New York Nutrition Obesity Research Center

Summary

Principal Investigator: Xavier Pi-Sunyer
Abstract: Description (provided by applicant): The NYONRC has created numerous strong research collaborations leading to scientific advances in obesity (Exhibit IV). The focus of the Research Base (RB) is described by themes below. The use of Core Laboratories for training, consultation, and service is high. In 2005, we added the Albert Einstein College of Medicine (AECOM). The scientists added to the RB are productive investigators who have added strength to the RB. There are 76 Members. Total RB funding is $71,715,484, with 31% from NIDDK and 81% from NIH. The instructions for this grant application state that only persons at our institutions can be listed in the RB. We have a large number of collaborations with outside scientists. This actually seems the intent of the NIH Roadmap: widening collaborations for greater productivity. These relationships are multiple and growing. The NYONRC has been funded for 29 yrs. In the past decade there have been striking changes in the prevalence of obesity and its co-morbidities, with institution of more aggressive interventions, including surgery and more rationally designed pharmaceuticals and radical changes in research strategies. The latter derive from the combination of molecular cloning of rodent obesity genes, sequencing of the mouse and human genomes, introduction of transgenic manipulations, availability of massive parallel gene expression arrays, accession of powerful bioinformatics techniques for dense genetic analysis, newer brain imaging, and the advent of sophisticated methods for characterizing humans and mice for energy homeostasis phenotypes.
Funding Period: 1996-12-01 - 2016-03-31
more information: NIH RePORT

Top Publications

  1. pmc Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study
    Muhammad S Mansour
    Institute of Human Nutrition, Columbia University, New York, NY 10036, USA
    Metabolism 61:1347-52. 2012
  2. pmc Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss
    S H Shah
    Department of Medicine, DUMC, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Diabetologia 55:321-30. 2012
  3. pmc Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity
    Darcy L Johannsen
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 97:242-50. 2012
  4. pmc Fat discrimination: a phenotype with potential implications for studying fat intake behaviors and obesity
    Lisa C H Liang
    Department of Research Medicine, New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, NY, NY 10025, USA
    Physiol Behav 105:470-5. 2012
  5. pmc Effects of weight loss and leptin on skeletal muscle in human subjects
    Kenneth M Baldwin
    Department of Physiology and Biophysics, School of Medicine, University of California at Irvine, Irvine, California, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1259-66. 2011
  6. pmc Diabetes remission after bariatric surgery: is it just the incretins?
    B Laferrere
    New York Obesity Nutrition Research Center, Division of Endocrinology and Diabetes, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Int J Obes (Lond) 35:S22-5. 2011
  7. pmc Adipose tissue, diabetes and Chagas disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Adv Parasitol 76:235-50. 2011
  8. pmc Do we really know why diabetes remits after gastric bypass surgery?
    BLANDINE LAFERRERE
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Endocrine 40:162-7. 2011
  9. pmc Evaluation of specific metabolic rates of major organs and tissues: comparison between nonobese and obese women
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York City, New York, USA
    Obesity (Silver Spring) 20:95-100. 2012
  10. pmc Body composition (sarcopenia) in obese patients: implications for care in the intensive care unit
    Dympna Gallagher
    Department of Medicine and Institute of Human Nutrition, Columbia University and St Luke s Roosevelt Hospital New York, New York, USA
    JPEN J Parenter Enteral Nutr 35:21S-8S. 2011

Research Grants

  1. CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
    Robert S Sandler; Fiscal Year: 2013
  2. CANCER CENTER SUPPORT GRANT
    TONY R HUNTER; Fiscal Year: 2013
  3. DIABETES AND ENDOCRINOLOGY RESEARCH CENTER
    Domenico Accili; Fiscal Year: 2013

Detail Information

Publications224 found, 100 shown here

  1. pmc Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study
    Muhammad S Mansour
    Institute of Human Nutrition, Columbia University, New York, NY 10036, USA
    Metabolism 61:1347-52. 2012
    ..The results, showing enhanced thermogenesis and reduced feelings of hunger with ginger consumption, suggest a potential role of ginger in weight management. Additional studies are necessary to confirm these findings...
