Depression treatment and risk for cardiovascular disease

Summary

Principal Investigator: MATTHEW CHARLES WHITED
Abstract: DESCRIPTION (provided by applicant): Matthew Whited, PhD is a clinical psychologist at the University of Massachusetts Medical School. His long- term goal is to elucidate the mechanisms of the association between depression and cardiovascular disease (CVD) and to identify depression treatments that influence both physical and mental long-term health. Depression is strongly and consistently associated with risk for CVD onset, but the influence of depression treatment on CVD onset is poorly understood. This indicates a need to investigate the effects of the various available depression treatments, and to more thoroughly understand the mechanisms of action by which depression treatments could influence CVD risk. The majority of studies that seek to influence CVD through depression treatment are studies of secondary prevention. This proposal will provide Dr. Whited with the training and mentorship needed to develop expertise in both epidemiological and clinical trials approaches that investigate the effects of depression treatments on primary CVD risk (first CVD event). Two studies are proposed to investigate the effects of each of two types of depression treatment (Selective Serotonin Reuptake Inhibitors: SSRIs and Cognitive Behavioral Therapy: CBT) on CVD risk. Autonomic balance (measured by heart rate variability;HRV) is associated with depression, and is also an established risk factor for CVD;autonomic balance will be the main CVD mechanism of interest in these studies. Study 1 of this proposal will help inform clinical recommendations of SSRI treatment by determining if SSRIs differentially influence primary CVD incidence in patients who are at higher or lower risk for CVD according to a predictive risk score (Framingham Risk Score: FRS). Following this, Heart Rate Variability (HRV) will be examined as a mediator of the SSRI and CVD association. Study 2 is a pilot clinical trial that will reduce depressive symptoms via an evidence-based psychotherapy to observe the effect of depression symptom reduction on HRV in the absence of pharmacotherapy. These studies are linked in that they both investigate the effects of depression treatment on autonomic balance by independently focusing on either antidepressant medications or psychotherapy. Dr. Whited's prior research in psychophysiology complements the training plan, which will provide Dr. Whited with additional knowledge in depression, its treatment, cardiovascular physiology, autonomic imbalance, along with the experience and expertise necessary to study primary CVD risk using epidemiological and clinical trials methodology. His long-term program of research will focus on understanding the influence of depression treatment on primary CVD risk and risk factors in order to inform clinical guidelines for depression treatment based on both physiological and psychological assessment and psychological and physiological treatment targets.
Funding Period: 2012-08-15 - 2017-05-31
more information: NIH RePORT

Top Publications

  1. pmc Depression severity, diet quality, and physical activity in women with obesity and depression
    Bradley M Appelhans
    Departments of Preventive Medicine and Behavioral Sciences, Rush University Medical Center, 1700 W Van Buren St, Chicago, IL 60612, USA
    J Acad Nutr Diet 112:693-8. 2012
  2. pmc Delay discounting and intake of ready-to-eat and away-from-home foods in overweight and obese women
    Bradley M Appelhans
    Department of Preventive Medicine, Rush University Medical Center, 1700 W Van Buren St, Chicago, IL 60612, USA
    Appetite 59:576-84. 2012
  3. pmc Can attention control conditions have detrimental effects on behavioral medicine randomized trials?
    Sherry L Pagoto
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01760, USA
    Psychosom Med 75:137-43. 2013
  4. pmc Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial
    S Pagoto
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Int J Obes (Lond) 37:1427-34. 2013
  5. pmc Assessing depression in obese women: an examination of two commonly-used measures
    Kristin L Schneider
    University of Massachusetts Medical School, United States Electronic address
    J Psychosom Res 75:425-30. 2013
  6. pmc Severity of depressive symptoms and accuracy of dietary reporting among obese women with major depressive disorder seeking weight loss treatment
    Matthew C Whited
    Department of Psychology, East Carolina University, Greenville, North Carolina, United States of America
    PLoS ONE 9:e90361. 2014

Detail Information

Publications6

  1. pmc Depression severity, diet quality, and physical activity in women with obesity and depression
    Bradley M Appelhans
    Departments of Preventive Medicine and Behavioral Sciences, Rush University Medical Center, 1700 W Van Buren St, Chicago, IL 60612, USA
    J Acad Nutr Diet 112:693-8. 2012
    ..Future studies should identify mechanisms linking depression to diet quality and determine whether diet quality improves with depression treatment...
  2. pmc Delay discounting and intake of ready-to-eat and away-from-home foods in overweight and obese women
    Bradley M Appelhans
    Department of Preventive Medicine, Rush University Medical Center, 1700 W Van Buren St, Chicago, IL 60612, USA
    Appetite 59:576-84. 2012
    ..Impulsivity was associated with the quantity of away-from-home and ready-to-eat foods consumed, but not the frequency of their consumption. Home food preparation may be critical to weight control for impulsive individuals...
  3. pmc Can attention control conditions have detrimental effects on behavioral medicine randomized trials?
    Sherry L Pagoto
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01760, USA
    Psychosom Med 75:137-43. 2013
    ..The primary aim of the present study is to demonstrate a scenario in which use of AC in a behavioral randomized trial was unnecessary and possibly detrimental...
  4. pmc Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial
    S Pagoto
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Int J Obes (Lond) 37:1427-34. 2013
    ..The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression before a lifestyle weight loss intervention improves both weight loss and depression...
  5. pmc Assessing depression in obese women: an examination of two commonly-used measures
    Kristin L Schneider
    University of Massachusetts Medical School, United States Electronic address
    J Psychosom Res 75:425-30. 2013
    ....
  6. pmc Severity of depressive symptoms and accuracy of dietary reporting among obese women with major depressive disorder seeking weight loss treatment
    Matthew C Whited
    Department of Psychology, East Carolina University, Greenville, North Carolina, United States of America
    PLoS ONE 9:e90361. 2014
    ..These results suggest that any study investigating associations between diet quality and depression should also include an index of reporting accuracy of dietary intake as accuracy varies with the severity of depressive symptoms...

