myod1

Summary

Gene Symbol: myod1
Description: myogenic differentiation 1
Alias: etID309723.25, myod, wu:fb57a01, zgc:136744, myoblast determination protein 1 homolog, myoblast determination 1, myogenic factor 1
Species: zebrafish

Top Publications

  1. ncbi Retinoic acid activates myogenesis in vivo through Fgf8 signalling
    Aline Hamade
    UMR866 Différenciation Cellulaire et Croissance, INRA, Montpellier, France
    Dev Biol 289:127-40. 2006
  2. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
  3. doi Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation
    Takamasa Mizoguchi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima, Japan
    Development 135:2521-9. 2008
  4. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
  5. ncbi The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
  6. ncbi A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula
    M Fürthauer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France
    Development 124:4253-64. 1997
  7. ncbi Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation
    Xuesong Feng
    Department of Biology, Wesleyan University, Middletown, CT 06459, USA
    Dev Biol 300:736-46. 2006
  8. doi Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos
    Xiang Li
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 114:5464-72. 2009
  9. pmc Cdkn1c drives muscle differentiation through a positive feedback loop with Myod
    Daniel P S Osborn
    King s College London, Randall Division for Cell and Molecular Biophysics, London, UK
    Dev Biol 350:464-75. 2011
  10. ncbi Zebrafish scl functions independently in hematopoietic and endothelial development
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Dev Biol 277:522-36. 2005

Detail Information

Publications180 found, 100 shown here

  1. ncbi Retinoic acid activates myogenesis in vivo through Fgf8 signalling
    Aline Hamade
    UMR866 Différenciation Cellulaire et Croissance, INRA, Montpellier, France
    Dev Biol 289:127-40. 2006
    ..DEAB reduces expression of the myogenic markers myoD and myogenin in somites, whereas RA induces increased expression of these genes and strongly induces premature myoD ..
  2. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
    ..1 in the bloodless mutant cloche resulted in myelopoietic rescue, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis...
  3. doi Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation
    Takamasa Mizoguchi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima, Japan
    Development 135:2521-9. 2008
    ....
  4. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells...
  5. ncbi The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
    ....
  6. ncbi A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula
    M Fürthauer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France
    Development 124:4253-64. 1997
    ..We conclude that FGF-8 is involved in defining dorsoventral identity and is an important organizing factor responsible for specification of mesodermal and ectodermal dorsolateral territories of the zebrafish gastrula...
  7. ncbi Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation
    Xuesong Feng
    Department of Biology, Wesleyan University, Middletown, CT 06459, USA
    Dev Biol 300:736-46. 2006
    ..We propose that Hedgehog signaling acts at multiple times on different lineages, through different downstream pathways, to promote myogenic differentiation...
  8. doi Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos
    Xiang Li
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 114:5464-72. 2009
    ..We conclude that Mta3-NuRD complex is essential for the initiation of primitive hematopoiesis. Thus, our findings provide new insight into the regulatory hierarchy of primitive hematopoiesis in vertebrates...
  9. pmc Cdkn1c drives muscle differentiation through a positive feedback loop with Myod
    Daniel P S Osborn
    King s College London, Randall Division for Cell and Molecular Biophysics, London, UK
    Dev Biol 350:464-75. 2011
    ..myogenesis in the vertebrate somite, in part by raising the activity of muscle regulatory factors (MRFs) of the Myod family above a threshold. Hh is known to enhance MRF expression...
  10. ncbi Zebrafish scl functions independently in hematopoietic and endothelial development
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Dev Biol 277:522-36. 2005
    ..Surprisingly, in cloche, lmo2 was not induced in response to scl over-expression. Taken together, these findings support distinct roles for scl in hematopoietic and endothelial development, downstream of hemangioblast development...
  11. ncbi The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors
    Ian C Scott
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 12:403-13. 2007
    ..These results support a model in which agtrl1b regulates the migration of cells fated to form myocardial progenitors...