  2. pmc Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss
    S H Shah
    Department of Medicine, DUMC, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Diabetologia 55:321-30. 2012
    ..Insulin resistance (IR) improves with weight loss, but this response is heterogeneous. We hypothesised that metabolomic profiling would identify biomarkers predicting changes in IR with weight loss...
  3. pmc Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity
    Darcy L Johannsen
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 97:242-50. 2012
    ..Recent studies suggest that skeletal muscle mitochondrial activity may underlie some age-associated metabolic abnormalities...
  4. pmc Fat discrimination: a phenotype with potential implications for studying fat intake behaviors and obesity
    Lisa C H Liang
    Department of Research Medicine, New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, NY, NY 10025, USA
    Physiol Behav 105:470-5. 2012
    ..53; p<0.01). If these results are replicated, fat discrimination may serve as clinical research tool to identify participants who are at risk for obesity and other chronic diseases due to increased fat intake...
  5. pmc Effects of weight loss and leptin on skeletal muscle in human subjects
    Kenneth M Baldwin
    Department of Physiology and Biophysics, School of Medicine, University of California at Irvine, Irvine, California, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1259-66. 2011
    ..These findings are consistent with the leptin-reversible increase in skeletal muscle chemomechanical work efficiency and decrease in the ratio of glycolytic/oxidative enzyme activities observed in subjects following dietary weight loss...
  6. pmc Diabetes remission after bariatric surgery: is it just the incretins?
    B Laferrere
    New York Obesity Nutrition Research Center, Division of Endocrinology and Diabetes, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Int J Obes (Lond) 35:S22-5. 2011
    ..Changes in rate of eating, gastric emptying, intestinal transit time, nutrient absorption and sensing, as well as bile acid metabolism, may all be implicated...
  7. pmc Adipose tissue, diabetes and Chagas disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Adv Parasitol 76:235-50. 2011
    ..The adipocyte is both a target of infection and a reservoir for the parasite during the chronic phase from which recrudescence of the infection may occur during periods of immunosuppression...
  8. pmc Do we really know why diabetes remits after gastric bypass surgery?
    BLANDINE LAFERRERE
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Endocrine 40:162-7. 2011
    ..Equally important would be to identify biological predictors of success or failure and to understand the mechanisms of weight regain and/or diabetes relapse...
  9. pmc Evaluation of specific metabolic rates of major organs and tissues: comparison between nonobese and obese women
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York City, New York, USA
    Obesity (Silver Spring) 20:95-100. 2012
    ..7 for skeletal muscle, 4.4 for adipose tissue, and 11.8 for residual mass. In conclusion, although Elia's K(i) values were validated in nonobese women, obesity-adjustments are appropriate for application in obese women...
  10. pmc Body composition (sarcopenia) in obese patients: implications for care in the intensive care unit
    Dympna Gallagher
    Department of Medicine and Institute of Human Nutrition, Columbia University and St Luke s Roosevelt Hospital New York, New York, USA
    JPEN J Parenter Enteral Nutr 35:21S-8S. 2011
    ..The recognition of patients with sarcopenic obesity has identified a potential high-risk patient population. These body composition abnormalities may have even greater importance in the intensive care patient...
  11. pmc Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
    Susmita Kaushik
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Metab 14:173-83. 2011
    ..Regulation of hypothalamic autophagy could become an effective intervention in conditions such as obesity and the metabolic syndrome...
  12. pmc Magnitude and variability of the glucagon-like peptide-1 response in patients with type 2 diabetes up to 2 years following gastric bypass surgery
    Bart J Van der Schueren
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, New York, NewYork, USA
    Diabetes Care 35:42-6. 2012
    ..To characterize the magnitude and variance of the change of glucose and glucagon-like peptide-1 (GLP-1) concentrations, and to identify determinants of glucose control up to 2 years after gastric bypass (GBP)...
  13. pmc Accelerated gastric emptying but no carbohydrate malabsorption 1 year after gastric bypass surgery (GBP)
    Gary Wang
    New York Obesity Nutrition Research Center, New York, NY, USA
    Obes Surg 22:1263-7. 2012
    ..The mechanisms of enhanced incretin release in response to nutrients after GBP is not elucidated and may be in relation to altered nutrient transit time and/or malabsorption...
