vmhc

Summary

Gene Symbol: vmhc
Description: ventricular myosin heavy chain
Alias: mg:cb02g011, smyhc3, ventricular myosin heavy chain
Species: zebrafish

Top Publications

  1. pmc GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation
    Tessa Peterkin
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    EMBO J 22:4260-73. 2003
  2. pmc Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation
    Mollie R Johnson Sorrell
    Molecular Cardiovascular Biology Division and The Heart Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 358:44-55. 2011
  3. pmc Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development
    Poulomi Bhattacharya
    Department of Biological Sciences, Illinois State University, Normal, USA
    J Endocrinol 211:187-200. 2011
  4. doi Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development
    Kelly A Smith
    Hubrecht Institute, KNAW and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands
    Development 138:4193-8. 2011
  5. doi Voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity
    Yelena Chernyavskaya
    Colorado State University, Department of Biology, Fort Collins, Colorado 80523, USA
    Dev Dyn 241:648-62. 2012
  6. ncbi Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility
    Yue xiang Wang
    Department of Molecular Genetics, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, 138 Yi Xueyuan Road, and Children s Hospital, Shanghai, 200032, P R China
    Cardiovasc Res 74:290-303. 2007
  7. pmc Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis
    Mieke Delvaeye
    KU Leuven, VIB Vesalius Research Center VRC, Gasthuisberg O and N 1, Herestraat 49, 3000 Leuven, Belgium
    BMC Dev Biol 9:25. 2009
  8. ncbi Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish
    D Yelon
    Programs in Human Genetics and Developmental Biology, University of California, San Francisco, San Francisco, California, 94143 0448, USA
    Dev Biol 214:23-37. 1999
  9. ncbi Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    Eli Berdougo
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 130:6121-9. 2003
  10. ncbi Na,K-ATPase is essential for embryonic heart development in the zebrafish
    Xiaodong Shu
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Development 130:6165-73. 2003

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. pmc GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation
    Tessa Peterkin
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    EMBO J 22:4260-73. 2003
    ..We therefore conclude that proper maturation of cardiac mesoderm requires GATA-6, which functions to maintain BMP-4 and Nkx2 expression...
  2. pmc Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation
    Mollie R Johnson Sorrell
    Molecular Cardiovascular Biology Division and The Heart Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 358:44-55. 2011
    ....
  3. pmc Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development
    Poulomi Bhattacharya
    Department of Biological Sciences, Illinois State University, Normal, USA
    J Endocrinol 211:187-200. 2011
    ..The considerable evolutionary conservation in genomic structure, synteny relationships, and expression of zebrafish pth2 and pth2r provides a foundation for exploring the endocrine roles of this system in developing vertebrate embryos...
  4. doi Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development
    Kelly A Smith
    Hubrecht Institute, KNAW and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands
    Development 138:4193-8. 2011
    ..Finally, we show that immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development...
  5. doi Voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity
    Yelena Chernyavskaya
    Colorado State University, Department of Biology, Fort Collins, Colorado 80523, USA
    Dev Dyn 241:648-62. 2012
    ..2 is a membrane associated guanylate kinase (MAGUK) protein. A major role of MAGUK proteins is to scaffold cellular junctions and multiprotein complexes...
  6. ncbi Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility
    Yue xiang Wang
    Department of Molecular Genetics, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, 138 Yi Xueyuan Road, and Children s Hospital, Shanghai, 200032, P R China
    Cardiovasc Res 74:290-303. 2007
    ..The molecular basis of the intrinsic system is largely unknown. Here, we test the hypothesis that bone morphogenetic protein-2 (BMP-2) mediates embryonic cardiac contractility upstream of myocyte-specific enhancer factor 2A (MEF2A)...
  7. pmc Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis
    Mieke Delvaeye
    KU Leuven, VIB Vesalius Research Center VRC, Gasthuisberg O and N 1, Herestraat 49, 3000 Leuven, Belgium
    BMC Dev Biol 9:25. 2009
    ..Prenatally, survivin is also highly expressed in several tissues. Fully delineating the properties of survivin in vivo in mice has been confounded by early lethal phenotypes following survivin gene inactivation...
  8. ncbi Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish
    D Yelon
    Programs in Human Genetics and Developmental Biology, University of California, San Francisco, San Francisco, California, 94143 0448, USA
    Dev Biol 214:23-37. 1999
    ..expression patterns of two zebrafish cardiac myosin genes, cardiac myosin light chain 2 (cmlc2) and ventricular myosin heavy chain (vmhc), allow us to distinguish two populations of myocardial precursors at an early stage, well ..
