notch1b

Summary

Gene Symbol: notch1b
Description: notch 1b
Alias: etID309871.5, wu:fc55e11, neurogenic locus notch homolog protein 1, notch homolog 1b, notch receptor protein 1b
Species: zebrafish

Top Publications

  1. doi Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos
    Young Seop Kim
    School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Biochem Biophys Res Commun 423:140-6. 2012
  2. pmc Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart
    Julien Vermot
    Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California, United States of America
    PLoS Biol 7:e1000246. 2009
  3. pmc Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, 2300 Children s Plaza M C 204, Chicago, IL 60614, USA
    Dev Biol 337:233-45. 2010
  4. pmc Chondroitin sulfate expression is required for cardiac atrioventricular canal formation
    David S Peal
    Harvard Medical School, Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Charlestown, Massachusetts, USA
    Dev Dyn 238:3103-10. 2009
  5. doi The lim domain only protein 7 is important in zebrafish heart development
    Elisabeth B Ott
    Institute of Biology, Department of Molecular and Cellular Biology, University of Leiden, Leiden, The Netherlands
    Dev Dyn 237:3940-52. 2008
  6. doi Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells
    Prisca Chapouton
    Zebrafish Neurogenetics Department, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    J Neurosci 30:7961-74. 2010
  7. doi Three novel Notch genes in zebrafish: implications for vertebrate Notch gene evolution and function
    J Westin
    Department of Developmental Neuroscience, BMC, Uppsala University, Box 587, 751 23, Uppsala, Sweden
    Dev Genes Evol 207:51-63. 1997
  8. pmc Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium
    Alessandro Alunni
    Institute of Neurobiology A Fessard, Laboratory of Neurobiology and Development, CNRS UPR3294, Team Zebrafish Neurogenetics, Avenue de la Terrasse, Building 5, F 91198 Gif sur Yvette, France
    Development 140:3335-47. 2013
  9. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
  10. pmc Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression
    Naznin Sultana
    Departments of Biological Sciences and Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Proc Natl Acad Sci U S A 105:4763-8. 2008

Scientific Experts

  • Rachel M Warga
  • S Just
  • Rakesh Kumar Banote
  • Priya Choudhry
  • David J Milan
  • Prisca Chapouton
  • Kelly A Smith
  • Sang Yeob Yeo
  • Didier Y R Stainier
  • Yun Jin Jiang
  • Calum A Macrae
  • Ye Bu
  • Xu Wang
  • Jun Dae Kim
  • Tae Lin Huh
  • Miriam A Moriarty
  • Maura Grealy
  • David S Peal
  • Catherine T Nguyen
  • Lucy Byrnes
  • Neil C Chi
  • Jau Nian Chen
  • Xiaowen Chen
  • You Mie Lee
  • James T Nichols
  • Aniket V Gore
  • Andrew Khayrullin
  • Matthew R Broadus
  • Lindsey Barske
  • James G Patton
  • Abigail F Olena
  • J Gage Crump
  • Leigh Ann Samsa
  • Jiang Gui
  • Jialiang Wang
  • Christian Dina
  • J Nicenboim
  • Miki Dozawa
  • Albert D Kim
  • Roger R Markwald
  • Russell A Norris
  • Eunmyong Lee
  • Long Zhao
  • Mengmeng Li
  • Sayumi Okigawa
  • Clay Conner
  • Marco Venturin
  • Qing Wu
  • Xiaojun Zhu
  • Koichi Kawakami
  • Jing Wei Xiong
  • Myungchull Rhee
  • Myoung Jin Kim
  • Alessandro Alunni
  • Juliane Münch
  • Soonil Koun
  • Natalia Sacilotto
  • Hyung Jin Ham
  • Toshihiro Banjo
  • Ruilin Zhang
  • Dong Liu
  • Martin D Burkhalter
  • Kartik Soni
  • Heather J Kolpa
  • David L Stachura
  • Franco Cotelli
  • Tatyana B Dias
  • Young Seop Kim
  • Yi Fan Lin
  • Heng Huang
  • Deborah Yelon
  • Nicole O Glenn
  • Bettina C Kirchmaier
  • Zhiqiang Dong
  • David Traver
  • Benno Jungblut
  • Angel Raya
  • C Geoffrey Burns
  • Janna Krueger
  • Joshua D Wythe
  • Ronald Totong
  • Aaron W Aday
  • Chinmoy Patra
  • Adam D Langenbacher
  • Jun K Takeuchi
  • Pei Chen Chung
  • Sarah De Val
  • Guson Kang
  • Stefan Schulte-Merker
  • Nathan D Lawson

Detail Information

Publications92

  1. doi Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos
    Young Seop Kim
    School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Biochem Biophys Res Commun 423:140-6. 2012
    ..In these embryos, expression of AVC myocardial bmp4 and AVC endocardial notch1b genes was markedly reduced with subsequent failure of EMT in the AVC endocardial cells...
