myh6

Summary

Gene Symbol: myh6
Description: myosin, heavy chain 6, cardiac muscle, alpha
Alias: amhc, myosin-7, atrial myosin heavy chain, cardiac muscle myosin heavy chain 6 alpha, myosin, heavy polypeptide 6, cardiac muscle, alpha, unm s459, unm_s459, wea, weak atrium
Species: zebrafish

Top Publications

  1. ncbi Mutations affecting the cardiovascular system and other internal organs in zebrafish
    J N Chen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:293-302. 1996
  2. ncbi Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    Eli Berdougo
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 130:6121-9. 2003
  3. ncbi Organization of cardiac chamber progenitors in the zebrafish blastula
    Brian R Keegan
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 131:3081-91. 2004
  4. pmc Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish
    Adam D Langenbacher
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:17699-704. 2005
  5. ncbi Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart
    Wolfgang Rottbauer
    Department of Medicine III, University of Heidelberg, Germany
    Circ Res 99:323-31. 2006
  6. pmc Functional modulation of cardiac form through regionally confined cell shape changes
    Heidi J Auman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Biol 5:e53. 2007
  7. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
  8. pmc Genetic and physiologic dissection of the vertebrate cardiac conduction system
    Neil C Chi
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 6:e109. 2008
  9. doi Cascade effect of cardiac myogenesis gene expression during cardiac looping in tbx5 knockdown zebrafish embryos
    Jen Her Lu
    Department of Pediatrics and Pediatric Cardiology, Veterans General Hospital Taipei, National Yang Ming University, Taipei, Taiwan, ROC
    J Biomed Sci 15:779-87. 2008
  10. pmc Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number
    KIMARA L TARGOFF
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 322:314-21. 2008

Research Grants

Scientific Experts

  • W Rottbauer
  • Anja Bühler
  • Melanie Philipp
  • Olga Svarcova
  • Yu Hisano
  • Priya Choudhry
  • Kelly A Smith
  • John P Incardona
  • Atsuo Kawahara
  • Huang Chieh Lee
  • Ian C Scott
  • Engda G Hagos
  • Lisa Maves
  • Haigen Huang
  • Neil C Chi
  • Deborah Yelon
  • Joshua S Waxman
  • Steffen Just
  • KIMARA L TARGOFF
  • Hugo A Katus
  • Didier Y R Stainier
  • Enrico D'Aniello
  • Jeroen Bakkers
  • Kota Y Miyasaka
  • Todd Evans
  • Sara R Marques
  • Jau Nian Chen
  • Vanessa George
  • Adam D Langenbacher
  • Yi Fan Lin
  • Tracy E Dohn
  • Sabine Marquart
  • Benjamin Meder
  • Anne Karine Lagendijk
  • Yuexiang Wang
  • Qiu Jiang
  • Audrey Holtzinger
  • Catherine T Nguyen
  • Jen Her Lu
  • Wen Der Wang
  • Yao Xiao
  • Haibo Jia
  • Pauline Sallin
  • Rebecca Powell
  • Tao P Zhong
  • Xueqian Wang
  • Yanli Zhang
  • Ariel Rydeen
  • Houyan Song
  • Xin Wang
  • Sophie Colombo
  • Junbo Li
  • Eleanor Y Chen
  • Xiangjun Tong
  • Stamatia Kalogirou
  • Che Yi Lin
  • Brian R Keegan
  • Xuejie Wang
  • Jaime Espina
  • Emily S Noël
  • Meifang Wu
  • Iris I Müller
  • Mollie R J Sorrell
  • Natasha Novikov
  • Jan Haas
  • Ruilin Zhang
  • Wei Wang
  • Tzu Chun Tsai
  • Corinna Singleman
  • Johannes Backs
  • Britta Vogel
  • Andreas Keller
  • Nicole O Glenn
  • Chiara Tobia
  • Dao Jie Xu
  • Jun K Takeuchi
  • Savo Lazic
  • Joshua D Wythe
  • Chinmoy Patra
  • Filipa Costa Simões
  • Tomoaki Fujii
  • Francesco Argenton
  • Ina M Berger
  • Nadine M Wolf
  • Thomas Wieland
  • Anya Sedletcaia
  • Samantha Maragh
  • Eva Patzel
  • Thomas Schell
  • Sie Lin Choo

Detail Information

Publications103 found, 100 shown here

  1. ncbi Mutations affecting the cardiovascular system and other internal organs in zebrafish
    J N Chen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:293-302. 1996
    ..The mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis...