  14. ncbi The impact of food branding on children's eating behavior and obesity
    Kathleen L Keller
    Department of Research Medicine, New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Physiol Behav 106:379-86. 2012
    ..Future studies are needed to better understand the influence that child age, sex, and obesity has on response to food branding and marketing...
  15. pmc Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI
    Eliza B Geer
    Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1055, New York, New York 10029, USA
    J Clin Endocrinol Metab 97:1702-11. 2012
    ..Cushing's Disease (CD) alters fat distribution, muscle mass, adipokine profile, and cardiovascular risk factors. It is not known whether remission entirely reverses these changes...
  16. pmc Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake
    Xiaoning Chen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e32511. 2012
    ..These findings have potential implications for designing selective SERT drugs for weight control and the treatment of metabolic syndromes...
  17. pmc Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery
    C N Ochner
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neuroscience 209:128-35. 2012
    ....
  18. pmc Gut feelings about diabetes
    BLANDINE LAFERRERE
    Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Endocrinol Nutr 59:254-60. 2012
    ..While most patients after bariatric surgery experienced sustained weight loss and improved metabolism, small scale studies have shown weight regain and diabetes relapse, the mechanisms of which remain unknown...
  19. ncbi Genetic influences on oral fat perception and preference: Presented at the symposium "The Taste for Fat: New Discoveries on the Role of Fat in Sensory Perception, Metabolism, Sensory Pleasure and Beyond" held at the Institute of Food Technologists 2011 An
    Kathleen L Keller
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia Univ College of Physicians and Surgeons, 1090 Amsterdam Avenue 14A, New York, NY 10025, USA
    J Food Sci 77:S143-7. 2012
    ..Assuming these data are confirmed in other populations, screening for CD36 genotype may provide helpful information to food companies for developing fat-modified products...
  20. pmc Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice
    Genevieve Marcelin
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Lipid Res 53:964-72. 2012
    ..Marcelin, G., S-M. Liu, X. Li, G. J. Schwartz, and S. Chua...
  21. pmc Gastric emptying and symptoms of bulimia nervosa: effect of a prokinetic agent
    Michael J Devlin
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 116, New York, NY 10032, USA
    Physiol Behav 106:238-42. 2012
    ..This study was designed to test these hypotheses as well as the efficacy of the prokinetic agent erythromycin in patients with BN...
  22. pmc Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans
    Kathleen L Keller
    Department of Research Medicine, New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 20:1066-73. 2012
    ..001), but only 2 D/D individuals were tested, so this finding needs replication. This is the first study to demonstrate an association between common variants in CD36 and fat ingestive behaviors in humans...
  23. pmc Leptin reverses declines in satiation in weight-reduced obese humans
    Harry R Kissileff
    St Luke s Roosevelt Hospital Medical Center, New York, NY, USA
    Am J Clin Nutr 95:309-17. 2012
    ..Because exogenous leptin inhibits feeding in congenitally leptin-deficient humans, reduced leptin signaling may reduce the expression of feeding inhibition in humans...
  24. pmc Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationship
    W Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Osteoporos Int 23:2293-301. 2012
    ..This suggests that the mechanisms that regulate the differentiation and proliferation of bone marrow stromal cells may differ in these populations...
  25. pmc Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    Linh Vong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, EC CLS717, Boston, MA 02215, USA
    Neuron 71:142-54. 2011
    ..As POMC neurons prevent obesity, their disinhibition by leptin action on presynaptic GABAergic neurons probably mediates, at least in part, leptin's antiobesity effects...
  26. pmc Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms
    Xiaosong Li
    Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 6:e17058. 2011
    ..The findings also suggest that: 1) both hepatic vagal and non-vagal pathways contribute to this improvement, and 2) central leptin alters glucose disposal in skeletal muscle in this model...
  27. pmc Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice
    Janette H Quennell
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, PO Box 913, Dunedin 9054, New Zealand
    Endocrinology 152:1541-50. 2011
    ..These data provide evidence that leptin's effects on reproductive function are regulated by kisspeptin neurons in both the ARC and RP3V, although in the latter site the effects are likely to be indirect...
