vcana

Summary

Gene Symbol: vcana
Description: versican a
Alias: br146, cspg2, cspg2a, sb:cb63, versican, chondroitin sulfate proteoglycan 2, chondroitin sulfate proteoglycan 2a
Species: zebrafish

Top Publications

  1. ncbi The Wnt/beta-catenin pathway regulates cardiac valve formation
    Adam F L Hurlstone
    Netherlands Institute for Developmental Biology, Hubrecht Laboratory and Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nature 425:633-7. 2003
  2. doi Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos
    Young Seop Kim
    School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Biochem Biophys Res Commun 423:140-6. 2012
  3. pmc Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, 2300 Children s Plaza M C 204, Chicago, IL 60614, USA
    Dev Biol 337:233-45. 2010
  4. pmc Chondroitin sulfate expression is required for cardiac atrioventricular canal formation
    David S Peal
    Harvard Medical School, Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Charlestown, Massachusetts, USA
    Dev Dyn 238:3103-10. 2009
  5. pmc Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos
    Chi Tang Tu
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 4:e4249. 2009
  6. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
  7. pmc Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish
    Xianghu Qu
    Department of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:486-96. 2008
  8. pmc NXT2 is required for embryonic heart development in zebrafish
    Haigen Huang
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA
    BMC Dev Biol 5:7. 2005
  9. ncbi The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome
    Deborah M Garrity
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 129:4635-45. 2002
  10. doi Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development
    Suchit Ahuja
    Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
    Dev Biol 412:71-82. 2016

Scientific Experts

  • Priya Choudhry
  • W Rottbauer
  • Haigen Huang
  • Huang Chieh Lee
  • Troy Camarata
  • Jau Nian Chen
  • Jun Dae Kim
  • Deborah M Garrity
  • Didier Y R Stainier
  • David S Peal
  • Huai Jen Tsai
  • Samuel J Capon
  • Suchit Ahuja
  • Junsu Kang
  • Janina Müller-Deile
  • Eunmyong Lee
  • Toshihiro Banjo
  • Hyung Jin Ham
  • Lindsay E Parrie
  • Ting Shuan Wu
  • Heather J Kolpa
  • Emma Monte
  • Tae Lin Huh
  • Martin D Burkhalter
  • Myoung Jin Kim
  • Soonil Koun
  • Myungchull Rhee
  • Ying Hsin Chen
  • Young Seop Kim
  • Nicole O Glenn
  • Brian L Black
  • Dao Jie Xu
  • Chinmoy Patra
  • Ronald Totong
  • Calum A Macrae
  • Xiaodong Shu
  • Catherine T Nguyen
  • Diana Snyder
  • Hans Georg Simon
  • Chi Tang Tu
  • Neil C Chi
  • Sarah U Morton
  • Xianghu Qu
  • Lu Cheng
  • Adam D Langenbacher
  • Jeong Suk Kang
  • Neil I Bower
  • Cas Simons
  • Benjamin M Hogan
  • Scott Paterson
  • Jason A da Silva
  • Gregory J Baillie
  • Kelly A Smith
  • Joseph A Goldman
  • Heiko Schenk
  • Amy L Dickson
  • Adam F L Hurlstone
  • Gregory Nachtrab
  • Ravi Karra
  • Patricia Schroder
  • Sven Reischauer
  • Finn Gellrich
  • Johan Lorenzen
  • Kenneth D Poss
  • Valerie A Tornini
  • Mario Schiffer
  • Jenny Nyström
  • Matthew Gemberling
  • Deepika Dogra
  • Jianxin Hu
  • Hermann Haller
  • Amy Juraszek
  • Yeon Koo
  • Hey Jin Kim
  • James F Amatruda
  • Beth Levine
  • Ondine Cleaver
  • Kate Luby-Phelps
  • Aylwin Ng
  • Yongjie Wei
  • Ramnik J Xavier
  • Jiann jou Yang
  • Shibnath Ghatak
  • Aimee Vander Wal
  • Sarah Franklin
  • Kazuaki Nagayama
  • Kevin Mouillesseaux
  • Erin M Renfrew
  • Daisuke Yoshino
  • Thomas M Vondriska