  2. pmc Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart
    Julien Vermot
    Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California, United States of America
    PLoS Biol 7:e1000246. 2009
    ....
  3. pmc Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, 2300 Children s Plaza M C 204, Chicago, IL 60614, USA
    Dev Biol 337:233-45. 2010
    ..These studies demonstrate that controlling the correct balance of Tbx5 activity is crucial for the specification of the AV boundary and valve formation...
  4. pmc Chondroitin sulfate expression is required for cardiac atrioventricular canal formation
    David S Peal
    Harvard Medical School, Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Charlestown, Massachusetts, USA
    Dev Dyn 238:3103-10. 2009
    ....
  5. doi The lim domain only protein 7 is important in zebrafish heart development
    Elisabeth B Ott
    Institute of Biology, Department of Molecular and Cellular Biology, University of Leiden, Leiden, The Netherlands
    Dev Dyn 237:3940-52. 2008
    ..We reveal the temporal and spatial expression patterns of this important gene during mouse, chicken and fish development and our findings suggest essential functions for LMO7 during vertebrate heart development...
  6. doi Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells
    Prisca Chapouton
    Zebrafish Neurogenetics Department, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    J Neurosci 30:7961-74. 2010
    ....
  7. doi Three novel Notch genes in zebrafish: implications for vertebrate Notch gene evolution and function
    J Westin
    Department of Developmental Neuroscience, BMC, Uppsala University, Box 587, 751 23, Uppsala, Sweden
    Dev Genes Evol 207:51-63. 1997
    ..Notch gene function, we isolated cDNA fragments of three novel Notch genes from zebrafish (Danio rerio), Notch1b, Notch5 and Notch6. Notch1b is a second zebrafish Notch1 gene...
  8. pmc Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium
    Alessandro Alunni
    Institute of Neurobiology A Fessard, Laboratory of Neurobiology and Development, CNRS UPR3294, Team Zebrafish Neurogenetics, Avenue de la Terrasse, Building 5, F 91198 Gif sur Yvette, France
    Development 140:3335-47. 2013
    ..By contrast, abrogation of notch1b function results in the generation of neurons at the expense of the activated NSC state...
  9. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
    ..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
  10. pmc Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression
    Naznin Sultana
    Departments of Biological Sciences and Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Proc Natl Acad Sci U S A 105:4763-8. 2008
    ..5 expression, which in turn promotes unidirectional, parallel alignment of myofibrils and the subsequent proper heart morphogenesis...
  11. pmc Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21
    Toshihiro Banjo
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba, Sendai, Miyagi 980 8577, Japan
    Nat Commun 4:1978. 2013
    ..We conclude that miR-21 is a central component of a flow-controlled mechanotransduction system in a physicogenetic regulatory loop...