  2. ncbi Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    Eli Berdougo
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 130:6121-9. 2003
    ..As weak atrium/atrial myosin heavy chain is expressed only in the atrium, the ventricular phenotypes in weak atrium mutants represent a secondary ..
  3. ncbi Organization of cardiac chamber progenitors in the zebrafish blastula
    Brian R Keegan
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 131:3081-91. 2004
    ..Indeed, via fate mapping, we demonstrate that Nodal signaling promotes ventricular fate specification near the margin, thereby playing an important early role during myocardial patterning...
  4. pmc Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish
    Adam D Langenbacher
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:17699-704. 2005
    ..These data signify the essential role of calcium homeostasis and NCX1h in establishing rhythmic contraction in the embryonic zebrafish heart...
  5. ncbi Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart
    Wolfgang Rottbauer
    Department of Medicine III, University of Heidelberg, Germany
    Circ Res 99:323-31. 2006
    ..Thus, our findings provide the first in vivo evidence that cardiac MLC-2 is required for thick-filament stabilization and contractility in the vertebrate heart...
  6. pmc Functional modulation of cardiac form through regionally confined cell shape changes
    Heidi J Auman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Biol 5:e53. 2007
    ..Together, these data establish regionally confined cell shape change as a cellular mechanism for chamber emergence and as a link in the relationship between form and function during organ morphogenesis...
  7. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
    ..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
  8. pmc Genetic and physiologic dissection of the vertebrate cardiac conduction system
    Neil C Chi
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 6:e109. 2008
    ....
  9. doi Cascade effect of cardiac myogenesis gene expression during cardiac looping in tbx5 knockdown zebrafish embryos
    Jen Her Lu
    Department of Pediatrics and Pediatric Cardiology, Veterans General Hospital Taipei, National Yang Ming University, Taipei, Taiwan, ROC
    J Biomed Sci 15:779-87. 2008
    ..Expression of cardiac myogenesis genes amhc, vmhc and cmlc2 were expressed constantly at the early embryonic development and reached its highest rate right ..
  10. pmc Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number
    KIMARA L TARGOFF
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 322:314-21. 2008
    ..Our data suggest that morphogenetic errors could originate during early stages of heart tube assembly in patients with NKX2-5 mutations...
  11. pmc Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential
    Natalie A Thomas
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 135:3789-99. 2008
    ..Thus, Hh signaling plays an essential early role in defining the optimal number of cardiomyocytes, making it an attractive target for manipulation of multipotent progenitor cells...
  12. doi The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
    Atsuo Kawahara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Science 323:524-7. 2009
    ..Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration...
  13. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
    ..Therefore, our results offer new perspectives on the mechanisms regulating organ size and the possible causes of congenital syndromes affecting both the heart and forelimb...
  14. doi Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a
    Carmen Gloria Feijóo
    Center for Genomics of the Cell, Universidad de Chile, Santiago, Chile
    Mol Cell Neurosci 40:328-37. 2009
    ..Our results point to irx4a as a critical gene for numerous developmental processes and highlight its role in the formation of placodal derivatives in vertebrates...
  15. pmc Physical interaction between TBX5 and MEF2C is required for early heart development
    Tushar K Ghosh
    Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Mol Cell Biol 29:2205-18. 2009
    ..interaction between TBX5 and MEF2C leading to a synergistic activation of the alpha-cardiac myosin heavy chain (MYH6). Mutants of TBX5, TBX5G80R, and TBX5R279X that produce severe cardiac phenotypes impair the synergy...
  16. pmc Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 238:1207-13. 2009
    ..These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart...
  17. pmc Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, 2300 Children s Plaza M C 204, Chicago, IL 60614, USA
    Dev Biol 337:233-45. 2010
    ..These studies demonstrate that controlling the correct balance of Tbx5 activity is crucial for the specification of the AV boundary and valve formation...
  18. pmc Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart
    Julien Vermot
    Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California, United States of America
    PLoS Biol 7:e1000246. 2009
    ....
