myog

Summary

Gene Symbol: myog
Description: myogenin
Alias: cb553, zgc:100763, myogenin, Myf4
Species: zebrafish

Top Publications

  1. pmc SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006
  2. ncbi Growth in the larval zebrafish pectoral fin and trunk musculature
    Sara E Patterson
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    Dev Dyn 237:307-15. 2008
  3. ncbi Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Development 134:3371-82. 2007
  4. pmc Mef2s are required for thick filament formation in nascent muscle fibres
    Yaniv Hinits
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, UK
    Development 134:2511-9. 2007
  5. pmc Effects of RAS on the genesis of embryonal rhabdomyosarcoma
    David M Langenau
    Stem Cell Program and Division of Hematology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 21:1382-95. 2007
  6. pmc Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations
    Yaniv Hinits
    Randall Division for Cell and Molecular Biophysics and MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, SE1 1UL, UK
    Development 136:403-14. 2009
  7. doi Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo
    Esther Schnapp
    Stem Cell Research Institute, DIBIT, San Raffaele Scientific Institute, 58 Via Olgettina, 20132 Milan, Italy
    J Cell Sci 122:481-8. 2009
  8. ncbi Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish
    Cheng Yung Lin
    Institute of Molecular and Cellular Biology, National Taiwan University, Room 307, Fisheries Science Building, No 1, Section 4, Roosevelt Road, Taipei 106, Taiwan
    Dev Biol 299:594-608. 2006
  9. ncbi Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio)
    T van der Meulen
    Experimental Zoology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 291:R1040-8. 2006
  10. ncbi Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors
    Peter J Schlueter
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Kraus Natural Science Bldg, Ann Arbor, MI 48109, USA
    FASEB J 20:1230-2. 2006

Research Grants

Scientific Experts

  • Lisa Maves
  • Anja Bühler
  • Michael P Housley
  • STEPHEN DEVOTO
  • Haruki Ochi
  • Yoshitsugu Masuda
  • Peter J Lyons
  • Arjan P Palstra
  • I Seiliez
  • Jihua Yao
  • Shang Wei Chong
  • Shao Jun Du
  • Yaniv Hinits
  • Simon M Hughes
  • Hung Chieh Lee
  • Huai Jen Tsai
  • David M Langenau
  • Jie Yang
  • Narie Y Storer
  • Cheng Yung Lin
  • Hiroyasu Kamei
  • Leonard I Zon
  • Jin Ming Tee
  • Cunming Duan
  • Daniel P S Osborn
  • Yau Hung Chen
  • Xungang Tan
  • Anna Pistocchi
  • Franco Cotelli
  • T van der Meulen
  • Matthew T Peterson
  • Jen Leih Wu
  • Hong Yi Gong
  • Huiqing Li
  • Tapan G Pipalia
  • Mei Li
  • Chiou Yueh Lee
  • Takahiro Hasumura
  • Zhen Zeng
  • Xiaoyuan Huang
  • Juncheng Wei
  • Quanfu Ma
  • Ding Ma
  • Qinglei Gao
  • Shuangmei Ye
  • Lijun Jiang
  • Mingfu Wu
  • Phong Dang Nguyen
  • Samantha Maragh
  • Ying Li
  • Colleen E Albacker
  • Kasper Kjaer-Sorensen
  • Matthew B Veldman
  • Pilar E Ulloa
  • Zizhen Yao
  • Yen Hsing Li
  • Bingyan Wang
  • James E N Minchin
  • Gnanapackiam Sheela Devakanmalai
  • Ian P G Amaral
  • Myron S Ignatius
  • Dinushan Nesan
  • Chiara Brusegan
  • Marcio Azevedo Figueiredo
  • Victoria C Williams
  • Yi Yen Chen
  • Ian C Scott
  • Ren Jun Hsu
  • Efrem Foglia
  • Tomoaki Fujii
  • Gang Hui Lee
  • Paul Delgado-Olguín
  • Giulio Cossu
  • Rafael Y Kuradomi
  • Shao Yang Hu
  • Julie Batut
  • Matthew S Alexander
  • Luis Fernando Marins
  • Christina L Hammond
  • Danica Zivkovic
  • Chandrashekara Mallappa
  • Carlos Eduardo da Rosa
  • Shuming Zou
  • Louis M Kunkel
  • A C H Ma
  • Esther Schnapp
  • Jeffrey R Guyon
  • Clarissa A Henry
  • Thomas A Hawkins
  • Sara E Patterson

Detail Information

Publications86

  1. pmc SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006
    ..Together, these data indicate that SmyD1a and SmyD1b are histone methyltransferases and play a critical role in myofibril organization during myofiber maturation...