  28. pmc Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency
    Na Luo
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 12401, USA
    Endocrinology 152:883-9. 2011
    ..Operant behavioral testing indicated that there were no alterations in the reward for a food pellet from the AGRP-specific LEPR deficiency...
  29. pmc Coffee consumption is inversely associated with type 2 diabetes in Chinese
    Wen Yuan Lin
    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
    Eur J Clin Invest 41:659-66. 2011
    ..We investigated the relationship between coffee consumption and T2DM in a population-based cohort of middle-aged Chinese...
  30. pmc Association of BMI and cardiovascular risk stratification in the elderly African-American females
    Fahad Javed
    New York Obesity Research Center, Division of Endocrinology, Diabetes, and Nutrition, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 19:1182-6. 2011
    ..Weight reduction to a greater extent than previously indicated could play an integral role in prevention and control of high blood pressure in this particular population...
  31. pmc Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica
    X Guo
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Mucosal Immunol 4:294-303. 2011
    ..We conclude that leptin-mediated resistance to amebiasis is via its actions on intestinal epithelium rather than hematopoietic cells or the brain, and requires leptin receptor signaling through both the STAT3 and SHP2/ERK pathways...
  32. ncbi The associations of different measurements of obesity with cardiovascular risk factors in Chinese
    Hua Shui Hsu
    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
    Eur J Clin Invest 41:393-404. 2011
    ..Obesity increases the risks of cardiovascular diseases (CVD). This study examined the optimal cut-off values for overweight and obesity for CVD risks using different anthropometric indices in middle-aged Taiwanese...
  33. pmc The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity
    Gwen V Childs
    Professor and Chair, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocrinology 152:69-81. 2011
    ..The specific ablation of the Lepr exon 17 gene in somatotropes resulted in GH deficiency with a consequential reduction in lipolytic activity normally maintained by GH and increased adiposity...
  34. pmc Larger body mass index and waist circumference are associated with lower mortality in Chinese long-term care facility residents
    Wen Yuan Lin
    Department of Family Medicine, China Medical University Hospital, corrected Taichung, Taiwan
    J Am Geriatr Soc 58:2092-8. 2010
    ..To investigate the association between body mass index (BMI) and waist circumference (WC) and all-cause mortality of Chinese residents in long-term care facilities in Taiwan...
  35. pmc Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling
    George Stratigopoulos
    Division of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    J Biol Chem 286:2155-70. 2011
    ....
  36. pmc A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
    Priya Duggal
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Clin Invest 121:1191-8. 2011
    ..These findings suggest that leptin signaling is important in mucosal defense against amebiasis and that polymorphisms in the leptin receptor explain differences in susceptibility of children in the Bangladesh cohort to amebiasis...
  37. pmc Body mass index and all-cause mortality in a large Chinese cohort
    Wen Yuan Lin
    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
    CMAJ 183:E329-36. 2011
    ..We examined the association between body mass index (BMI) and the risk of death in a large population of adult Chinese people...
  38. pmc Higher infant body fat with excessive gestational weight gain in overweight women
    Holly R Hull
    New York Obesity Nutrition Research Center, New York, NY, USA
    Am J Obstet Gynecol 205:211.e1-7. 2011
    ..This study examined whether differences exist in infant body composition based on 2009 GWG recommendations...
  39. pmc Responses of gut microbiota to diet composition and weight loss in lean and obese mice
    Yann Ravussin
    Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 20:738-47. 2012
    ..Together, these results suggest that both host adiposity and diet composition impact microbiota composition, possibly through leptin-mediated regulation of mucus production and/or inflammatory processes that alter the gut habitat...
  40. pmc Comparison of glucostatic parameters after hypocaloric diet or bariatric surgery and equivalent weight loss
    Leona Plum
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 19:2149-57. 2011
    ..In conclusion, RYGB produced greater improvement in Si and DI compared with diet at equivalent weight loss in T2DM subjects. Such a beneficial effect was not observed in nondiabetic subjects at this early time-point...
  41. pmc Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss
    BLANDINE LAFERRERE
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Sci Transl Med 3:80re2. 2011
    ..These data suggest that the enhanced decrease in circulating AAs after GBP occurs by mechanisms other than weight loss and may contribute to the better improvement in glucose homeostasis observed with the surgical intervention...