  19. doi Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish
    Savo Lazic
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Dev Biol 354:123-33. 2011
    ..Further, as congenital heart disease is often associated with defects in second heart field development, the embryological and genetic advantages of the zebrafish model can be applied to study the vertebrate second heart field...
  20. doi MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production
    Anne Karine Lagendijk
    Hubrecht Institute for Developmental Biology and Stem Cell Research, CT Utrecht, The Netherlands
    Circ Res 109:649-57. 2011
    ..Although roles for microRNAs in the myocardium during embryo development and cardiac disease have been demonstrated, very little is know about their role in the endocardium or during cardiac valve formation...
  21. pmc Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart
    Yi Fan Lin
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Biol 362:242-53. 2012
    ....
  22. ncbi Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points
    Sonja Chocron
    Cardiac Development and Genetics Group, Hubrecht Laboratory, Uppsalalaan 8, Utrecht, The Netherlands
    Dev Biol 305:577-88. 2007
    ..The identification of these two distinct and opposing activities of BMP signaling provides new insight into how BMP signaling can regulate LR patterning...
  23. pmc Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish
    Xianghu Qu
    Department of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:486-96. 2008
    ..Together, our studies reveal an essential role of ndrg4 in regulating proliferation and growth of cardiomyocytes, suggesting that ndrg4 may function downstream of tbx5 during heart development and growth...
  24. doi Celecoxib impairs heart development via inhibiting cyclooxygenase-2 activity in zebrafish embryos
    Dao Jie Xu
    Department of Anesthesiology, Xinhua Hospital, Medical School, Shanghai Jiaotong University, Shanghai, China
    Anesthesiology 114:391-400. 2011
    ..Although use of celecoxib is associated with increased cardiovascular risk in adults, its effect on fetal heart development remains unknown...
  25. doi Protein kinase D2 controls cardiac valve formation in zebrafish by regulating histone deacetylase 5 activity
    Steffen Just
    Department of Medicine II, University of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    Circulation 124:324-34. 2011
    ..The molecular mechanisms that guide heart valve formation are not well understood. However, elucidation of the genetic basis of congenital heart disease is one of the prerequisites for the development of tissue-engineered heart valves...
  26. pmc DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation
    Priya Choudhry
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e58145. 2013
    ..This is the first study linking tbx1 and non-canonical Wnt signaling and extends our understanding of DGS and heart development...
  27. pmc Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling
    Natasha Novikov
    Department of Surgery, Weill Cornell Medical College, Cornell University, 1300 York Ave, LC 708, New York, NY, USA
    Development 140:3787-98. 2013
    ..Tmem88a is a novel component of the regulatory mechanism controlling the second phase of biphasic WNT activity essential for embryonic cardiogenesis. ..
  28. doi Effects of low-level hexabromocyclododecane (HBCD) exposure on cardiac development in zebrafish embryos
    Meifang Wu
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, People s Republic of China
    Ecotoxicology 22:1200-7. 2013
    ..However, HBCD exposure did not significantly change the expression of Actc1l, Tnnt2, and Myh6, which are mainly muscle contractile genes that play key roles in the formation of cardiac structure...
  29. pmc Low temperature mitigates cardia bifida in zebrafish embryos
    Che Yi Lin
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
    PLoS ONE 8:e69788. 2013
    ..Our study reveals that temperature coordinates the development of the heart tube and somitogenesis, and that extracellular matrix genes (fibronectin 1, tenascin-c and tenascin-w) are involved...
  30. pmc Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development
    Yu Hisano
    Laboratory for Cardiovascular Molecular Dynamics, RIKEN Quantitative Biology Center, Furuedai 6 2 3, Suita, Osaka 565 0874, Japan
    Biol Open 2:789-94. 2013
    ..These results strongly suggest that Spns2-S1PR2 signaling and fibronectin cooperatively regulate both cardiac and lower jaw development in zebrafish. ..
  31. doi A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality
    Emily S Noël
    Hubrecht Institute KNAW and University Medical Center Utrecht, 3584CT Utrecht, The Netherlands
    Nat Commun 4:2754. 2013
    ..We find that Nodal signalling regulates actin gene expression, supporting a model in which Nodal signalling amplifies this tissue-intrinsic mechanism of heart looping. ..