  9. ncbi Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    Eli Berdougo
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 130:6121-9. 2003
    ..These findings are relevant to our understanding of congenital defects in cardiac chamber morphogenesis...
  10. ncbi Na,K-ATPase is essential for embryonic heart development in the zebrafish
    Xiaodong Shu
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Development 130:6165-73. 2003
    ..Furthermore, instead of interfering with primitive heart tube formation or cardiac chamber differentiation, blocking the translation of Na,K-ATPase alpha2 isoform leads to cardiac laterality defects...
  11. ncbi Organization of cardiac chamber progenitors in the zebrafish blastula
    Brian R Keegan
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 131:3081-91. 2004
    ..Indeed, via fate mapping, we demonstrate that Nodal signaling promotes ventricular fate specification near the margin, thereby playing an important early role during myocardial patterning...
  12. pmc Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts
    A M Ebert
    Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 102:17705-10. 2005
    ..Thus, the inhibition of NCX1h versus SERCA2 activity differentially affects the pathophysiology of rhythm in the developing heart and suggests that relative levels of NCX1 and SERCA2 function are essential for normal development...
  13. pmc Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish
    Adam D Langenbacher
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:17699-704. 2005
    ..These data signify the essential role of calcium homeostasis and NCX1h in establishing rhythmic contraction in the embryonic zebrafish heart...
  14. ncbi Notch1b and neuregulin are required for specification of central cardiac conduction tissue
    David J Milan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Development 133:1125-32. 2006
    ....
  15. pmc Cadherin2 (N-cadherin) plays an essential role in zebrafish cardiovascular development
    Brian Bagatto
    Department of Biology, University of Akron, Akron, Ohio, USA
    BMC Dev Biol 6:23. 2006
    ..To gain insight into cadherin2 role in the formation and function of the heart, we analyzed cardiac differentiation and performance in a cadherin2 mutant, glass onion (glo)...
  16. pmc Functional modulation of cardiac form through regionally confined cell shape changes
    Heidi J Auman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Biol 5:e53. 2007
    ..Together, these data establish regionally confined cell shape change as a cellular mechanism for chamber emergence and as a link in the relationship between form and function during organ morphogenesis...
  17. pmc Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression
    Naznin Sultana
    Departments of Biological Sciences and Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Proc Natl Acad Sci U S A 105:4763-8. 2008
    ..5 expression, which in turn promotes unidirectional, parallel alignment of myofibrils and the subsequent proper heart morphogenesis...
  18. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
    ..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
  19. pmc Genetic and physiologic dissection of the vertebrate cardiac conduction system
    Neil C Chi
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 6:e109. 2008
    ....
  20. pmc Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 321:397-406. 2008
    ..Together, our data demonstrate that a single signaling pathway can act reiteratively to coordinate organ size and proportion...
  21. doi Cascade effect of cardiac myogenesis gene expression during cardiac looping in tbx5 knockdown zebrafish embryos
    Jen Her Lu
    Department of Pediatrics and Pediatric Cardiology, Veterans General Hospital Taipei, National Yang Ming University, Taipei, Taiwan, ROC
    J Biomed Sci 15:779-87. 2008
    ..Expression of cardiac myogenesis genes amhc, vmhc and cmlc2 were expressed constantly at the early embryonic development and reached its highest rate right before ..
  22. pmc Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number
    KIMARA L TARGOFF
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 322:314-21. 2008
    ..Our data suggest that morphogenetic errors could originate during early stages of heart tube assembly in patients with NKX2-5 mutations...
  23. pmc Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential
    Natalie A Thomas
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 135:3789-99. 2008
    ..Thus, Hh signaling plays an essential early role in defining the optimal number of cardiomyocytes, making it an attractive target for manipulation of multipotent progenitor cells...
  24. doi The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
    Atsuo Kawahara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Science 323:524-7. 2009
    ..Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration...
  25. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
    ..Therefore, our results offer new perspectives on the mechanisms regulating organ size and the possible causes of congenital syndromes affecting both the heart and forelimb...
  26. doi Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a
    Carmen Gloria Feijóo
    Center for Genomics of the Cell, Universidad de Chile, Santiago, Chile
    Mol Cell Neurosci 40:328-37. 2009
    ..Our results point to irx4a as a critical gene for numerous developmental processes and highlight its role in the formation of placodal derivatives in vertebrates...