  12. ncbi Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
    Gonzalo del Monte
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco, Madrid, Spain
    Dev Dyn 236:2594-614. 2007
    ..We found that Notch1 transcription and activity was severely reduced in zebrafish and mouse Notch pathway mutants, suggesting that vertebrate Notch1 expression is regulated by a positive feedback loop...
  13. pmc Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling
    Ines Ribeiro
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 2:e398. 2007
    ..Cardiomyocytes in the future chamber myocardium acquire different cellular and physiological characteristics through activation of a chamber-specific genetic program, which is in part mediated by T-box genes...
  14. pmc A positive regulatory loop between foxi3a and foxi3b is essential for specification and differentiation of zebrafish epidermal ionocytes
    Chung Der Hsiao
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
    PLoS ONE 2:e302. 2007
    ..However, the mechanism controlling epidermal ionocyte specification and differentiation remains unknown...
  15. ncbi Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm
    Andrea Pasini
    Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 7AA, UK
    Development 131:1529-41. 2004
    ....
  16. ncbi Evolutionary analysis of vertebrate Notch genes
    R D Kortschak
    Discipline of Genetics, Department of Molecular Bioscience, Adelaide University, North Terrace, Adelaide 5005, Australia
    Dev Genes Evol 211:350-4. 2001
    ..Sequence similarities between the ankyrin repeats and the region immediately C-terminal of the repeats further suggests that this region may be involved in the modulation of ankyrin repeat function...
  17. ncbi UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish
    E C Walsh
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, CA 94143 0448, USA
    Science 293:1670-3. 2001
    ..The atrioventricular border cells do not differentiate from their neighbors in jekyll mutants, suggesting that Jekyll is required in a cell signaling event that establishes a boundary between the atrium and ventricle...
  18. pmc Activation of Notch signaling pathway precedes heart regeneration in zebrafish
    Angel Raya
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:11889-95. 2003
    ..Preceding Msx activation, there is a marked increase in the expression of notch1b and deltaC, which we show are also up-regulated during fin regeneration...
  19. ncbi The Wnt/beta-catenin pathway regulates cardiac valve formation
    Adam F L Hurlstone
    Netherlands Institute for Developmental Biology, Hubrecht Laboratory and Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nature 425:633-7. 2003
    ..Our findings identify a novel role for Wnt/beta-catenin signalling in determining endocardial cell fate...
  20. doi Notch signaling controls generation of motor neurons in the lesioned spinal cord of adult zebrafish
    Tatyana B Dias
    Centre for Neuroregeneration, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Neurosci 32:3245-52. 2012
    ..This demonstrates that Notch is a negative signal for regenerative neurogenesis, and, importantly, that spinal motor neuron regeneration can be augmented in an adult vertebrate by inhibiting Notch signaling...
  21. ncbi Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy
    Kristin Lorent
    Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    Development 131:5753-66. 2004
    ..These data confirm an evolutionarily conserved role for Notch signaling in vertebrate liver development, and support the zebrafish as a model system for diseases of the human biliary system...
  22. pmc Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish
    You Mie Lee
    Vascular Biology Program, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Dev Dyn 235:29-37. 2006
    ..Taken together, these data demonstrate a novel function for VEGF-Rs in the endocardial endothelium of the developing cardiac valve...
  23. ncbi Notch1b and neuregulin are required for specification of central cardiac conduction tissue
    David J Milan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Development 133:1125-32. 2006
    ..Finally, both neuregulin and notch1b are necessary for the development of atrioventricular conduction tissue...
  24. ncbi Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis
    Jonathan D Leslie
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 134:839-44. 2007
    ..Thus, Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf...
  25. ncbi Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine
    Cecile Crosnier
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 132:1093-104. 2005
    ..These findings demonstrate the central role of Notch signalling in the gut stem-cell system and establish the zebrafish as a model for study of the mechanisms controlling renewal of gut epithelium...