  32. doi Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish
    Xiangjun Tong
    1 Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, PR China 2
    Nat Commun 5:3153. 2014
    ..Our results reveal a new essential factor for cardiac development and suggest that KCTD10 could be considered as a new causative gene of congenital heart disease. ..
  33. pmc Excessive nitrite affects zebrafish valvulogenesis through yielding too much NO signaling
    Junbo Li
    Model Animal Research Center, Ministry of Education Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    PLoS ONE 9:e92728. 2014
    ..Taken together, our results show that excessive nitrite affects early valve leaflet formation by producing too much NO signaling. ..
  34. pmc Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma
    Eleanor Y Chen
    Departments of Pathology and Regenerative Medicine and the Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114
    Proc Natl Acad Sci U S A 111:5349-54. 2014
    ..In total, we have identified an unconventional tumor suppressive role for the canonical WNT/β-catenin pathway in regulating self-renewal of ERMS and revealed therapeutic strategies to target differentiation of TPCs in ERMS. ..
  35. pmc Intracardiac flow dynamics regulate atrioventricular valve morphogenesis
    Stamatia Kalogirou
    Developmental Biology, Biomedical Research Foundation Academy of Athens, Soranou Ephessiou 4, 11527 Athens, Greece
    Cardiovasc Res 104:49-60. 2014
    ..However, these two factors have proved difficult to uncouple, especially since altering myocardial function affects the intracardiac flow pattern...
  36. pmc Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development
    Melanie Philipp
    From the Institute of Biochemistry and Molecular Biology and
    J Biol Chem 289:26119-30. 2014
    ..In summary, we found that GRK2 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes...
  37. doi Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida
    Xueqian Wang
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Qixiu Road 19, 226001, Nantong, China
    In Vitro Cell Dev Biol Anim 51:211-7. 2015
    ..hybridization analysis with ventricular marker ventricular myosin heavy chain (vmhc) and atrial marker atrial myosin heavy chain (amhc) showed each of the heart contained both distinct atria and ventricle...
  38. doi Tissue factor pathway inhibitor-2 is critical in zebrafish cardiogenesis
    Yanli Zhang
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Institutes of Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China
    Biochem Biophys Res Commun 456:827-33. 2015
    ..Changes of cardiogenic markers, vmhc, amhc and bmp4, confirmed zTfpi-2 knockdown caused cardiac defects, including retrenched ventricle, enlarged atrium and ..
  39. pmc An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood
    Vanessa George
    Division of Pediatric Cardiology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032 USA
    Dev Biol 400:10-22. 2015
    ....
  40. pmc Maternal and Zygotic Sphingosine Kinase 2 Are Indispensable for Cardiac Development in Zebrafish
    Yu Hisano
    From the Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198
    J Biol Chem 290:14841-51. 2015
    ..The contribution of maternally supplied lipid mediators during vertebrate organogenesis presents as a requirement for maternal-zygotic Sphk2. ..
  41. pmc Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling
    Ariel Rydeen
    Molecular Cardiovascular Biology Division and Heart Institute, Cincinnati Children s Research Foundation, Cincinnati, USA Molecular and Developmental Biology Graduate Program, University of Cincinnati Medical Center, Cincinnati, USA
    Dev Biol 405:47-55. 2015
    ..Therefore, our results provide novel insights into the teratogenic mechanisms of RA signaling and the cellular mechanisms by which Cyp26a1 expression can shape a RA gradient. ..
  42. pmc Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish
    Anja Bühler
    Molecular Cardiology, University of Ulm, 89081 Ulm, Germany
    Int J Mol Sci 17:. 2016
    ....
  43. pmc Acute stress is detrimental to heart regeneration in zebrafish
    Pauline Sallin
    Department of Biology, University of Fribourg, Chemin du Musee 10, 1700 Fribourg, Switzerland
    Open Biol 6:. 2016
    ..These findings indicate that the natural regenerative ability of the zebrafish heart is vulnerable to the systemic paracrine stress response. ..
  44. pmc Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish
    Rebecca Powell
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA
    Mol Med Rep 14:2665-78. 2016
    ..However, the chamber‑specific markers amhc and vmhc were unaffected. Interestingly, knockdown of wtip disrupts early left‑right (LR) asymmetry...