  27. pmc Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos
    Chi Tang Tu
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 4:e4249. 2009
    ..5 and Nkx-2.3. Nkx2.7 and Nkx2.5 express in zebrafish heart fields of lateral plate mesoderm. The temporal and spatial expression patterns of Nkx2.7 are similar to those of Nkx2.5, but their functions during cardiogenesis remain unclear...
  28. pmc Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression
    Ruilin Zhang
    Department of Biochemistry and Molecular Biology Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Dev Dyn 238:1564-73. 2009
    The zebrafish ventricular myosin heavy chain (vmhc) gene exhibits restricted expression in the ventricle. However, the molecular mechanism underlying this chamber-specific expression is unclear...
  29. pmc Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 238:1207-13. 2009
    ..These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart...
  30. pmc Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, 2300 Children s Plaza M C 204, Chicago, IL 60614, USA
    Dev Biol 337:233-45. 2010
    ..These studies demonstrate that controlling the correct balance of Tbx5 activity is crucial for the specification of the AV boundary and valve formation...
  31. pmc Effect of vascular cadherin knockdown on zebrafish vasculature during development
    Ian C Mitchell
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e8807. 2010
    ..Vascular endothelial cadherin (VE-cad) is essential for endothelial barrier integrity and vascular sprouting. However, the role of this important protein in cardiovascular development is only recently becoming apparent...
  32. pmc Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function
    Zayra V Garavito-Aguilar
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Development 137:3215-20. 2010
    ..Together, our data provide a novel example of a tissue creating a favorable environment for its morphogenesis: the Hand2 pathway establishes an appropriate environment for cardiac fusion through negative modulation of Fn1 levels...
  33. pmc Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration
    Kazu Kikuchi
    Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Dev Cell 20:397-404. 2011
    ....
  34. doi Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish
    Savo Lazic
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Dev Biol 354:123-33. 2011
    ..The late ventricular region has cardiogenic properties, expressing myocardial markers such as vmhc and nkx2.5, but does not express a full complement of differentiated cardiomyocyte markers, lacking myl7 expression...
  35. doi MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production
    Anne Karine Lagendijk
    Hubrecht Institute for Developmental Biology and Stem Cell Research, CT Utrecht, The Netherlands
    Circ Res 109:649-57. 2011
    ..Although roles for microRNAs in the myocardium during embryo development and cardiac disease have been demonstrated, very little is know about their role in the endocardium or during cardiac valve formation...
  36. pmc Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation
    Yaniv Hinits
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, King s College London, UK
    Dev Biol 369:199-210. 2012
    ..Mef2cb single mutants have a functional heart and are viable adults. Our results show that the key role of Mef2c in myocardial differentiation is conserved throughout the vertebrate heart...
  37. ncbi The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development
    D Yelon
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA, USA
    Development 127:2573-82. 2000
    ..Thus, these studies reveal early functions for Hand2 in several cellular processes and highlight a genetic parallel between heart and forelimb development...
  38. ncbi The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome
    Deborah M Garrity
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 129:4635-45. 2002
    ..However, the syndromic deficiencies of tbx5 mutation are remarkably well retained between fish and mammals...
  39. pmc NXT2 is required for embryonic heart development in zebrafish
    Haigen Huang
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA
    BMC Dev Biol 5:7. 2005
    ..NXT2 is a member of NXT family proteins that are generally involved in exporting nuclear RNA in eukaryotic cells. It is not known if NXT2 has any function in specific biological processes...
  40. ncbi Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart
    Wolfgang Rottbauer
    Department of Medicine III, University of Heidelberg, Germany
    Circ Res 99:323-31. 2006
    ..Thus, our findings provide the first in vivo evidence that cardiac MLC-2 is required for thick-filament stabilization and contractility in the vertebrate heart...
  41. ncbi Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points
    Sonja Chocron
    Cardiac Development and Genetics Group, Hubrecht Laboratory, Uppsalalaan 8, Utrecht, The Netherlands
    Dev Biol 305:577-88. 2007
    ..The identification of these two distinct and opposing activities of BMP signaling provides new insight into how BMP signaling can regulate LR patterning...
