nos1

Summary

Gene Symbol: nos1
Description: nitric oxide synthase 1 (neuronal)
Alias: nNOS, nos, nitric oxide synthase, brain
Species: zebrafish

Top Publications

  1. doi Inter-species transplantation and migration of primordial germ cells in cyprinid fish
    Taiju Saito
    Nanae Fresh Water Laboratory, Field Science Center for Northern Biosphere, Hokkaido University, Nanae, Japan
    Int J Dev Biol 54:1481-86. 2010
  2. doi Comparative analysis of zebrafish nos2a and nos2b genes
    Sandrine Lepiller
    Inserm UMR 866, University of Burgundy, Institut Fédératif de Recherche Santé STIC, 21000 Dijon, France
    Gene 445:58-65. 2009
  3. ncbi Expression pattern of neuronal nitric oxide synthase in embryonic zebrafish
    Kar Lai Poon
    Institute of Molecular and Cell Biology, 1 Research Link, Singapore, Singapore
    Gene Expr Patterns 3:463-6. 2003
  4. pmc A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide
    Christine Wittmann
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein Leopoldshafen, Germany
    PLoS ONE 10:e0137286. 2015
  5. pmc The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model
    Nadhir Yousfi
    INSERM, UMR 866, Equipe Labellisée Ligue contre le Cancer, Dijon, France University of Burgundy, UFR SVTE, Dijon, France
    PLoS ONE 10:e0120435. 2015
  6. pmc S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury
    Andrew G Cox
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 6:56-69. 2014
  7. ncbi [Expression of gdnf and nos in adult zebrafish brain during the regeneration after spinal cord injury]
    Lin Xie
    Center for Neuroscience, Shantou University Medical College, Shantou, China
    Yi Chuan 35:495-501. 2013
  8. pmc Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity
    Hui Xu
    Department of Anatomy and Cell Biology, University of Iowa, 1 400 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Development 139:57-62. 2012
  9. doi A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos
    Lu Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Key Laboratory of Stem Cell Development, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Blood 118:4102-10. 2011
  10. doi Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons
    Sophie Bradley
    Department of Biology, College of Medicine, Biological Sciences, and Psychology, University of Leicester, Leicester LE1 7RH, United Kingdom
    J Neurosci 30:16818-31. 2010

Scientific Experts

  • Taiju Saito
  • Yukinori Kazeto
  • Trista E North
  • Rie Goto-Kazeto
  • Christine Wittmann
  • Nadhir Yousfi
  • Andrew G Cox
  • Lin Xie
  • Nathalie Franche
  • Hui Xu
  • Eric Solary
  • Véronique Laurens
  • Johanna Chluba
  • Wolfram Goessling
  • Lu Wang
  • Kwok Hong Lo
  • Yutaka Kawakami
  • Stefania Nicoli
  • Sophie Bradley
  • Etsuro Yamaha
  • Katsutoshi Arai
  • Sandrine Lepiller
  • Tasha Olden
  • Barbara A Westermann
  • Jacy Pietsch
  • Loredana Bordieri
  • B Holmqvist
  • Kar Lai Poon
  • Eva Kronfuss
  • Asmi H Shah
  • Urban Liebel
  • Ralf Mikut
  • Carmen Garrido
  • Clemens Grabher
  • Françoise Salvadori
  • Benoist Pruvot
  • Markus Reischl
  • Lea Magadoux
  • Tatiana Lopez
  • Laurent Pichon
  • Diane C Saunders
  • Julio F Marchini
  • Dorothy B Colagiovanni
  • Kristin K Brown
  • Gary J Rosenthal
  • Jonathan S Stamler
  • Yevgenia Tesmenitsky
  • Allie A Conway
  • Peter B Kelsey
  • KEVIN J CROCE
  • Ping Fang
  • Jin Fei Lin
  • Hong Chao Pan
  • Fan Zhang
  • Yan qin Shen
  • Fang Lin
  • Songhai Chen
  • Erez Raz
  • Elena Kardash
  • Panpan Zhang
  • Shuk Han Cheng
  • Richard Man Kit Yu
  • Yonglong Wei
  • Feng Liu
  • Michelle Nga Yu Hui
  • Roger Patient
  • Ya Gao
  • Rudolf Shiu Sun Wu
  • Paul Walker
  • Kevin E Fogarty
  • Misae Takagi
  • Rachel Lockley
  • Kyoko Tossell
  • Adam Hurlstone
  • Jonathan Robert McDearmid
  • Takafumi Fujimoto
  • Yoshiyuki Takahashi
  • Shogo Higaki
  • Nathan D Lawson
  • Clive Standley
  • Paul Huang
  • Leonard I Zon
  • Allegra M Lord
  • Craig Ceol
  • Gerhard J Weber
  • Claire C Cutting
  • James Harris
  • Pulin Li
  • Marian Peeters
  • Elaine Dzierzak

