six3b

Summary

Gene Symbol: six3b
Description: SIX homeobox 3b
Alias: SIX3, cb347, six3.2, six6, SIX homeobox 3b, sine oculis homeobox homolog 3b, sine oculis homeobox homolog 6
Species: zebrafish

Top Publications

  1. ncbi A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
    Koichi Kawakami
    Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 7:133-44. 2004
  2. ncbi The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis
    Dean Yimlamai
    Cellular and Molecular Physiology, Tufts University School of Medicine, 136 Harrison Avenue, M and V 709, Boston, MA 02111, USA
    Dev Biol 279:44-57. 2005
  3. pmc Six3 represses nodal activity to establish early brain asymmetry in zebrafish
    Adi Inbal
    Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Neuron 55:407-15. 2007
  4. pmc Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling
    Terence J Van Raay
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA
    Dev Biol 309:151-68. 2007
  5. ncbi The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways
    K Fekany-Lee
    Department of Molecular Biology, Vanderbilt University, Box 1820, Station B, Nashville, TN 37235, USA
    Development 127:2333-45. 2000
  6. ncbi Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation
    Chris Jopling
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Mech Dev 124:129-36. 2007
  7. pmc Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects
    Chris Jopling
    Hubrecht Institute, Utrecht, The Netherlands
    PLoS Genet 3:e225. 2007
  8. ncbi Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish
    M Kobayashi
    Department of Biology, Jichi Medical School, Minamikawachi, Tochigi 329 0498, Japan
    Development 125:2973-82. 1998
  9. ncbi Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish
    Seok Hyung Kim
    Department of Genetic Engineering, Kyungpook National University, Daegu 702 701, Korea
    Development 129:4443-55. 2002
  10. ncbi The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish
    Y Imai
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 128:2407-20. 2001

Research Grants

  1. Genetic methods using the Tol2 transposable element
    Koichi Kawakami; Fiscal Year: 2006

Scientific Experts

  • Ting Zhang
  • Jennifer L Thomas
  • Kelly E O'Quin
  • Koichi Kawakami
  • Muriel Rhinn
  • Breandan N Kennedy
  • Brian Perkins
  • Adi Inbal
  • Jeroen Paardekooper Overman
  • Lilianna Solnica-Krezel
  • Seok Hyung Kim
  • Jeroen den Hertog
  • Evyn J Loucks
  • Chris Jopling
  • Jing Xia Liu
  • Zhao Qin
  • Anat Samuel
  • Mailin Sotolongo-Lopez
  • Susov Dhakal
  • Romain Fontaine
  • Monica Bonetti
  • Christian Preisinger
  • Alicia M Ebert
  • Xiaofeng Xu
  • Adriana I Iglesias
  • Piero Giansanti
  • Jenny R Lenkowski
  • Yukiko Nakayama
  • Gilbert Lauter
  • Megumi Hashiguchi
  • Evyn Loucks
  • Wuhan Xiao
  • Dan Carlin
  • Qiuhong Chen
  • Pamela A Raymond
  • Xun Wei Xie
  • Nadine L Vastenhouw
  • Clotilde S Suh
  • Rosa A Uribe
  • Kyo Yamasu
  • Diane Sepich
  • Nicholas A Sanek
  • Rebecca C Coyle
  • Patricia A Gongal
  • Naoki Nakaya
  • Sara C Ahlgren
  • Terence J Van Raay
  • Sophia von der Hardt
  • Jill A Kreiling
  • Jae Yeon Jeong
  • Catherine W McCollum
  • Marlene J Rau
  • Akihiko Muto
  • Zhihui Sun
  • Abhilasha Gulati-Leekha
  • Fumitaka Inoue
  • Gang Peng
  • Yong I Cha
  • Gaia Gestri
  • Hideki Ando
  • Dean Yimlamai
  • Hyunju Ro
  • Jimann Shin
  • Ilona G Bebenek
  • Tae Lin Huh
  • Myungchull Rhee
  • Cheol Hee Kim
  • James M Fadool
  • Carole J Saade
  • Karen Alvarez-Delfin
  • Ariel M Rubinstein
  • Daniel L Vera
  • Tehila T Azar
  • Zohar Ben-Moshe Livne
  • Catherine Pasqualini
  • Ingrid Colin
  • Seth Adamson
  • Philippe Vernier
  • Craig B Stevens
  • Ruth A Frey
  • Charlotte Bureau
  • Sylvie Dufour
  • Pierre Affaticati
  • Eric A Shelden
  • Deborah L Stenkamp
  • Kei Yamamoto
  • Michael Demarque
  • Meyrav Sebbagh
  • Omri Weiss
  • Andre G Uitterlinden