  26. pmc Autophagy is essential for cardiac morphogenesis during vertebrate development
    Eunmyong Lee
    Department of Internal Medicine University of Texas Southwestern Medical Center Dallas, TX USA
    Autophagy 10:572-87. 2014
    ..Thus, autophagy plays an essential, conserved role in cardiac morphogenesis during vertebrate development. ..
  27. pmc Cilia Control Vascular Mural Cell Recruitment in Vertebrates
    Xiaowen Chen
    Vesalius Research Center, VIB KUL, Leuven 3000, Belgium
    Cell Rep 18:1033-1047. 2017
    ..In summary, we have identified a hemodynamic-dependent mechanism in the developing vasculature that controls vMC recruitment...
  28. pmc Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration
    Long Zhao
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129
    Proc Natl Acad Sci U S A 111:1403-8. 2014
    ..Taken together, our data uncover the exquisite sensitivity of regenerative cardiomyocyte proliferation to perturbations in Notch signaling. ..
  29. doi ADAP2 in heart development: a candidate gene for the occurrence of cardiovascular malformations in NF1 microdeletion syndrome
    Marco Venturin
    Dipartimento di Biotecnologie mediche e Medicina traslazionale, Universita degli Studi di Milano, Milan, Italy
    J Med Genet 51:436-43. 2014
    ..In order to identify which genes could be responsible for cardiovascular malformations in the deleted patients, we carried out expression studies in mouse embryos and functional studies in zebrafish...
  30. doi Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish
    Ye Bu
    Beijing Key Laboratory of Cardiometabolic Molecular Medicine and State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Peking University, Beijing, 100871 China
    J Cell Sci 127:2761-70. 2014
    ....
  31. doi Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination
    Sayumi Okigawa
    Graduate School of Science, Nagoya University, Nagoya, Aichi 464 8602, Japan
    Dev Biol 391:196-206. 2014
    ..Two ligands, DeltaA and DeltaD, and three receptors, Notch1a, Notch1b, and Notch3 redundantly contribute to p2 progenitor maintenance...
  32. pmc Zebrafish Crip2 plays a critical role in atrioventricular valve development by downregulating the expression of ECM genes in the endocardial cushion
    Jun Dae Kim
    Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Mol Cells 37:406-11. 2014
    ..but the expression of bone morphogenetic protein 4 (bmp4) and T-box 2b (tbx2b) in the myocardium and of notch1b in the endocardium in the AVC did not change...
  33. doi Protein kinase D2 controls cardiac valve formation in zebrafish by regulating histone deacetylase 5 activity
    Steffen Just
    Department of Medicine II, University of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    Circulation 124:324-34. 2011
    ..The molecular mechanisms that guide heart valve formation are not well understood. However, elucidation of the genetic basis of congenital heart disease is one of the prerequisites for the development of tissue-engineered heart valves...
  34. pmc The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development
    Bettina C Kirchmaier
    Cell and Developmental Biology, University of Wurzburg, Biocenter, Am Hubland, 97074 Wurzburg, Germany
    Dev Biol 363:438-50. 2012
    ..Our results identify popdc2 as a gene important for striated muscle differentiation and cardiac morphogenesis. In addition it is required for the development of the cardiac conduction system...
  35. doi Overexpression of miR-19b impairs cardiac development in zebrafish by targeting ctnnb1
    Mengmeng Li
    State Key Laboratory of Reproductive Medicine, Department of Pediatrics, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, China
    Cell Physiol Biochem 33:1988-2002. 2014
    ..We aimed to identify the biological significance of miR-19b in cardiac development and its underlying molecular mechanism of action in vivo...
  36. doi Valproic acid, a histone deacetylase inhibitor, regulates cell proliferation in the adult zebrafish optic tectum
    Miki Dozawa
    Department of Life Science and Medical Bio Science, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    Dev Dyn 243:1401-15. 2014
    ..While VPA is known to cause teratogenic changes in the embryonic zebrafish brain, its effects on neural stem cells (NSCs) in both the embryonic and adult zebrafish are not well understood...