  2. ncbi Growth in the larval zebrafish pectoral fin and trunk musculature
    Sara E Patterson
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    Dev Dyn 237:307-15. 2008
    ..Our results suggest that regulation of fiber type development and muscle growth may differ in the pectoral fin and trunk...
  3. ncbi Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Development 134:3371-82. 2007
    ..Pbx homeodomain proteins mark promoters of a subset of Myod target genes, including myogenin (Myog); thus, Pbx proteins might modulate the program of myogenesis driven by Myod...
  4. pmc Mef2s are required for thick filament formation in nascent muscle fibres
    Yaniv Hinits
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, UK
    Development 134:2511-9. 2007
    ..Our findings show that Mef2 controls skeletal muscle formation after terminal differentiation and define a new maturation step in vertebrate skeletal muscle development at which thick filament gene expression is controlled...
  5. pmc Effects of RAS on the genesis of embryonal rhabdomyosarcoma
    David M Langenau
    Stem Cell Program and Division of Hematology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 21:1382-95. 2007
    ..When coupled with gene expression studies of this cell population, we propose that the zebrafish RMS cancer stem cell shares similar self-renewal programs as those found in activated satellite cells...
  6. pmc Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations
    Yaniv Hinits
    Randall Division for Cell and Molecular Biophysics and MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, SE1 1UL, UK
    Development 136:403-14. 2009
    ..Myod-driven Myogenin activity alone is sufficient for lateral fast somitic and pectoral fin fibre formation from the lateral ..
  7. doi Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo
    Esther Schnapp
    Stem Cell Research Institute, DIBIT, San Raffaele Scientific Institute, 58 Via Olgettina, 20132 Milan, Italy
    J Cell Sci 122:481-8. 2009
    ..in all vertebrates, but their role has been studied in great detail only in the mouse embryo, where all but myogenin--Myod, Myf5 and Mrf4--are sufficient to activate (albeit not completely) skeletal myogenesis...
  8. ncbi Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish
    Cheng Yung Lin
    Institute of Molecular and Cellular Biology, National Taiwan University, Room 307, Fisheries Science Building, No 1, Section 4, Roosevelt Road, Taipei 106, Taiwan
    Dev Biol 299:594-608. 2006
    ..On the basis of the expression patterns of myf5 and myod, we propose a model to present how Myf5 and Myod are involved in head myogenesis of zebrafish...
  9. ncbi Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio)
    T van der Meulen
    Experimental Zoology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 291:R1040-8. 2006
    ..At the end of 10 wk of training, heart and axial muscle showed increased expression of the muscle growth factor myogenin and proliferating cell nuclear antigen, but there were major differences between cardiac and axial muscle...
  10. ncbi Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors
    Peter J Schlueter
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Kraus Natural Science Bldg, Ann Arbor, MI 48109, USA
    FASEB J 20:1230-2. 2006
    ....
  11. pmc Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish
    S H Devoto
    Biology Department, Wesleyan University, Middletown, CT 06457, USA
    Evol Dev 8:101-10. 2006
    ..Some of the pax7-expressing cells also express the differentiation-promoting myogenic regulatory factor Myogenin and appear to enter into the myotome...
  12. ncbi Foxd3 mediates zebrafish myf5 expression during early somitogenesis
    Hung Chieh Lee
    Institute of Molecular and Cellular Biology, National Taiwan University, No 1, Section 4, Roosevelt Road, Taipei 106, Taiwan
    Dev Biol 290:359-72. 2006
    ..This report is the first study to show that Foxd3, a well-known regulator in neural crest development, is also involved in myf5 regulation...
  13. ncbi Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish
    Julie A Groves
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Development 132:4211-22. 2005
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  14. ncbi Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos
    E S Weinberg
    Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
    Development 122:271-80. 1996
    ..We also show that MyoD expression precedes myogenin expression and follows or is coincident with expression of snaill in some regions that express this gene.
