lcp1

Summary

Gene Symbol: lcp1
Description: lymphocyte cytosolic protein 1 (L-plastin)
Alias: cb245, fj24b12, wu:fj24b12, plastin-2, L-plastin, leucocyte-specific plastin 1, lymphocyte cytosolic plastin 1
Species: zebrafish

Top Publications

  1. ncbi Myelopoiesis in the zebrafish, Danio rerio
    C M Bennett
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:643-51. 2001
  2. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
  3. ncbi Zebrafish scl functions independently in hematopoietic and endothelial development
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Dev Biol 277:522-36. 2005
  4. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
  5. ncbi Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    Jenna L Galloway
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 8:109-16. 2005
  6. ncbi Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome
    Sarah E Craven
    DNA Way, South San Francisco, CA 94080, USA
    Blood 105:3528-34. 2005
  7. pmc Hematopoietic stem cell fate is established by the Notch-Runx pathway
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2331-42. 2005
  8. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
  9. pmc MyD88 innate immune function in a zebrafish embryo infection model
    Astrid M van der Sar
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Infect Immun 74:2436-41. 2006
  10. ncbi Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation
    Michael J Redd
    Cell Motility Group, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    Cell Motil Cytoskeleton 63:415-22. 2006

Scientific Experts

  • Rachel M Warga
  • Chun Guang Ren
  • Elspeth M Payne
  • Saulius Sumanas
  • Yi Feng
  • JING RUEY JOANNA YEH
  • Aihua Gu
  • Annemarie H Meijer
  • Chris Hall
  • Stephen A Renshaw
  • Niccolò Bolli
  • Sarah E Craven
  • Leonard I Zon
  • Min Deng
  • Ting Xi Liu
  • Yi Chen
  • Yong Zhang
  • Jennifer Rhodes
  • Zhu Chen
  • Sai Juan Chen
  • Kevin B Walters
  • A Thomas Look
  • Yi Jin
  • Anna Huttenlocher
  • John P Kanki
  • Mei Dong
  • Ana Cvejic
  • Kang Yong Zhu
  • M Ernest Dodd
  • Jonathan R Mathias
  • Yan Fang Fu
  • Matthias Hammerschmidt
  • Michael J Redd
  • Chang Bin Jing
  • Hilary Clay
  • Herman P Spaink
  • Roger Patient
  • Jason N Berman
  • Hao Jin
  • Tessa Peterkin
  • Jiang Zhu
  • Paul Martin
  • Clifford Liongue
  • Thomas Boehm
  • Adam Amsterdam
  • Elsie S Place
  • Huang Ying Le
  • Shintaro Imamura
  • Alister C Ward
  • Thomas J Carney
  • Graham J Lieschke
  • Ming Yang Chang
  • Antonia Chatzopoulou
  • Adriana De La Garza
  • Michael Schorpp
  • Qiuping He
  • A P Deveau
  • Dongyuan Ma
  • Chunxia Zhang
  • Feng Liu
  • Sunny Gupta
  • Anskar Y H Leung
  • Lu Wang
  • Haisen Li
  • Qin Tang
  • Yonglong Wei
  • Caroline Erter Burns
  • Sheran H W Law
  • Rebecca A Jones
  • Madhumita Jagannathan-Bogdan
  • Sachin Kumar Singh
  • Jaime Espina
  • Dong Liang
  • Jiulin Du
  • Shannon McKinney-Freeman
  • Fränze Progatzky
  • Caghan Kizil
  • Jun Zhu
  • Erin L Cadwalader
  • Stefan H Oehlers
  • Hao Yuan
  • Janna Krueger
  • Li Li
  • Ting Zhou
  • Maria Cristina Keightley
  • Filipa Costa Simões
  • Rui Monteiro
  • Ning Ma
  • David M Langenau
  • Cristian Soza-Ried

Detail Information

Publications102 found, 100 shown here

  1. ncbi Myelopoiesis in the zebrafish, Danio rerio
    C M Bennett
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:643-51. 2001
    ..The morphologic and molecular genetic evidence presented here supports the zebrafish as an informative model system for the study of normal and aberrant human myelopoiesis. (Blood. 2001;98:643-651)..