  45. pmc Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes
    Yao Xiao
    Department of Genetics, College of Life Sciences, Wuhan University, Wuhan 430072, P R China
    Stem Cell Reports 7:370-82. 2016
    ..The technology provides a new platform for the study of heart development and regeneration, in addition to drug discovery, disease modeling, and assessment of cardiotoxic agents. ..
  46. pmc Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish
    Mollie R J Sorrell
    Molecular Cardiovascular Biology Division and The Heart Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 380:199-210. 2013
    ..This study expands our understanding of the in vivo developmental requirements of Tcf7l1 proteins and the mechanisms directing CM development in vertebrates...
  47. pmc Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid
    Enrico D'Aniello
    The Heart Institute, Molecular Cardiovascular Biology and Developmental Biology Divisions, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS Genet 9:e1003689. 2013
    ..Our results support an intriguing novel mechanism by which depletion of RARs elicits a previously unrecognized positive feedback loop that can result in developmental defects due to teratogenic increases in embryonic RA. ..
  48. pmc Nkx genes are essential for maintenance of ventricular identity
    KIMARA L TARGOFF
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 140:4203-13. 2013
    ..Moreover, in these Nkx-deficient embryos, expression of vmhc, a ventricular gene, fades, whereas expression of amhc, an atrial gene, expands...
  49. pmc Identification of RNA binding motif proteins essential for cardiovascular development
    Samantha Maragh
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    BMC Dev Biol 11:62. 2011
    ....
  50. pmc Distinct phases of Wnt/β-catenin signaling direct cardiomyocyte formation in zebrafish
    Tracy E Dohn
    Molecular and Developmental Biology Graduate Program, University of Cincinnati, USA
    Dev Biol 361:364-76. 2012
    ....
  51. pmc The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish
    Nicole O Glenn
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Mol Cell Biol 32:3527-40. 2012
    ..Our study underscores the importance of the W-loop for actin functionality and will help us to understand the structural and physiological consequences of ACTC mutations in human congenital disorders...
  52. pmc The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos
    Tzu Chun Tsai
    Department of Medical Research and Education, National Yang Ming University Hospital, Yilan, Taiwan, Republic of China
    J Biomed Sci 19:63. 2012
    ..Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome...
  53. doi Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish
    Heng Huang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Arterioscler Thromb Vasc Biol 32:2158-70. 2012
    ..The aim of this study was to investigate the physiological functions of PAQR10 and PAQR11...
  54. doi Sphingosine-1-phosphate receptor-1 controls venous endothelial barrier integrity in zebrafish
    Chiara Tobia
    Department of Biomedical Sciences and Biotechnology, Unit of General Pathology and Immunology, School of Medicine, University of Brescia, Italy
    Arterioscler Thromb Vasc Biol 32:e104-16. 2012
    ..Here, we characterized the role of the zS1P(1) ortholog in vascular development in zebrafish...
  55. pmc Analysis of postembryonic heart development and maturation in the zebrafish, Danio rerio
    Corinna Singleman
    Department of Biology, Queens College, City University of New York, Flushing New York and The Graduate Center, City University of New York, New York, New York, USA
    Dev Dyn 241:1993-2004. 2012
    ..We conducted a systematic analysis of cardiac maturation from larvae through to adulthood and assessed cardiac features influenced by genetic and environmental factors...
  56. pmc Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm
    Iris I Müller
    Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dis Model Mech 6:332-41. 2013
    ..These results implicate, for the first time, regulators of BMP signaling in human AF, providing mechanistic insights into the pathogenesis of the disease and identifying potential new therapeutic targets...
  57. pmc csrnp1a is necessary for the development of primitive hematopoiesis progenitors in zebrafish
    Jaime Espina
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    PLoS ONE 8:e53858. 2013
    ..These and previous observations suggest an important role of Csnrps transcription factors in progenitor biology, both in the neural and hematopoietic linages...
  58. pmc Alterations in cardiac DNA methylation in human dilated cardiomyopathy
    Jan Haas
    Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
    EMBO Mol Med 5:413-29. 2013
    ..In vivo studies of orthologous ly75 and adora2a in zebrafish demonstrate a functional role of these genes in adaptive or maladaptive pathways in heart failure...