  12. doi Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells
    A C Binot
    GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
    Dev Biol 340:397-407. 2010
    ..On the basis of our data, we propose a model in which nkx6.1 and nkx6.2, by allowing the establishment of the endocrine progenitor pool, control alpha- and beta-cell differentiation...
  13. ncbi sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development
    C T Miller
    Institute of Neuroscience, Eugene, OR 97403 1254, USA
    Development 127:3815-28. 2000
    ..Ventral premyogenic condensations fail to express myoD, which correlates with a ventral muscle defect...
  14. ncbi Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo
    Georgina E Hollway
    The Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Dev Cell 12:207-19. 2007
    ..We also show that formation of this compartment occurs via whole-somite rotation, a process that requires the action of the Sdf family of secreted cytokines...
  15. ncbi Differential regulation of chordin expression domains in mutant zebrafish
    V E Miller-Bertoglio
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Dev Biol 192:537-50. 1997
    ..1989), while axial mesodermal expression was affected. This finding reveals an unexpected function for spadetail in midline mesoderm and in differential regulation of chordin expression during gastrulation...
  16. ncbi Heparan sulfate 6-o-sulfotransferase is essential for muscle development in zebrafish
    Robert J Bink
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    J Biol Chem 278:31118-27. 2003
    ..In conclusion, our results show that transfer of sulfate to specific positions on glycosaminoglycans is essential for muscle development...
  17. ncbi Characterization of hey bHLH genes in teleost fish
    Christoph Winkler
    Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    Dev Genes Evol 213:541-53. 2003
    ..Overexpression of dlD on the other hand results in the ectopic expression of hey1 in the axial mesoderm. Hence, hey1 represents a target of Delta-Notch signaling dynamically expressed during somite formation in zebrafish...
  18. ncbi Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction
    Jared W Ragland
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 276:16-30. 2004
    ....
  19. ncbi Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish
    Julie A Groves
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Development 132:4211-22. 2005
    ..Here, we show that Fgf8 signalling in the somite is required for myod expression and terminal differentiation of a subset of fast muscle cells in the zebrafish lateral somite...
  20. ncbi Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites
    Akinori Kawamura
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    Dev Cell 9:735-44. 2005
    ..Thus, ripply1 plays dual roles in the transition from the PSM to somites: termination of the segmentation program in the PSM and maintenance of the rostrocaudal polarity...
  21. ncbi Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis
    Thomas J Carney
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 134:3461-71. 2007
    ..Our work provides direct genetic evidence for antagonistic in vivo roles of Hai1 and Matriptase1a to regulate skin homeostasis and remodeling...
  22. ncbi Growth in the larval zebrafish pectoral fin and trunk musculature
    Sara E Patterson
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    Dev Dyn 237:307-15. 2008
    ..Our results suggest that regulation of fiber type development and muscle growth may differ in the pectoral fin and trunk...
  23. pmc Bmp2 signaling regulates the hepatic versus pancreatic fate decision
    Won Suk Chung
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 15:738-48. 2008
    ..These data provide in vivo evidence for the existence of bipotential hepatopancreatic progenitors and indicate that their fate is regulated by the medio-lateral patterning of the endodermal sheet, a process controlled by Bmp2b...
  24. doi Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation
    Jungwon Seo
    Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Cell Biochem 110:1022-37. 2010
    ..Furthermore, non-canonical Wnt signaling may coordinate vertebrate CE movements by triggering Jnk activation that represses the expression of the CE-triggering ligand wnt11...
  25. doi Segment number and axial identity in a segmentation clock period mutant
    Christian Schroter
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Curr Biol 20:1254-8. 2010
    ....
  26. pmc The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis
    Vladislav S Golubkov
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:35740-9. 2010
    ..Further insight into these novel mechanisms may promote understanding of directional cell motility and lead to the identification of therapeutics to treat PCP-related developmental disorders and malignancy...
  27. pmc Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence
    Jianfeng Zhou
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e3926. 2008
    ..Elevated expression of IGFBP-2 is often associated with progression of many types of cancers...
  28. ncbi Zebrafish foxd3 is selectively required for neural crest specification, migration and survival
    Rodney A Stewart
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:174-88. 2006
    ....