  42. pmc Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish
    Xianghu Qu
    Department of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:486-96. 2008
    ..Together, our studies reveal an essential role of ndrg4 in regulating proliferation and growth of cardiomyocytes, suggesting that ndrg4 may function downstream of tbx5 during heart development and growth...
  43. ncbi heart of glass regulates the concentric growth of the heart in zebrafish
    John D Mably
    Cardiovascular Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 13:2138-47. 2003
    ..In heart of glass mutant embryos, the number of cells in the myocardium is normal, but they are not added in the concentric direction. As a consequence, the chambers are huge and dysfunctional, and the myocardium remains a single layer...
  44. ncbi Effects of methotrexate on the developments of heart and vessel in zebrafish
    Shuna Sun
    Children s Hospital, Fudan University, Shanghai 201102, China
    Acta Biochim Biophys Sin (Shanghai) 41:86-96. 2009
    ..Our results indicated that the disrupted development of the heart and vessels in MTX-treated embryos is related to the reduced transcript levels of hand2, mef2a, mef2c, and flk-1...
  45. doi Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1
    Naida Yin
    Key Laboratory of Biodiversity and Conservation of Aquatic Organisms, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, PR China
    Toxicol Appl Pharmacol 238:20-6. 2009
    ..Thus, our present data indicate that the production of teleost VTG in vivo can be regulated not only by estrogenic agents, but by adrenergic signals as well...
  46. ncbi Effect of Tbx1 knock-down on cardiac performance in zebrafish
    Li Feng Zhang
    Children s Hospital, Fudan University, Shanghai 200032, China
    Chin Med J (Engl) 123:1182-9. 2010
    ..Therefore, myocardial performance was explored in Tbx1 morpholino injected zebrafish embryos...
  47. doi Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish
    Heng Huang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Arterioscler Thromb Vasc Biol 32:2158-70. 2012
    ..The aim of this study was to investigate the physiological functions of PAQR10 and PAQR11...
  48. doi Sphingosine-1-phosphate receptor-1 controls venous endothelial barrier integrity in zebrafish
    Chiara Tobia
    Department of Biomedical Sciences and Biotechnology, Unit of General Pathology and Immunology, School of Medicine, University of Brescia, Italy
    Arterioscler Thromb Vasc Biol 32:e104-16. 2012
    ..Here, we characterized the role of the zS1P(1) ortholog in vascular development in zebrafish...
  49. doi F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo
    Sebastian Spaich
    Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
    Circ Res 111:1504-16. 2012
    ..The emerging role of the ubiquitin-proteasome system in cardiomyocyte function and homeostasis implies the necessity of tight regulation of protein degradation. However, little is known about cardiac components of this machinery...
  50. pmc In vivo cardiac reprogramming contributes to zebrafish heart regeneration
    Ruilin Zhang
    Department of Medicine, Division of Cardiology, University of California, San Diego, La Jolla, California 92093, USA
    Nature 498:497-501. 2013
    ....
  51. pmc Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development
    Yu Hisano
    Laboratory for Cardiovascular Molecular Dynamics, RIKEN Quantitative Biology Center, Furuedai 6 2 3, Suita, Osaka 565 0874, Japan
    Biol Open 2:789-94. 2013
    ..These results strongly suggest that Spns2-S1PR2 signaling and fibronectin cooperatively regulate both cardiac and lower jaw development in zebrafish. ..
  52. pmc Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid
    Enrico D'Aniello
    The Heart Institute, Molecular Cardiovascular Biology and Developmental Biology Divisions, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS Genet 9:e1003689. 2013
    ..Our results support an intriguing novel mechanism by which depletion of RARs elicits a previously unrecognized positive feedback loop that can result in developmental defects due to teratogenic increases in embryonic RA. ..
  53. pmc Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes
    Emma Monte
    Department of Anesthesiology, University of California, Los Angeles, Los Angeles, California
    Am J Physiol Heart Circ Physiol 305:H1624-38. 2013
    ..Validation studies in the complementary model system of zebrafish examine the role of Nucleolin to orchestrate genomic reprogramming events shared between development and disease...
  54. doi Mechanisms of cadmium-caused eye hypoplasia and hypopigmentation in zebrafish embryos
    Ting Zhang
    College of Fisheries, Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China Electronic address
    Aquat Toxicol 167:68-76. 2015
    ..Moreover, we found that compounds BIO or RA could neutralize the toxic effects of Cd...