  37. pmc Discrete Notch signaling requirements in the specification of hematopoietic stem cells
    Albert D Kim
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA
    EMBO J 33:2363-73. 2014
    ..The orthologues of the murine Notch1 receptor, Notch1a and Notch1b, are each required intrinsically to fate HSCs, just prior to their emergence from aortic hemogenic endothelium...
  38. pmc Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells
    Clay Conner
    Department of Biological Sciences and the Center for Zebrafish Research, Galvin Life Sciences Building, University of Notre Dame, Notre Dame, Indiana 46556
    J Neurosci 34:14403-19. 2014
    ....
  39. doi Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish
    Jialiang Wang
    The Education Ministry Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio membrane and Membrane Bio engineering, School of Life Sciences, Peking University, Beijing 100871, China
    J Neurosci 35:234-44. 2015
    ..These newly uncovered roles for Atoh1and Sox9 in zebrafish otic development may be relevant to study in other species. ..
  40. pmc miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development
    Abigail F Olena
    Department of Biological Sciences, Vanderbilt University, United States
    Dev Biol 400:72-81. 2015
    ..We propose a model in which SNX5, precisely controlled by miR-216a, is a vital partner of Mib in promoting endocytosis of Delta and subsequent activation of Notch signaling. ..
  41. ncbi Lymphatic vessels arise from specialized angioblasts within a venous niche
    J Nicenboim
    Nature 522:56-61. 2015
    ..More broadly, our findings highlight the cardinal vein as a heterogeneous structure, analogous to the haematopoietic niche in the aortic floor...
  42. pmc Testing multiple hypotheses through IMP weighted FDR based on a genetic functional network with application to a new zebrafish transcriptome study
    Jiang Gui
    Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA Dartmouth Hitchcock Medical Center, 883 Rubin Bldg, HB7927, One Medical Center Dr, Lebanon, NH USA
    BioData Min 8:17. 2015
    ..We compared the mRNA expression for each group and found over 200 differentially expressed genes and several enriched pathways including defense response pathways, arsenic response pathways, and the Notch signaling pathway. ..
  43. pmc Genetic association analyses highlight biological pathways underlying mitral valve prolapse
    Christian Dina
    INSERM Unité Mixte de Recherche UMR 1087, Centre National de la Recherche Scientifique CNRS UMR 6291, Institut du Thorax, Nantes, France
    Nat Genet 47:1206-11. 2015
    ..This study identifies the first risk loci for MVP and suggests new mechanisms involved in mitral valve regurgitation, the most common indication for mitral valve repair. ..
  44. pmc Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish
    Leigh Ann Samsa
    Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA McAllister Heart Institute, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 142:4080-91. 2015
    ..contraction, we showed that cardiac contraction is required for trabeculation through its role in regulating notch1b transcription in the ventricular endocardium...
  45. pmc Epigenetic regulation of hematopoiesis by DNA methylation
    Aniket V Gore
    Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States
    elife 5:e11813. 2016
    ..Our results reveal an epigenetic mechanism supporting the maintenance of hematopoietic cell fate via DNA methylation-mediated perdurance of a key transcription factor in HSPCs. ..
  46. pmc Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face
    Lindsey Barske
    Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 12:e1005967. 2016
    ..These findings support a model in which Notch-mediated restriction of cartilage differentiation, particularly in the second pharyngeal arch, helps to establish a distinct skeletal pattern in the upper face. ..
  47. pmc Identification of a Paralog-Specific Notch1 Intracellular Domain Degron
    Matthew R Broadus
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 15:1920-9. 2016
    ..Our studies reveal a mechanism by which degradation of NICD1 is regulated by the N1-Box to minimize stochastic flux and to establish a threshold for Notch1 pathway activation. ..