Detail Information

Publications39

  1. ncbi The Wnt/beta-catenin pathway regulates cardiac valve formation
    Adam F L Hurlstone
    Netherlands Institute for Developmental Biology, Hubrecht Laboratory and Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nature 425:633-7. 2003
    ..Our findings identify a novel role for Wnt/beta-catenin signalling in determining endocardial cell fate...
  2. doi Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos
    Young Seop Kim
    School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Biochem Biophys Res Commun 423:140-6. 2012
    ..Taken together, our results demonstrated that HDAC activity plays a pivotal role in vertebrate heart tube formation by activating Wnt/β-catenin signaling which induces bmp4 expression in AVC myocardial cells...
  3. pmc Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, 2300 Children s Plaza M C 204, Chicago, IL 60614, USA
    Dev Biol 337:233-45. 2010
    ..These studies demonstrate that controlling the correct balance of Tbx5 activity is crucial for the specification of the AV boundary and valve formation...
  4. pmc Chondroitin sulfate expression is required for cardiac atrioventricular canal formation
    David S Peal
    Harvard Medical School, Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Charlestown, Massachusetts, USA
    Dev Dyn 238:3103-10. 2009
    ....
  5. pmc Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos
    Chi Tang Tu
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 4:e4249. 2009
    ..5 and Nkx-2.3. Nkx2.7 and Nkx2.5 express in zebrafish heart fields of lateral plate mesoderm. The temporal and spatial expression patterns of Nkx2.7 are similar to those of Nkx2.5, but their functions during cardiogenesis remain unclear...
  6. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
    ..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
  7. pmc Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish
    Xianghu Qu
    Department of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:486-96. 2008
    ..We reveal that ndrg4 is required for restricting the expression of versican and bmp4 to the developing atrioventricular canal...
  8. pmc NXT2 is required for embryonic heart development in zebrafish
    Haigen Huang
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA
    BMC Dev Biol 5:7. 2005
    ..NXT2 is a member of NXT family proteins that are generally involved in exporting nuclear RNA in eukaryotic cells. It is not known if NXT2 has any function in specific biological processes...
  9. ncbi The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome
    Deborah M Garrity
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 129:4635-45. 2002
    ..However, the syndromic deficiencies of tbx5 mutation are remarkably well retained between fish and mammals...
  10. doi Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development
    Suchit Ahuja
    Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
    Dev Biol 412:71-82. 2016
    ..We further show that id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt signaling in the developing AVC endocardium. ..
  11. pmc Amiodarone Induces Overexpression of Similar to Versican b to Repress the EGFR/Gsk3b/Snail Signaling Axis during Cardiac Valve Formation of Zebrafish Embryos
    Hung Chieh Lee
    Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan
    PLoS ONE 10:e0144751. 2015
    ..Here, we proved that Amiodarone acts as an upstream regulator, stimulating similar to versican b (s-vcanb) overexpression at zebrafish embryonic heart and promoting cdh-5 overexpression by inhibiting snail1b ..
  12. pmc Cancer metastasis and EGFR signaling is suppressed by amiodarone-induced versican V2
    Hung Chieh Lee
    Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan
    Oncotarget 6:42976-87. 2015
    Extracellular matrix components play an active role in cancer progression and prognosis. Versican, a large extracellular matrix proteoglycan, can promote cancer metastasis through facilitating cell proliferation, adhesion, migration and ..
  13. pmc Modulation of tissue repair by regeneration enhancer elements
    Junsu Kang
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 532:201-6. 2016
    ..Our findings provide evidence for 'tissue regeneration enhancer elements' (TREEs) that trigger gene expression in injury sites and can be engineered to modulate the regenerative potential of vertebrate organs. ..
  14. pmc Zebrafish Crip2 plays a critical role in atrioventricular valve development by downregulating the expression of ECM genes in the endocardial cushion
    Jun Dae Kim
    Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Mol Cells 37:406-11. 2014
