damage to the insula, anterior cingulate, and medial prefrontal cortices
    Carissa L Philippi
    Division of Behavioral Neurology and Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e38413. 2012
    ..Our findings are compatible with the hypothesis that SA is likely to emerge from more distributed interactions among brain networks including those in the brainstem, thalamus, and posteromedial cortices...
  5. pmc Hemispheric side of damage influences sex-related differences in smoking cessation in neurological patients
    Natassia Gaznick
    a Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, Tranel Lab, University of Iowa, Iowa City, IA, USA
    J Clin Exp Neuropsychol 36:551-8. 2014
    ..Our study provides further evidence for differences in lateralization of complex behavior between the sexes, which has significant implications for differences in treatment strategies between the sexes. ..
  6. ncbi Neurological and psychiatric aspects of emotion
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Handb Clin Neurol 106:53-74. 2012
    ..Future studies will validate specific diagnostic criteria for the various cognitive, emotional, and behavioral problems reported among patients with neurological disorders, which may result in more specific and effective treatments...
  7. pmc Authoritarianism, religious fundamentalism, and the human prefrontal cortex
    Erik Asp
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, IA City, IA 52242, USA
    Neuropsychology 26:414-21. 2012
    ..Here, we put our theory to an empirical test, hypothesizing that patients with prefrontal cortex damage would have a doubt deficit that would manifest as higher authoritarianism and religious fundamentalism...
  8. pmc Anterior prefrontal cortex contributes to action selection through tracking of recent reward trends
    Christopher K Kovach
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 32:8434-42. 2012
    ....
  9. pmc Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex
    Jan Gläscher
    Division of Humanities and Social Sciences and Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 109:14681-6. 2012
    ..By contrast, regions in the ventral PFC were required for decision-making. These findings provide detailed causal evidence for a remarkable functional-anatomical specificity in the human PFC...
  10. pmc Famous face identification in temporal lobe epilepsy: support for a multimodal integration model of semantic memory
    Daniel L Drane
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cortex 49:1648-67. 2013
    ..These findings challenge several assumptions underlying amodal models of semantic memory, and provide support for the integrated multimodal theories of semantic memory and a distributed representation of concepts...
  11. pmc Myopia for the future or hypersensitivity to reward? Age-related changes in decision making on the Iowa Gambling Task
    A S Bauer
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, IA, USA
    Emotion 13:19-24. 2013
    ....
  12. pmc Abnormal causal attribution leads to advantageous economic decision-making: a neuropsychological approach
    Timothy R Koscik
    University of Iowa College of Medicine, USA
    J Cogn Neurosci 25:1372-82. 2013
    ..The findings help clarify the important (and sometimes disadvantageous) role of social inference in economic decision-making. ..
  13. ncbi Decision-making deficits in normal elderly persons associated with executive personality disturbances
    Christopher M Nguyen
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa, USA
    Int Psychogeriatr 25:1811-9. 2013
    ....
  14. ncbi What might have been? The role of the ventromedial prefrontal cortex and lateral orbitofrontal cortex in counterfactual emotions and choice
    Sara M Levens
    Department of Psychology, University of North Carolina Charlotte, 4033 Colvard, 9201 University City Boulevard, Charlotte, NC 28223, United States Electronic address
    Neuropsychologia 54:77-86. 2014
    ....
  15. pmc Arrested development: early prefrontal lesions impair the maturation of moral judgement
    Bradley C Taber-Thomas
    1 Department of Psychology, Pennsylvania State University, University Park, PA 16802, USA
    Brain 137:1254-61. 2014
    ..Disruption to this affective neural system early in life interrupts moral development...
  16. pmc Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression
    Michael Koenigs
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 28:12341-8. 2008
    ..These findings demonstrate that vmPFC and dorsal PFC are critically and causally involved in depression, although with very different roles: vmPFC damage confers resistance to depression, whereas dorsal PFC damage confers vulnerability...
  17. pmc Selective developmental neuropsychological disorders
    Daniel Tranel
    Cortex 43:667-71. 2007
  18. pmc Right anterior cingulate: a neuroanatomical correlate of aggression and defiance in boys
    Aaron D Boes
    Department of Psychiatry and Medical Scientist Training Program, University of Iowa Carver College of Medicine, USA
    Behav Neurosci 122:677-84. 2008
    ..The authors discuss this finding in light of its implications for understanding the neural correlates of antisocial behavior...