  2. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells...
  3. ncbi Zebrafish scl functions independently in hematopoietic and endothelial development
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Dev Biol 277:522-36. 2005
    ..Surprisingly, in cloche, lmo2 was not induced in response to scl over-expression. Taken together, these findings support distinct roles for scl in hematopoietic and endothelial development, downstream of hemangioblast development...
  4. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
    ..1 in the bloodless mutant cloche resulted in myelopoietic rescue, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis...
  5. ncbi Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    Jenna L Galloway
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 8:109-16. 2005
    ..Our studies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstrate that gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis...
  6. ncbi Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome
    Sarah E Craven
    DNA Way, South San Francisco, CA 94080, USA
    Blood 105:3528-34. 2005
    ..Thus, we identify an essential role for Hspa9b in hematopoiesis and implicate both loss of HSPA9B specifically and mitochondrial dysfunction generally in the pathogenesis of the MDS...
  7. pmc Hematopoietic stem cell fate is established by the Notch-Runx pathway
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2331-42. 2005
    ..These data define the Notch-Runx pathway as critical for the developmental specification of HSC fate and the subsequent homeostasis of HSC number, thus providing a mechanism for amplifying stem cells in vivo...
  8. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
    ..1 expression, but the role of alk8 was independent of the scl-dependent cell-fate pathway. Furthermore, the role of Alk8 in myelopoiesis was genetically separable from its earlier role in dorsal-ventral embryonic patterning...
  9. pmc MyD88 innate immune function in a zebrafish embryo infection model
    Astrid M van der Sar
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Infect Immun 74:2436-41. 2006
    ....
  10. ncbi Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation
    Michael J Redd
    Cell Motility Group, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    Cell Motil Cytoskeleton 63:415-22. 2006
    ..Taken together, these results suggest that destabilizing microtubules activates Rho kinase and that this increase in Rho kinase activity interferes with leukocyte recruitment in vivo...
  11. ncbi A transgenic zebrafish model of neutrophilic inflammation
    Stephen A Renshaw
    MRC Centre for Developmental and Biomedical Genetics, Acadamic Unit of Respiratory Medicine, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Blood 108:3976-8. 2006
    ..fmk, demonstrating that experimental manipulation of the resolution of inflammation is possible in this model...
  12. pmc The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    BMC Dev Biol 7:42. 2007
    ..A number of blood-specific lines have provided a means to exploit the exquisite optical clarity that this vertebrate system offers and provide a level of insight into dynamic inflammatory processes previously unavailable...
  13. pmc Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish
    Xiuning Le
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:9410-5. 2007
    ..Moreover, these tumors and hyperplasia closely resemble human diseases at both the morphologic and molecular levels...
  14. ncbi Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Dev Comp Immunol 32:36-49. 2008
    ..re-examined specificity of described myeloid markers by multiplex fluorescent in situ hybridization, showing that lcp1 can be considered as a general leukocyte marker, csf1r as a macrophage-specific marker, and mpx and lyz as ..
  15. ncbi Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis
    Thomas J Carney
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 134:3461-71. 2007
    ..Our work provides direct genetic evidence for antagonistic in vivo roles of Hai1 and Matriptase1a to regulate skin homeostasis and remodeling...
  16. ncbi Origins and unconventional behavior of neutrophils in developing zebrafish
    Dorothée Le Guyader
    Unité Macrophages et Développement de l Immunité, Centre National de la Recherche Scientifique Unité de Recherche Associée 2578, Institut Pasteur, Paris, France
    Blood 111:132-41. 2008
    ..They are also attracted to variously stressed or malformed tissues, suggesting a wider role than antimicrobial defense...