Detail Information

Publications60

  1. ncbi A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
    Koichi Kawakami
    Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 7:133-44. 2004
    ..We propose our gene trap approach should facilitate studies of vertebrate development and organogenesis...
  2. ncbi The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis
    Dean Yimlamai
    Cellular and Molecular Physiology, Tufts University School of Medicine, 136 Harrison Avenue, M and V 709, Boston, MA 02111, USA
    Dev Biol 279:44-57. 2005
    ..Its loss results in early morphogenetic defects. dscam knockdown results in impaired cell movement during epiboly as well as in subsequent stages. We propose that migrating cells utilize dscam to remodel the developing embryo...
  3. pmc Six3 represses nodal activity to establish early brain asymmetry in zebrafish
    Adi Inbal
    Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Neuron 55:407-15. 2007
    ..Here, we show that Six3, a transcription factor essential for forebrain formation and associated with holoprosencephaly in humans, ..
  4. pmc Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling
    Terence J Van Raay
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA
    Dev Biol 309:151-68. 2007
    ..Finally, reducing Nkd1 function in slb mutants suppressed the axial mesendoderm C&E defect. These data indicate that zebrafish Nkd1 and Nkd2 function to limit both canonical and non-canonical Wnt signaling...
  5. ncbi The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways
    K Fekany-Lee
    Department of Molecular Biology, Vanderbilt University, Box 1820, Station B, Nashville, TN 37235, USA
    Development 127:2333-45. 2000
    ..In addition, by negative regulation of Wnt signaling, boz promotes organizer formation and limits posteriorization of neuroectoderm in the late gastrula...
  6. ncbi Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation
    Chris Jopling
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Mech Dev 124:129-36. 2007
    ..The Csk knock down phenotype was rescued by simultaneous partial knock down of Fyn and Yes. We conclude that Csk acts upstream of Fyn and Yes to control vertebrate gastrulation cell movements...
  7. pmc Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects
    Chris Jopling
    Hubrecht Institute, Utrecht, The Netherlands
    PLoS Genet 3:e225. 2007
    ..The finding that defective Shp2 signaling induced cell movement defects as early as gastrulation may have implications for the monitoring and diagnosis of Noonan and LEOPARD syndrome...
  8. ncbi Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish
    M Kobayashi
    Department of Biology, Jichi Medical School, Minamikawachi, Tochigi 329 0498, Japan
    Development 125:2973-82. 1998
    ..Its murine homolog, Six3, is expressed in the anterior neural plate and eye anlage, and may have crucial functions in eye and brain ..
  9. ncbi Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish
    Seok Hyung Kim
    Department of Genetic Engineering, Kyungpook National University, Daegu 702 701, Korea
    Development 129:4443-55. 2002
    ..In conclusion, we suggest that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula...
  10. ncbi The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish
    Y Imai
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 128:2407-20. 2001
    ..Our results support a model in which BMP signaling induces the expression of ventral genes, while vox and vent act redundantly to prevent the expression of chordin, goosecoid and other dorsal genes in the lateral and ventral mesendoderm...
  11. doi Maternal Vsx1 plays an essential role in regulating prechordal mesendoderm and forebrain formation in zebrafish
    Xiaofeng Xu
    College of Life Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China
    Dev Biol 394:264-76. 2014
    ..Our results reveal a pivotal role for maternal Vsx1 as a direct transcriptional repressor of ntl expression at the margin of the zebrafish gastrula to ensure directional cell polarization and migration of PME cells. ..
  12. pmc Zebrafish olfactomedin 1 regulates retinal axon elongation in vivo and is a modulator of Wnt signaling pathway
    Naoki Nakaya
    Section of Molecular Mechanisms of Glaucoma, Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:7900-10. 2008
    ..of full-length Olfm1 increased the lateral separation of the expression domains of eye-field markers, rx3 and six3. The Olfm1-MO had the opposite effect...
  13. pmc Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling
    Jenny R Lenkowski
    Molecular, Cellular, and Developmental Biology, University of Michigan, 830 N University, Ann Arbor, Michigan, USA
    Glia 61:1687-97. 2013
    ..Here, we demonstrate that regulation of TGFβ signaling by the corepressors Tgif1 and Six3b is critical for the proliferative response to photoreceptor destruction in the adult zebrafish retina...
  14. doi Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner
    Yukiko Nakayama
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama City, Saitama 338 8570, Japan
    Mech Dev 130:532-52. 2013
    ....
  15. doi Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age
    Adriana I Iglesias
    Department of Epidemiology
    Hum Mol Genet 23:1320-32. 2014
    ..Previously, genome-wide significant evidence for the association of rs10483727 in SIX1-SIX6 locus with VCDR and subsequent POAG was found...
  16. pmc PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice
    Jeroen Paardekooper Overman
    Hubrecht Institute KNAW and University Medical Center Utrecht, Utrecht, Netherlands
    Mol Cell Biol 34:2874-89. 2014
    ..Hence, we identify PZR as an NS and LS target. Enhanced PZR-mediated membrane recruitment of Shp2 serves as a common mechanism to direct overlapping pathophysiological characteristics of these PTPN11 mutations...
  17. doi Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion
    Alicia M Ebert
    Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Calgary, Alberta T2N 4N1, Canada
    Development 141:2473-82. 2014
    ..We propose a novel, tissue-autonomous mechanism of organ cohesion, with neutralization of repulsion suggested as a means to promote interactions between cells within a tissue domain...
  18. doi Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling
    Rebecca C Coyle
    Department of Medicine Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Exp Cell Res 314:2150-62. 2008
    ..Together, our results support the notion that pathways regulating pericellular proteolysis and cell polarity converge to promote efficient cell migration...
  19. pmc Phosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndrome
    Jeroen Paardekooper Overman
    Hubrecht Institute Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e106682. 2014
    ..Moreover, Fer knockdown cooperated with NS and LS, but not wild type Shp2 to induce developmental defects, suggesting a role for Fer in the pathogenesis of both NS and LS. ..
  20. doi Dopaminergic Neurons Controlling Anterior Pituitary Functions: Anatomy and Ontogenesis in Zebrafish
    Romain Fontaine
    Université Paris Saclay, Université Paris Sud R F, P A, C B, I C, M D, P V, K Y, C P, Centre National de la Recherche Scientifique, Paris Saclay Institute of Neuroscience, 91190, Gif sur Yvette, France and Museum National d Histoire Naturelle S D, Sorbonne Universités, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, Institut de Recherche pour le Developpement, Universite de Caen Basse Normandie, 75231 Paris Cedex 05, France
    Endocrinology 156:2934-48. 2015
    ..This study offers some insights into the regional identity of the preoptic area and provides the first bases for future functional genetic studies on the development of DA neurons controlling anterior pituitary functions. ..
  21. doi Mechanisms of cadmium-caused eye hypoplasia and hypopigmentation in zebrafish embryos
    Ting Zhang
    College of Fisheries, Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China Electronic address
    Aquat Toxicol 167:68-76. 2015
    ..Moreover, we found that compounds BIO or RA could neutralize the toxic effects of Cd...
  22. pmc Abnormal retinal development in Cloche mutant zebrafish
    Susov Dhakal
    Department of Biological Sciences, University of Idaho, Moscow, Idaho
    Dev Dyn 244:1439-55. 2015
    ..These studies are possible in zebrafish embryos, which do not yet rely upon the vasculature for tissue oxygenation...
  23. doi Reactive gliosis in the adult zebrafish retina
    Jennifer L Thomas
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, 48201, USA Electronic address
    Exp Eye Res 143:98-109. 2016
    ..Interestingly, when cell cycle inhibition is released, a partial recovery of regeneration is observed. Together, these data demonstrate that zebrafish Müller glia possess both gliotic and regenerative potential. ..
  24. pmc Six3 regulates optic nerve development via multiple mechanisms
    Anat Samuel
    Department of Medical Neurobiology, Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Sci Rep 6:20267. 2016