  15. pmc Cdkn1c drives muscle differentiation through a positive feedback loop with Myod
    Daniel P S Osborn
    King s College London, Randall Division for Cell and Molecular Biophysics, London, UK
    Dev Biol 350:464-75. 2011
    ..we show that Hh is also essential at a second step that increases Myod protein activity, permitting it to promote Myogenin expression...
  16. pmc Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish
    Yaniv Hinits
    Randall Division for Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, King s College London, SE1 1UL, UK
    Dev Biol 358:102-12. 2011
    ..A mutation in myog, encoding a second MRF, has little obvious phenotype at early stages, but exacerbates the loss of somitic muscle ..
  17. pmc Pbx acts with Hand2 in early myocardial differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 333:409-18. 2009
    ..Our findings demonstrate new roles for Pbx proteins in vertebrate cardiac development and also provide new insight into connections between the transcriptional regulation of skeletal and cardiac muscle differentiation programs...
  18. ncbi Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1
    Aseervatham Anusha Amali
    Laboratory of Marine Molecular Biology and Biotechnology, Institute of Zoology, Academia Sinica, Nankang, Taipei, Taiwan
    Dev Dyn 229:847-56. 2004
    ..Moreover, analyses of MRFs, MSP, and IGFs in the knock-down embryos by RT-PCR revealed the up-regulation of MyoD, Myogenin, and Mck transcription, whereas IGF-2 transcription showed mild response with no effect on IGF-1, Desmin, and ..
  19. ncbi Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Comp Biochem Physiol B Biochem Mol Biol 134:123-34. 2003
    b>Myogenin is a member of the basic Helix-Loop-Helix transcription factor family that play key roles in myoblast specification and differentiation...
  20. doi Smad4 is required for the development of cardiac and skeletal muscle in zebrafish
    Jie Yang
    Cancer Biology Research Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030 PR China Electronic address
    Differentiation 92:161-168. 2016
    ..Collectively, these data suggest that smad4 plays an important role in heart and skeletal muscle development...
  21. pmc In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma
    Myron S Ignatius
    Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cancer Cell 21:680-93. 2012
    ..of late-stage ERMS revealed that myf5+ cells populate newly formed tumor only after seeding by highly migratory myogenin+ ERMS cells...
  22. pmc Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity
    Kasper Kjaer-Sorensen
    Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark
    J Biol Chem 288:9982-92. 2013
    ..We conclude that Papp-a possesses biological functions independent of its proteolytic activity. Our data represent the first evidence for a non-proteolytic function of PAPP-A...
  23. doi Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes
    Yi Yen Chen
    Max Planck Institut fur Entwicklungsbiologie, Department of Genetics, Tuebingen, Germany
    Mech Dev 129:13-23. 2012
    ..For the first time, this transgenic line unravels the heterogeneity in the EVL and will serve as an important tool in understanding the molecular basis of the DV patterning of the EVL...
  24. pmc asb11 is a regulator of embryonic and adult regenerative myogenesis
    Jin Ming Tee
    Hubrecht Institute KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
    Stem Cells Dev 21:3091-103. 2012
    ..Hence, we provide evidence that d-asb11 is a principal regulator of embryonic as well as adult regenerative myogenesis...
  25. doi Growth response and expression of muscle growth-related candidate genes in adult zebrafish fed plant and fishmeal protein-based diets
    Pilar E Ulloa
    Departamento de Ciencias Quimicas, Programa de Doctorado en Ciencias de Recursos Naturales, Facultad de Ciencias Ingeniería y Administración, Universidad de La Frontera, Temuco, Chile
    Zebrafish 10:99-109. 2013
    ..At 98 dpf, growth-related genes Igf1a, Igf2a, mTOR, Pld1a, Mrf4, Myod, Myogenin, and Myostatin1b were evaluated. In males, Myogenin, Mrf4, and Igf2a showed changes attributable to the PP diet...
  26. pmc Postprandial regulation of growth- and metabolism-related factors in zebrafish
    Iban Seiliez
    Institut National de la Recherche Agronomique, UR1067 Nutrition Métabolisme Aquaculture, St Pée sur Nivelle, France
    Zebrafish 10:237-48. 2013
    ..In the muscle, refeeding increased transcript levels of myogenesis (Myf5, Myogenin), inhibited those of Ub-proteasomal proteolytic system (Atrogin1, Murf1a, Murf1b), and induced the activation of ..