  29. ncbi Apelin and its receptor control heart field formation during zebrafish gastrulation
    Xin Xin I Zeng
    Vanderbilt University, Department of Biological Sciences, VU Station B 35 1634, Nashville, TN 37235, USA
    Dev Cell 12:391-402. 2007
    ..Our results implicate GPCR signaling in movements of discrete cell populations that establish organ rudiments during vertebrate gastrulation...
  30. pmc The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis
    Jennifer A Tucker
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Cell 14:108-19. 2008
    ..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously...
  31. ncbi Guidance of primordial germ cell migration by the chemokine SDF-1
    Maria Doitsidou
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    Cell 111:647-59. 2002
    ..Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs...
  32. doi Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling
    Rebecca C Coyle
    Department of Medicine Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Exp Cell Res 314:2150-62. 2008
    ..Together, our results support the notion that pathways regulating pericellular proteolysis and cell polarity converge to promote efficient cell migration...
  33. doi Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo
    Esther Schnapp
    Stem Cell Research Institute, DIBIT, San Raffaele Scientific Institute, 58 Via Olgettina, 20132 Milan, Italy
    J Cell Sci 122:481-8. 2009
    ..all vertebrates, but their role has been studied in great detail only in the mouse embryo, where all but myogenin--Myod, Myf5 and Mrf4--are sufficient to activate (albeit not completely) skeletal myogenesis...
  34. doi The transcription factor Six1a plays an essential role in the craniofacial myogenesis of zebrafish
    Cheng Yung Lin
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    Dev Biol 331:152-66. 2009
    ..Although Six1a was also necessary for myod and myogenin expression in head muscles, it did not affect myf5 expression in cranial muscles that originate from ..
  35. pmc VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish
    Annie Reynolds
    Department of Obstetrics and Gynecology, CHU Sainte Justine Research Center and University of Montreal, Montreal, Quebec, Canada H3T 1C5
    Mech Dev 127:385-92. 2010
    ..Our study demonstrates a high degree of functional conservation of VANGL genes across evolution and provides a model system for studying potential variants identified in human NTDs...
  36. doi Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa
    Bastian Linder
    Department of Biochemistry, University of Wurzburg, Wurzburg, Germany
    Hum Mol Genet 20:368-77. 2011
    ..Hence, various routes affecting the tri-snRNP can elicit tissue-specific gene expression defects and lead to the RP phenotype...
  37. pmc Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression
    Naznin Sultana
    Departments of Biological Sciences and Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Proc Natl Acad Sci U S A 105:4763-8. 2008
    ..5 expression, which in turn promotes unidirectional, parallel alignment of myofibrils and the subsequent proper heart morphogenesis...
  38. pmc An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes
    Chunmei Li
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    PLoS Genet 4:e1000044. 2008
    ..Our findings therefore implicate MIP-T3 in a previously unknown but critical role in cilium biogenesis and further highlight the emerging role of this organelle in vertebrate development...
  39. pmc Identification of a novel retinoid by small molecule screening with zebrafish embryos
    Chetana Sachidanandan
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 3:e1947. 2008
    ....
  40. ncbi Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90
    Z Lele
    Department of Anatomy and Cell Biology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada
    Dev Biol 210:56-70. 1999
    ..The data are consistent with there being a temporal and spatial requirement for Hsp90 function within somitic cells which is necessary for the formation of eng-2-expressing muscle pioneers and possibly other striated muscle fiber types...
  41. ncbi Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development
    Ujwal J Pyati
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Development 132:2333-43. 2005
    ..We conclude that the role of Bmp signaling in the ventral and posterior mesoderm changes as gastrulation proceeds...
  42. ncbi Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity
    Ricardo G Correa
    The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Curr Biol 15:1291-5. 2005
    ..Here, we report that Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB...
  43. pmc Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation
    Takashi Akanuma
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    EMBO Rep 8:858-63. 2007
    ..Therefore, zebrafish homologues of the yeast Paf1 complex seem to preferentially affect a subset of genes, including Notch-regulated genes, during embryogenesis...