  55. pmc Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis
    Enrico D'Aniello
    The Heart Institute, Molecular Cardiovascular Biology and Developmental Biology Divisions, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, United States of America
    PLoS ONE 10:e0138588. 2015
    ..Altogether, our results demonstrate that Rdh10a has a conserved requirement in the first step of RA production within vertebrate embryos. ..
  56. pmc Chamber Specific Gene Expression Landscape of the Zebrafish Heart
    Angom Ramcharan Singh
    Genomics and Molecular Medicine, CSIR Institute of Genomics and Integrative Biology, Mathura Road, Delhi 110025, India
    PLoS ONE 11:e0147823. 2016
    ..It is also postulated that this transcriptome atlas will help utilize zebrafish in a better way as a model for studying cardiac development and to explore functional role of gene networks in cardiac disease pathogenesis. ..
  57. pmc Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish
    Rebecca Powell
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA
    Mol Med Rep 14:2665-78. 2016
    ..However, the chamber‑specific markers amhc and vmhc were unaffected. Interestingly, knockdown of wtip disrupts early left‑right (LR) asymmetry...
  58. ncbi Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish
    Feng Cheng
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100049, China
    Development 143:3522-3531. 2016
    ..Together, our results reveal a previously unappreciated function of vinculin in epicardium and endocardium and reinforce the notion that well-balanced FAK activity is essential for coronary vessel development...
  59. pmc Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling
    Terri T Ni
    State Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
    Chem Biol 18:1658-68. 2011
    ..These findings demonstrate that in vivo small-molecule screens targeting heart size can reveal compounds with cardiomyogenic effects and identify underlying target pathways...
  60. doi RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility
    Kar Lai Poon
    Institute of Molecular and Cell Biology, 61 Biopolis Dr, 08 13 Proteos, Singapore 138673, Singapore
    Cardiovasc Res 94:418-27. 2012
    ..Our studies of the transcriptome of human embryonic stem cell-derived cardiomyocytes identified novel genes up-regulated during cardiac differentiation, including RBM24. We therefore studied how its deficiency affected heart development...
  61. pmc Induction of myocardial infarction in adult zebrafish using cryoinjury
    Fabian Chablais
    Department of Biology, Unit of Zoology, University of Fribourg, Fribourg, Switzerland
    J Vis Exp . 2012
    ..A conceptual and molecular understanding of heart regeneration in zebrafish will impact both developmental biology and regenerative medicine...
  62. pmc The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish
    Nicole O Glenn
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Mol Cell Biol 32:3527-40. 2012
    ..Our study underscores the importance of the W-loop for actin functionality and will help us to understand the structural and physiological consequences of ACTC mutations in human congenital disorders...
  63. pmc The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos
    Tzu Chun Tsai
    Department of Medical Research and Education, National Yang Ming University Hospital, Yilan, Taiwan, Republic of China
    J Biomed Sci 19:63. 2012
    ..Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome...
  64. pmc A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development
    Sharon L Paige
    Department of Pathology, University of Washington, Seattle, 98109, USA
    Cell 151:221-32. 2012
    ..Temporal chromatin signatures should be broadly applicable to other models of stem cell differentiation to identify regulators and provide key insights into major developmental decisions...
  65. pmc Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm
    Iris I Müller
    Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dis Model Mech 6:332-41. 2013
    ..These results implicate, for the first time, regulators of BMP signaling in human AF, providing mechanistic insights into the pathogenesis of the disease and identifying potential new therapeutic targets...
  66. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells...
  67. ncbi Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase
    Yuexiang Wang
    Department of Molecular Genetics, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, PR China
    Biochem Biophys Res Commun 331:303-8. 2005
    ..Our findings may provide new insights into the cardiomyocyte function and disfunction...
  68. pmc VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart
    Wolfgang Rottbauer
    Department of Medicine III, University of Heidelberg, D 69120 Heidelberg, Germany
    Genes Dev 19:1624-34. 2005
    ..Thus, the muscle of the heart uses the VEGF-PLCgamma1 cascade to control the strength of the heart beat. We speculate that this paracrine system may contribute to normal and pathological regulation of cardiac contractility...
  69. ncbi Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis
    Stefan Rohr
    Max Delbrück Center MDC Strasse 10, 13125 Berlin, Germany
    Development 133:107-15. 2006
    ....