  27. pmc Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion
    James E N Minchin
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, UK
    Development 140:2972-84. 2013
    ..Together, our data demonstrate Pax3-expressing somite cells as a source of OSM and SHM fibres, and highlight a conserved role of Pax3 genes in the genesis of these feeding muscles of vertebrates. ..
  28. pmc The chemokine Sdf-1 and its receptor Cxcr4 are required for formation of muscle in zebrafish
    Shang Wei Chong
    Laboratory of Fish Developmental Biology, Institute of Molecular and Cell Biology, Proteos, Singapore
    BMC Dev Biol 7:54. 2007
    ..During development cell migration takes place prior to differentiation of many cell types. The chemokine receptor Cxcr4 and its ligand Sdf1 are implicated in migration of several cell lineages, including appendicular muscles...
  29. ncbi Muscle regulatory factor gene: zebrafish (Danio rerio) myogenin cDNA
    Y H Chen
    Institute of Fisheries Science, National Taiwan University, Taipei, ROC
    Comp Biochem Physiol B Biochem Mol Biol 127:97-103. 2000
    b>Myogenin is one of the basic helix-loop-helix proteins that regulate muscle-specific gene expression...
  30. pmc Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair
    Tapan G Pipalia
    Randall Division of Cell and Molecular Biophysics, Guy s Campus, King s College London, London SE1 1UL, UK
    Dis Model Mech 9:671-84. 2016
    ..Pax7(+) cells proliferate and then undergo terminal differentiation involving Myogenin accumulation and subsequent loss of Pax7 followed by elongation and fusion to repair fast muscle fibres...
  31. doi Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1
    Phong Dang Nguyen
    1 Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia 2
    Nature 512:314-8. 2014
    ..This study reveals the molecular basis for a novel somite lineage restriction mechanism and defines a new paradigm in induction of definitive HSCs. ..
  32. pmc Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy
    Mei Li
    Department of Physiology and Pharmacology, Department of Cell and Molecular Biology, and Department of Women s and Children s Health, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Gen Physiol 147:309-22. 2016
    ..In conclusion, lack of MyBPC-2 results in a severe skeletal myopathy with structural changes and muscle weakness. ..
  33. pmc Rbm24a and Rbm24b are required for normal somitogenesis
    Samantha Maragh
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e105460. 2014
    ....
  34. doi Exercise quantity-dependent muscle hypertrophy in adult zebrafish (Danio rerio)
    Takahiro Hasumura
    Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi, 321 3497, Japan
    J Comp Physiol B 186:603-14. 2016
    ..These results open up the possibility for further investigations on the effects of exercise on skeletal muscle in adult zebrafish. ..
  35. pmc Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish
    Anja Bühler
    Molecular Cardiology, University of Ulm, 89081 Ulm, Germany
    Int J Mol Sci 17:. 2016
    ....
  36. doi Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish
    Gang Hui Lee
    Graduate Institute of Life Sciences, Tamkang University, No 151 Ying chun Road, Tamsui, Taipei County 251, Taiwan
    Cell Mol Life Sci 68:4065-78. 2011
    ..Therefore, we propose a putative regulatory network to understand how capsulin/musculin regulate distinctly either myf5 or myod during zebrafish craniofacial myogenesis...
  37. pmc Cited3 activates Mef2c to control muscle cell differentiation and survival
    Gnanapackiam Sheela Devakanmalai
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Biol Open 2:505-14. 2013
    ..Our findings demonstrate that Cited3 is a critical transcriptional coactivator functioning during muscle differentiation and its absence leads to defects in terminal differentiation and survival of muscle cells. ..
  38. doi Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish
    Marcio Azevedo Figueiredo
    Programa de Pós Graduação em Aqüicultura, Instituto de Oceanografia, Universidade Federal do Rio Grande FURG, Rio Grande, RS, Brazil
    Transgenic Res 21:457-69. 2012
    ..Therefore, it seems that hypertrophy and hyperplasia follow two different routes for entire muscle growth, both of them triggered by GHR activation, but regulated by different mechanisms...
  39. doi Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish
    Ian P G Amaral
    Scottish Oceans Institute, School of Biology, University of St Andrews, Fife, Scotland, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 302:R193-206. 2012
    ..The role of circadian clocks in regulating muscle maintenance and growth are discussed...