  17. pmc Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo
    Julien Y Bertrand
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0380, USA
    Development 134:4147-56. 2007
    ..These studies provide phenotypic and functional analyses of the first hematopoietic progenitors in the zebrafish embryo and demonstrate that definitive hematopoiesis proceeds through two distinct waves during embryonic development...
  18. pmc Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 2:29-39. 2007
    ..We propose that residence within macrophages represents an evolutionary trade-off for pathogenic mycobacteria that slows their early growth but provides a mechanism for tissue dissemination...
  19. ncbi AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 135:401-10. 2008
    ..Thus, this zebrafish model facilitates in vivo dissection of AML1-ETO-mediated signaling, and will enable large-scale chemical screens to identify suppressors of the in vivo effects of AML1-ETO...
  20. pmc Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation
    Saulius Sumanas
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, USA
    Blood 111:4500-10. 2008
    ..We further demonstrate that the choice of endothelial versus myeloid fate depends on a combinatorial effect of etsrp, scl, and alk8 genes...
  21. ncbi In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury
    Yong Zhang
    Laboratory of Development and Diseases and State Key Laboratory for Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Immunol 181:2155-64. 2008
    ..The results indicate that the JNK-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo...
  22. doi Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia
    Tamayo Uechi
    Frontier Science Research Center, University of Miyazaki, Miyazaki 889 1692, Japan
    Hum Mol Genet 17:3204-11. 2008
    ..The RPS19-deficient zebrafish will provide a valuable tool for investigating the molecular mechanisms of DBA development in humans...
  23. doi Analysis of WASp function during the wound inflammatory response--live-imaging studies in zebrafish larvae
    Ana Cvejic
    Departments of Biochemistry and Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
    J Cell Sci 121:3196-206. 2008
    ....
  24. doi Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration
    Clifford Liongue
    School of Medicine, Deakin University, Waurn Ponds, Vic, Australia
    Blood 113:2535-46. 2009
    ....
  25. pmc The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish
    M Ernest Dodd
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 136:2591-600. 2009
    ....
  26. pmc Characterization of zebrafish larval inflammatory macrophages
    Jonathan R Mathias
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    Dev Comp Immunol 33:1212-7. 2009
    ..These findings identify distinct functional and morphological characteristics of inflammatory macrophages in zebrafish larvae...
  27. pmc Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells
    Xi Ren
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, China
    Blood 115:5338-46. 2010
    ....
  28. doi An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation
    Chun Tang Fu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People s Republic of China
    Blood 115:4715-24. 2010
    ..This study uncovers a novel molecular pathway, PTEN-C/EBPalpha-CTNNA1, which is evolutionarily conserved and might be therapeutically targeted to eradicate LICs with low CTNNA1 expression...
  29. doi Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis
    Li Li
    State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Blood 117:1359-69. 2011
    ..1 but is insufficient to promote macrophage development in the absence of Pu.1. Our findings demonstrate that Irf8 is a critical determinant for neutrophil versus macrophage fate choice during zebrafish primitive myelopoiesis...
  30. pmc Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation
    Yi Feng
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS Biol 8:e1000562. 2010
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds...
  31. pmc The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ
    Rui Monteiro
    Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK
    EMBO J 30:1093-103. 2011
    ..1 in primitive erythroid and prodefinitive erythromyeloid progenitors. We therefore conclude that the gata1/pu.1 paradigm for lineage decisions takes different forms in different cellular contexts and is modulated by tif1γ...
  32. doi Dominant-negative C/ebpα and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis
    Ting Zhou
    Key Laboratory of Stem Cell Biology and State Key Laboratory of Medical Genomics and Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Blood 118:3842-52. 2011
    ..The results indicate that Bmi1 acts immediately downstream of C/ebpαDN to regulate the survival and self-renewal of HSPCs and contribute to the erythropoietic dysplasia...