  48. doi Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development
    Rachel M Warga
    Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008, USA Electronic address
    Dev Biol 418:307-22. 2016
    ..We conclude that while RacGAP1 function is crucial for cytokinesis and its activity at different levels controls different aspects of cytokinesis, these defects have occluded other critical roles of this interesting protein. ..
  49. doi Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle
    Andrew Khayrullin
    Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 479:590-595. 2016
    ..Furthermore, zebrafish may serve as a useful model for better understanding the role of microRNAs in alcohol-related tissue damage...
  50. pmc Grk5l controls heart development by limiting mTOR signaling during symmetry breaking
    Martin D Burkhalter
    Leibniz Institute for Age Research, Fritz Lippmann Institute, 07745 Jena, Germany
    Cell Rep 4:625-32. 2013
    ..By fine-tuning mTORC1, GRK5 thus serves an unanticipated function during early development, besides its well-characterized role in the adult heart. These findings could implicate GRK5 as a susceptibility allele for certain cases of CHD. ..
  51. doi Loss of plakophilin 2 disrupts heart development in zebrafish
    Miriam A Moriarty
    Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland
    Int J Dev Biol 56:711-8. 2012
    ..These results indicate that plakophilin 2 has both structural and signalling roles in zebrafish heart development...
  52. pmc Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3477-87. 2010
    ..Together, our observations reveal a genetic regulatory network that explains why atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the pLLp...
  53. pmc Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development
    Natalia Sacilotto
    Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 110:11893-8. 2013
    ..Fascinatingly, this combinatorial ablation leads to a loss of arterial markers and the absence of a detectable dorsal aorta, demonstrating the essential roles of SoxF and Notch, together, in the acquisition of arterial identity. ..
  54. pmc In vivo cardiac reprogramming contributes to zebrafish heart regeneration
    Ruilin Zhang
    Department of Medicine, Division of Cardiology, University of California, San Diego, La Jolla, California 92093, USA
    Nature 498:497-501. 2013
    ....
  55. pmc miR-21 represses Pdcd4 during cardiac valvulogenesis
    Heather J Kolpa
    Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Development 140:2172-80. 2013
    ..PDCD4 knockdown alone was sufficient to enhance endothelial cell migration. These results demonstrate that miR-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4...
  56. pmc DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation
    Priya Choudhry
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e58145. 2013
    ..This is the first study linking tbx1 and non-canonical Wnt signaling and extends our understanding of DGS and heart development...
  57. pmc miR-34 is maternally inherited in Drosophila melanogaster and Danio rerio
    Kartik Soni
    CSIR Institute of Genomics and Integrative Biology, Delhi 110 007, India, Ambedkar Centre for Biomedical Research, Delhi University, Delhi 110007, India
    Nucleic Acids Res 41:4470-80. 2013
    ..Here, we report for the first time, the maternal inheritance of an miRNA involved in development of the neuronal system in a vertebrate model system...
  58. pmc Genetic interaction between pku300 and fbn2b controls endocardial cell proliferation and valve development in zebrafish
    Xu Wang
    Institute of Molecular Medicine, Peking University, Yi He Yuan Lu 5, Hai Dian Qu, Beijing 100871, China
    J Cell Sci 126:1381-91. 2013
    ..We conclude that pku300 and fbn2b represent the few genes capable of regulating endocardial cell proliferation and signaling in zebrafish cardiac valve development...
  59. doi Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration
    Juliane Münch
    Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain
    Development 140:1402-11. 2013
    ..We conclude that Notch signalling maintains blastema cells in a plastic, undifferentiated and proliferative state, an essential requirement for fin regeneration...
  60. doi Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish
    Heng Huang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Arterioscler Thromb Vasc Biol 32:2158-70. 2012
    ..The aim of this study was to investigate the physiological functions of PAQR10 and PAQR11...
  61. pmc The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish
    Nicole O Glenn
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Mol Cell Biol 32:3527-40. 2012
    ..Our study underscores the importance of the W-loop for actin functionality and will help us to understand the structural and physiological consequences of ACTC mutations in human congenital disorders...