  40. doi Glucocorticoid receptor signaling is essential for mesoderm formation and muscle development in zebrafish
    Dinushan Nesan
    University of Waterloo, Department of Biology, 200 University Avenue West, Waterloo, Ontario, Canada
    Endocrinology 153:1288-300. 2012
    ..This correlated with altered expression of myogenic markers, including myogenin, myostatin, and muscle-specific myosin heavy chain and troponin genes...
  41. pmc Ccdc80-l1 Is involved in axon pathfinding of zebrafish motoneurons
    Chiara Brusegan
    Dipartimento di Biologia, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 7:e31851. 2012
    ..Indeed, we reported that ccdc80-l1 expression is positively regulated by the Hedgehog pathway in adaxial cells and muscle pioneers. These findings strongly indicate ccdc80-l1 as a down-stream effector of the Hedgehog pathway...
  42. pmc Wdr68 requires nuclear access for craniofacial development
    Bingyan Wang
    Department of Biological Sciences, California State University Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e54363. 2013
    ..Dyrk1b is required for myogenin (myog) expression in differentiating mouse C2C12 cells and here we report that wdr68 is also important for myog ..
  43. pmc Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells
    Yen Hsing Li
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 115, Taiwan
    Sci Rep 3:1176. 2013
    ..In conclusion, we demonstrate a critical role for PGRN in the maintenance of MPC and suggest that muscle atrophy under PGRN loss may begin with MPC during postembryonic myogenesis...
  44. doi Sema4d is required for the development of the hindbrain boundary and skeletal muscle in zebrafish
    Jie Yang
    Cancer Biology Research Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Biochem Biophys Res Commun 433:213-9. 2013
    ..2, and two myogenic regulatory factors, myod and myog. Further, a notable increase of cell apoptosis appeared in the sema4d knockdown embryos, while no obvious reduction ..
  45. pmc Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish
    Ying Li
    CAS MPG Partner Institute for Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Comput Biol 9:e1002940. 2013
    ..Our study describes a systematic method to discover previously unidentified TFs involved in circadian physiology in complex organisms...
  46. pmc Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor Etv2
    Matthew B Veldman
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People s Republic of China
    PLoS Biol 11:e1001590. 2013
    ..Given the evolutionarily conserved function of this transcription factor and the responsiveness of mammalian myoblasts to Etv2, it is likely that mammalian muscle cells will respond similarly. ..
  47. doi Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution
    Anna Pistocchi
    Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy
    Development 140:1528-36. 2013
    ..We conclude that, during vertebrate evolution, the transcription factor Nfix lost some specific functions, probably as a consequence of the different environment in which teleosts and mammals develop...
  48. pmc Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis
    Narie Y Storer
    Stem Cell Program and Division of Hematology Oncology, Boston Children s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Development 140:3040-50. 2013
    ....
  49. pmc Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish
    Zizhen Yao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Biol Open 2:546-55. 2013
    ..Our findings provide an example of how Pbx homeodomain proteins act in a balance with other transcription factors to regulate subsets of a cellular differentiation program. ..
  50. pmc The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish
    Colleen E Albacker
    Stem Cell Program and Division of Hematology Oncology, Boston Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e64969. 2013
    ..Gene expression profiling at these stages revealed that in the context of KRAS(G12D) overexpression, SUV39H1 may suppress cell cycle progression. Our studies provide evidence for the role of SUV39H1 as a tumor suppressor...
  51. pmc The methyltransferases PRMT4/CARM1 and PRMT5 control differentially myogenesis in zebrafish
    Julie Batut
    Université de Toulouse Paul Sabatier, Centre de Biologie du Developpement, Toulouse, France
    PLoS ONE 6:e25427. 2011
    ..While PRMT5 regulates myod, myf5 and myogenin expression and thereby slow and fast fiber formation, PRMT4/CARM1 regulates myogenin expression, fast fiber ..
  52. pmc Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish
    Tomoaki Fujii
    Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Japan
    PLoS ONE 6:e23491. 2011
    ..heart-chamber markers including cmlc2, amhc and vmhc, and abnormal expression of myogenic regulatory factors including myod and myog. These data suggest that Smyd3 plays an important role in the development of heart and skeletal muscle.
