Dynamic Measures of Neurochemistry in Mood Disorders

Summary

Principal Investigator: Benjamin Johnson
Abstract: DESCRIPTION: (provided by applicant) My research effort is directed toward unraveling the relationships between mood and temporal, rhythmic changes in monoamine levels in CSF. The current project merges serotonin and depression interests from previous work at Yale with techniques in CSF sampling developed at Vanderbilt. Pilot data indicate that oscillatory patterns in monoamine metabolite levels may be more important than absolute concentrations. We are able at Vanderbilt to monitor CSF neurochemistry over 48-hour periods with q10 minute samples, to demonstrate dynamic oscillations in monoamine metabolite levels using Fourier transform methods, and to isolate dominant period lengths of these cycles. These methods are extremely promising as a hard science/engineering approach to understanding the dynamic interactions between monoamine systems that contribute to depression. The K23 Research Career Award will create dedicated time needed for my research career to become an independent researcher in this area. Although I have good psychiatric skills, my training program will require additional knowledge in applied mathematics and statistics to enable me to analyze further the neurochemical data and develop better methods for assessing oscillations in monoaminergic function. Plans for the award period include didactic courses in these areas as well as in the responsible and ethical conduct of research. The research strategy will develop under the guidance of mentors who specialize in different areas but who, together can help me produce quality research with a novel approach. My long range career goals are to honor the legacy of my mentors by bringing a new generation of researchers to the challenge and rewards of discovery, and to further the understanding of the physiologic basis of mood regulation with the aim of discovering more reliable and direct means for alleviating depression.
Funding Period: 2002-07-11 - 2007-12-30
more information: NIH RePORT

Top Publications

  1. pmc Increased oxidative stress in patients with depression and its relationship to treatment
    Cecilia P Chung
    Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN, USA
    Psychiatry Res 206:213-6. 2013
  2. ncbi Treatment enhances ultradian rhythms of CSF monoamine metabolites in patients with major depressive episodes
    Ronald M Salomon
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neuropsychopharmacology 30:2082-91. 2005
  3. pmc Central neurochemical ultradian variability in depression
    Ronald M Salomon
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Dis Markers 22:65-72. 2006
  4. ncbi Interpreting tryptophan depletion in tobacco smokers
    Ronald M Salomon
    Biol Psychiatry 63:e29; author reply e31-2. 2008
  5. pmc Detecting change in biological rhythms: a multivariate permutation test approach to Fourier-transformed data
    Jennifer Urbano Blackford
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37212, USA
    Chronobiol Int 26:258-81. 2009
  6. pmc Prior MDMA (Ecstasy) use is associated with increased basal ganglia-thalamocortical circuit activation during motor task performance in humans: an fMRI study
    John Karageorgiou
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN 37072, USA
    Neuroimage 46:817-26. 2009

Scientific Experts

  • Jennifer Urbano Blackford
  • Benjamin Johnson
  • Ronald M Salomon
  • Cecilia P Chung
  • John Karageorgiou
  • Dennis E Schmidt
  • Dennis Schmidt
  • Charles Michael Stein
  • Jason D Morrow
  • Neil D Woodward
  • Evonne J Charboneau
  • Ronald L Cowan
  • Mary S Dietrich
  • Joseph Kwentus
  • John F Gouda
  • Richard G Shiavi
  • John S Kennedy
  • Harry E Gwirtsman
  • Jennifer Urbano Blackford

Detail Information

Publications6

  1. pmc Increased oxidative stress in patients with depression and its relationship to treatment
    Cecilia P Chung
    Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN, USA
    Psychiatry Res 206:213-6. 2013
    ..These results suggest that alternative mechanisms, beyond oxidative stress, may be involved in the development of depression and subsequent responses to treatment...
  2. ncbi Treatment enhances ultradian rhythms of CSF monoamine metabolites in patients with major depressive episodes
    Ronald M Salomon
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neuropsychopharmacology 30:2082-91. 2005
    ..Further studies including comparisons with healthy subject data are in progress...
  3. pmc Central neurochemical ultradian variability in depression
    Ronald M Salomon
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Dis Markers 22:65-72. 2006
    ..We hypothesized that changes in variability would be observed after treatment. Mechanisms that control such variability may be critical to the pathophysiology of depression...
  4. ncbi Interpreting tryptophan depletion in tobacco smokers
    Ronald M Salomon
    Biol Psychiatry 63:e29; author reply e31-2. 2008
  5. pmc Detecting change in biological rhythms: a multivariate permutation test approach to Fourier-transformed data
    Jennifer Urbano Blackford
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37212, USA
    Chronobiol Int 26:258-81. 2009
    ..Together, Fourier with MPT methods provides a statistically powerful approach for detecting change in biological rhythms from time series data...
  6. pmc Prior MDMA (Ecstasy) use is associated with increased basal ganglia-thalamocortical circuit activation during motor task performance in humans: an fMRI study
    John Karageorgiou
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN 37072, USA
    Neuroimage 46:817-26. 2009
    ..Further studies examining behavioral correlates and the specific neurophysiological basis of the observed findings are warranted...