  33. doi Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
    Chang Bin Jing
    Key Laboratory of Stem Cell Biology, Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, People s Republic of China
    Dev Biol 374:24-31. 2013
    ..These results suggested that plcg1 functioned specifically in zebrafish ICM granulopoiesis for the first time. Our studies suggest that specific pathways regulate the differentiation of the hematopoietic lineages...
  34. doi Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination
    J Tristan Dobson
    IWK Health Centre, Dalhousie University, Halifax, NS, USA
    Blood 112:2969-72. 2008
    ..1, but not gata-1 or fog-1, are necessary for early MC development. These studies validate the zebrafish as an in vivo tool for studying MC ontogeny and function with future capacity for modeling human MC diseases...
  35. doi Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos
    Lixin Yang
    Institute of Toxicology and Genetics Forschungszentrum Karlsruhe Karlsruhe Institute of Technology 76021 Karlsruhe, Germany
    Toxicol Sci 115:379-90. 2010
    ..Our data suggest that MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13...
  36. pmc Characterization of a weak allele of zebrafish cloche mutant
    Ning Ma
    Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    PLoS ONE 6:e27540. 2011
    ....
  37. pmc The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain
    Caghan Kizil
    DFG Center for Regenerative Therapies Dresden Cluster of Excellence CRTD, Technische Universitat Dresden, Fetscherstr, 105, Dresden, 01307, Germany
    Neural Dev 7:27. 2012
    ..Thus, understanding the underlying principles of this regeneration capacity of the zebrafish brain is an interesting research realm that may offer vast clinical ramifications...
  38. pmc csrnp1a is necessary for the development of primitive hematopoiesis progenitors in zebrafish
    Jaime Espina
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    PLoS ONE 8:e53858. 2013
    ..These and previous observations suggest an important role of Csnrps transcription factors in progenitor biology, both in the neural and hematopoietic linages...
  39. pmc Hematopoiesis
    Madhumita Jagannathan-Bogdan
    HHMI Children s Hospital Boston, Boston, MA 02115, USA
    Development 140:2463-7. 2013
    ..Here, we provide a broad overview of vertebrate hematopoiesis. We also highlight the benefits of using zebrafish as a model...
  40. pmc Modelling of human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using in vivo live imaging
    Rebecca A Jones
    School of Biochemistry, Faculty of Medical and Veterinary Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 126:4077-84. 2013
    ..This model provides a unique insight into WASp-related immunodeficiency at both a cellular and whole organism level. ..
  41. pmc Proteome mapping of adult zebrafish marrow neutrophils reveals partial cross species conservation to human peripheral neutrophils
    Sachin Kumar Singh
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
    PLoS ONE 8:e73998. 2013
    ..This study provides the first zebrafish neutrophil proteome and may serve as a valuable resource for an understanding of neutrophil biology and innate immunity. ..
  42. pmc Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis
    Haisen Li
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell biology Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Shanghai, China
    EMBO J 33:1383-96. 2014
    ..Taken together, we identified LPA as an important nutrient-derived developmental cue for primitive hematopoiesis as well as a novel mechanism of hemangioblast regulation. ..
  43. doi Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish
    Yonglong Wei
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Blood 124:1578-85. 2014
    ..Thus, our findings identify a novel regulatory mechanism for Ncor2 through Fos-Vegfd-Notch signaling cascade during HSC development in zebrafish embryos. ..
  44. pmc Optimized cell transplantation using adult rag2 mutant zebrafish
    Qin Tang
    1 Molecular Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA 4 Harvard Stem Cell Institute, Cambridge, Massachusetts, USA 5
    Nat Methods 11:821-4. 2014
    ..Mutant fish engraft muscle, blood stem cells and various cancers. rag2(E450fs) mutant zebrafish are the first immunocompromised zebrafish model that permits robust, long-term engraftment of multiple tissues and cancer. ..
  45. doi Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates
    Qiuping He
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Blood 125:1098-106. 2015
    ..Our findings establish a previously unrecognized link between inflammatory signaling and HSPC emergence, and provide new insights into regenerative medicine and novel therapies to treat innate immune-related diseases. ..