  53. doi GH overexpression modifies muscle expression of anti-oxidant enzymes and increases spinal curvature of old zebrafish
    Carlos Eduardo da Rosa
    PPGCF FAC, Instituto de Ciencias Biologicas, Universidade Federal do Rio Grande, Brazil
    Exp Gerontol 45:449-56. 2010
    ..The results obtained here indicate that GH overexpression reduces the transcription of anti-oxidant defense system and myogenesis-related genes, which probably accelerates senescence in the zebrafish transgenic model used...
  54. ncbi Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo
    Marzanna Deniziak
    Institut de Biologie Moleculaire et Cellulaire, UPR ARN du CNRS Université Louis Pasteur, 15 rue Rene Descartes, 67084 Strasbourg, France
    Exp Cell Res 313:156-67. 2007
    ..Moreover, alteration of myofibrils architecture and tendon-like structure in embryo deficient for SelN function provide new insights into the pathological mechanism of SelN-related myopathy...
  55. doi The role of survivin2 in primitive hematopoiesis during zebrafish development
    A C H Ma
    Division of Haematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Leukemia 23:712-20. 2009
    ..In conclusion, sur2 is important in maintaining hematopoietic stem and lineage committed cells during zebrafish development, by virtue of its antiapoptotic activity in a caspase dependent and cell autonomous fashion...
  56. doi Feeding restriction alters expression of some ATP related genes more sensitively than the RNA/DNA ratio in zebrafish, Danio rerio
    Yoshitsugu Masuda
    National Research Institute of Aquaculture, Minami Ise, Mie, Japan
    Comp Biochem Physiol B Biochem Mol Biol 152:287-91. 2009
    ..levels of nucleoside diphosphate kinase (NDK)-Z2, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and myogenin genes of RE fish were higher than those of FR fish, although the RNA/DNA ratio and the protein/DNA ratio were ..
  57. doi Six1a is required for the onset of fast muscle differentiation in zebrafish
    Dmitri A Bessarab
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, Singapore
    Dev Biol 323:216-28. 2008
    ..In the six1a loss-of-function conditions, initiation of myog expression was compromised in fast muscle precursors whereas myod expression appeared unaffected suggestive of ..
  58. pmc Muscle development is disrupted in zebrafish embryos deficient for fibronectin
    Chelsi J Snow
    School of Biology and Ecology, University of Maine, Orono, Maine 04469 5735, USA
    Dev Dyn 237:2542-53. 2008
    ..Fast- and slow-twitch muscle lengths are also more frequently uncoupled. These data suggest that fn may function to regulate fiber organization and limit fast-twitch muscle fiber length...
  59. pmc The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis
    Thomas A Hawkins
    Department of Anatomy and Developmental Biology, UCL, London, UK
    Development 135:1147-56. 2008
    ..Our studies reveal a surprisingly specific developmental role for a single Hsp90 gene in a regulatory pathway controlling late steps in sarcomere assembly...
  60. pmc Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle
    Yaniv Hinits
    MRC Centre for Developmental Neurobiology and Randall Division of Cell and Molecular Biophysics, 4th Floor South, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, UK
    Gene Expr Patterns 7:738-45. 2007
    ..helix-loop-helix (bHLH) myogenic regulatory transcription factor (MRF) family, which also contains Myod, Myf5 and myogenin. Mrf4 is implicated in commitment of amniote cells to skeletal myogenesis and is also abundantly expressed in ..
  61. ncbi Cloning and expression analysis of myogenin from flounder (Paralichthys olivaceus) and promoter analysis of muscle-specific expression
    Peng Xu
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao, PR China
    Comp Biochem Physiol B Biochem Mol Biol 147:135-45. 2007
    b>Myogenin is a bHLH transcription factor of the MyoD family. It plays a crucial role in myoblast differentiation and maturation. We report here the isolation of flounder myogenin gene and the characterization of its expression patterns...
  62. ncbi Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression
    P J Schlueter
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Death Differ 14:1095-105. 2007
    ....
  63. doi skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization
    Huiqing Li
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt St, Baltimore, MD 21202, USA
    FASEB J 23:1988-2000. 2009
    ..Western blot analysis revealed that myosin protein levels were significantly reduced. Collectively, these results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation...