Detail Information

Publications20

  1. doi Inter-species transplantation and migration of primordial germ cells in cyprinid fish
    Taiju Saito
    Nanae Fresh Water Laboratory, Field Science Center for Northern Biosphere, Hokkaido University, Nanae, Japan
    Int J Dev Biol 54:1481-86. 2010
    ....
  2. doi Comparative analysis of zebrafish nos2a and nos2b genes
    Sandrine Lepiller
    Inserm UMR 866, University of Burgundy, Institut Fédératif de Recherche Santé STIC, 21000 Dijon, France
    Gene 445:58-65. 2009
    ..Three NOS isoforms have been identified in mammals, namely a neuronal (NOS1), an inducible (NOS2) and an endothelial (NOS3) enzyme...
  3. ncbi Expression pattern of neuronal nitric oxide synthase in embryonic zebrafish
    Kar Lai Poon
    Institute of Molecular and Cell Biology, 1 Research Link, Singapore, Singapore
    Gene Expr Patterns 3:463-6. 2003
    ..Here, we report the cloning and expression pattern of the zebrafish nnos. This gene was mapped to zebrafish linkage group 5...
  4. pmc A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide
    Christine Wittmann
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein Leopoldshafen, Germany
    PLoS ONE 10:e0137286. 2015
    ..Together, we show that our screening method can help to identify novel immune-modulatory activities and provide new mechanistic insights into the regulation of inflammatory processes. ..
  5. pmc The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model
    Nadhir Yousfi
    INSERM, UMR 866, Equipe Labellisée Ligue contre le Cancer, Dijon, France University of Burgundy, UFR SVTE, Dijon, France
    PLoS ONE 10:e0120435. 2015
    ....
  6. pmc S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury
    Andrew G Cox
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 6:56-69. 2014
    ..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury. ..
  7. ncbi [Expression of gdnf and nos in adult zebrafish brain during the regeneration after spinal cord injury]
    Lin Xie
    Center for Neuroscience, Shantou University Medical College, Shantou, China
    Yi Chuan 35:495-501. 2013
    ..applied to reveal the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos) mRNA expression in various regions of zebrafish brain...
  8. pmc Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity
    Hui Xu
    Department of Anatomy and Cell Biology, University of Iowa, 1 400 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Development 139:57-62. 2012
    ..Our results indicate that during PGC migration in vivo, Gβγ signaling regulates Rac activity to control cell polarity, which is required for the responsiveness to chemokine signaling...
  9. doi A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos
    Lu Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Key Laboratory of Stem Cell Development, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Blood 118:4102-10. 2011
    ..Furthermore, the expression of NO synthase (nos) was reduced in klf2a knockdown embryos, and ChIP analysis showed that endogenous Klf2a is bound to the promoters ..
  10. doi Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons
    Sophie Bradley
    Department of Biology, College of Medicine, Biological Sciences, and Psychology, University of Leicester, Leicester LE1 7RH, United Kingdom
    J Neurosci 30:16818-31. 2010
    ..In the immature nervous system, the neuronal isoform of NOS (NOS1) is often expressed during periods of axon outgrowth and elaboration...
  11. pmc Hypoxia impairs primordial germ cell migration in zebrafish (Danio rerio) embryos
    Kwok Hong Lo
    Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR, China
    PLoS ONE 6:e24540. 2011
    ..Previous studies have mainly focused on the effect of hypoxia in adult animals. However, the effect of hypoxia and the underlying mechanism of how hypoxia affects embryonic development of aquatic animals remain unclear...
