tlx2

Summary

Gene Symbol: tlx2
Description: T-cell leukemia, homeobox 2
Alias: Tlx-3a, hox11l, tlx3a, tlxA, T-cell leukemia homeobox protein 2, T-cell leukemia, homeobox 3a
Species: zebrafish

Top Publications

  1. ncbi Expression of Otx homeodomain proteins induces cell aggregation in developing zebrafish embryos
    G Bellipanni
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
    Dev Biol 223:339-53. 2000
  2. ncbi Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio)
    D M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mech Dev 117:243-8. 2002
  3. ncbi The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line
    David J Kozlowski
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 277:27-41. 2005
  4. pmc dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula
    Takao Kaji
    Department of Craniofacial Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Dev Biol 276:523-40. 2004
  5. doi Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish
    Jialiang Wang
    The Education Ministry Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio membrane and Membrane Bio engineering, School of Life Sciences, Peking University, Beijing 100871, China
    J Neurosci 35:234-44. 2015
  6. pmc Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest
    Eric Van Otterloo
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, IA 52242, USA
    Development 139:720-30. 2012
  7. ncbi Delta-Notch signaling regulates oligodendrocyte specification
    Hae Chul Park
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Development 130:3747-55. 2003
  8. ncbi Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm
    Young Ki Bae
    Laboratory for Vertebrate Axis Formation, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Development 132:1375-85. 2005
  9. pmc Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
    David M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:6068-73. 2005
  10. ncbi NOTCH1-induced T-cell leukemia in transgenic zebrafish
    J Chen
    Department of Medical Oncology, Dana Farber Cancer Institute of Harvard Medical School, Boston, MA 02115, USA
    Leukemia 21:462-71. 2007

Detail Information

Publications11

  1. ncbi Expression of Otx homeodomain proteins induces cell aggregation in developing zebrafish embryos
    G Bellipanni
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
    Dev Biol 223:339-53. 2000
    ..These results suggest that promotion of cell adhesion or mediation of cell repulsion may be one of the normal functions of the Otx proteins in the establishment of the anterior brain...
  2. ncbi Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio)
    D M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mech Dev 117:243-8. 2002
    ..However, only Tlx-3a is expressed in the statoacoustic cranial ganglia, enteric neurons and non-neural tissues such as the fin bud and pharyngeal arches and Tlx-3b is only expressed in the dorsal root ganglia...
  3. ncbi The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line
    David J Kozlowski
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 277:27-41. 2005
    ..Determination of eya gene function during zebrafish organogenesis will facilitate understanding the molecular etiology of human vestibular and hearing disorders...
  4. pmc dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula
    Takao Kaji
    Department of Craniofacial Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Dev Biol 276:523-40. 2004
    ..These data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via BMP activity...
  5. doi Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish
    Jialiang Wang
    The Education Ministry Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio membrane and Membrane Bio engineering, School of Life Sciences, Peking University, Beijing 100871, China
    J Neurosci 35:234-44. 2015
    ..Sox9a and Atoh1a coregulate numerous downstream factors identified through our ChIP-seq analyses, including Tlx2 and Eya2...
  6. pmc Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest
    Eric Van Otterloo
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, IA 52242, USA
    Development 139:720-30. 2012
    ..Together, these results show that mutations resulting in novel Tfap2-mediated regulation of sox10 and other targets contributed to the evolution of the neural crest...
  7. ncbi Delta-Notch signaling regulates oligodendrocyte specification
    Hae Chul Park
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Development 130:3747-55. 2003
    ..Our data provide evidence that Notch signaling maintains subsets of ventral spinal cord precursors during neuronal birth and, acting with other temporally and spatially restricted factors, specifies them for oligodendrocyte fate...
  8. ncbi Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm
    Young Ki Bae
    Laboratory for Vertebrate Axis Formation, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Development 132:1375-85. 2005
    ..These data indicate that her3 and her9 function as prepattern genes that link the positional dorsoventral polarity information in the posterior neuroectoderm to the spatial regulation of neurogenesis...
  9. pmc Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
    David M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:6068-73. 2005
    ....
  10. ncbi NOTCH1-induced T-cell leukemia in transgenic zebrafish
    J Chen
    Department of Medical Oncology, Dana Farber Cancer Institute of Harvard Medical School, Boston, MA 02115, USA
    Leukemia 21:462-71. 2007
    ..The ability of this model to detect a strong interaction between NOTCH1 and bcl2 suggests that genetic modifier screens have a high likelihood of revealing other genes that can cooperate with NOTCH1 to induce T-ALL...
  11. pmc Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos
    Wei Li
    Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 304:338-54. 2007
    ....