  19. pmc Interoceptive awareness in experienced meditators
    Sahib S Khalsa
    Neuroscience Graduate Program, Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Psychophysiology 45:671-7. 2008
    ..These results provide evidence against the notion that practicing attention to internal body sensations, a core feature of meditation, enhances the ability to sense the heartbeat at rest...
  20. pmc Amygdala contribution to selective dimensions of emotion
    Gary G Berntson
    Department of Psychology, Ohio State University, Columbus, Ohio 43210, USA
    Soc Cogn Affect Neurosci 2:123-9. 2007
    ..The relative lack of emotional arousal to negative stimuli may account for many of the clinical features of amygdala lesions...
  21. pmc Prefrontal cortex damage abolishes brand-cued changes in cola preference
    Michael Koenigs
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Soc Cogn Affect Neurosci 3:1-6. 2008
    ..The result that VMPC damage abolishes the 'Pepsi paradox' suggests that the VMPC is an important part of the neural substrate for translating commercial images into brand preferences...
  22. pmc The orbitofrontal cortex, real-world decision making, and normal aging
    Natalie L Denburg
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242 1053, USA
    Ann N Y Acad Sci 1121:480-98. 2007
    ..Finally, we present data demonstrating that poor decision makers are more likely to fall prey to deceptive advertising, suggesting compromise of real-world judgment and decision-making abilities...
  23. pmc Is the prefrontal cortex important for fluid intelligence? A neuropsychological study using Matrix Reasoning
    Daniel Tranel
    Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Clin Neuropsychol 22:242-61. 2008
    ..Our findings do not support a connection between fluid intelligence and the frontal lobes, although a viable alternative interpretation is that the Matrix Reasoning subtest lacks construct validity as a measure of fluid intelligence...
  24. pmc Does the Clock Drawing Test have focal neuroanatomical correlates?
    Daniel Tranel
    Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa, IA, USA
    Neuropsychology 22:553-62. 2008
    ....
  25. pmc Stress and emotional memory retrieval: effects of sex and cortisol response
    Tony W Buchanan
    Department of Neurology, University of Iowa, USA
    Neurobiol Learn Mem 89:134-41. 2008
    ..At the same time, stress can enhance memory retrieval performance, especially for emotional stimuli, when the cortisol response is absent...
  26. pmc Preserved proper naming following left anterior temporal lobectomy is associated with early age of seizure onset
    Chad J Yucus
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Epilepsia 48:2241-52. 2007
    ..Here, we tested the hypothesis that early age of seizure onset would be a reliable factor "protecting" patients from developing proper naming defects following left ATL...
  27. pmc Impaired behavior on real-world tasks following damage to the ventromedial prefrontal cortex
    Daniel Tranel
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Exp Neuropsychol 29:319-32. 2007
    ....
  28. pmc Damage to the prefrontal cortex increases utilitarian moral judgements
    Michael Koenigs
    Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Nature 446:908-11. 2007
    ..These findings indicate that, for a selective set of moral dilemmas, the VMPC is critical for normal judgements of right and wrong. The findings support a necessary role for emotion in the generation of those judgements...
  29. pmc Irrational economic decision-making after ventromedial prefrontal damage: evidence from the Ultimatum Game
    Michael Koenigs
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 27:951-6. 2007
    ..These results suggest that emotion regulation processes subserved by VMPC are a critical component of normal economic decision making...
  30. pmc Age of seizure onset, functional reorganization, and neuropsychological outcome in temporal lobectomy
    Stefanie Griffin
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Exp Neuropsychol 29:13-24. 2007
    ..Our findings are consistent with the notion that functional reorganization may be an explanatory factor for the better neuropsychological outcome of EO epilepsy patients following anterior temporal lobectomy...
  31. pmc Ventromedial prefrontal cortex damage does not impair the development and use of common ground in social interaction: implications for cognitive theory of mind
    Rupa Gupta
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa, Iowa City, IA 52242, USA
    Neuropsychologia 50:145-52. 2012
    ....