Research Grants60

  1. Establishing Moderators/Biosignatures of Antidepressant Response- Clinical Care
    Madhukar H Trivedi; Fiscal Year: 2013
    ..This team will also be guided by internationally known biomarker scientists (Holsboer, Schatzberg, Krystal, Charney, Goodman), as well as a highly qualified group of biostatisticians (Kraemer, Wisniewski, Schoenfeld). ..
  2. Bridging Research, Innovation, Training &Education Solutions for Minority Health
    Vickie M Mays; Fiscal Year: 2013
    ..abstract_text> ..
  3. Examination of Reward Processing in the Treatment of Adolescent Major Depression
    Randy Patrick Auerbach; Fiscal Year: 2013
    ....
  4. 1/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Charles F Reynolds; Fiscal Year: 2013
    ..There are is no evidence-based pharmacotherapy for TRLLD;thus, this study seeks to address a major gap in the evidence base for treating depression. ..
  5. Neuroimaging Acupuncture Effects Brain Activity in Chronic low Back Pain
    Bruce R Rosen; Fiscal Year: 2013
    ..Understanding the neural influence of somatosensation on acupuncture placebo effects will significantly impact our understanding of acupuncture and allow for development of more inert acupuncture placebos. ..
  6. INTEGRATING DEPRESSION CARE FOR ACS PATIENTS IN LOW-RESOURCE HOSPITALS IN CHINA
    Xin Yu; Fiscal Year: 2013
    ....
  7. Novel Therapies for Muco-Obstructive Lung Diseases
    RICHARD CHARLES BOUCHER; Fiscal Year: 2013
    ..abstract_text> ..
  8. UNIVERSITY OF WASHINGTON CENTER FOR AIDS RESEARCH
    King K Holmes; Fiscal Year: 2013
    ..The CFAR will support and provide added value for future local, national and international HIV/AIDS research priorities. ..
  9. Cumulative Stress and CVD Risk in Middle-Aged and Older Women
    Michelle A Albert; Fiscal Year: 2013
    ..Thus, this proposed study will provide valuable clinical information that can result in the development of behavioral and therapeutic interventions aimed at decreasing the effects of cumulative stressors on CVD health. ..
  10. 3/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Benoit H Mulsant; Fiscal Year: 2013
    ..There are is no evidence-based pharmacotherapy for TRLLD;thus, this study seeks to address a major gap in the evidence base for treating depression. ..
  11. Sleep: A Novel Pathway Linking Major Depression and Cardiovascular Disease
    MARTICA HELON HALL; Fiscal Year: 2013
    ....
  12. Southwest Center for Agricultural Health, Injury Prevention, and Education
    Jeffrey L Levin; Fiscal Year: 2013
    ..The Center's impact will be expanded by a Feasibilty program that augments the proposed scope of work and is responsive to emerging issues. ..
  13. Biobehavioral Responses to Cancer
    Barbara L Andersen; Fiscal Year: 2013
    ..abstract_text> ..
  14. Prepubertal Stress, Windows of Risk &Sex Bias for Affective Disturbance
    C NEILL NEILL EPPERSON; Fiscal Year: 2013
    ..The Center would provide an intellectual platform with important resources to encourage established investigators, and their mentees, to consider sex and gender as crucial factors in their research. ..
  15. INNATE AND ADAPTIVE IMMUNE RESPONSES IN TH2-HIGH ASTHMA
    John V Fahy; Fiscal Year: 2013
    ..Including studies in human biospecimens in a PPG that promises to advance understanding of airway TH2 inflammation in ways that are highly relevant to patients with asthma. ..
  16. 2/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Eric J Lenze; Fiscal Year: 2013
    ..There are is no evidence-based pharmacotherapy for TRLLD;thus, this study seeks to address a major gap in the evidence base for treating depression. ..
  17. Comprehensive NeuroAIDS Core Center
    Kamel Khalili; Fiscal Year: 2013
    ..abstract_text> ..
  18. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  19. Biobehavioral inflexibility and risk for juvenile-onset depression
    JONATHAN ADAM ROTTENBERG; Fiscal Year: 2013
    ..abstract_text> ..
  20. Cellular S-nitrosothiol signaling in respiratory biology
    Lisa Palmer; Fiscal Year: 2013
    ..This program will make extensive use of intramural and extramural collaborations, as well as Program Core facilities, to make good use of our institutional strengths in S-nitrosothiol biology. ..
  21. MOLECULAR GENETICS OF COAGULATION DISORDERS
    David Ginsburg; Fiscal Year: 2013
    ..This Project will identify key genes in this system that should provide valuable new diagnostic tools as well as suggest novel approaches to treatment. ..
