CLIN RESEARCH CENTER FOR THE STUDY OF SENILE DEMENTIA

Summary

Principal Investigator: Jerome Yesavage
Abstract: This renewal of our Aging Clinical Research Center (ACRC) reflects the continuing commitment of the Department of Psychiatry and Behavioral Sciences at Stanford to the study of Alzheimer's Disease (AD). The structure of the Center has been that of an "enabling center" or "core center" designed to facilitate the development of independent research projects using the Center's core resources in a more efficient manner than if they were replicated over a number of independent projects. We feel that we have been successful in this endeavor, fostering a major increase in funded AD research at Stanford, while at the same time minimizing the burden of patient participation in research. Our plan for the future is to continue along this successful track and to emphasize recent advances in certain areas of AD research, especially neurochemistry and genetics. Throughout the life of the Center, its theme has been the heterogeneity of AD. In particular, we have been impressed by the wide variability in the clinical manifestations and clinical course of the illness. For example, decline of our patients, in terms of percentage of total Mini-Mental State Exam (MMSE) or Alzheimer's Disease Assessment Scale (ADAS) score lost per year, ranges from nearly no change to over 25% decline. What is the basis of this variability of rate of decline? This is one question we have continued to address using an increasingly sophisticated set of methodological and biostatistical tools. In this application, we plan to further a strengthening of our Biostatistical Core by increasing the availability of senior investigators committed to the development of methodological tools we need to answer this difficult question.
Funding Period: 1984-09-30 - 2002-05-31
more information: NIH RePORT

Top Publications

  1. ncbi The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease
    Jenny Y J Chuu
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, and the VA Sierra Pacific Mental Illness Research Education and Clinical Center, Palo Alto, CA, USA
    J Alzheimers Dis 9:43-9. 2006
  2. ncbi Long-term effects of mnemonic training in community-dwelling older adults
    Ruth O'Hara
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
    J Psychiatr Res 41:585-90. 2007
  3. ncbi Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele
    Ruth O'Hara
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
    J Psychiatr Res 42:199-204. 2008
  4. ncbi The impact of autobiographic writing on memory performance in older adults: a preliminary investigation
    Kate de Medeiros
    Copper Ridge Institute, Sykesville, MD 21784 7650, USA
    Am J Geriatr Psychiatry 15:257-61. 2007
  5. ncbi Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E
    Simon P Selwood
    Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neurobiol Aging 30:574-90. 2009
  6. pmc Creation and the empirical validation of the dignity card-sort tool to assess factors influencing erosion of dignity at life's end
    Vyjeyanthi S Periyakoil
    Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    J Palliat Med 12:1125-30. 2009
  7. pmc Circadian clock gene polymorphisms and sleep-wake disturbance in Alzheimer disease
    Jerome A Yesavage
    Department of Veterans Affairs Health Care System, Stanford University School of Medicine, Palo Alto, California
    Am J Geriatr Psychiatry 19:635-43. 2011
  8. pmc Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ɛ4 allele
    Maheen M Adamson
    Department of Veterans Affairs, Sierra Pacific MIRECC and WRIISC Palo Alto, CA, USA
    Neuropsychologia 49:2448-55. 2011

Scientific Experts

  • Maheen M Adamson
  • Ruth O'Hara
  • Jerome A Yesavage
  • Leah Friedman
  • Simon P Selwood
  • Vyjeyanthi S Periyakoil
  • Art Noda
  • Greer M Murphy
  • Jerome Yesavage
  • Helena C Kraemer
  • Kate de Medeiros
  • Jenny Y J Chuu
  • Elizabeth Landsverk
  • Renaud David
  • Jauhtai J Cheng
  • Jared R Tinklenberg
  • Philippe Robert
  • Jamie M Zeitzer
  • Joachim Hallmayer
  • Beatriz Hernandez
  • Arthur Noda
  • S Parvathy
  • Helena Chmura Kraemer
  • Laura C Lazzeroni
  • Valerie Vincent
  • Farshid Oshidari
  • Heather S Ryan
  • Barbara Cordell
  • Nate Way
  • Greer Murphy
  • Joy Taylor
  • Barbara Sommer
  • Kevin S Morgan
  • Rosemary Lindley
  • Quinn Kennedy
  • Carmen M Schröder
  • Ruth O' Hara
  • Thomas Cole
  • John O Brooks
  • Joy L Taylor
  • Jared Tinklenberg

Detail Information

Publications8

  1. ncbi The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease
    Jenny Y J Chuu
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, and the VA Sierra Pacific Mental Illness Research Education and Clinical Center, Palo Alto, CA, USA
    J Alzheimers Dis 9:43-9. 2006
    ..These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD...
  2. ncbi Long-term effects of mnemonic training in community-dwelling older adults
    Ruth O'Hara
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
    J Psychiatr Res 41:585-90. 2007
    ..Our findings suggest that mnemonic training has long-term benefits for some older adults, particularly those who continue to employ the mnemonic...
  3. ncbi Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele
    Ruth O'Hara
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
    J Psychiatr Res 42:199-204. 2008
    ..These findings provide continued support for the negative impact of the epsilon4 allele on cognition and further suggest that speed-of-processing during memory tasks may have the potential to detect subtle cognitive deficits...
  4. ncbi The impact of autobiographic writing on memory performance in older adults: a preliminary investigation
    Kate de Medeiros
    Copper Ridge Institute, Sykesville, MD 21784 7650, USA
    Am J Geriatr Psychiatry 15:257-61. 2007
    ..The authors also found a decline in idea density, suggesting that more research is needed to better understand how interpretation of the language assessment tool may be affected by improvements in writing...
  5. ncbi Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E
    Simon P Selwood
    Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neurobiol Aging 30:574-90. 2009
    ..These results provide a global molecular profile of hippocampal and cortical gene expression during the initial and intermediate stages Abeta deposition, and the effects of APOE deletion on this process...
  6. pmc Creation and the empirical validation of the dignity card-sort tool to assess factors influencing erosion of dignity at life's end
    Vyjeyanthi S Periyakoil
    Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    J Palliat Med 12:1125-30. 2009
    ..The DCT is a promising tool that may help clinicians identify key factors resulting in perceptions of erosion of dignity in adult palliative care patients...
  7. pmc Circadian clock gene polymorphisms and sleep-wake disturbance in Alzheimer disease
    Jerome A Yesavage
    Department of Veterans Affairs Health Care System, Stanford University School of Medicine, Palo Alto, California
    Am J Geriatr Psychiatry 19:635-43. 2011
    ..The goal of this study is to report indices of sleep-wake function collected from individuals with AD in relation to relevant polymorphisms in circadian clock-related genes...
  8. pmc Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ɛ4 allele
    Maheen M Adamson
    Department of Veterans Affairs, Sierra Pacific MIRECC and WRIISC Palo Alto, CA, USA
    Neuropsychologia 49:2448-55. 2011
    ..These results have implications for fMRI studies that investigate the default-mode network (DMN) in middle-aged to older APOE ɛ4 carriers to help evaluate AD risk in this otherwise cognitively normal population...