  46. doi Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98-HOXA9-induced myeloid disease
    A P Deveau
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Leukemia 29:2086-97. 2015
    ..Our work proposes novel drug targets in NHA9-induced myeloid disease, and suggests rational therapies by combining minimal doses of known bioactive compounds. ..
  47. doi Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish
    Antonia Chatzopoulou
    Institute of Biology, Leiden University, 2333CC Leiden, The Netherlands
    Endocrinology 157:2772-84. 2016
    ....
  48. pmc Spliceosomal component Sf3b1 is essential for hematopoietic differentiation in zebrafish
    Adriana De La Garza
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Exp Hematol 44:826-837.e4. 2016
    ....
  49. pmc Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae
    Ming Yang Chang
    Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Sci Rep 6:27838. 2016
    ..This model might permit the future exploration of the virulence and molecular pathways of different leptospiral outer membrane proteins. ..
  50. pmc Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes
    Elsie S Place
    Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
    PLoS ONE 12:e0171143. 2017
    ..Vascular patterning and primitive haematopoiesis are unaffected in atoh8sa1465/sa1465 mutant embryos. Together, the data suggest that Atoh8 is dispensible for zebrafish development under standard laboratory conditions...
  51. pmc Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
    Abbhirami Rajagopal
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Nature 453:1127-31. 2008
    ..Thus, uncovering the mechanisms of haem transport in C. elegans may provide insights into human disorders of haem metabolism and reveal new drug targets for developing anthelminthics to combat worm infestations...
  52. pmc Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 5:236-43. 2009
    ..This approach may open doors for developing therapeutics targeting oncogene function within leukemic stem cells...
  53. pmc Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression
    Jennifer Rhodes
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Mol Cell Biol 29:5911-22. 2009
    ..Our results cast Emi1 as a critical regulator of genomic fidelity during embryogenesis and suggest that the factor may act as a tumor suppressor...
  54. doi Macrophage-specific gene functions in Spi1-directed innate immunity
    Anna Zakrzewska
    Institute of Biology, Leiden University, Leiden, The Netherlands
    Blood 116:e1-11. 2010
    ..Therefore, based on our combined transcriptome analyses, we discovered novel early macrophage-specific marker genes, including a signal transducer pivotal for macrophage migration in the innate immune response...
  55. pmc cpsf1 is required for definitive HSC survival in zebrafish
    Niccolò Bolli
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 117:3996-4007. 2011
    ..These studies show that cpsf1 is essential for HSC survival and differentiation in caudal hematopoietic tissue...
  56. pmc Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo
    Janna Krueger
    Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine, D13125 Berlin, Germany
    Development 138:2111-20. 2011
    ..Thus, Flt1 acts in a Notch-dependent manner as a negative regulator of tip cell differentiation and branching. Flt1 distribution may be fine-tuned, involving interactions with the developing nervous system...
  57. doi Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish
    Hao Yuan
    Centre National de la Recherche Scientifique LIA124, Sino French Research Center for Life Sciences and Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, China
    Blood 117:7014-20. 2011
    ..Our results therefore implicate sumoylation in early lineage determination and reveal the possible molecular mechanism underlying the puzzling biased primitive hematopoiesis in vertebrates...
  58. pmc The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish
    Stefan H Oehlers
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland 1001, New Zealand
    Dis Model Mech 4:832-41. 2011
    ..This work highlights the potential use of zebrafish larvae in the study of components of IBD pathogenesis...
  59. pmc Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators
    Filipa Costa Simões
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington OX3 9DS, UK
    Development 138:3235-45. 2011
    ..We propose that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart...
  60. pmc Mediator subunit 12 is required for neutrophil development in zebrafish
    Maria Cristina Keightley
    Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e23845. 2011
    ..Syr shows defects in hematopoiesis, which predominantly affect the myeloid lineage. Syr has identified a hematopoietic cell-specific requirement for Med12, suggesting a new role for this transcriptional regulator...