  70. ncbi TBX1, a DiGeorge syndrome candidate gene, is inhibited by retinoic acid
    Lifeng Zhang
    Children s Hospital of Fudan University, Shanghai, P R China
    Int J Dev Biol 50:55-61. 2006
    ..The results suggested that RA could produce an altered Tbx1 expression pattern in zebrafish. In addition, RA could repress Tbx1 expression in a dose-dependent manner...
  71. pmc Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development
    John P Incardona
    Ecotoxicology and Environmental Fish Health Program, Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, USA
    Environ Health Perspect 113:1755-62. 2005
    ..These findings have multiple implications for the assessment of PAH impacts on coastal habitats...
  72. ncbi Delta-sarcoglycan is necessary for early heart and muscle development in zebrafish
    Lu Cheng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Biochem Biophys Res Commun 344:1290-9. 2006
    ..These data together suggest that delta-sarcoglycan plays an important role in early heart and muscle development...
  73. ncbi santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish
    John D Mably
    Cardiovascular Research Center, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 133:3139-46. 2006
    ..This suggests that concentric growth of the myocardium, crucial for blood pressure generation, is dictated by a heg-san-vtn signaling pathway...
  74. ncbi Zebrafish cypher is important for somite formation and heart development
    David L M van der Meer
    Institute of Biology, Department of Integrative Zoology University of Leiden, Kaiserstraat 3, 2311 GN, The Netherlands
    Dev Biol 299:356-72. 2006
    ..Taken together, our data suggest that cypher may play a role downstream of sonic hedgehog, in a late stage of somite development, when slow muscle fibers differentiate and migrate from the adaxial cells...
  75. ncbi The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish
    Serene L Wohlgemuth
    Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Dev Biol 303:483-92. 2007
    ..These results suggest that Unc45b acts as a chaperone that aids in the folding of myosin isoforms required for skeletal, cranial and cardiac muscle contraction...
  76. ncbi The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors
    Ian C Scott
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 12:403-13. 2007
    ..These results support a model in which agtrl1b regulates the migration of cells fated to form myocardial progenitors...
  77. pmc A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development
    Gang Lu
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:784-96. 2007
    ..These data suggest that PP2Cm is a novel mitochondrial protein phosphatase that has a critical function in cell death and survival, and may play a role in regulating the MPTP opening...
  78. pmc Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish
    Engda G Hagos
    Department of Cellular Biology, The University of Georgia, Athens, GA, USA
    BMC Dev Biol 7:22. 2007
    ..This permitted us to directly examine when Nodal signals specify cell types independently of dosage effects...
  79. pmc Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin
    Kota Y Miyasaka
    Department of Developmental Neurobiology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo, Aoba, Sendai 980 8575, Japan
    Proc Natl Acad Sci U S A 104:11274-9. 2007
    ..Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs...
  80. pmc Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo
    Huang Chieh Lee
    Institute of Molecular and Cellular Biology, National Taiwan University, NO, 1, Roosevelt Road, Sec, 4, Taipei 106, Taiwan
    BMC Dev Biol 7:93. 2007
    ..At this study, we attempt to specifically inhibit either GSK3alpha or GSK3beta and uncover the isoform-specific roles that GSK3 plays during cardiogenesis...
  81. ncbi Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Development 134:3371-82. 2007
    ..Our results reveal that Pbx proteins modulate Myod activity to drive fast-muscle gene expression, thus showing that homeodomain proteins can direct bHLH proteins to establish a specific cell-type identity...
  82. pmc Redundancy and evolution of GATA factor requirements in development of the myocardium
    Tessa Peterkin
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Dev Biol 311:623-35. 2007
    ....
  83. doi Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells
    Kelly A Smith
    Hubrecht Institute for Developmental Biology and Stem Cell Research, 3584 CT Utrecht, The Netherlands
    Dev Cell 14:287-97. 2008
    ..Together, these results support a model in which CPCs migrate toward a BMP source during development of the linear heart tube, providing a mechanism by which the left-right axis drives asymmetric development of the vertebrate heart...
  84. pmc Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms
    Zhenyue Chen
    Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Cardiovasc Res 79:97-108. 2008
    ....
  85. pmc Loss of unc45a precipitates arteriovenous shunting in the aortic arches
    Matthew J Anderson
    Tumor Biology Training Program, Georgetown University Medical Center, Washington, DC 20057, USA
    Dev Biol 318:258-67. 2008
    ..Our results are the first to ascribe a role for Unc45a, a putative myosin chaperone, in vertebrate development, and identify a novel mechanism by which an AVM can form...