  44. doi Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish
    Sandra Van't Padje
    CBG Department of Clinical Genetics, Erasmus MC, 3015 CE Rotterdam, The Netherlands
    J Exp Biol 212:2564-70. 2009
    ..This cardiac phenotype has not been previously described and suggests that fxr1 is essential for normal cardiac form and function...
  45. doi N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling
    Fang Xu
    Model Animal Research Center, MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing 210061, China
    Mech Dev 126:771-80. 2009
    ..Taken together, our results demonstrate that N-CoR is essential for early hindbrain patterning by actively repressing retinoid signaling...
  46. doi The predominant protein arginine methyltransferase PRMT1 is critical for zebrafish convergence and extension during gastrulation
    Yun Jung Tsai
    Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan
    FEBS J 278:905-17. 2011
    ..The results obtained in the present study demonstrate a direct link of early development with protein arginine methylation catalyzed by PRMT1...
  47. doi Alkali-like myosin light chain-1 (myl1) is an early marker for differentiating fast muscle cells in zebrafish
    A C Burguière
    Umeå Centre for Molecular Medicine, UCMM, Umea University, Umea, Sweden
    Dev Dyn 240:1856-63. 2011
    ..3. In summary, this study introduces a novel marker for early differentiating fast muscle cells...
  48. pmc Ptena and ptenb genes play distinct roles in zebrafish embryogenesis
    Jessica A Croushore
    Department of Pharmacology, Penn State University College of Medicine, Hershey, 17033, USA
    Dev Dyn 234:911-21. 2005
    ..These results indicate that ptena and ptenb encode functional enzymes and that each pten gene plays a distinct role during zebrafish embryogenesis...
  49. pmc Notch signaling functions as a cell-fate switch between the endothelial and hematopoietic lineages
    Christina Y Lee
    McAllister Heart Institute, Department of Cell and Molecular Physiology, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Biol 19:1616-22. 2009
    ....
  50. doi RPTPalpha and PTPepsilon signaling via Fyn/Yes and RhoA is essential for zebrafish convergence and extension cell movements during gastrulation
    Mark van Eekelen
    Hubrecht Institute KNAW and University Medical Center Utrecht, The Netherlands
    Dev Biol 340:626-39. 2010
    ..Our results demonstrate that RPTPalpha and PTPepsilon are essential for C&E movements in a signaling pathway parallel to non-canonical Wnts and upstream of Fyn, Yes and RhoA...
  51. pmc Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations
    Yaniv Hinits
    Randall Division for Cell and Molecular Biophysics and MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, SE1 1UL, UK
    Development 136:403-14. 2009
    Myogenic regulatory factors of the Myod family (MRFs) are transcription factors essential for mammalian skeletal myogenesis...
  52. ncbi Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
    M Hammerschmidt
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 10:647-58. 1996
    ..These results, together with epistasis studies on the block of ectopic Hh signaling by PKA*, indicate that PKA acts in target cells as a common negative regulator of Hedgehog signaling...
  53. ncbi Specific localization of zebrafish hsp90 alpha mRNA to myoD-expressing cells suggests a role for hsp90 alpha during normal muscle development
    J B Sass
    Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Canada
    Mech Dev 54:195-204. 1996
    ..Several of the molecules with which hsp90 interacts, such as the bHLH transcription factor myoD, are known to be important regulators of developmental events in vertebrates...
  54. ncbi Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
    ..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield...
  55. ncbi Genetic interactions in zebrafish midline development
    M E Halpern
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Dev Biol 187:154-70. 1997
    ..From these findings we propose that ntl+ plays an early role in cell fate choice at the dorsal midline, mediated by the Ntl protein acting to antagonize floor plate development as well as to promote notochord development...
  56. ncbi Specification of the hindbrain fate in the zebrafish
    K Woo
    Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 197:283-96. 1998
    ..These results suggest that planar induction may constitute a significant component in the zebrafish neural patterning pathway...
  57. ncbi Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish
    E A Ober
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, Tubingen, 72076, Germany
    Dev Biol 215:167-81. 1999
    ..In addition, these experiments show that the establishment of the anteroposterior axis is independent of the dorsoventral axis...