  32. pmc Medial PFC damage abolishes the self-reference effect
    Carissa L Philippi
    University of Iowa, USA
    J Cogn Neurosci 24:475-81. 2012
    ..We found that damage to the mPFC abolished the SRE. The results demonstrate that the mPFC is necessary for the SRE and suggest that this structure is important for self-referential processing and the neural representation of self...
  33. pmc A somatic marker perspective of immoral and corrupt behavior
    Mona Sobhani
    Brain and Creativity Institute, University of Southern California, Los Angeles, CA 90089 2520, USA
    Soc Neurosci 6:640-52. 2011
    ....
  34. pmc Dimensions of personality disturbance after focal brain damage: investigation with the Iowa Scales of Personality Change
    Joseph Barrash
    Department of Neurology, University of Iowa, Iowa City, USA
    J Clin Exp Neuropsychol 33:833-52. 2011
    ..The findings indicate that conceptually distinctive dimensions with differential relationships to vmPFC can be derived from the Iowa Scales of Personality Change...
  35. pmc Bilateral amygdala damage impairs the acquisition and use of common ground in social interaction
    Rupa Gupta
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa, 200 Hawkins Drive, IA City, IA 52242, USA
    Neuropsychology 25:137-46. 2011
    ..Here, we investigate the contribution of the amygdala to these processes...
  36. pmc Cognition and nondysphoric depression among adoptees at high risk for psychopathology
    Sergio Paradiso
    Department of Psychiatry, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Compr Psychiatry 52:498-506. 2011
    ..Nondysphoric depression and depressed subjects were expected to show poorer premorbid and current cognition than nondepressed participants...
  37. pmc The human amygdala and the induction and experience of fear
    Justin S Feinstein
    University of Iowa, Iowa City, IA 52242, USA
    Curr Biol 21:34-8. 2011
    ..The findings support the conclusion that the human amygdala plays a pivotal role in triggering a state of fear and that the absence of such a state precludes the experience of fear itself...
  38. pmc Pervasive olfactory impairment after bilateral limbic system destruction
    Daniel Tranel
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Exp Neuropsychol 34:117-25. 2012
    ..demonstrated a strikingly severe and complete anosmia. This contrast in olfactory abilities and deficits as a result of different anatomical pathology affords new insights into the neural substrates of olfactory processing in humans...
  39. pmc The human ventromedial prefrontal cortex is critical for transitive inference
    Timothy R Koscik
    University of Iowa College of Medicine, IA, USA
    J Cogn Neurosci 24:1191-204. 2012
    ..Given the usefulness of transitivity in inferring social relationships, this deficit may be one of the basic features of social conduct problems associated with vmPFC damage...
  40. pmc Smoking cessation after brain damage does not lead to increased depression: implications for understanding the psychiatric complications of varenicline
    Daniel Tranel
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Cogn Behav Neurol 25:16-24. 2012
    ..However, the cause of depression and related symptoms in persons who quit smoking after taking varenicline remains uncertain, because smoking cessation itself can cause such symptoms...
  41. pmc Brain evolution and human neuropsychology: the inferential brain hypothesis
    Timothy R Koscik
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa, USA
    J Int Neuropsychol Soc 18:394-401. 2012
    ..This shift is believed to be a driving force for the evolution of the large human cortex. (JINS, 2012, 18, 394-401)...
  42. pmc Effects of age-related differences in empathy on social economic decision-making
    Janelle N Beadle
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Int Psychogeriatr 24:822-33. 2012
    ..Previous economic decision-making research has shown that in younger adults empathy is associated with prosocial behavior. The effects of empathy on older adult social economic decision-making are not well understood...
  43. pmc Detestable or marvelous? Neuroanatomical correlates of character judgments
    Katie E Croft
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, IA, USA
    Neuropsychologia 48:1789-801. 2010
    ....
  44. pmc Trait empathy as a predictor of individual differences in perceived loneliness
    Janelle N Beadle
    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Psychol Rep 110:3-15. 2012
    ..Underlying this relationship may be negative perceptions of personal social proclivity as a function of difficulty in understanding the mental states of others and high trait neuroticism...
  45. pmc Sex-related functional asymmetry of the amygdala: preliminary evidence using a case-matched lesion approach
    Daniel Tranel
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Neurocase 15:217-34. 2009
    ....
