Mathematical Model of Linked Longitudinal Data
Principal Investigator: P M Meyer
Abstract: DESCRIPTION (provided by applicant): This five year quantitative research career development award proposes training in two areas: 1) using mathematical modeling of linked longitudinal data (LLD) to better understand complex biological patterns; and 2) cardiology and cardiovascular epidemiology. The Candidate will develop expertise in longitudinal analytic methods and extend these to include the joint modeling of LLD, working under Dr. Scott Zeger at Johns Hopkins University. The Candidate will develop a grasp of anatomy, physiology, cardiology and the ethics of research through coursework and a training program for cardiology fellows under Dr. Joseph Parrillo at Rush Medical Center. Longitudinal techniques will be applied in four research projects. The first three projects build upon ongoing studies while the fourth is designed and executed by the candidate. Project 1: Left ventricular assist devices were developed to help bridge the time to transplant. In an American Heart Association funded study, six standardized quality of life (QOL) measures are being followed in 108 subjects from pre-implant to post-transplant at 8 or more timepoints. Project 1 aims to determine patterns of QOL and how these are related to implant and transplant. Project 2: Study of Women's Health Across the Nation (SWAN) is an NIA funded longitudinal study of the menopausal transition in a cohort of 3300 women from five ethnic groups in 7 seven cities. Project 2 aims to describe the phases of the menopausal transition in terms of hormonal patterns. Project 3: A SWAN substudy funded by NHLBI examines the development of subclinical atherosclerosis during the menopausal transition. Carotid ultrasound, electron beam tomography of coronary and aorta, vascular stiffness and endothelial function will be measured each year for three years. Project 3 aims to describe the changes in subclinical disease patterns as women pass through the menopausal transition. Project 4: Current models of risk in unstable angina focus on individual predictors available at admission. Additional routine clinical information will be collected during the first 24 hours, such as vital signs and ST monitoring via serial electrocardiograms. This data will be analyzed as LLD to determine if recognizing typical patterns of change during the first 24 hours can improve risk estimation. The Candidate will develop the necessary skills to be an independent researcher in biostatistics, cardiovascular epidemiology and cardiology through the training and research projects.
Funding Period: 2002-05-01 - 2007-04-30
more information: NIH RePORT
- Cognitive functioning and sex steroid hormone gene polymorphisms in women at midlifeHoward M Kravitz
Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612, USA
Am J Med 119:S94-S102. 2006..We conclude that selected genes involved in estrogen synthesis and metabolism may be associated with performance differences on cognitive function tests. Also, the relevant estrogen-related polymorphisms may vary by race/ethnicity...
- Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trialTheodore Mazzone
Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois College of Medicine, Chicago 60612, USA
JAMA 296:2572-81. 2006..While studies of relatively short duration have suggested that thiazolidinediones such as pioglitazone might reduce progression of CIMT in persons with diabetes, the results of longer studies have been less clear...
- Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysisWilliam J Elliott
Department of Preventive Medicine, Rush Medical College of Rush University at Rush University Medical Center, Chicago, IL 60612, USA
Lancet 369:201-7. 2007..We therefore undertook a network meta-analysis, which accounts for both direct and indirect comparisons to assess the effects of antihypertensive agents on incident diabetes...
- Atlas vertebra realignment and achievement of arterial pressure goal in hypertensive patients: a pilot studyG Bakris
Department of Preventive Medicine, Rush University Hypertension Center, Chicago, IL, USA
J Hum Hypertens 21:347-52. 2007..5 beats per minute, placebo). No adverse effects were recorded. We conclude that restoration of Atlas alignment is associated with marked and sustained reductions in BP similar to the use of two-drug combination therapy...
- Characterizing daily urinary hormone profiles for women at midlife using functional data analysisPeter M Meyer
Department of Preventive Medicine, Rush University Medical Center, Chicago, IL, USA
Am J Epidemiol 165:936-45. 2007..Longer cycles were characterized by increasing dyssynchrony between follicle-stimulating hormone and luteinizing hormone in the luteal phase...
- Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitusMichael Davidson
Pritzker School of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Circulation 117:2123-30. 2008..Compared with glimepiride, pioglitazone has been shown to slow the progression of atherosclerosis measured by CIMT in patients with type 2 diabetes mellitus...