  58. ncbi Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation
    B Schmid
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, Philadelphia, PA 19104 6058, USA
    Development 127:957-67. 2000
    ....
  59. ncbi Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites
    A Sawada
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Development 127:1691-702. 2000
    ..These embryos show a reduction in expression of the posterior genes, myoD and notch5, with uniform expression of the anterior genes, FGFR1, papc and notch6...
  60. ncbi Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish
    L Durbin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Development 127:1703-13. 2000
    ....
  61. ncbi Treatment with Myf5-morpholino results in somite patterning and brain formation defects in zebrafish
    Yau Hung Chen
    Institute of Fisheries Science, National Taiwan University, 1 Roosevelt Road, Sec 4, Taipei, Taiwan
    Differentiation 70:447-56. 2002
    ..1 gene was completely down-regulated; myoD was expressed normally; myogenin was substantially down-regulated in whole somites; and desmin was partly inhibited ..
  62. ncbi Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Comp Biochem Physiol B Biochem Mol Biol 134:123-34. 2003
    ..In addition, because these regulatory elements control myogenin expression in mouse and human embryos, these data suggest that the regulatory mechanism controlling myogenin expression might be conserved during evolution...
  63. ncbi cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
    Alan J Davidson
    Department of Medicine, Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Nature 425:300-6. 2003
    ..Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis...
  64. ncbi Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo
    Y Nakano
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Dev Biol 269:381-92. 2004
    ....
  65. ncbi Receptor tyrosine phosphatase psi is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm
    Birgit Aerne
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 131:3391-9. 2004
    ..Impairing RPTPpsi activity also interferes with convergent extension during gastrulation. We discuss this dual requirement for RPTPpsi in terms of potential functions in Notch and Wnt signalling...
  66. pmc The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish
    Ian G Woods
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 3:e66. 2005
    ..Our positional cloning and functional studies demonstrate that You is a novel extracellular component of the Hedgehog pathway in vertebrates...
  67. pmc Cooperative function of deltaC and her7 in anterior segment formation
    Andrew C Oates
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Biol 280:133-49. 2005
    ..Thus, anterior segmentation requires the functions of both her and delta family members in a parallel manner, suggesting that the segmentation oscillator operates in paraxial mesoderm along the entire vertebrate axis...
  68. ncbi Neuronal calcium sensor-1 gene ncs-1a is essential for semicircular canal formation in zebrafish inner ear
    Brian Blasiole
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Neurobiol 64:285-97. 2005
    ..These studies identify a novel function for ncs-1a in inner ear development and suggest that this calcium sensor plays an important role in vestibular function...
  69. pmc Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites
    Akinori Kawamura
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    Genes Dev 19:1156-61. 2005
    ..Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1...
  70. ncbi A 23-amino acid motif spanning the basic domain targets zebrafish myogenic regulatory factor myf5 into nucleolus
    Yun Hsin Wang
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan, Republic of China
    DNA Cell Biol 24:651-60. 2005
    ..In contrast, zebrafish MyoD-EGFP was localized in the nucleus but did not condense in the nucleolus...
  71. ncbi Induction and prepatterning of the zebrafish pectoral fin bud requires axial retinoic acid signaling
    Yann Gibert
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Konstanz, Germany
    Development 133:2649-59. 2006
    ..Thus, RA signaling from flanking somites plays a dual early role in the condensing limb bud mesenchyme...
  72. ncbi Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction
    Nadia Mercader
    European Molecular Biology Laboratory EMBL Heidelberg, Germany
    Development 133:2805-15. 2006
    ..tbx5 is required for Fgf signaling in the limb bud leading to activation of prdm1 expression, which in turn is required for downstream activation of fgf10 expression...
  73. pmc Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish
    Christina L Hammond
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Dev Biol 302:504-21. 2007
    ..Pax3 is required upstream of myod for lateral dermomyotomal cells in the amniote somite to form particular muscle cells...