  62. pmc Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia
    Zhiqiang Dong
    Programs in Human Genetics and Biological Sciences, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143 2811, USA
    Neuron 74:65-78. 2012
    ..These findings reveal with single-cell resolution how self-renewal and differentiation become precisely segregated within asymmetrically dividing neural progenitor/stem lineages...
  63. pmc Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division
    Bruce B Riley
    Department of Biology, Texas A and M University, College Station, Texas, USA
    Dev Dyn 239:828-43. 2010
    ..Despite relatively normal gross patterning, harpy mutants show several defects in morphogenesis, cell migration and differentiation resulting directly or indirectly from the arrest of cell division...
  64. pmc Notch signaling functions as a cell-fate switch between the endothelial and hematopoietic lineages
    Christina Y Lee
    McAllister Heart Institute, Department of Cell and Molecular Physiology, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Biol 19:1616-22. 2009
    ....
  65. pmc microRNA-138 modulates cardiac patterning during embryonic development
    Sarah U Morton
    Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:17830-5. 2008
    ....
  66. doi Her4 is necessary for establishing peripheral projections of the trigeminal ganglia in zebrafish
    Ju Hoon So
    Department of Biology, Chungnam National University, Daejeon, Republic of Korea
    Biochem Biophys Res Commun 379:22-6. 2009
    ..These observations suggest that Her4 and Notch play a role in peripheral outgrowth of sensory neurons...
  67. pmc Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos
    Ho Kim
    Graduate School of Medicine, Korea University, Ansan, Gyeonggido, Republic of Korea
    Dev Dyn 237:2081-9. 2008
    ....
  68. doi Plakoglobin has both structural and signalling roles in zebrafish development
    Eva D Martin
    Department of Pharmacology and Therapeutics and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland
    Dev Biol 327:83-96. 2009
    ..post fertilisation (hpf), and cmlc2 and vmhc at 48 hpf, while there is lack of restriction of the valve markers notch1b and bmp4 at 48 hpf...
  69. pmc Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries
    Xuehui Qiu
    Laboratory of Developmental Signalling and Patterning, Genes and Development Division, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Singapore, Singapore
    Dev Genes Evol 219:339-51. 2009
    ....
  70. ncbi A regulator of transcriptional elongation controls vertebrate neuronal development
    S Guo
    Department of Molecular Biology, Genentech Inc, South San Francisco, California 94080, USA
    Nature 408:366-9. 2000
    ..The mutation disrupts its repressive but not its stimulatory activity. Our results provide molecular, genetic and biochemical evidence that negative regulators of transcription elongation control key aspects of neuronal development...
  71. pmc Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary
    Sunit Dutta
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Biol 319:248-57. 2008
    ..We propose that Notch mediated lateral inhibition regulates the relative numbers of specified hormone cell types in the three pituitary subdomains...
  72. pmc 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure prevents cardiac valve formation in developing zebrafish
    Vatsal Mehta
    Molecular and Environmental Toxicology Center, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705 2222, USA
    Toxicol Sci 104:303-11. 2008
    ..of endothelial cells at the AV and BV junctions and altered the localized expression of mRNAs bmp4 and notch1b normally associated with the nascent valves...
  73. doi Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line
    Eva Y Ma
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Neurosci 28:2261-73. 2008
    ..Excess hair cells result from increased support cell proliferation. These results suggest a model where Notch signaling limits the number of hair cells produced during regeneration by regulating support cell proliferation...
  74. ncbi Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment
    Zhiyuan Ke
    Department of Biological Sciences, National University of Singapore, Singapore
    Mol Cell Neurosci 37:388-401. 2008
    ..Gli2b acts in cell proliferation and plays an early role in the hindbrain within a regulatory cascade involving Notch and Ngn1, as well as a role as specific activator in rhombomere 4...
