Immune regulatory mechanisms and fungus-specific memory T cell responses

Summary

Principal Investigator: Vanessa Espinosa
Abstract: DESCRIPTION (provided by applicant): The opportunistic fungal pathogen Aspergillus fumigatus is the causative agent of more than 90% of all Invasive Aspergillosis (IA) infections diagnosed in immunosuppressed patients. Exposure to A. fumigatus can also lead to the development of allergic asthma and Allergic Bronchopulmonary Aspergillosis (ABPA) in patients with atopic asthma or Cystic Fibrosis. Fungus-specific CD4 T cell responses are important in defense against invasive disease and mediate the development of allergic responses. Thus, understanding the factors that control the expansion and formation of fungus-specific memory CD4 T cells will lay the foundation for the future development of novel immune-based therapeutic strategies to enhance or inhibit fungus-specific immunity. In this proposal, the applicant will examine the contributions of regulatory T cells (Tregs) and T cell-intrinsic inhibitry receptors (PD-1 and CTLA-4) in controlling fungus-specific CD4 T cell responses. Moreover, the proposed studies will determine the mechanism of action of inhibitory receptors and Tregs and how they impact fungus-driven allergic airway disease progression. The applicant will be supported by a comprehensive training plan to promote her career development as an independent scientist and to help her attain a PhD degree. The long-term goal of the applicant is to become a successful, well- funded, independent researcher. As a woman of Hispanic descent the applicant is committed to contributing to the future development of research programs to address health disparities and diversity in biomedical science's workforce.
Funding Period: 2013-01-01 - 2013-06-30
more information: NIH RePORT

Top Publications

  1. pmc Inflammatory monocytes orchestrate innate antifungal immunity in the lung
    Vanessa Espinosa
    Rutgers, New Jersey Medical School, Department of Pediatrics, Center for Immunity and Inflammation, Newark, New Jersey, United States of America Rutgers, Graduate School of Biomedical Sciences, Newark, New Jersey, United States of America
    PLoS Pathog 10:e1003940. 2014

Detail Information

Publications1

  1. pmc Inflammatory monocytes orchestrate innate antifungal immunity in the lung
    Vanessa Espinosa
    Rutgers, New Jersey Medical School, Department of Pediatrics, Center for Immunity and Inflammation, Newark, New Jersey, United States of America Rutgers, Graduate School of Biomedical Sciences, Newark, New Jersey, United States of America
    PLoS Pathog 10:e1003940. 2014
    ..Our findings illustrate both indirect and direct functions for CCR2⁺Mo and their derivatives in innate antifungal immunity in the lung...

Research Grants30

  1. Northeast Biodefense Center
    W Ian Lipkin; Fiscal Year: 2013
    ..As a Center based in a School of Public Health and a State Department of Health, the NBC has a firm commitment to and practical understanding of Emergency Preparedness. ..
  2. BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION
    John C Crabbe; Fiscal Year: 2013
    ..An Education and Outreach component trains pre- and post-doctoral students in alcohol research, disseminates research findings to the public, and engages in a range of activities with elementary-to-high school students. ..
  3. International Comparisons of Well-Being, Health and Retirement
    ARIE KAPTEYN; Fiscal Year: 2013
    ..unreadable] Make harmonized institutional information available to the wider research community. ..
  4. Pacific NorthWest Regional Center of Excellence (PNWRCE)
    Jay A Nelson; Fiscal Year: 2013
    ..pseudomallei host pathogen response during both the septicemic as well as the intracellular phases of the disease. ..
  5. The role of cyclooxygenase in the adaptive immune response and tolerance
    Ray Stokes Peebles; Fiscal Year: 2013
    ....
  6. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2013
    ..Such studies will help to design novel therapeutic interventions for allergic diseases. ..
  7. Molecular Mechanisms of Arterigenesis
    Michael Simons; Fiscal Year: 2013
    ..matrix (Project 2), evaluate the central role of mTOR in balancing various arteriogenic signaling inputs (Project 3) and determine the role of shear stress and other mechanical factors in initiating arteriogenesis in ad ..