  74. pmc Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord
    Isaac Skromne
    Department of Organismal Biology and Anatomy, The University of Chicago, 1027 E 57th Street R107, Chicago, IL 60637, USA
    Development 134:2147-58. 2007
    ..We propose that by preventing the posterior-most region of the neural plate from following a hindbrain developmental program, Cdx factors help determine the size of the prospective hindbrain and spinal cord territories...
  75. pmc The chemokine Sdf-1 and its receptor Cxcr4 are required for formation of muscle in zebrafish
    Shang Wei Chong
    Laboratory of Fish Developmental Biology, Institute of Molecular and Cell Biology, Proteos, Singapore
    BMC Dev Biol 7:54. 2007
    ..During development cell migration takes place prior to differentiation of many cell types. The chemokine receptor Cxcr4 and its ligand Sdf1 are implicated in migration of several cell lineages, including appendicular muscles...
  76. ncbi A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
    Bhylahalli P Srinivas
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Nat Genet 39:781-6. 2007
    ..These findings uncover a substantial degree of evolutionary conservation in the genetic regulation of myoblast fusion...
  77. ncbi Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
    Jantje M Gerdes
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 39:1350-60. 2007
    ....
  78. pmc Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle
    Michael J Jurynec
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 105:12485-90. 2008
    ....
  79. pmc Knockdown of a galectin-1-like protein in zebrafish (Danio rerio) causes defects in skeletal muscle development
    Hafiz Ahmed
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
    Glycoconj J 26:277-83. 2009
    ....
  80. pmc Dusp-5 and Snrk-1 coordinately function during vascular development and disease
    Kallal Pramanik
    Department of Pediatrics, Children s Research Institute Developmental Vascular Biology Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 113:1184-91. 2009
    ..Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease...
  81. doi Specification of vertebrate slow-twitch muscle fiber fate by the transcriptional regulator Blimp1
    Hoe Peng Liew
    Institute of Molecular and Cell Biology, Cancer and Developmental Cell Biology Division, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
    Dev Biol 324:226-35. 2008
    ..Taken together, these findings provide new insights into the molecular basis of vertebrate muscle fiber-type specification, and underscore Blimp1 as the central determinant of this process...
  82. doi skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization
    Huiqing Li
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt St, Baltimore, MD 21202, USA
    FASEB J 23:1988-2000. 2009
    ..Western blot analysis revealed that myosin protein levels were significantly reduced. Collectively, these results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation...
  83. ncbi Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish
    L Solnica-Krezel
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:67-80. 1996
    ..These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates...
  84. ncbi Mutations affecting the formation of the notochord in the zebrafish, Danio rerio
    J Odenthal
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:103-15. 1996
    ..In addition to the four mutants with defects in early notochord formation, we have isolated 84 mutants, defining at least 15 genes, with defects in later stages of notochord development. These are listed in an appendix to this study...
  85. ncbi Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
    F Reifers
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 125:2381-95. 1998
    ..Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others...
  86. pmc Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm
    A Yamamoto
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, California 90095 1662, USA
    Development 125:3389-97. 1998
    ..The PAPC structural cell-surface protein may provide a link between regulatory transcription factors and the actual cell biological behaviors that execute morphogenesis during gastrulation...
  87. pmc Eph signaling is required for segmentation and differentiation of the somites
    L Durbin
    Department of Anatomy and Developmental Biology, University College, London, WC1E 6BT, UK
    Genes Dev 12:3096-109. 1998
    ..Interruption of Eph signaling leads to abnormal somite boundary formation and reduced or disturbed myoD expression in the myotome...
  88. ncbi Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling
    K E Lewis
    Krebs Institute, University of Sheffield, United Kingdom
    Dev Biol 216:469-80. 1999
    ....
  89. ncbi Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway
    V H Nguyen
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, 421 Curie Blvd, Philadelphia, PA 19104 6058, USA
    Development 127:1209-20. 2000
    ....
  90. ncbi The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity
    M J Barresi
    Biology Department, Wesleyan University, Middletown, CT 06459, USA
    Development 127:2189-99. 2000
    ..Therefore, Hedgehog signaling through Slow-muscle-omitted is necessary for slow muscle fiber type development. We propose that smu encodes a vital component in the Hedgehog response pathway...