    ..Here we show that in zebrafish, reduced function of transcription factor Six3 results in optic nerve hypoplasia and a wide repertoire of RGC axon pathfinding errors...
  25. pmc Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish
    Mailin Sotolongo-Lopez
    Department of Biological Science, The Florida State University, Tallahassee, Florida, United States of America
    PLoS Genet 12:e1005968. 2016
    ..using TALENs and knockdown strategies confirm ljrp23ahub as a hypomorphic allele of six7, a teleost orthologue of six3, with known roles in forebrain patterning and expression of opsins...
  26. pmc Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression
    Gaia Gestri
    Sezione di Biologia Cellulare e dello Sviluppo, Dipartimento di Fisiologia, e Biochimica, Universita degli Studi di Pisa, Via Carducci 13, 56010 Ghezzano Pisa, Italy
    Development 132:2401-13. 2005
    Although it is well established that Six3 is a crucial regulator of vertebrate eye and forebrain development, it is unknown whether this homeodomain protein has a role in the initial specification of the anterior neural plate...
  27. pmc Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation
    Yong I Cha
    Department of Medicine and Cancer Biology, Cell and Developmental Biology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232 2279, USA
    Genes Dev 20:77-86. 2006
    ..This work demonstrates a critical requirement of PGE(2) signaling in promoting cell motility through the COX-1-Ptges-EP4 pathway, a previously unrecognized role for this biologically active lipid in early animal development...
  28. ncbi A reporter-assisted mutagenesis screen using alpha 1-tubulin-GFP transgenic zebrafish uncovers missteps during neuronal development and axonogenesis
    Abhilasha Gulati-Leekha
    Molecular and Behavioral Neuroscience Institute, Department of Biological Chemistry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 070, USA
    Dev Biol 296:29-47. 2006
    ..Molecular identification of these loci and analysis of the remaining mutational repertoire will offer unique insights into the genetic inputs that go on to make a mature, differentiated neuron...
  29. doi Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon
    Gilbert Lauter
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    J Comp Neurol 521:1093-118. 2013
    ..Our comparative gene expression analysis conformed with the idea of a common bauplan for the diencephalon of anamniote and amniote vertebrates from fish to mammals...
  30. pmc Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling
    Dan Carlin
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Development 139:2614-24. 2012
    ..Six3 in telencephalon development, we analyzed zebrafish embryos deficient in two out of three Six3-related genes, six3b and six7, representing a partial loss of Six3 function...
  31. pmc Assessing teratogenic changes in a zebrafish model of fetal alcohol exposure
    Evyn Loucks
    Program in Developmental Biology, Children s Memorial Research Center, Northwestern University, USA
    J Vis Exp . 2012
    ..Described here are the basic techniques used to study and manipulate the zebrafish FAS model...
  32. doi Loss of Porcupine impairs convergent extension during gastrulation in zebrafish
    Qiuhong Chen
    Okazaki Institute for Integrative Bioscience and National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    J Cell Sci 125:2224-34. 2012
    ..Thus, a decrease of Porcn activity does not equivalently affect trafficking and lipidation of different Wnt proteins in zebrafish embryos and in cultured mammalian cells...
  33. doi Eaf1 and Eaf2 negatively regulate canonical Wnt/β-catenin signaling
    Jing Xia Liu
    Key Laboratory of Biodiversity and Conservation of Aquatic Organisms, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, PR China
    Development 140:1067-78. 2013
    ..In summary, our evidence points to a novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/β-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity...
  34. pmc Quantitative genetic analysis of retinal degeneration in the blind cavefish Astyanax mexicanus
    Kelly E O'Quin
    Department of Biology, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e57281. 2013
    ..The regions we identify serve as a starting point for future studies on the genetics of retinal degeneration and eye disease using the evolutionary mutant model Astyanax...
  35. pmc Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock
    Megumi Hashiguchi