  61. doi Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide
    Christopher J Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Cell Stem Cell 10:198-209. 2012
    ..These results provide new insights into the reactive capacity of HSPCs and how the blood system is "fine-tuned" in response to inflammatory stress...
  62. pmc 2-O-sulfotransferase regulates Wnt signaling, cell adhesion and cell cycle during zebrafish epiboly
    Erin L Cadwalader
    Department of Neurobiology and Anatomy, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 139:1296-305. 2012
    ..Together, these results indicate that 2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3β and β-catenin intracellular localization and function...
  63. pmc Retinoic acid signaling plays a restrictive role in zebrafish primitive myelopoiesis
    Dong Liang
    Model Animal Research Center, MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    PLoS ONE 7:e30865. 2012
    ..Taken together, our results demonstrate that RA signaling restricts zebrafish primitive myelopoiesis through acting downstream of gata4/5/6, upstream of, or parallel to, cloche, and upstream of scl...
  64. doi The role of Nfil3 in zebrafish hematopoiesis
    Fränze Progatzky
    Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, London, UK
    Dev Comp Immunol 38:187-92. 2012
    ..Collectively, these results describe a conserved expression pattern of Nfil3 in evolutionarily divergent species and indicate that Nfil3 is central to myeloid lineage commitment...
  65. pmc Maternal pak4 expression is required for primitive myelopoiesis in zebrafish
    Sheran H W Law
    Section on Vertebrate Development, Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD, USA
    Mech Dev 130:181-94. 2013
    ....
  66. pmc The transcriptional landscape of hematopoietic stem cell ontogeny
    Shannon McKinney-Freeman
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02115, USA
    Cell Stem Cell 11:701-14. 2012
    ..Our analysis and web resource will enhance efforts to identify regulators of HSC ontogeny and facilitate the engineering of hematopoietic specification...
  67. pmc Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs
    Yong Zhang
    Blood Cell Development and Cancer Keystone, Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Cell 24:411-25. 2013
    ..Accordingly, circumstances that tip the balance of these paralogs in favor of Rpl22 (e.g., Rpl22l1 knockdown or Rpl22 overexpression) result in repression of Smad1 and blockade of HSC emergence...
  68. ncbi Zebrafish gcmb is required for pharyngeal cartilage formation
    Ryuki Hanaoka
    Laboratory for Developmental Gene Regulation, The Institute of Physical and Chemical Research, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Mech Dev 121:1235-47. 2004
    ..These results suggest that gcmb is required for normal pharyngeal cartilage formation in zebrafish and that its expression is dependent on fgf3 activity...
  69. ncbi Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos
    Anskar Y H Leung
    Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 277:235-54. 2005
    ..BMP4, but not BMP2b or 7, was involved in this process. The results provide ground for further research into the mechanisms of embryonic hematopoietic cell expansion...
  70. ncbi Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion
    Sara M N Onnebo
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Exp Hematol 33:182-8. 2005
    ..Such fusions can mediate factor-independent growth of hematopoietic cell lines and induction of malignancy in mouse models...
  71. ncbi Distinct roles for SCL in erythroid specification and maturation in zebrafish
    Marianne A Juarez
    Department of Internal Medicine, Division of Hematology Oncology and Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:41636-44. 2005
    ..Our results revealed that Scl participates in multiple processes requiring different levels and functions. Further, we identified an Scl hypomorphic phenotype distinct from the null state...
  72. pmc Fgf21 is essential for haematopoiesis in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    EMBO Rep 7:649-54. 2006
    ..These results indicate that Fgf21 is a newly identified factor essential for the determination of myelo-erythroid progenitor cell fate in vivo...
  73. ncbi BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis
    Sunny Gupta
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 133:2177-87. 2006
    ....