  22. Puberty and Threat/Reward Processing in the Trajectory from Anxiety to Depression
    Jennifer S Silk; Fiscal Year: 2013
    ....
  23. EARLY EVENTS IN ALZHEIMER PATHOGENESIS
    SUE TILTON GRIFFIN; Fiscal Year: 2013
    ..The synergy between our aims, approaches, and measures will enable us to meet our goal of defining early cellular interactions toward development of rational interventions in AD. ..
  24. MOLECULAR &CELLULAR MECHANISMS IN TRANSFUSION MEDICINE
    Peter J Newman; Fiscal Year: 2013
    ..abstract_text> ..
  25. Psychological Stress and Risk of Cardiovascular Disease
    Beth Cohen; Fiscal Year: 2013
    ..Karen Seal), and the social sciences (Dr. Judith Moskowitz). This dedicated mentorship team, combined with a rigorous, supportive research environment, will ensure Dr. Cohen develops into a successful independent investigator. ..
  26. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2013
    ..abstract_text> ..
  27. COBRE Center for Central Nervous System Function
    Jerome N Sanes; Fiscal Year: 2013
    ..The COBRE Center will leverage the administrative resources available through the Brown Institute for Brain Science to ensure efficient operation and coordinate with other brain science research activities at Brown. ..
  28. Unique cardiovascular Risk Factors in Women Research and Mentoring Progam
    Ellen W Seely; Fiscal Year: 2013
    ..This application will determine if there is a safer way to give HRT and an effective way to decrease the number of GDM women who develop Type 2 DM. . (End of Abstract) ..
  29. Is mental disorder a preventable cause of age-related disease? The Dunedin Study.
    TERRIE EDITH MOFFITT; Fiscal Year: 2013
    ..abstract_text> ..
  30. Tech-Based Depression and Anxiety Treatment for Youth in High Risk Environments
    Michelle Nicole Burns; Fiscal Year: 2013
    ..Studies 2 and 3 will provide preliminary data for an R01 proposing a larger RCT. ..
  31. 1/3-Improving Depression Outcome by Adding CBT for Insomnia to Antidepressants
    Rachel Manber; Fiscal Year: 2013
    ..The results of this study may offer a method for improving the treatment of major depression without the use of additional medication. ..
  32. 1/2-Personalized Antidepressant Adherence Strategies for Depressed Elders
    Jo Anne Sirey; Fiscal Year: 2013
    ..As a brief manualized intervention, TIP-PC is designed to fit easily within primary care practices and to be delivered by non-MD staff. ..
  33. Promoting Independence Through Pain and Symptom Management
    Albert L Siu; Fiscal Year: 2013
    ..The proposed Center will bridge geriatrics and palliative care and serve as a model for a new focused area of research within geriatrics. ..
  34. Family and Neighborhood Interventions to Reduce Heart Disease Risk in East L.A.
    Alexander N Ortega; Fiscal Year: 2013
    ....
  35. Notch-Mediated Expansion of Cord Blood Progenitors for Stem Cell Transplant
    Colleen Delaney; Fiscal Year: 2013
    ..Our goal is to now determine the clinical efficacy of this approach in a phase II clinical trial. ..
  36. 1/2-Preventing Perinatal Depression (PRE-D): Developing Tools and Interventions
    Robin B Jarrett; Fiscal Year: 2013
    ..We predict that both P-CT and C-AIM can be integrated within primary care community clinics, if these constituencies are included in development and contingent upon successful tests of effectiveness. ..
  37. 2/2-Personalized Antidepressant Adherence Strategies for Depressed Elders
    Helen C Kales; Fiscal Year: 2013
    ..As a brief manualized intervention, TIP-PC is designed to fit easily within primary care practices and to be delivered by non-MD staff. ..
  38. INTEGRATED MECHANISMS OF CARDIAC MALADAPTATION
    R John Solaro; Fiscal Year: 2013
    ..Studies proposed here offer the potential for novel diagnostic procedures early in the progression of the disorders, and targets for novel therapies. (End of Abstract) ..
  39. Course and Outcome of Bipolar Disorder in Youth
    Boris Birmaher; Fiscal Year: 2013
    ..abstract_text> ..
  40. Early Phase Psychosis: Informing Treatment Decisions
    John M Kane; Fiscal Year: 2013
    ..Our ability to intervene appropriately, effectively and consistently in this population can have profound long-term public health consequences. ..
  41. Boston Puerto Rican Health Study - CVD Risk Factors
    Katherine L Tucker; Fiscal Year: 2013
    ..abstract_text> ..