  59. ncbi Retinol dehydrogenase, RDH1l, is essential for the heart development and cardiac performance in zebrafish
    Wei Wang
    Cardiovascular Center, Children s Hospital, Fudan University, Shanghai 201102, China
    Chin Med J (Engl) 126:722-8. 2013
    ..Retinol dehydrogenases1l (RDH1l) is a novel zebrafish retinol dehydrogenase. Herein we investigated the role of zebrafish RDH1l in heart development and cardiac performance in detail...
  60. pmc In vivo cardiac reprogramming contributes to zebrafish heart regeneration
    Ruilin Zhang
    Department of Medicine, Division of Cardiology, University of California, San Diego, La Jolla, California 92093, USA
    Nature 498:497-501. 2013
    ....
  61. pmc Knockdown of FABP3 impairs cardiac development in Zebrafish through the retinoic acid signaling pathway
    Xuejie Wang
    Department of Emergency, Subei People Hospital, Yangzhou, Jiangsu 225001, China
    Int J Mol Sci 14:13826-41. 2013
    ..As a result, these studies identify FABP3 as a candidate gene underlying the etiology of congenital heart defects. ..
  62. pmc NXT2 is required for embryonic heart development in zebrafish
    Haigen Huang
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA
    BMC Dev Biol 5:7. 2005
    ..NXT2 is a member of NXT family proteins that are generally involved in exporting nuclear RNA in eukaryotic cells. It is not known if NXT2 has any function in specific biological processes...
  63. ncbi Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase
    Yuexiang Wang
    Department of Molecular Genetics, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, PR China
    Biochem Biophys Res Commun 331:303-8. 2005
    ..Our findings may provide new insights into the cardiomyocyte function and disfunction...
  64. pmc VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart
    Wolfgang Rottbauer
    Department of Medicine III, University of Heidelberg, D 69120 Heidelberg, Germany
    Genes Dev 19:1624-34. 2005
    ..Thus, the muscle of the heart uses the VEGF-PLCgamma1 cascade to control the strength of the heart beat. We speculate that this paracrine system may contribute to normal and pathological regulation of cardiac contractility...
  65. ncbi Gata4 regulates the formation of multiple organs
    Audrey Holtzinger
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 132:4005-14. 2005
    ..In addition, both Gata4 and Gata6 are essential and non-redundant for liver growth following initial budding...
  66. ncbi Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility
    Yue xiang Wang
    Department of Molecular Genetics, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, PR China
    FEBS Lett 579:4843-50. 2005
    ..Dysregulation of cardiac genes in MEF2A morphants suggests that sarcomere assembly disturbances account for the cardiac contractile deficiency. Our studies suggested that MEF2A is essential in cardiac contractility...
  67. ncbi Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis
    Stefan Rohr
    Max Delbrück Center MDC Strasse 10, 13125 Berlin, Germany
    Development 133:107-15. 2006
    ....
  68. ncbi TBX1, a DiGeorge syndrome candidate gene, is inhibited by retinoic acid
    Lifeng Zhang
    Children s Hospital of Fudan University, Shanghai, P R China
    Int J Dev Biol 50:55-61. 2006
    ..The results suggested that RA could produce an altered Tbx1 expression pattern in zebrafish. In addition, RA could repress Tbx1 expression in a dose-dependent manner...
  69. pmc Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development
    John P Incardona
    Ecotoxicology and Environmental Fish Health Program, Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, USA
    Environ Health Perspect 113:1755-62. 2005
    ..These findings have multiple implications for the assessment of PAH impacts on coastal habitats...
  70. ncbi Heart-targeted overexpression of Nip3a in zebrafish embryos causes abnormal heart development and cardiac dysfunction
    Wen Der Wang
    Vanderbilt University, LH529, 2215 Garland Avenue, Nashville, TN 37232 0275, USA
    Biochem Biophys Res Commun 347:979-87. 2006
    ..These results showed that myocyte apoptosis is a universal pathogenic factor for congenital heart failure using zebrafish as a model organism...
  71. ncbi The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish
    Serene L Wohlgemuth
    Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Dev Biol 303:483-92. 2007
    ..These results suggest that Unc45b acts as a chaperone that aids in the folding of myosin isoforms required for skeletal, cranial and cardiac muscle contraction...
  72. ncbi The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors
    Ian C Scott
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 12:403-13. 2007
    ..These results support a model in which agtrl1b regulates the migration of cells fated to form myocardial progenitors...