  74. ncbi Conserved functions of Ikaros in vertebrate lymphocyte development: genetic evidence for distinct larval and adult phases of T cell development and two lineages of B cells in zebrafish
    Michael Schorpp
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    J Immunol 177:2463-76. 2006
    ..By contrast, B cells expressing the igz isotype do not develop, providing genetic evidence for two separate B cell lineages in zebrafish. Thus, Ikaros appears to play similar roles in fish and mammalian lymphopoiesis...
  75. ncbi The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells
    Xiangen Li
    Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Development 133:3641-50. 2006
    ..These findings establish a unique regulatory role for ZBP-89, positioned at the interface between early blood and blood vessel development...
  76. pmc Smad1 and Smad5 differentially regulate embryonic hematopoiesis
    Lisa J McReynolds
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 110:3881-90. 2007
    ..Our results suggest that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5...
  77. doi Multiplex fluorescent in situ hybridization in zebrafish embryos using tyramide signal amplification
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington 98195, USA
    Zebrafish 2:105-11. 2005
    ..To this effect, we demonstrate that this approach can be combined with standard horseradish peroxidase (HRP)-mediated immunocytochemistry procedures in addition to FISH...
  78. pmc Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival
    Farshid Dayyani
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Blood 111:4338-47. 2008
    ..This study is the first to implicate the TLEs as potential tumor suppressor genes in myeloid leukemia...
  79. doi A role for the transcription intermediary factor 2 in zebrafish myelopoiesis
    Julia Zhuravleva
    INSERM, University of Burgundy, Dijon, France
    Exp Hematol 36:559-67. 2008
    ..Therefore, we decided to choose the zebrafish model to study TIF2. The aim of this study was to characterize the role of this HAT during embryonic development...
  80. doi eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish
    Huang Ying Le
    Laboratory of Development and Diseases and State Key Laboratory of Medical Genomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 283:17652-61. 2008
    ..The results suggest that eena plays an important role in the development of the myeloid cell through activation of the ERK pathway and may provide a valuable reference for future studies of the role of EEN in leukemogenesis...
  81. pmc Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    Samuel Sidi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 133:864-77. 2008
    ..The evolutionarily conserved "Chk1-suppressed" pathway defines a novel apoptotic process, whose responsiveness to Chk1 inhibitors and insensitivity to p53 and BCL2 alterations have important implications for cancer therapy...
  82. pmc A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis
    Shintaro Imamura
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3364. 2008
    ..The data also provide insights into a non-canonical pathway by which TERT functions to modulate specification of hematopoietic stem/progenitor cells during vertebrate development. (276 words)...
  83. doi Gene expression and functional analysis of zebrafish larval fin fold regeneration
    Nozomi Yoshinari
    Department of Biological Information, Tokyo Institute of Technology, Midori ku, Yokohama 226 8501, Japan
    Dev Biol 325:71-81. 2009
    ..Thus, our results demonstrate that the regeneration model of juvenile zebrafish offers a powerful assay to dissect the regeneration processes...
  84. doi Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2
    Ulrich Pannicke
    Institute for Transfusion Medicine, University of Ulm, Ulm, Germany
    Nat Genet 41:101-5. 2009
    ..These observations suggest that reticular dysgenesis is the first example of a human immunodeficiency syndrome that is causally linked to energy metabolism and that can therefore be classified as a mitochondriopathy...
  85. pmc Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24
    Kevin B Walters
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Dev Dyn 238:86-99. 2009
    ....
  86. pmc Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation
    Alex Bukrinsky
    Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1606, USA
    Blood 113:2038-46. 2009
    ..1 cells and its function is necessary and sufficient for macrophage and granulocyte differentiation. These results establish a critical role for spi-1l in zebrafish myeloid cell differentiation...
  87. doi Fluorescence-activated cell sorting (FACS) of whole mount in situ hybridization (WISH) labelled haematopoietic cell populations in the zebrafish
    Joseph T Dobson
    IWK Health Centre, Dalhousie University, Halifax, NS, Canada
    Br J Haematol 144:732-5. 2009
    ....