  64. ncbi Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish
    Sara A Carney
    Molecular and Environmental Toxicology Program, University of Wisconsin, Madison, Wisconsin 53705, USA
    Mol Pharmacol 70:549-61. 2006
    ..More than 70% of the transcripts in this heart-specific cluster promote cellular growth and proliferation. Thus, the developing heart stands out as being responsive to TCDD at both the level of toxicity and gene expression...
  65. ncbi Retinoic acid activates myogenesis in vivo through Fgf8 signalling
    Aline Hamade
    UMR866 Différenciation Cellulaire et Croissance, INRA, Montpellier, France
    Dev Biol 289:127-40. 2006
    ..DEAB reduces expression of the myogenic markers myoD and myogenin in somites, whereas RA induces increased expression of these genes and strongly induces premature myoD expression ..
  66. ncbi Effects of decreased muscle activity on developing axial musculature in nicb107 mutant zebrafish (Danio rerio)
    T van der Meulen
    Experimental Zoology Group, Wageningen Institute of Animal Sciences, Wageningen University, The Netherlands
    J Exp Biol 208:3675-87. 2005
    ..In addition, skin stiffness is affected. In conclusion, the lack of muscle fibre activity did not prevent the basal muscle components developing but influenced further organisation and differentiation of these components...
  67. ncbi Semaphorin-plexin signaling guides patterning of the developing vasculature
    Jesus Torres-Vazquez
    Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 7:117-23. 2004
    ..These results reveal the fundamental conservation of repulsive patterning mechanisms between axonal migration in the central nervous system and vascular endothelium during angiogenesis...
  68. ncbi Characterization of muscle-regulatory genes, Myf5 and myogenin, from striped bass and promoter analysis of muscle-specific expression
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Mar Biotechnol (NY) 4:537-45. 2002
    Myf5 and Myogenin are basic helix-loop-helix transcription factors that belong to the muscle regulatory factor (MRF) gene family, which plays important roles in regulating skeletal muscle development and growth...
  69. ncbi Treatment with Myf5-morpholino results in somite patterning and brain formation defects in zebrafish
    Yau Hung Chen
    Institute of Fisheries Science, National Taiwan University, 1 Roosevelt Road, Sec 4, Taipei, Taiwan
    Differentiation 70:447-56. 2002
    ..1 gene was completely down-regulated; myoD was expressed normally; myogenin was substantially down-regulated in whole somites; and desmin was partly inhibited in newly forming somites...
  70. ncbi Restricted expression of the zebrafish hsp90alpha gene in slow and fast muscle fiber lineages
    J B Sass
    Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Canada
    Int J Dev Biol 43:835-8. 1999
    ..Thus, hsp90alpha is expressed in developing muscle progenitors during short temporal and spatial windows of both slow and fast fiber lineages in the zebrafish somite...
  71. pmc Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors
    Matthew S Alexander
    Howard Hughes Medical Institute, Center for Life Science, Room CLS15027 1, Children s Hospital Boston, 3 Blackfan Circle, Boston, Massachusetts 02115, USA
    Muscle Nerve 43:741-50. 2011
    ..Although several protocols exist for the isolation of adult myoblast progenitors from larger fish, no standardized protocol exists for the isolation of myogenic progenitors from adult zebrafish muscle...
  72. pmc Lbx2 regulates formation of myofibrils
    Haruki Ochi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    BMC Dev Biol 9:13. 2009
    ..Tetrapods have two homologous genes (Lbx). Lbx1 functions in migration and/or proliferation of hypaxial myoblasts, whereas the function of Lbx2 is poorly understood...
  73. doi The transcription factor Six1a plays an essential role in the craniofacial myogenesis of zebrafish
    Cheng Yung Lin
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    Dev Biol 331:152-66. 2009
    ..Although Six1a was also necessary for myod and myogenin expression in head muscles, it did not affect myf5 expression in cranial muscles that originate from head ..
  74. pmc Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling
    Jin Ming Tee
    Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center, Utrecht, The Netherlands
    PLoS ONE 4:e5880. 2009
    ..Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis...
  75. doi Suppression of myostatin with vector-based RNA interference causes a double-muscle effect in transgenic zebrafish
    Chiou Yueh Lee
    Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, ROC
    Biochem Biophys Res Commun 387:766-71. 2009
    ..Also, the mRNA levels of myogenic regulatory factor markers such as MyoD, myogenin, Mrf4, and Myf5 were dramatically elevated in myostatin-suppressed transgenic fish compared to the non-transgenic ..