  86. doi Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity
    Stone Elworthy
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 135:2115-26. 2008
    ..We find that although some of these later-forming fibres also express smyhc1, others express smyhc2 or smyhc3. We show that the smyhc1-positive fibres express the ubo (prdm1) gene and adopt fast twitch fibre characteristics ..
  87. doi Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos
    Long Zhao
    Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People s Republic of China
    Cardiovasc Res 80:200-8. 2008
    ..So far, little is known about Tpm4 function in embryonic heart development and its involvement in the cardiovascular diseases. In this study, we investigated functions of different isoforms of tpm4 in embryonic heartbeat in zebrafish...
  88. pmc Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex
    Martin Lange
    Group Cardiovascular Genetics, Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany
    Genes Dev 22:2370-84. 2008
    ..Furthermore, this shows that plant homeodomain proteins play a yet unexplored role in recruiting chromatin remodeling complexes to acetylated histones...
  89. pmc microRNA-138 modulates cardiac patterning during embryonic development
    Sarah U Morton
    Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:17830-5. 2008
    ....
  90. doi Plakoglobin has both structural and signalling roles in zebrafish development
    Eva D Martin
    Department of Pharmacology and Therapeutics and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland
    Dev Biol 327:83-96. 2009
    ..5 at 24 hours post fertilisation (hpf), and cmlc2 and vmhc at 48 hpf, while there is lack of restriction of the valve markers notch1b and bmp4 at 48 hpf...
  91. doi Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development
    Jae Sun Park
    Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Seoul, Korea
    Dev Dyn 238:1574-81. 2009
    ..chain reaction product containing the 5'-flanking region of the zebrafish ventricular myosin heavy-chain gene (vmhc)...
  92. pmc The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish
    Catherine T Nguyen
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 341:167-75. 2010
    ..Taken together, these results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations...
  93. doi Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing
    Rainer D Will
    Department of Internal Medicine III, University of Heidelberg, Germany
    Circ Res 107:1253-64. 2010
    ..In contrast to other sarcomeric structures, eg, the Z-disc, only few M-band-specific proteins have been identified to date, and its exact molecular composition remains unclear...
  94. pmc Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish
    Joshua D Wythe
    Department of Oncological Sciences and Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Dis Model Mech 4:607-21. 2011
    ....
  95. pmc Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators
    Filipa Costa Simões
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington OX3 9DS, UK
    Development 138:3235-45. 2011
    ..We propose that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart...
  96. pmc Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish
    Chinmoy Patra
    Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany
    Development 138:4499-509. 2011
    ..Taken together, our results identify Npnt as a novel upstream regulator of Bmp4-Has2 signaling that plays a crucial role in AV canal differentiation...
  97. pmc Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function
    Sharina Palencia-Desai
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 138:4721-32. 2011
    ....
  98. ncbi Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility
    Yue xiang Wang
    Department of Molecular Genetics, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, PR China
    FEBS Lett 579:4843-50. 2005
    ..Dysregulation of cardiac genes in MEF2A morphants suggests that sarcomere assembly disturbances account for the cardiac contractile deficiency. Our studies suggested that MEF2A is essential in cardiac contractility...
  99. pmc Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5
    Haibo Jia
    Department of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:14008-13. 2007
    ..Hence, our studies suggest that Grl regulates embryonic heart growth via opposing Gata5, at least in part through their protein interactions in modulating gene expression...
  100. pmc Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 328:472-82. 2009
    ..Together, our studies uncover a new role for BMP signaling in the regulation of chamber size, supporting a model in which differential reception of cardiac inductive signals establishes chamber proportion...

Research Grants3

  1. GENETIC DISSECTION OF HEART MORPHOGENESIS IN ZEBRAFISH
    JOHN MABLY; Fiscal Year: 2002
    ..Third, these genes may have relevance to congenital disorders, such as hypoplastic heart syndromes, and to potential therapeutic replenishment of contractile myocardium of the failing heart. ..
  2. Role of caderhins in the developing zebrafish CV system
    Brian Bagatto; Fiscal Year: 2005
    ..These strengths together will produce a truly original and significant study. ..
  3. Zebrafish Heart Mutants:Physiological & Genetic Analyses
    Neil Chi; Fiscal Year: 2008
    ..These zebrafish mutants ultimately may serve as a novel gateway to gain new insight into the cellular and molecular mechanisms of human cardiac arrhythmias and heart failure. ..