  88. doi The role of survivin2 in primitive hematopoiesis during zebrafish development
    A C H Ma
    Division of Haematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Leukemia 23:712-20. 2009
    ..In conclusion, sur2 is important in maintaining hematopoietic stem and lineage committed cells during zebrafish development, by virtue of its antiapoptotic activity in a caspase dependent and cell autonomous fashion...
  89. pmc Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI
    Hao Jin
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, People s Republic of China
    Development 136:647-54. 2009
    ..Our results highlight the importance of niche in shaping the differentiation output of developing HSPCs...
  90. pmc Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants
    Anne E Clatworthy
    Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Infect Immun 77:1293-303. 2009
    ..aeruginosa, the role of individual components of host immune defense, and small-molecule modulators of infection...
  91. pmc Fate mapping embryonic blood in zebrafish: multi- and unipotential lineages are segregated at gastrulation
    Rachel M Warga
    Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008, USA
    Dev Cell 16:744-55. 2009
    ..Our results demonstrate the existence of primitive hematopoietic progenitors that are segregated very early in development and that are specified to produce either a unipotent or a multipotent blood cell lineage...
  92. doi Identification of phagocytic cells, NK-like cytotoxic cell activity and the production of cellular exudates in the coelomic cavity of adult zebrafish
    Lauren D Moss
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Dev Comp Immunol 33:1077-87. 2009
    ..E. coli injected into the CC were phagocytosed in a dose and time dependent fashion by granulocytes, monocytes and macrophages. NCC lysed mammalian target cells and NCAMP-1 expressing hybridoma cells in redirected lysis assays...
  93. pmc The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development
    Krasimir Slanchev
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    PLoS Genet 5:e1000563. 2009
    ..In addition, EpCAM is required for the interaction of the epithelia with underlying cell layers...
  94. doi A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera
    Alvin C H Ma
    Department of Medicine, The University of Hong Kong, Hong Kong
    Exp Hematol 37:1379-1386.e4. 2009
    ..In this study, we generated a zebrafish ortholog of human JAK2(V617F) (referred herewith jak2a(V581F)) by site-directed mutagenesis and examined its relevance as a model of human PV...
  95. pmc Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish
    Christiane L Belele
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 114:5162-72. 2009
    ..Our findings suggest that the impact of Gata1 on hematopoiesis correlates with its DNA-binding ability and that primitive hematopoiesis is more sensitive to reduction in Gata1 function than definitive hematopoiesis...
  96. doi Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish
    Cheng Huang
    Institute for Nutritional Sciences and Key Laboratory of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Dev Biol 339:89-100. 2010
    ..These results suggest that SIOD may be caused by defects in cell cycle regulation. Our study provides a model of SIOD and reveals its cellular and molecular bases...
  97. pmc Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome
    Kevin B Walters
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI, USA
    Blood 116:2803-11. 2010
    ..The findings suggest that this transgenic zebrafish model of WHIM syndrome may provide a valuable tool to screen for agents that modify CXCR4-SDF1 retention signals...
  98. pmc Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved
    Cristian Soza-Ried
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 107:17304-8. 2010
    ..Our results, therefore, suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution...
  99. pmc The role of meis1 in primitive and definitive hematopoiesis during zebrafish development
    Ana Cvejic
    Department of Haematology, University of Cambridge, Long Road, Cambridge CB2 0PT, UK
    Haematologica 96:190-8. 2011
    ..Here we characterized the role of the proto-oncogene, meis1, during zebrafish primitive and definitive hematopoiesis...
  100. doi Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis
    Yan Fang Fu
    Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Blood 113:1340-9. 2009
    ..The selective effect of the miR-144-Klfd pathway on globin gene regulation may thereby constitute a novel therapeutic target for improving the clinical outcome of patients with thalassemia...
  101. pmc Common genetic control of haemangioblast and cardiac development in zebrafish
    Tessa Peterkin
    Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK
    Development 136:1465-74. 2009
    ....