  42. pmc Reduced kidney function and preclinical atherosclerosis in HIV-infected individuals: the study of fat redistribution and metabolic change in HIV infection (FRAM)
    Vasantha Jotwani
    University of California, San Francisco, Calif, USA
    Am J Nephrol 33:453-60. 2011
    ..We investigated whether reduced estimated glomerular filtration rate (eGFR) and albuminuria are associated with subclinical vascular disease, as assessed by carotid intima-medial thickness (cIMT)...
  43. pmc Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice
    Clemence Blouet
    Department of Medicine and Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 31:6019-27. 2011
    ..Thus, mediobasal hypothalamic TXNIP plays a critical role in nutrient sensing and the regulation of fuel utilization...
  44. pmc Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine
    Jin Fu
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, California 92697 4625, USA
    J Neurosci 31:5730-6. 2011
    ..The results suggest that sympathetic activity controls fat-induced satiety by enabling the coordinated production of local (OEA) and systemic (NPPE) satiety signals in the small intestine...
  45. pmc Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss
    Rushika Conroy
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Metabolism 60:1222-6. 2011
    ..These results suggest that both decreased bone formation and increased bone resorption underlie bone loss associated with weight loss. Leptin administration did not prevent the uncoupling of bone remodeling that accompanies weight loss...
  46. pmc Evaluation of specific metabolic rates of major organs and tissues: comparison between men and women
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Hum Biol 23:333-8. 2011
    ..However, it is unknown whether gender influences the K(i) values. The aim of the present study was to compare the K(i) values observed in nonelderly nonobese men to the corresponding values in women...
  47. pmc Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein
    John D Overton
    Division of Molecular Genetics, Department of Pediatrics, Naomi Berrie Diabetes Center and the Institute of Human Nutrition, Columbia University, New York, New York 10032, USA
    J Biol Chem 286:18914-29. 2011
    ....
  48. pmc Effects of chronic weight perturbation on energy homeostasis and brain structure in mice
    Y Ravussin
    1Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1352-62. 2011
    ..The mouse model described here could help to identify the molecular/cellular mechanisms underlying both the defense mechanisms against sustained weight loss and the upward resetting of those mechanisms following sustained weight gain...
  49. pmc Are normal-weight Americans over-fat?
    Marie Pierre St-Onge
    Department of Medicine, New York Obesity Research Center, St Luke s Roosevelt Hospital and College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 18:2067-8. 2010
    ..These data should make one reflect on the health status of Americans in all BMI categories and the use of these data for public health recommendations...
  50. ncbi HIV/hepatitis C virus coinfection ameliorates the atherogenic lipoprotein abnormalities of HIV infection
    Amber L Wheeler
    aDepartment of Medicine, University of California San Francisco bDivision of Endocrinology and Metabolism, Department of Veterans Affairs Medical Center San Francisco, San Francisco cDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, California dDepartment of Epidemiology, University of Washington, Seattle, Washington eDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco fDivision of Research, Kaiser Permanente, Oakland, California, USA
    AIDS 28:49-58. 2014
    ..The extent to which HIV infection and HIV/hepatitis C virus (HCV) coinfection are associated with abnormalities of lipoprotein subclasses is unknown...
  51. pmc Fasting plasma adropin concentrations correlate with fat consumption in human females
    Marie Pierre St-Onge
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and College of Physicians and Surgeons, Columbia University, New York, 10025, USA
    Obesity (Silver Spring) 22:1056-63. 2014
    ..This study investigated whether plasma adropin concentrations are influenced by sleep restriction and correlate with dietary preferences...
  52. ncbi A gut lipid messenger links excess dietary fat to dopamine deficiency
    Luis A Tellez
    The John B Pierce Laboratory, New Haven, CT 06519, USA
    Science 341:800-2. 2013
    ..Our findings suggest that high-fat-induced gastrointestinal dysfunctions play a key role in dopamine deficiency and that restoring gut-generated lipid signaling may increase the reward value of less palatable, yet healthier, foods. ..