  46. pmc The insula and evaluative processes
    Gary G Berntson
    The Ohio State University, OH, USA
    Psychol Sci 22:80-6. 2011
    ..Results support the view that the insular cortex may play a broad role in integrating affective and cognitive processes, whereas the amygdala may have a more selective role in affective arousal, especially for negative stimuli...
  47. pmc Does vivid emotional imagery depend on body signals?
    Eduardo Paulo Morawski Vianna
    Max Planck Institute for Neurological Research, Cologne, Germany
    Int J Psychophysiol 72:46-50. 2009
    ..theoretical framework, which predicts such a dissociation between a "body loop" and an "as if body loop" for the experiencing and re-experiencing of emotions and feelings...
  48. pmc Recognition without awareness in a patient with simultanagnosia
    Natalie L Denburg
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1053, USA
    Int J Psychophysiol 72:5-12. 2009
    ....
  49. pmc Lesion mapping of cognitive abilities linked to intelligence
    Jan Gläscher
    Division of Humanities and Social Sciences, Caltech, Pasadena, CA 91125, USA
    Neuron 61:681-91. 2009
    ..Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease...
  50. pmc Hippocampal damage abolishes the cortisol response to psychosocial stress in humans
    Tony W Buchanan
    Department of Psychology, Saint Louis University, St Louis, MO 63103, USA
    Horm Behav 56:44-50. 2009
    ..These findings support the idea that the functions of the human HC extend beyond learning and memory, and suggest that the HC is necessary for producing the cortisol response to psychosocial stress...
  51. pmc Economic games quantify diminished sense of guilt in patients with damage to the prefrontal cortex
    Ian Krajbich
    Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 29:2188-92. 2009
    ..Instead, the findings argue for a specific insensitivity to guilt, an abnormality that we suggest characterizes a key contribution made by the VMPFC to social behavior...
  52. pmc Neuroanatomical correlates of the Benton Facial Recognition Test and Judgment of Line Orientation Test
    Daniel Tranel
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA, USA
    J Clin Exp Neuropsychol 31:219-33. 2009
    ..These findings put new empirical teeth in the localizing value of the FRT and JLO tests, and they extend and sharpen previous work that had pointed to right posterior structures as being important for FRT and JLO performance..
  53. pmc Consistency of neuropsychological outcome following damage to prefrontal cortex in the first years of life
    Steven W Anderson
    Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Exp Neuropsychol 31:170-9. 2009
    ..Our studies recapitulate and confirm the core messages set forth by Ackerly and Benton more than a half-century ago...
  54. pmc Executive control deficits in substance-dependent individuals: a comparison of alcohol, cocaine, and methamphetamine and of men and women
    Ellen A A van der Plas
    Department of Neurology, University of Iowa, Iowa City, IA, USA
    J Clin Exp Neuropsychol 31:706-19. 2009
    ..Together, these findings suggest that drug of choice and sex have different effects on executive functioning, which, if replicated, may help tailor intervention...
  55. pmc A neuroanatomical dissociation for emotion induced by music
    Erica L Johnsen
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int J Psychophysiol 72:24-33. 2009
    ..The findings provide evidence for a double dissociation between feeling emotions and autonomic responses to emotions, in response to music stimuli...
  56. pmc Right ventromedial prefrontal cortex: a neuroanatomical correlate of impulse control in boys
    Aaron D Boes
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Soc Cogn Affect Neurosci 4:1-9. 2009
    ..These results are consistent with the notion that right vmPFC provides a neuroanatomical correlate of the normal variance in impulse control observed in boys...
  57. pmc Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness
    S S Khalsa
    Neuroscience Graduate Program, Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int J Psychophysiol 72:34-45. 2009
    ....
  58. pmc The effects of voluntary regulation of positive and negative emotion on psychophysiological responsiveness
    David Driscoll
    Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int J Psychophysiol 72:61-6. 2009
    ....
  59. pmc Declarative memory is critical for sustained advantageous complex decision-making
    Rupa Gupta
    Department of Neurology, University of Iowa, United States
    Neuropsychologia 47:1686-93. 2009
    ....
