A Drosophila Model Linking Diet-induced Obesity and Cancer (PQ 1)

Summary

Principal Investigator: ROSS LEIGH CAGAN
Abstract: DESCRIPTION (provided by applicant): Epidemiological studies have demonstrated that increased cancer risk is associated with obesity, but the underlying mechanism remains poorly understood. We have recently developed a Drosophila model of obesity;raising Drosophila on a diet high in carbohydrates led to metabolic dysfunction including hyperglycemia, insulin-resistance and accumulation of fat. Feeding a high dietary sucrose to Ras/Src co- activated Drosophila cancer model developed aggressive tumor with emergent metastasis in a diet-dependent manner. The goal of this Application is to further utilize Drosophila as a useful in situ model to explore mechanistic link between diet-induced obesity and tumor progression.
Funding Period: 2012-08-20 - 2016-05-31
more information: NIH RePORT

Top Publications

  1. pmc Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors
    T K Das
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, USA
    Oncogene 32:3184-97. 2013
  2. pmc Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling
    Susumu Hirabayashi
    Department of Developmental and Regenerative Biology, Annenberg 25 40, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, Box 1020, New York, NY 10029, USA
    Cell 154:664-75. 2013

Research Grants

  1. MMC, VICC &TSU: Partners in Eliminating Cancer Disparities ( 1 of 3)
    Steven N Wolff; Fiscal Year: 2013
  2. CELLULAR AND MOLECULAR MECHANISMS OF GASTROINTESTINAL CANCERS
    Lopa Mishra; Fiscal Year: 2013
  3. Molecular Pathogenesis of Basal-like Breast Cancer
    Richard J Baer; Fiscal Year: 2013
  4. UAB / UMN SPORE in Pancreatic Cancer
    Donald J Buchsbaum; Fiscal Year: 2013
  5. Functional Annotation of the Pancreatic Cancer Genome
    Steven D Leach; Fiscal Year: 2013
  6. Coordinating Center of Excellence in Social Promotion of Health Equity Research
    GLORIA S MCCUTCHEON; Fiscal Year: 2013
  7. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2013
  8. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth H Cowan; Fiscal Year: 2013
  9. DF/HCC Kidney Cancer SPORE
    David McDermott; Fiscal Year: 2013
  10. SPORE in Soft Tissue Sarcoma
    Samuel Singer; Fiscal Year: 2013

Detail Information

Publications2

  1. pmc Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors
    T K Das
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, USA
    Oncogene 32:3184-97. 2013
    ..Tumor progression may commonly rely on such 'modules of invasion' under the control of broad transcriptional regulators. ..
  2. pmc Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling
    Susumu Hirabayashi
    Department of Developmental and Regenerative Biology, Annenberg 25 40, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, Box 1020, New York, NY 10029, USA
    Cell 154:664-75. 2013
    ..By targeting multiple steps in this circuit with rationally applied drug combinations, we demonstrate the potential of combinatorial drug intervention to treat diet-enhanced malignant tumors. ..

Research Grants42

  1. MMC, VICC &TSU: Partners in Eliminating Cancer Disparities ( 1 of 3)
    Steven N Wolff; Fiscal Year: 2013
    ....
  2. CELLULAR AND MOLECULAR MECHANISMS OF GASTROINTESTINAL CANCERS
    Lopa Mishra; Fiscal Year: 2013
    ..Significantly, this program promises to yield new therapies targeted at these difficult-to-treat lethal cancers at the bench, and then to translate the results rapidly into clinical care, at the bedside. ..
  3. Molecular Pathogenesis of Basal-like Breast Cancer
    Richard J Baer; Fiscal Year: 2013
    ..e., metastasis, and develop strategies for therapy. ..
  4. UAB / UMN SPORE in Pancreatic Cancer
    Donald J Buchsbaum; Fiscal Year: 2013
    ..The application has strong institutional support from UAB and UMN, excellent pancreatic cancer populations and concurrence with federal guidelines. ..
  5. Functional Annotation of the Pancreatic Cancer Genome
    Steven D Leach; Fiscal Year: 2013
    ..Together, these studies will dramatically accelerate the functional annotation of the pancreatic cancer genome, setting the stage for future therapeutic applications. ..
  6. Coordinating Center of Excellence in Social Promotion of Health Equity Research
    GLORIA S MCCUTCHEON; Fiscal Year: 2013
    ..abstract_text> ..
  7. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2013
    ....
  8. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth H Cowan; Fiscal Year: 2013
    ....
  9. DF/HCC Kidney Cancer SPORE
    David McDermott; Fiscal Year: 2013
    ..The overall goal of the DF/HCC Kidney Cancer SPORE is the translation of biological and technological advances into clinically meaningful advances for patients with kidney cancer. ..
  10. SPORE in Soft Tissue Sarcoma
    Samuel Singer; Fiscal Year: 2013
    ..abstract_text> ..
  11. A MULTILEVEL APPROACH TO ENERGY BALANCE AND CANCER ACROSS THE LIFECOURSE
    Graham A Colditz; Fiscal Year: 2013
    ..To address these aims, we propose four research projects and five cores that form a cohesive, transdisciplinary center focused on research, training/career development, and dissemination. ..
  12. Penn TREC Survivor Center
    Kathryn H Schmitz; Fiscal Year: 2013
    ..abstract_text> ..