  73. pmc A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development
    Gang Lu
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:784-96. 2007
    ..These data suggest that PP2Cm is a novel mitochondrial protein phosphatase that has a critical function in cell death and survival, and may play a role in regulating the MPTP opening...
  74. pmc Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish
    Engda G Hagos
    Department of Cellular Biology, The University of Georgia, Athens, GA, USA
    BMC Dev Biol 7:22. 2007
    ..This permitted us to directly examine when Nodal signals specify cell types independently of dosage effects...
  75. pmc Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin
    Kota Y Miyasaka
    Department of Developmental Neurobiology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo, Aoba, Sendai 980 8575, Japan
    Proc Natl Acad Sci U S A 104:11274-9. 2007
    ..Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs...
  76. pmc Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo
    Huang Chieh Lee
    Institute of Molecular and Cellular Biology, National Taiwan University, NO, 1, Roosevelt Road, Sec, 4, Taipei 106, Taiwan
    BMC Dev Biol 7:93. 2007
    ..At this study, we attempt to specifically inhibit either GSK3alpha or GSK3beta and uncover the isoform-specific roles that GSK3 plays during cardiogenesis...
  77. pmc Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5
    Haibo Jia
    Department of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:14008-13. 2007
    ..Hence, our studies suggest that Grl regulates embryonic heart growth via opposing Gata5, at least in part through their protein interactions in modulating gene expression...
  78. pmc Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes
    Audrey Holtzinger
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 312:613-22. 2007
    ..In contrast, embryos depleted of Gata4 and Gata6, or Gata4 and Gata5, develop defective heart tubes. Our study identifies a specific pair of vertebrate transcription factor paralogs that is essential for cardiomyocyte specification...
  79. ncbi Emilin genes are duplicated and dynamically expressed during zebrafish embryonic development
    Martina Milanetto
    Department of Histology, Microbiology, and Medical Biotechnologies University of Padova, Padova, Italy
    Dev Dyn 237:222-32. 2008
    ..Expression of certain emilin genes in peculiar areas, such as the central nervous system or the posterior notochord, suggests that they may play a role in key morphogenetic processes...
  80. doi Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells
    Kelly A Smith
    Hubrecht Institute for Developmental Biology and Stem Cell Research, 3584 CT Utrecht, The Netherlands
    Dev Cell 14:287-97. 2008
    ..Together, these results support a model in which CPCs migrate toward a BMP source during development of the linear heart tube, providing a mechanism by which the left-right axis drives asymmetric development of the vertebrate heart...
  81. doi Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos
    Long Zhao
    Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People s Republic of China
    Cardiovasc Res 80:200-8. 2008
    ..So far, little is known about Tpm4 function in embryonic heart development and its involvement in the cardiovascular diseases. In this study, we investigated functions of different isoforms of tpm4 in embryonic heartbeat in zebrafish...
  82. pmc Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 321:397-406. 2008
    ..Together, our data demonstrate that a single signaling pathway can act reiteratively to coordinate organ size and proportion...
  83. pmc Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex
    Martin Lange
    Group Cardiovascular Genetics, Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany
    Genes Dev 22:2370-84. 2008
    ..Furthermore, this shows that plant homeodomain proteins play a yet unexplored role in recruiting chromatin remodeling complexes to acetylated histones...
  84. pmc microRNA-138 modulates cardiac patterning during embryonic development
    Sarah U Morton
    Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:17830-5. 2008
    ....
  85. ncbi Effects of methotrexate on the developments of heart and vessel in zebrafish
    Shuna Sun
    Children s Hospital, Fudan University, Shanghai 201102, China
    Acta Biochim Biophys Sin (Shanghai) 41:86-96. 2009
    ..Our results indicated that the disrupted development of the heart and vessels in MTX-treated embryos is related to the reduced transcript levels of hand2, mef2a, mef2c, and flk-1...
  86. pmc Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 328:472-82. 2009
    ..Together, our studies uncover a new role for BMP signaling in the regulation of chamber size, supporting a model in which differential reception of cardiac inductive signals establishes chamber proportion...
  87. pmc Pbx acts with Hand2 in early myocardial differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 333:409-18. 2009
    ..Our findings demonstrate new roles for Pbx proteins in vertebrate cardiac development and also provide new insight into connections between the transcriptional regulation of skeletal and cardiac muscle differentiation programs...