  60. pmc Interoceptive awareness declines with age
    Sahib S Khalsa
    Department of Neurology and Neuroscience Program, University of Iowa, Iowa City, IA, USA
    Psychophysiology 46:1130-6. 2009
    ..These findings provide clear empirical evidence that interoception, much like exteroception and proprioception, declines with age...
  61. pmc Harming kin to save strangers: further evidence for abnormally utilitarian moral judgments after ventromedial prefrontal damage
    Bradley C Thomas
    Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Cogn Neurosci 23:2186-96. 2011
    ..Trends in Cognitive Sciences, 11, 322-323, 2007; Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., et al. Damage to the prefrontal cortex increases utilitarian moral judgments. Nature, 446, 908-911, 2007]...
  62. pmc The amygdala and decision-making
    Rupa Gupta
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa, Iowa City, IA 52242, USA
    Neuropsychologia 49:760-6. 2011
    ..We have posited that the amygdala is part of an "impulsive," habit type system that triggers emotional responses to immediate outcomes...
  63. pmc The human amygdala is necessary for developing and expressing normal interpersonal trust
    Timothy R Koscik
    Division of Behavioral Neurology and Cognitive Neuroscience, Department of Neurology, University of Iowa College of Medicine, IA 52246, USA
    Neuropsychologia 49:602-11. 2011
    ..Moreover, increased benevolence may increase the likelihood or opportunity to be taken advantage of by others...
  64. pmc Altered neural activity and emotions following right middle cerebral artery stroke
    Sergio Paradiso
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Stroke Cerebrovasc Dis 20:94-104. 2011
    ..The knowledge acquired in this study begins to explain the mechanisms underlying emotional changes following right MCA stroke. Recognizing these changes may improve diagnoses, management and rehabilitation of right MCA stroke victims...
  65. pmc Asymmetrical use of eye information from faces following unilateral amygdala damage
    Frederic Gosselin
    Departement de Psychologie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada
    Soc Cogn Affect Neurosci 6:330-7. 2011
    ..The findings have implications for the amygdala's role in emotion recognition and gaze direction during face processing...
  66. pmc Sustained experience of emotion after loss of memory in patients with amnesia
    Justin S Feinstein
    Division of Cognitive Neuroscience, Department of Neurology, University of Iowa College of Medicine, University of Iowa, Iowa City, IA 52242 1053, USA
    Proc Natl Acad Sci U S A 107:7674-9. 2010
    ..These findings provide direct evidence that a feeling of emotion can endure beyond the conscious recollection for the events that initially triggered the emotion...
  67. pmc Damage to ventromedial prefrontal cortex impairs judgment of harmful intent
    Liane Young
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 65:845-51. 2010
    ..These results highlight the critical role of the VMPC in processing harmful intent for moral judgment...
  68. pmc Distributed neural system for general intelligence revealed by lesion mapping
    J Gläscher
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:4705-9. 2010
    ..We suggest that general intelligence draws on connections between regions that integrate verbal, visuospatial, working memory, and executive processes...
  69. pmc The pathways of interoceptive awareness
    Sahib S Khalsa
    Department of Neurology and Neuroscience Program, University of Iowa, Iowa City, Iowa, USA
    Nat Neurosci 12:1494-6. 2009
    ..Instead, this awareness was mediated by both somatosensory afferents from the skin and a network that included the insula and ACC. Together, these pathways enable the core human experience of the cardiovascular state of the body...
  70. pmc Medial prefrontal cortex damage affects physiological and psychological stress responses differently in men and women
    Tony W Buchanan
    Department of Psychology, Saint Louis University, St Louis, MO 63103, United States
    Psychoneuroendocrinology 35:56-66. 2010
    ..These findings support the idea that the mPFC is involved in the regulation of physiological and psychological responses to stress and that this regulation may differ between men and women...
  71. pmc Bilateral limbic system destruction in man
    Justin S Feinstein
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA, USA
    J Clin Exp Neuropsychol 32:88-106. 2010
    ....
  72. pmc Central and peripheral nervous system interactions: from mind to brain to body
    Tony W Buchanan
    Department of Psychology, Saint Louis University, 221 North Grand Boulevard, St Louis, MO 63103, USA
    Int J Psychophysiol 72:1-4. 2009
    ....