  12. doi Generation of germ-line chimera zebrafish using primordial germ cells isolated from cultured blastomeres and cryopreserved embryoids
    Yutaka Kawakami
    Nanae Fresh Water Laboratory, Field Science Center of Northern Biosphere, Hokkaido University, Nanae, Japan
    Int J Dev Biol 54:1493-501. 2010
    ..Offspring were obtained from natural spawning between normal females and chimeric males. These results provide the basis for new methods of gene preservation in zebrafish...
  13. doi Isolation of teleost primordial germ cells using flow cytometry
    Rie Goto-Kazeto
    Nanae Fresh Water Laboratory, Field Science Center for Northern Biosphere, Hokkaido University, Hakodate, Hokkaido, Japan
    Int J Dev Biol 54:1487-92. 2010
    ..In zebrafish, medaka and goldfish, the PGCs were labeled by injecting the gfp-nos1 3UTR mRNA into 1- 4 cell embryos...
  14. pmc MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis
    Stefania Nicoli
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1196-200. 2010
    ..Taken together, our work describes a novel genetic mechanism in which a microRNA facilitates integration of a physiological stimulus with growth factor signalling in endothelial cells to guide angiogenesis...
  15. pmc Hematopoietic stem cell development is dependent on blood flow
    Trista E North
    Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:736-48. 2009
    ..Morpholino knockdown of nos1 (nnos/enos) blocked HSC development, and its requirement was shown to be cell autonomous...
  16. doi Differentiation of the zebrafish enteric nervous system and intestinal smooth muscle
    Tasha Olden
    Department of Biology, Clarkson University, Potsdam, New York, USA
    Genesis 46:484-98. 2008
    ..Enteric precursors continue proliferating and differentiating into the third day of embryogenesis. nNOS neurons form early while serotonin neurons form late toward the end of enteric neural differentiation...
  17. doi Nitric oxide synthase in photoreceptive pineal organs of fish
    Barbara A Westermann
    Max Planck Institute for Brain Research, Neuroanatomical Dept, Frankfurt M, Germany
    Comp Biochem Physiol A Mol Integr Physiol 151:198-204. 2008
    ..However, despite the significant rise in cGMP levels nitric oxide donors did neither affect acute light-dependent melatonin formation in the trout pineal nor the rhythmic production of melatonin in the zebrafish pineal...
  18. pmc lessen encodes a zebrafish trap100 required for enteric nervous system development
    Jacy Pietsch
    Department of Biology, Emory University, Rollins Research Center, Atlanta, GA 30322, USA
    Development 133:395-406. 2006
    ..These studies demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of ENS precursors in the intestine...
  19. ncbi Partial cloning of neuronal nitric oxide synthase (nNOS) cDNA and regional distribution of nNOS mRNA in the central nervous system of the Nile tilapia Oreochromis niloticus
    Loredana Bordieri
    Department of Animal and Human Biology, La Sapienza University, Via A Borelli, 50 00161 Rome, Italy
    Brain Res Mol Brain Res 142:123-33. 2005
    ..The predicted 206-long amino acid sequence showed a high degree of identity with other vertebrate neuronal NOS (nNOS) protein sequences...
  20. ncbi The early ontogeny of neuronal nitric oxide synthase systems in the zebrafish
    B Holmqvist
    Department of Pathology, Lund University, Sölvegatan 25, S 221 85 Lund, Sweden
    J Exp Biol 207:923-35. 2004
    To examine a putative role for neuronal nitric oxide synthase (nNOS) in early vertebrate development we investigated nNOS mRNA expression and cGMP production during development of the zebrafish Danio rerio...