  53. pmc Biological mechanisms that promote weight regain following weight loss in obese humans
    Christopher N Ochner
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA Mount Sinai Adolescent Health Center, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA Electronic address
    Physiol Behav 120:106-13. 2013
    ..It may be necessary to develop interventions that attenuate these biological mechanisms in order to achieve long-term weight reduction in obese individuals. ..
  54. pmc Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein
    James P Warne
    Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 33:11972-85. 2013
    ....
  55. pmc ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis
    Kazuhisa Watanabe
    Naomi Berrie Diabetes Center and Department of Pediatrics, Columbia University, New York, New York, United States of America
    PLoS ONE 8:e67234. 2013
    ..Given these reciprocal interactions, and the relatively extended time-course over which these studies were conducted, we cannot assign causal primacy to either the effects on hepatic lipid homeostasis or ER stress responses. ..
  56. ncbi Electroretinographic detection of human brain dopamine response to oral food stimulation
    J A Nasser
    Department of Medicine, St Luke s Roosevelt Hospital Center, New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    Obesity (Silver Spring) 21:976-80. 2013
    ..Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain dopamine concentration was postulated...
  57. pmc Greater short-term weight loss in women 20-45 versus 55-65 years of age following bariatric surgery
    Christopher N Ochner
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Obes Surg 23:1650-4. 2013
    ..Estrogens regulate body composition in women and animals, and increase weight loss in a rodent model of gastric bypass, suggesting that premenopausal women may lose more weight following bariatric surgery...
  58. pmc Functional organization of neuronal and humoral signals regulating feeding behavior
    Gary J Schwartz
    Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Annu Rev Nutr 33:1-21. 2013
    ....
  59. pmc Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity
    Richard Gill
    Division of Molecular Genetics Department of Pediatrics, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA
    Obesity (Silver Spring) 22:576-84. 2014
    ..Despite evidence for a strong genetic contribution to susceptibility to obesity, previous efforts to discover the relevant genes using positional cloning have failed to account for most of the apparent genetic risk variance...
  60. pmc Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction
    Sharone Sheffer-Babila
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
    Am J Physiol Endocrinol Metab 305:E1512-20. 2013
    ..These studies suggest that AGRP imposes an inhibitory effect on puberty and that TAC2 neurons may transmit melanocortinergic inhibition of GnRH neurons. ..
  61. pmc A differential dielectric affinity glucose sensor
    Xian Huang
    Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA
    Lab Chip 14:294-301. 2014
    ..This sensor can potentially be used clinically as a subcutaneously implanted continuous monitoring device in diabetic patients. ..
  62. pmc Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice
    George Stratigopoulos
    Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA Electronic address
    Cell Metab 19:767-79. 2014
    ..These findings suggest that RPGRIP1L may be partly or exclusively responsible for the obesity susceptibility signal at the FTO locus...
  63. pmc Body composition changes in pregnancy: measurement, predictors and outcomes
    E M Widen
    1 New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA 2 Institute of Human Nutrition and Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA 3 Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA
    Eur J Clin Nutr 68:643-52. 2014
    ..Consideration is given to factors that may influence changes in maternal body composition, as well as long-term maternal and offspring outcomes. Finally, we provide recommendations for future research in this area...
  64. pmc Validity of bioelectrical impedance analysis for measuring changes in body water and percent fat after bariatric surgery
    Elizabeth M Widen
    Institute of Human Nutrition and Department of Epidemiology, Columbia University, New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, 1111 Amsterdam Avenue, Scrymser Bsmt, New York, NY, 10025, USA
    Obes Surg 24:847-54. 2014
    ..Few studies have validated bioelectrical impedance analysis (BIA) following bariatric surgery...
  65. ncbi Association of glucocorticoid receptor haplotypes with body composition and metabolic parameters in HIV-infected patients from the FRAM study
    Laura Manenschijn
    aDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands bDepartment of Medicine, University of California and Veterans Affairs Medical Center, San Francisco, California cDepartment of Medicine, New York University Medical Center, New York, New York, USA
    Pharmacogenet Genomics 24:156-61. 2014
    ....
  66. ncbi Ghrelin levels after a cold pressor stress test in obese women with binge eating disorder
    Marci E Gluck
    National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Obesity and Diabetes Clinical Research Section, 4212 North 16th St, Room 541, Phoenix, AZ 85016
    Psychosom Med 76:74-9. 2014
    ..Our aim was to assess ghrelin levels after a cold pressor test (CPT) in women with BED. We also examined the relationship between the cortisol stress response and changes in ghrelin levels...