  76. pmc Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development
    Shuming Zou
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
    PLoS ONE 4:e7026. 2009
    ..These results not only provide new insights into the functional conservation and divergence of the multiple igf genes but also reveal a novel role of IGF signaling in midline formation and notochord development in a vertebrate model...
  77. doi FoxD5 mediates anterior-posterior polarity through upstream modulator Fgf signaling during zebrafish somitogenesis
    Hung Chieh Lee
    Institute of Molecular and Cellular Biology, National Taiwan University, Room 307, Fisheries Science Building, No 1, Section 4, Roosevelt Road, Taipei, Taiwan
    Dev Biol 336:232-45. 2009
    ..We concluded that FoxD5 is required for maintaining anterior-posterior polarity within a somite and that the striped pattern of FoxD5 in anterior PSM is mainly regulated by Fgf. An Fgf-FoxD5-Mesps signaling network is therefore proposed...
  78. pmc Hedgehog signaling and laminin play unique and synergistic roles in muscle development
    Matthew T Peterson
    School of Biology and Ecology, University of Maine, Orono, Maine 04469, USA
    Dev Dyn 239:905-13. 2010
    ..Finally, we present evidence that suggests that Hh signaling is indirectly required via slow fiber specification for recovery of fast fiber elongation in laminin gamma1 mutant embryos...
  79. pmc Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function
    Chandrashekara Mallappa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Cell Biol 30:3176-86. 2010
    ..The results implicate ATP-dependent chromatin remodelers in myogenic microRNA gene regulation...
  80. pmc Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish
    Jihua Yao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e10945. 2010
    ..We have examined the effects of the atoh8 gene on the differentiation of retina and skeletal muscle during early development in zebrafish...
  81. doi GH overexpression causes muscle hypertrophy independent from local IGF-I in a zebrafish transgenic model
    Rafael Y Kuradomi
    Programa de Pós Graduação em Aqüicultura, Instituto de Oceanografia, FURG, Rio Grande, Brazil
    Transgenic Res 20:513-21. 2011
    ..In addition, transgenic males exhibited significant induction of myogenin gene (myog) expression, indicating that myog may mediate hypertrophic growth in zebrafish males overexpressing GH...
  82. pmc Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding
    Peter J Lyons
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e12967. 2010
    ..If mutations in CPA6 contribute to Duane syndrome, our results also suggest that Duane syndrome can be a chondrogenic rather than a myogenic or neurogenic developmental disorder...
  83. pmc dickkopf-3-related gene regulates the expression of zebrafish myf5 gene through phosphorylated p38a-dependent Smad4 activity
    Ren Jun Hsu
    Institute of Molecular and Cellular Biology, National Taiwan University, No 1, Section 4, Roosevelt Road, Taipei 106, Taiwan
    J Biol Chem 286:6855-64. 2011
    ..Therefore, we concluded that Dkk3r regulates p38a phosphorylation to maintain Smad4 stability, in turn enabling the Smad2·Smad3a·Smad4 complex to form and activate the myf5 promoter...
  84. pmc Establishing zebrafish as a novel exercise model: swimming economy, swimming-enhanced growth and muscle growth marker gene expression
    Arjan P Palstra
    Departament de Fisiologia, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e14483. 2010
    ..Therefore, we have performed individual and group-wise swimming experiments to quantify swimming economy and to demonstrate the exercise effects on growth in adult zebrafish...
  85. doi Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability
    Hiroyasu Kamei
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Development 138:777-86. 2011
    ..These results suggest that the evolutionarily conserved IGF signaling pathway coordinates growth and temporal development in zebrafish embryos in response to oxygen availability...
  86. pmc CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Biol Chem 286:12483-94. 2011
    ..CTCF enhances the myogenic potential of MyoD and myogenin and establishes direct interactions with MyoD, indicating that CTCF regulates MRF-mediated muscle differentiation...

Research Grants2

  1. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  2. Selecting for novel Hedgehog signaling mutations
    STEPHEN DEVOTO; Fiscal Year: 2006
    ..In addition, these mutations will identify genes that are likely to play important roles in the development of human cancer. ..