  75. pmc A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development
    Gang Lu
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:784-96. 2007
    ..These data suggest that PP2Cm is a novel mitochondrial protein phosphatase that has a critical function in cell death and survival, and may play a role in regulating the MPTP opening...
  76. ncbi Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis
    Xueying Lin
    Department of Biochemistry and Molecular Biology Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Dev Biol 303:536-48. 2007
    ..Thus, Med10 appears to be a unique MED subunit that differentially transduces information from distinct signaling pathways during zebrafish embryogenesis...
  77. ncbi Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos
    Sang Yeob Yeo
    Department of Genetic Engineering, Kyungpook National University, Daegu 702 701, Korea
    Dev Biol 301:555-67. 2007
    ..The establishment of a reporter line with Notch-Su(H)-dependent fluorescent gene expression provides a tool to explore the complex role of Notch signaling in the development of vertebrate nervous system...
  78. pmc Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish
    Joshua D Wythe
    Department of Oncological Sciences and Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Dis Model Mech 4:607-21. 2011
    ....
  79. doi Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos
    Lori Hartnett
    Department of Biochemistry, National University of Ireland, Galway, Ireland
    Int J Dev Biol 54:573-83. 2010
    ..The finding that igf-2a and igf-2b do not act exclusively in a redundant manner may explain why both genes have been stably maintained in the genome...
  80. pmc Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo
    Julien Y Bertrand
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0380, USA
    Blood 115:2777-83. 2010
    ..These studies establish that HSCs are the only hematopoietic precursor that requires Notch signaling and help to clarify the signaling events underlying the specification of the 2 distinct waves of definitive hematopoiesis...
  81. pmc The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish
    Catherine T Nguyen
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 341:167-75. 2010
    ..Taken together, these results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations...
  82. pmc Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate
    Charles Williams
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Dev Biol 341:196-204. 2010
    ..Collectively, these studies suggest that arterial endothelial cells are specified and formed via repressing venous cell fate at the lateral plate mesoderm by Hh signaling during vasculogenesis...
  83. doi Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
    ..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
  84. doi Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos
    Jonathan M Rowlinson
    Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Blood 116:2046-56. 2010
    ..These results establish an essential role for Hey2 upstream of Notch in HSC formation...
  85. pmc Chromatin remodelling complex dosage modulates transcription factor function in heart development
    Jun K Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nat Commun 2:187. 2011
    ....
  86. pmc The PAF1 complex differentially regulates cardiomyocyte specification
    Adam D Langenbacher
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 353:19-28. 2011
    ..Our findings demonstrate critical but differential requirements for PAF1C components in zebrafish cardiac specification and heart morphogenesis...
  87. pmc Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites
    Aaron W Aday
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01602, USA
    Dev Biol 357:450-62. 2011
    ....
  88. pmc Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo
    Janna Krueger
    Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine, D13125 Berlin, Germany
    Development 138:2111-20. 2011
    ..Thus, Flt1 acts in a Notch-dependent manner as a negative regulator of tip cell differentiation and branching. Flt1 distribution may be fine-tuned, involving interactions with the developing nervous system...
  89. pmc Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis
    Pei Chen Chung
    School of Medicine, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan
    PLoS ONE 6:e19394. 2011
    ....
  90. pmc Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish
    Chinmoy Patra
    Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany
    Development 138:4499-509. 2011
    ..expanded and endocardial cells along the extended tube-like structure exhibit characteristics of AV cells (has2, notch1b and Alcam expression, cuboidal cell shape)...
  91. pmc The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis
    Ronald Totong
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 138:4199-205. 2011
    ..Together, our data reveal that Tmem2 is an essential mediator of myocardium-endocardium coordination during cardiac morphogenesis...
  92. doi Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development
    Kelly A Smith
    Hubrecht Institute, KNAW and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands
    Development 138:4193-8. 2011
    ..Finally, we show that immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development...