    ..While the appropriately regulated expression of the major ECM components, Versican and Hyaluronan, that form the endocardial cushion is important for heart valve development, the underlying ..
  15. pmc Utilising polymorphisms to achieve allele-specific genome editing in zebrafish
    Samuel J Capon
    Division of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Biol Open 6:125-131. 2017
    ..These experiments demonstrate that single nucleotide polymorphisms (SNPs) present throughout the genome can be utilised to increase the efficiency of in cis genome editing using CRISPR/Cas9 in the zebrafish model...
  16. pmc Autophagy is essential for cardiac morphogenesis during vertebrate development
    Eunmyong Lee
    Department of Internal Medicine University of Texas Southwestern Medical Center Dallas, TX USA
    Autophagy 10:572-87. 2014
    ..Thus, autophagy plays an essential, conserved role in cardiac morphogenesis during vertebrate development. ..
  17. pmc Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes
    Emma Monte
    Department of Anesthesiology, University of California, Los Angeles, Los Angeles, California
    Am J Physiol Heart Circ Physiol 305:H1624-38. 2013
    ..Validation studies in the complementary model system of zebrafish examine the role of Nucleolin to orchestrate genomic reprogramming events shared between development and disease...
  18. doi Cardiotoxicity of mycotoxin citrinin and involvement of microRNA-138 in zebrafish embryos
    Ting Shuan Wu
    Institute of Medicine
    Toxicol Sci 136:402-12. 2013
    ..5. Furthermore, the heart areas of CTN-exposed embryos demonstrated an elevated levels of aldh1a2 and cspg2 messenger RNA; these 2 cardiac-related genes are known to be involved in retinoic acid (RA) pathway as well as ..
  19. pmc Grk5l controls heart development by limiting mTOR signaling during symmetry breaking
    Martin D Burkhalter
    Leibniz Institute for Age Research, Fritz Lippmann Institute, 07745 Jena, Germany
    Cell Rep 4:625-32. 2013
    ..By fine-tuning mTORC1, GRK5 thus serves an unanticipated function during early development, besides its well-characterized role in the adult heart. These findings could implicate GRK5 as a susceptibility allele for certain cases of CHD. ..
  20. ncbi Overexpression of TGF-β Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans
    Janina Müller-Deile
    Department of Medicine Nephrology, Hannover Medical School, Hannover, Germany
    Cell Physiol Biochem 40:819-830. 2016
    ..Since miR-143-3p (miR-143) is described as a TGF-β inducible miR in other cell types, we examined this specific miR and its ability to induce glomerular pathology...
  21. doi The toxic effect of Amiodarone on valve formation in the developing heart of zebrafish embryos
    Ying Hsin Chen
    Institute of Medical Sciences, Buddhist Tzu Chi University, Taiwan
    Reprod Toxicol 33:233-44. 2012
    ..Although some studies have suggested that this drug is safe for fetuses, they have been conducted on mothers with fetuses at or beyond six months of gestational age...
  22. pmc The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish
    Nicole O Glenn
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Mol Cell Biol 32:3527-40. 2012
    ..Our study underscores the importance of the W-loop for actin functionality and will help us to understand the structural and physiological consequences of ACTC mutations in human congenital disorders...
  23. doi Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish
    Heng Huang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Arterioscler Thromb Vasc Biol 32:2158-70. 2012
    ..The aim of this study was to investigate the physiological functions of PAQR10 and PAQR11...
  24. doi Zebrafish tbx5 paralogs demonstrate independent essential requirements in cardiac and pectoral fin development
    Lindsay E Parrie
    Colorado State University CSU, Department of Biology, Fort Collins, Colorado 80523, USA
    Dev Dyn 242:485-502. 2013
    ..Homozygous mutation of zebrafish tbx5a leads to lethal defects in cardiac looping morphogenesis, blocks pectoral fin initiation, and impairs outgrowth. Recently, a second zebrafish tbx5 gene was described, termed tbx5b...
  25. pmc DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation
    Priya Choudhry
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e58145. 2013
    ..This is the first study linking tbx1 and non-canonical Wnt signaling and extends our understanding of DGS and heart development...
  26. pmc miR-21 represses Pdcd4 during cardiac valvulogenesis
    Heather J Kolpa
    Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Development 140:2172-80. 2013
    ..PDCD4 knockdown alone was sufficient to enhance endothelial cell migration. These results demonstrate that miR-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4...
  27. pmc Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21
    Toshihiro Banjo
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba, Sendai, Miyagi 980 8577, Japan
    Nat Commun 4:1978. 2013
    ..We conclude that miR-21 is a central component of a flow-controlled mechanotransduction system in a physicogenetic regulatory loop...
  28. doi Celecoxib impairs heart development via inhibiting cyclooxygenase-2 activity in zebrafish embryos
    Dao Jie Xu
    Department of Anesthesiology, Xinhua Hospital, Medical School, Shanghai Jiaotong University, Shanghai, China
    Anesthesiology 114:391-400. 2011
    ..Although use of celecoxib is associated with increased cardiovascular risk in adults, its effect on fetal heart development remains unknown...
  29. pmc Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish
    Adam D Langenbacher
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:17699-704. 2005
    ..These data signify the essential role of calcium homeostasis and NCX1h in establishing rhythmic contraction in the embryonic zebrafish heart...
  30. ncbi Na,K-ATPase is essential for embryonic heart development in the zebrafish
    Xiaodong Shu
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Development 130:6165-73. 2003
    ..Furthermore, instead of interfering with primitive heart tube formation or cardiac chamber differentiation, blocking the translation of Na,K-ATPase alpha2 isoform leads to cardiac laterality defects...
  31. ncbi Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones
    Jeong Suk Kang
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Mech Dev 121:301-12. 2004
    ..comparison covering the C-terminal globular domain demonstrated that dermacan shows high homology with zebrafish versican but is distinct from any other identified lecticans...
  32. ncbi Delta-sarcoglycan is necessary for early heart and muscle development in zebrafish
    Lu Cheng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Biochem Biophys Res Commun 344:1290-9. 2006
    ..These data together suggest that delta-sarcoglycan plays an important role in early heart and muscle development...
  33. ncbi Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart
    Wolfgang Rottbauer
    Department of Medicine III, University of Heidelberg, Germany
    Circ Res 99:323-31. 2006
    ..Thus, our findings provide the first in vivo evidence that cardiac MLC-2 is required for thick-filament stabilization and contractility in the vertebrate heart...
  34. pmc Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo
    Huang Chieh Lee
    Institute of Molecular and Cellular Biology, National Taiwan University, NO, 1, Roosevelt Road, Sec, 4, Taipei 106, Taiwan
    BMC Dev Biol 7:93. 2007
    ..At this study, we attempt to specifically inhibit either GSK3alpha or GSK3beta and uncover the isoform-specific roles that GSK3 plays during cardiogenesis...
  35. pmc microRNA-138 modulates cardiac patterning during embryonic development
    Sarah U Morton
    Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:17830-5. 2008
    ..This activity was complemented by miR-138-mediated ventricular repression of the gene encoding versican (cspg2), which was positively regulated by retinoic-acid signaling...
  36. pmc The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish
    Catherine T Nguyen
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 341:167-75. 2010
    ..Taken together, these results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations...
  37. pmc Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, Chicago, IL 60614, USA
    BMC Dev Biol 10:104. 2010
    ..This Tbx5 regulation is critical in heart formation, but the coexpression of both proteins in other developing tissues suggests a broader functional role...
  38. pmc The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis
    Ronald Totong
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 138:4199-205. 2011
    ..Together, our data reveal that Tmem2 is an essential mediator of myocardium-endocardium coordination during cardiac morphogenesis...
  39. pmc Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish
    Chinmoy Patra
    Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany
    Development 138:4499-509. 2011
    ..In addition, the expression of myocardial genes involved in cardiac valve formation (cspg2, fibulin 1, tbx2b, bmp4) is expanded and endocardial cells along the extended tube-like structure exhibit ..