  67. ncbi Postprandial thermogenesis and substrate oxidation are unaffected by sleep restriction
    A Shechter
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Int J Obes (Lond) 38:1153-8. 2014
    ..Short sleep may induce changes in resting metabolic rate (RMR), thermic effect of food (TEF) and postprandial substrate oxidation...
  68. pmc Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice
    Alicja A Skowronski
    Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Obesity (Silver Spring) 22:1287-95. 2014
    ..Our aim was to establish a protocol that allows for evaluation of efficacy of weight maintenance agents and to assess the effectiveness of AZD2820, a novel melanocortin 4 receptor (MC4R) agonist in such a paradigm...
  69. pmc Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation
    Xiaoyuan Xu
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, New York, NY 07043, USA
    Cell Metab 18:816-30. 2013
    ..These data argue that ATMs contribute quantitatively to the development of obesity-induced inflammation but also serve an important role in lipid trafficking independent of their inflammatory phenotype. ..
  70. pmc Limited recovery of β-cell function after gastric bypass despite clinical diabetes remission
    Roxanne Dutia
    Department of Medicine, St Luke s Roosevelt Hospital Center, New York, NY
    Diabetes 63:1214-23. 2014
    ..This impairment can be rescued by oral glucose stimulation, suggesting that RYGBP leads to an important gastrointestinal effect, critical for improved β-cell function after surgery. ..
  71. pmc Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling
    Lale Ozcan
    Department of Medicine, Columbia University, New York, NY 10032, USA Electronic address
    Cell Metab 18:803-15. 2013
    ..These findings increase our understanding of the molecular mechanisms linking obesity to selective insulin resistance and suggest new therapeutic targets for type 2 diabetes and metabolic syndrome. ..
  72. pmc β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome
    Linshan Shang
    The New York Stem Cell Foundation Research Institute, New York, NY
    Diabetes 63:923-33. 2014
    ....
  73. pmc Comparison among T1-weighted magnetic resonance imaging, modified dixon method, and magnetic resonance spectroscopy in measuring bone marrow fat
    Wei Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14K, New York, NY 10025, USA
    J Obes 2013:298675. 2013
    ..Our aim is to compare the measurements of bone marrow fat among T1-weighted magnetic resonance imaging (MRI), modified Dixon method (also called fat fraction MRI (FFMRI)), and magnetic resonance spectroscopy (MRS)...
  74. ncbi Supermarket discounts of low-energy density foods: effects on purchasing, food intake, and body weight
    Allan Geliebter
    New York Obesity Nutrition Research Center, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University Medical Center, New York, NY 10025 Department of Psychology, Touro College, New York, NY 10010
    Obesity (Silver Spring) 21:E542-8. 2013
    ..To assess the effects of a 50% discount on low-energy density (ED) fruits and vegetables (F&V), bottled water, and diet sodas on shoppers' purchasing, food intake, and body weight...
  75. pmc Predictors of parental perceptions and concerns about child weight
    Kathleen L Keller
    Department of Nutritional Sciences, The Pennsylvania State University, 321 Chandlee Laboratory, University Park, PA 16802, USA
    Appetite 62:96-102. 2013
    ..Parental perceptions and concerns about child weight are best explained by models that account for children's eating behavior and body fat distribution...
  76. pmc Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding
    Clemence Blouet
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Metab 16:579-87. 2012
    ....
  77. pmc Short sleep duration, glucose dysregulation and hormonal regulation of appetite in men and women
    Marie Pierre St-Onge
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Sleep 35:1503-10. 2012
    ..To determine the hormonal effects of reducing sleep duration under controlled feeding conditions...
  78. pmc TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism
    Lixia Gan
    Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Endocrinology 153:5821-33. 2012
    ....
  79. pmc Plasma cortisol levels in response to a cold pressor test did not predict appetite or ad libitum test meal intake in obese women
    Allan Geliebter
    NY Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Appetite 59:956-9. 2012
    ..There was also no significant relationship between cortisol levels following stress and TMI, indicating that cortisol did not predict subsequent intake in obese women...