  91. ncbi The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain
    G Begemann
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Western Bank, UK
    Development 128:3081-94. 2001
    ....
  92. ncbi Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists
    Daniel S Wagner
    Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Dev Biol 245:109-23. 2002
    ..As has been proposed for the fly orthologue of chordin, short gastrulation, our paradoxical results can be explained by a model whereby Chordin both antagonizes and promotes BMP activity...
  93. ncbi Differential expression of two MyoD genes in fast and slow muscles of gilthead seabream ( Sparus aurata)
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Dev Genes Evol 212:207-17. 2002
    ..We have demonstrated that seabream contain two distinct non-allelic MyoDgenes, MyoD1 and MyoD2. Sequence analysis revealed that these two MyoD genes shared a similar gene structure...
  94. pmc Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
    Jason R Jessen
    Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235, USA
    Nat Cell Biol 4:610-5. 2002
    ..We propose Trilobite/Stbm mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis...
  95. ncbi Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    Rolf O Karlstrom
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 130:1549-64. 2003
    ..These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets...
  96. ncbi Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
    Filipa Carreira-Barbosa
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:4037-46. 2003
    ..In addition, Pk1 interacts with Tri to mediate posterior migration of branchiomotor neurons, probably independent of the noncanonical Wnt pathway...
  97. ncbi Regulation of Msx genes by a Bmp gradient is essential for neural crest specification
    Celeste Tribulo
    Millennium Nucleus in Developmental Biology, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Development 130:6441-52. 2003
    ..We propose a model where a gradient of Bmp activity specifies the expression of Msx genes in the neural folds, and that this expression is essential for the early specification of the neural crest...
  98. ncbi Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome
    Fernando Cortes
    Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Edinburgh EH4 2XU, Scotland, UK
    Dev Cell 5:865-76. 2003
    ..Removing or altering the expression of either protein within the myotome perturbs migration. These results provide a definitive example of homophilic cell adhesion shaping cellular behavior during vertebrate development...
  99. ncbi Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation
    Jeroen Bakkers
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 131:525-37. 2004
    ..In addition, they suggest that the same HA pathways are active to auto-stimulate cell migration during tumor invasion and vertebrate embryogenesis...
  100. ncbi fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos
    Ying Cao
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Biol 271:130-43. 2004
    ..Like fgf8, activation of fgf17b expression depends on Nodal signaling...
  101. ncbi Role of BMP signaling and the homeoprotein Iroquois in the specification of the cranial placodal field
    Alvaro Glavic
    Millennium Nucleus in Developmental Biology, Laboratory of Developmental Biology, Facultad de Ciencias, Universidad de Chile, Santiago
    Dev Biol 272:89-103. 2004
    ....

Research Grants9

  1. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  2. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2005
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  3. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007
    ..Thus it is critical to identify and study all the genetic players in this process. ..
  4. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2009
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  5. Molecular Control of Pituitary Development and Tumorigenesis
    Rolf O Karlstrom; Fiscal Year: 2010
    ..Comment [MB1]: I assume that stat is in the US? I would insert US here, given that you are applying for PHS money. ..
  6. A Screen For Drugs:Promote Oligodendrocyte Formatio(RMI)
    Bruce Appel; Fiscal Year: 2005
    ..Neural diseases and injuries have devastating impacts on human health. This work will provide a foundation for identifying and investigating genes and drugs that promote neural regeneration and recovery. ..
  7. BIOLOGY OF BAMACAN IN TUMORIGENESIS
    Giancarlo Ghiselli; Fiscal Year: 2006
    ..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
  8. Role of cdx genes and RA in regionalizing the endoderm
    MARY KINKEL; Fiscal Year: 2007
    ..Finally, I will investigate the role of RA signaling in regulating Cdx genes utilizing loss-of-function approaches as well as treatment with exogenous RA. ..
  9. Genetic Analysis of the Zebrafish Somitogenesis Oscillator
    Scott A Holley; Fiscal Year: 2010
    ..Using timelapse imaging and celt tracking, we will determine the velocity. direction and neighbor relationships of celts in different rQ9ions of the tail bud. ..