Genomes and Genes
Gene Symbol: tlx1
Description: T-cell leukemia, homeobox 1
Alias: SI:dZ46P4.1, Tlx-1, hox11, ztlx-1, T-cell leukemia homeobox protein 1
- Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio)D M Langenau
Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Mech Dev 117:243-8. 2002Tlx (Hox11) genes are orphan homeobox genes that play critical roles in the regulation of early developmental processes in vertebrates...
- Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemiaDavid M Langenau
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:6068-73. 2005....
- NOTCH1-induced T-cell leukemia in transgenic zebrafishJ Chen
Department of Medical Oncology, Dana Farber Cancer Institute of Harvard Medical School, Boston, MA 02115, USA
Leukemia 21:462-71. 2007..The ability of this model to detect a strong interaction between NOTCH1 and bcl2 suggests that genetic modifier screens have a high likelihood of revealing other genes that can cooperate with NOTCH1 to induce T-ALL...
- Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1Lynnsey A Zweier-Renn
Department of Anatomy and Regenerative Biology, The George Washington University, Washington, DC 20037, USA
Genes Chromosomes Cancer 49:119-31. 2010Translocations resulting in ectopic expression of the TLX1 homeobox gene (previously known as HOX11) are recurrent events in human T-cell acute lymphoblastic leukemia (T-ALL)...