  88. pmc The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function
    Hans Joerg Hippe
    Department of Internal Medicine III, University of Heidelberg, INF 410, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 106:16269-74. 2009
    ..Thus, our results suggest a role for the interaction of NDPK B with Gbetagamma dimers and caveolins in regulating membranous G protein content and maintaining normal G protein function in vivo...
  89. pmc The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish
    Catherine T Nguyen
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 341:167-75. 2010
    ..Taken together, these results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations...
  90. doi CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function
    Abdelaziz Beqqali
    Hubrecht Institute, Developmental Biology and Stem Cell Research, 3584 CT, Utrecht, The Netherlands
    J Cell Sci 123:1141-50. 2010
    ..These findings suggest that CHAP is a critical component of the sarcomere with an important role in muscle development...
  91. pmc Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development
    Wade A Znosko
    Department of Microbiology and Molecular Genetics, 3501 Fifth Avenue, BST3 5062, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Dev Biol 342:11-25. 2010
    ..We further demonstrated the interaction of Pea3 ETS factors with the Dusp6 promoter both in vitro and in vivo. These results revealed the requirement of ETS factors in transducing FGF signals in developmental processes...
  92. doi Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing
    Rainer D Will
    Department of Internal Medicine III, University of Heidelberg, Germany
    Circ Res 107:1253-64. 2010
    ..In contrast to other sarcomeric structures, eg, the Z-disc, only few M-band-specific proteins have been identified to date, and its exact molecular composition remains unclear...
  93. doi Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143
    Kota Y Miyasaka
    Graduate School of Life Sciences, Institute of Development, Aging and Cancer, Tohoku University, 4 1, Seiryo, Aoba, Sendai, Miyagi 980 8575, Japan
    Mech Dev 128:18-28. 2011
    ..Our data uncover a novel epigenetic link between heartbeat and cardiac development, with miR-143 as an essential component of the mechanotransduction cascade...
  94. pmc Chromatin remodelling complex dosage modulates transcription factor function in heart development
    Jun K Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nat Commun 2:187. 2011
    ....
  95. pmc The PAF1 complex differentially regulates cardiomyocyte specification
    Adam D Langenbacher
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 353:19-28. 2011
    ..Our findings demonstrate critical but differential requirements for PAF1C components in zebrafish cardiac specification and heart morphogenesis...
  96. pmc Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes
    Anya Sedletcaia
    Department of Surgery, Weill Cornell Medical College, New York, New York 10065, USA
    Dev Dyn 240:1548-57. 2011
    ..Therefore, in zebrafish, two tbx2 genes are functionally redundant for regulating chamber development, while each gene is required independently for development of the AVC...
  97. pmc Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish
    Joshua D Wythe
    Department of Oncological Sciences and Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Dis Model Mech 4:607-21. 2011
    ....
  98. pmc Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators
    Filipa Costa Simões
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington OX3 9DS, UK
    Development 138:3235-45. 2011
    ..We propose that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart...
  99. doi The myosin-interacting protein SMYD1 is essential for sarcomere organization
    Steffen Just
    Department of Medicine II, University of Ulm, 89081 Ulm, Germany
    J Cell Sci 124:3127-36. 2011
    ..By contrast, ectopic expression of myosin-binding-deficient SMYD1 does not rescue fla mutants, implicating an essential role for the SMYD1-myosin interaction in cardiac and fast-twitch skeletal muscle thick filament assembly...
  100. pmc Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish
    Tomoaki Fujii
    Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Japan
    PLoS ONE 6:e23491. 2011
    ..addition, these phenotypes were associated with abnormal expression of three heart-chamber markers including cmlc2, amhc and vmhc, and abnormal expression of myogenic regulatory factors including myod and myog...
  101. doi Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development
    Kelly A Smith
    Hubrecht Institute, KNAW and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands
    Development 138:4193-8. 2011
    ..Finally, we show that immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development...

Research Grants1

  1. Zebrafish Heart Mutants:Physiological & Genetic Analyses
    Neil Chi; Fiscal Year: 2008
    ..These zebrafish mutants ultimately may serve as a novel gateway to gain new insight into the cellular and molecular mechanisms of human cardiac arrhythmias and heart failure. ..