  80. pmc Alterations in sleep architecture in response to experimental sleep curtailment are associated with signs of positive energy balance
    Ari Shechter
    1New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, New York 10025, USA
    Am J Physiol Regul Integr Comp Physiol 303:R883-9. 2012
    ....
  81. pmc Neural responsivity to food cues in fasted and fed states pre and post gastric bypass surgery
    Christopher N Ochner
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, NY 10025, USA
    Neurosci Res 74:138-43. 2012
    ..Results were opposite to that predicted and appear inconsistent with the initial hypothesis that postoperative increases in postprandial gut peptides are the primary driver of postoperative changes in neural responsivity...
  82. pmc Ablation of leptin signaling to somatotropes: changes in metabolic factors that cause obesity
    Noor Akhter
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocrinology 153:4705-15. 2012
    ..These findings signify that leptin signals to somatotropes are vital for the normal metabolic activity needed to optimize body composition...
  83. pmc Dual-energy X-ray absorptiometry prediction of adipose tissue depots in children and adolescents
    Jacqueline Bauer
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, USA
    Pediatr Res 72:420-5. 2012
    ..The study aim was to derive mathematical models to predict total AT (TAT) and subdepots from total body fat derived from a dual-energy X-ray absorptiometry (DXA) scan...
  84. pmc Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice
    Yann Ravussin
    Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Am J Physiol Regul Integr Comp Physiol 303:R438-48. 2012
    ....
  85. pmc Estimating energy expenditure in mice using an energy balance technique
    Y Ravussin
    Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA
    Int J Obes (Lond) 37:399-403. 2013
    ..To compare, in mice, the accuracy of estimates of energy expenditure (EE) using an energy balance technique (TEEbal: food energy intake and body composition change) vs indirect calorimetry (TEEIC)...
  86. pmc Children who are pressured to eat at home consume fewer high-fat foods in laboratory test meals
    Heewon Lee
    Department of Health and Behavior, Teacher s College, Columbia University, New York, NY, USA
    J Acad Nutr Diet 112:271-5. 2012
    ..These findings suggest that greater pressure to eat is associated with lower intake of some high-fat foods in the laboratory, where no pressure is applied...
  87. pmc Central obesity and albuminuria: both cross-sectional and longitudinal studies in Chinese
    Wen Yuan Lin
    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
    PLoS ONE 7:e47960. 2012
    ..We aimed to assess the association between central obesity and prevalence and incidence of albuminuria in a middle-aged population-based cohort study...
  88. ncbi What makes a BIA equation unique? Validity of eight-electrode multifrequency BIA to estimate body composition in a healthy adult population
    A Bosy-Westphal
    Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universität zu Liel, Kiel, Germany
    Eur J Clin Nutr 67:S14-21. 2013
    ..Improvement in BIA technology could overcome these limitations and reduce the population specificity of the BIA algorithm...
  89. pmc Recombinant human growth hormone and rosiglitazone for abdominal fat accumulation in HIV-infected patients with insulin resistance: a randomized, double-blind, placebo-controlled, factorial trial
    Marshall J Glesby
    Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    PLoS ONE 8:e61160. 2013
    ..We aimed to determine if adding rosiglitazone to rhGH would abrogate the adverse effects of rhGH on insulin sensitivity (SI) and subcutaneous adipose tissue (SAT) volume...
  90. pmc Comparison of body adiposity index (BAI) and BMI with estimations of % body fat in clinically severe obese women
    Allan Geliebter
    New York Obesity Nutrition Research Center, Medical Service, St Luke s Roosevelt Hospital Center, New York, New York, USA
    Obesity (Silver Spring) 21:493-8. 2013
    ....

Research Grants30

  1. CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
    Robert S Sandler; Fiscal Year: 2013
    ..Through all of its activities, the Center improves communication, promotes collaboration, develops careers and generally enriches the intellectual climate for digestive disease research. ..
  2. CANCER CENTER SUPPORT GRANT
    TONY R HUNTER; Fiscal Year: 2013
    ....
  3. DIABETES AND ENDOCRINOLOGY RESEARCH CENTER
    Domenico Accili; Fiscal Year: 2013
    ....