    Department of Cell and Developmental Biology, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104 6058, USA
    Development 140:1970-80. 2013
    ..Thus, DV and AP patterning are intimately coordinated to allow cells to acquire both positional and temporal information simultaneously...
  36. ncbi Lhx2 mediates the activity of Six3 in zebrafish forebrain growth
    Hideki Ando
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Dev Biol 287:456-68. 2005
    ..Lhx2, a LIM-homeodomain protein, and Six3s (Six3b and Six3a), another homeodomain proteins, show very similar expression patterns early in forebrain development, ..
  37. ncbi Sinup, a novel Siaz-interacting nuclear protein, modulates neural plate formation in the zebrafish embryos
    Hyunju Ro
    School of Bioscience and Biotechnology, College of Natural Sciences, Chungnam National University, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 332:993-1003. 2005
    ..Our report suggests that sinup expression should be tightly regulated during early embryonic development for the proper neural plate formation...
  38. ncbi Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as in differentiation during zebrafish retinal development
    Akihiko Muto
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Dev Biol 292:90-102. 2006
    ....
  39. ncbi Activation and roles of ALK4/ALK7-mediated maternal TGFbeta signals in zebrafish embryo
    Zhihui Sun
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Biochem Biophys Res Commun 345:694-703. 2006
    ....
  40. ncbi Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development
    Marlene J Rau
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 296:83-93. 2006
    ..Mediator is a coactivator complex transducing the interaction of DNA-binding transcription factors with RNA polymerase II, and our results reveal a critical function of the Trap230 subunit as a coactivator for Sox9...
  41. ncbi dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina
    Brian D Perkins
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Dev Dyn 233:680-94. 2005
    ..Taken together, our studies suggest a role for the dazed gene in rod and Muller cell development and overall retinal cell survival and maintenance...
  42. ncbi sine oculis in basal Metazoa
    Ilona G Bebenek
    Department of Organismic Biology Ecology and Evolution, University of California Los Angeles, 621 Charles E Young Drive South, Los Angeles, CA 90095 1606, USA
    Dev Genes Evol 214:342-51. 2004
    ....
  43. ncbi Zebrafish rx3 and mab21l2 are required during eye morphogenesis
    Breandan N Kennedy
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Dev Biol 270:336-49. 2004
    ..We propose that mab21l2 is an early downstream effector of rx3 and is critical for survival of eye progenitors...
  44. ncbi The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
    ....
  45. ncbi Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation
    H Hashimoto
    Division of Molecular Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Dev Biol 217:138-52. 2000
    ..These data indicate that Dkk1, expressed in dorsal mesendoderm, functions in the formation of both the anterior nervous system and the axial mesendoderm in zebrafish...
  46. pmc Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis
    Xun Wei Xie
    Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People s Republic of China
    PLoS ONE 6:e24469. 2011
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis...
  47. pmc Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics
    Rosa A Uribe
    Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, TX 78722, USA
    Development 137:3763-74. 2010
    ....
  48. pmc Chromatin signature of embryonic pluripotency is established during genome activation
    Nadine L Vastenhouw
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 464:922-6. 2010
    ..These results indicate that bivalent and monovalent domains might poise embryonic genes for activation and that the chromatin profile associated with pluripotency is established during the maternal-zygotic transition...
  49. doi Autoregulatory binding sites in the zebrafish six3a promoter region define a new recognition sequence for Six3 proteins
    Clotilde S Suh
    Department of Molecular Biology, University of Bergen, Norway
    FEBS J 277:1761-75. 2010
    The homeodomain (HD) transcription factor Six3, which is a member of the Six/Sine oculis family, is essential for development of the eyes and forebrain in vertebrates...
  50. pmc Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression
