tlx1

Summary

Gene Symbol: tlx1
Description: T-cell leukemia, homeobox 1
Alias: SI:dZ46P4.1, Tlx-1, hox11, ztlx-1, T-cell leukemia homeobox protein 1
Species: zebrafish

Top Publications

  1. ncbi Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio)
    D M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mech Dev 117:243-8. 2002
  2. pmc Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
    David M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:6068-73. 2005
  3. ncbi NOTCH1-induced T-cell leukemia in transgenic zebrafish
    J Chen
    Department of Medical Oncology, Dana Farber Cancer Institute of Harvard Medical School, Boston, MA 02115, USA
    Leukemia 21:462-71. 2007
  4. pmc Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1
    Lynnsey A Zweier-Renn
    Department of Anatomy and Regenerative Biology, The George Washington University, Washington, DC 20037, USA
    Genes Chromosomes Cancer 49:119-31. 2010

Detail Information

Publications4

  1. ncbi Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio)
    D M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mech Dev 117:243-8. 2002
    Tlx (Hox11) genes are orphan homeobox genes that play critical roles in the regulation of early developmental processes in vertebrates...
  2. pmc Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
    David M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:6068-73. 2005
    ....
  3. ncbi NOTCH1-induced T-cell leukemia in transgenic zebrafish
    J Chen
    Department of Medical Oncology, Dana Farber Cancer Institute of Harvard Medical School, Boston, MA 02115, USA
    Leukemia 21:462-71. 2007
    ..The ability of this model to detect a strong interaction between NOTCH1 and bcl2 suggests that genetic modifier screens have a high likelihood of revealing other genes that can cooperate with NOTCH1 to induce T-ALL...
  4. pmc Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1
    Lynnsey A Zweier-Renn
    Department of Anatomy and Regenerative Biology, The George Washington University, Washington, DC 20037, USA
    Genes Chromosomes Cancer 49:119-31. 2010
    Translocations resulting in ectopic expression of the TLX1 homeobox gene (previously known as HOX11) are recurrent events in human T-cell acute lymphoblastic leukemia (T-ALL)...