lycat

Summary

Gene Symbol: lycat
Description: lysocardiolipin acyltransferase
Alias: lclat1, wu:fj17g04, zgc:77380, lysocardiolipin acyltransferase 1
Species: zebrafish

Top Publications

  1. ncbi tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish
    D G Ahn
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mech Dev 95:253-8. 2000
  2. pmc Vessel and blood specification override cardiac potential in anterior mesoderm
    Jeffrey J Schoenebeck
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 13:254-67. 2007
  3. pmc Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation
    Chengyan Wang
    Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing, China
    Blood 110:3601-9. 2007
  4. ncbi Endocardium is necessary for cardiomyocyte movement during heart tube assembly
    Nathalia Glickman Holtzman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 134:2379-86. 2007
  5. pmc A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos
    Suk Won Jin
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
    Dev Biol 307:29-42. 2007
  6. pmc The "Ets" factor: vessel formation in zebrafish--the missing link?
    Lucy J Patterson
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Headington, Oxford, United Kingdom
    PLoS Biol 4:e24. 2006
  7. ncbi Transcriptional regulation of hematopoietic stem cell development in zebrafish
    Nelson Hsia
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:1007-14. 2005
  8. ncbi Zebrafish as a model for myelopoiesis during embryogenesis
    Jason N Berman
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:997-1006. 2005
  9. ncbi Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Dev Biol 276:508-22. 2004
  10. ncbi Fibronectin regulates epithelial organization during myocardial migration in zebrafish
    L A Trinh
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 6:371-82. 2004

Research Grants

Scientific Experts

  • Suk Won Jin
  • Jing Wei Xiong
  • D G Ahn
  • Jeffrey J Schoenebeck
  • Chengyan Wang
  • Nathalia Glickman Holtzman
  • Deborah Yelon
  • Lucy J Patterson
  • Jason N Berman
  • Nelson Hsia
  • L A Trinh
  • Benjamin M Hogan
  • Michael Schorpp
  • C M Bennett
  • T Blake
  • Patrick W Faloon
  • Yu Ge
  • Brian R Keegan
  • Pengbo Zhang
  • Huai Jen Tsai
  • Zhijia Tan
  • Hongkui Deng
  • Yaxin Lv
  • Roger Patient
  • Leonard I Zon
  • A Thomas Look
  • John P Kanki
  • Graham J Lieschke
  • Andrew C Oates
  • Meredith O Crowhurst
  • Joan K Heath
  • Michael P Hunter
  • Didier Y R Stainier
  • Nathan E Hall
  • Victoria E Prince
  • Matthias Hammerschmidt
  • Elvira Nold
  • Waltraud Wiest
  • Annette Haas-Assenbaum
  • Thomas Boehm
  • Markus Leicht
  • L I Zon
  • A Delahaye-Brown
  • D M Langenau
  • J P Kanki
  • M W Kieran
  • B H Paw
  • J Rhodes
  • T X Liu
  • A T Look
  • M D Fleming
  • A Chitnis
  • P P Liu
  • A C Oates
  • N Adya
  • B M Weinstein
  • L Zon
  • C H Kim

Detail Information

Publications14

  1. ncbi tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish
    D G Ahn
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mech Dev 95:253-8. 2000
    ..During development, tbx20 is expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons, and the roof of the dorsal aorta...
  2. pmc Vessel and blood specification override cardiac potential in anterior mesoderm
    Jeffrey J Schoenebeck
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 13:254-67. 2007
    ..This regulatory relationship between cardiovascular pathways suggests strategies for directing progenitor cell differentiation to facilitate cardiac regeneration...
  3. pmc Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation
    Chengyan Wang
    Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing, China
    Blood 110:3601-9. 2007
    ..Here we report the isolation of mouse lysocardiolipin acyltransferase (Lycat) based on homology to zebrafish lycat, a candidate gene for the cloche locus...
  4. ncbi Endocardium is necessary for cardiomyocyte movement during heart tube assembly
    Nathalia Glickman Holtzman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 134:2379-86. 2007
    ..Together, our data reveal a dynamic cellular mechanism by which tissue interactions establish organ architecture...
  5. pmc A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos
    Suk Won Jin
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
    Dev Biol 307:29-42. 2007
    ..The analysis of the newly defined loci should lead to a greater understanding of vascular development and possibly provide new drug targets to treat the numerous pathologies associated with dysregulated blood vessel growth...
  6. pmc The "Ets" factor: vessel formation in zebrafish--the missing link?
    Lucy J Patterson
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Headington, Oxford, United Kingdom
    PLoS Biol 4:e24. 2006
  7. ncbi Transcriptional regulation of hematopoietic stem cell development in zebrafish
    Nelson Hsia
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:1007-14. 2005
    ..Future studies using new technologies in the zebrafish model will enhance our understanding of the molecular networks regulating HSC pluripotency and differentiation...
  8. ncbi Zebrafish as a model for myelopoiesis during embryogenesis
    Jason N Berman
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:997-1006. 2005
    ....
  9. ncbi Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Dev Biol 276:508-22. 2004
    ..This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies...
  10. ncbi Fibronectin regulates epithelial organization during myocardial migration in zebrafish
    L A Trinh
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 6:371-82. 2004
    ..These data suggest that myocardial migration is dependent on epithelial integrity...
  11. ncbi A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
    Michael Schorpp
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Mech Dev 118:179-85. 2002
    ..Our results provide the first specific marker for the epithelial compartment of the zebrafish thymus...
  12. ncbi Myelopoiesis in the zebrafish, Danio rerio
    C M Bennett
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:643-51. 2001
    ..The morphologic and molecular genetic evidence presented here supports the zebrafish as an informative model system for the study of normal and aberrant human myelopoiesis. (Blood. 2001;98:643-651)..
  13. ncbi Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis
    T Blake
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 96:4178-84. 2000
    ..Our results indicate that cbfb is expressed in early hematopoietic progenitors and that its expression pattern in the hematopoietic mutants is similar to that of scl. (Blood. 2000;96:4178-4184)..
  14. pmc An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish
    Jing Wei Xiong
    The Nephrology Division, Massachusetts General Hospital East, Harvard Medical School, 149 13th St, Room 8216, Charlestown, MA 02129, USA
    Circ Res 102:1057-64. 2008
    ..Here, we show that a lysocardiolipin acyltransferase, lycat, is critical for the establishment of both hematopoietic and endothelial lineages...

Research Grants1

  1. Cloning and Function of Cloche in Vascular Development
    Jing Wei Xiong; Fiscal Year: 2006
    ..Ultimately, our findings may have impact on the understanding and management of pathological processes of angiogenesis, and application of endothelial and hematopoietic stem cells in human is ischemic heart diseases. ..