    Nicholas A Sanek
    Department of Zoology and Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 136:3791-800. 2009
    ..We demonstrate that in zebrafish, as in mouse, Hh signaling activates transcription of six3b in the developing forebrain. zic2a is also activated by Hh signaling, and represses six3b non-cell-autonomously, i...
  51. pmc Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
    Zhao Qin
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, 830 North University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 106:9310-5. 2009
    ..Comparison of gene expression profiles from regenerating zebrafish retina, caudal fin, and heart muscle revealed additional candidate genes potentially implicated in injury-induced epimorphic regeneration in diverse zebrafish tissues...
  52. pmc Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal
    Muriel Rhinn
    Biotechnology Center, and Center for Regenerative Therapies Dresden, CRTD, Dresden University of Technology, Dresden, Germany
    Neural Dev 4:12. 2009
    ..Zebrafish gbx2, on the other hand, acts relatively late at the MHB. To investigate the function of zebrafish gbx1 within the early neural plate, we used a combination of gain- and loss-of-function experiments...
  53. doi Deciphering the role of Shh signaling in axial defects produced by ethanol exposure
    Evyn J Loucks
    Children s Memorial Research Center Program in Developmental Biology, Chicago, Illinois 60640, USA
    Birth Defects Res A Clin Mol Teratol 85:556-67. 2009
    ..We have previously demonstrated that Sonic hedgehog signaling (Shh-s) was reduced in both chicken and zebrafish embryos when exposed to ethanol...
  54. ncbi Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists
    Gang Peng
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Development 133:3191-200. 2006
    ..Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists...
  55. ncbi Genomic organization, alternative splicing, and multiple regulatory regions of the zebrafish fgf8 gene
    Fumitaka Inoue
    Department of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama City, Saitama 338 8570, Japan
    Dev Growth Differ 48:447-62. 2006
    ..Furthermore, comparison of the genomic sequence of fgf8 among different vertebrate species suggests that this regulatory mechanism is conserved during vertebrate evolution...
  56. ncbi Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism
    Patricia A Gongal
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Hum Mol Genet 17:525-38. 2008
    ..The consequences of abnormal RA levels for forebrain patterning are profound, and imply that in human patients with TGIF deficiencies, increased forebrain RA levels contribute to the development of HPE...
  57. pmc A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3
    Catherine W McCollum
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA
    Dev Biol 309:373-85. 2007
    ..We suggest that lmo4b activity is required at the neural boundary to restrict six3b expression, and later within the neural plate to for attenuation of rx3 expression independently of its effect on ..
  58. ncbi Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl
    Jae Yeon Jeong
    Program in Developmental Biology, Department of Biopharmaceutical Sciences, University of California San Francisco, CA 94143 2811, USA
    Development 134:127-36. 2007
    ..Our findings reveal that Fezl is crucial for establishing regional subdivisions within the diencephalon and may also play a role in the development of the telencephalon and hypothalamus...
  59. ncbi Molecular changes associated with teratogen-induced cyclopia
    Evyn J Loucks
    Children s Memorial Research Center Program in Developmental Biology, Chicago, Illinois, USA
    Birth Defects Res A Clin Mol Teratol 79:642-51. 2007
    ..Exposure of zebrafish embryos to a number of teratogens results in cyclopia, but little is known about the underlying molecular changes...
  60. ncbi Early embryonic exposure to polychlorinated biphenyls disrupts heat-shock protein 70 cognate expression in zebrafish
    Jill A Kreiling
    Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    J Toxicol Environ Health A 70:1005-13. 2007
    ..The structural and biochemical changes in the developing central nervous system following early embryonic exposure to Aroclor 1254 may lead to alterations in the function of the affected regions...

Research Grants1

  1. Genetic methods using the Tol2 transposable element
    Koichi Kawakami; Fiscal Year: 2006
    ..abstract_text> ..