hbae1

Summary

Gene Symbol: hbae1
Description: hemoglobin, alpha embryonic 1
Alias: HBA2r, HBAA1, SI:dZ118J2.10, SI:dZ118J2.8, dZ118J2.6, hba2, si:by119c3.1, si:by119c3.3, si:xx-119c3.3, wu:fa12a11, wu:fb74f06, zgc:86936, hemoglobin, alpha embryonic 1, HbA, alphae1globin, etID40432.3, globin alphae1, hemoglobin alpha-2 chain
Species: zebrafish

Top Publications

  1. doi SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish
    Xiuling Li
    State Key Laboratory of Molecular Neuroscience, Center of Systems Biology and Human Health, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P R China
    Development 139:4321-9. 2012
  2. doi C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis
    Jie Mei
    State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
    Dev Biol 319:273-84. 2008
  3. doi Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
    Blood 112:5228-37. 2008
  4. pmc Hematopoiesis
    Madhumita Jagannathan-Bogdan
    HHMI Children s Hospital Boston, Boston, MA 02115, USA
    Development 140:2463-7. 2013
  5. pmc Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs
    Yong Zhang
    Blood Cell Development and Cancer Keystone, Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Cell 24:411-25. 2013
  6. doi Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
    Chang Bin Jing
    Key Laboratory of Stem Cell Biology, Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, People s Republic of China
    Dev Biol 374:24-31. 2013
  7. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
  8. pmc Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR
    Jared J Ganis
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, and Harvard Stem Cell Institute, Harvard Medical School, 1 Blackfan Cir, Karp 7, Boston, MA 02115, USA
    Dev Biol 366:185-94. 2012
  9. ncbi Characterization of embryonic globin genes of the zebrafish
    Alison Brownlie
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 255:48-61. 2003
  10. ncbi Myelopoiesis in the zebrafish, Danio rerio
    C M Bennett
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:643-51. 2001

Scientific Experts

  • Xiaofan Zhu
  • Chun Guang Ren
  • Laurel A Rohde
  • A C Oates
  • Han Wang
  • Aihua Gu
  • Laxminarayana R Devireddy
  • Sarah E Craven
  • C Kwok
  • Fiona C Wardle
  • Leonard I Zon
  • Min Deng
  • Ting Xi Liu
  • Jennifer Rhodes
  • Yi Zhou
  • Hao Yuan
  • Zhu Chen
  • Yi Chen
  • Zilong Wen
  • Alvin C H Ma
  • Jun Zhu
  • Yong Zhang
  • Wenqing Zhang
  • A Thomas Look
  • Shuo Lin
  • Jie Mei
  • Xiaohui Liu
  • Ke Ma
  • Lei Gao
  • Hugues De The
  • Jun Zhou
  • Mei Dong
  • Sai Juan Chen
  • Yiyue Zhang
  • John P Kanki
  • Xiuling Li
  • Anskar Y H Leung
  • Raman Sood
  • Jin Xu
  • Karl Hsu
  • Stephen C Ekker
  • Hao Jin
  • Michela Guarienti
  • Xiaoe Jia
  • Alberto Rissone
  • Christoph Seiler
  • Sonia Mercurio
  • Evisa Gjini
  • Weijun Pan
  • Saijuan Chen
  • Yanli Zhang
  • Bai Liang He
  • Alison N Bilbee
  • Dietmar J Kappes
  • Zhenhong Su
  • David L Wiest
  • Wei Qin
  • Qin Li
  • Li Ting Chen
  • Haibo Jia
  • Imelda T Sandoval
  • Petra Haunhorst
  • Ryo Hirabayashi
  • Zhaojun Zhang
  • Jaime Espina
  • Chang Bin Jing
  • Madhumita Jagannathan-Bogdan
  • Joseph Kramer
  • Yi Jin
  • Jinrong Peng
  • Peng Fei Xu
  • Lei Wang
  • Alison M Taylor
  • Miriam Blank
  • Sarah A Hutchinson
  • Hemant Suryawanshi
  • Jared J Ganis
  • Efrat Dresner
  • Martha Kirby
  • Thorsten Burmester
  • Paul Delgado-Olguín
  • Ting Zhou
  • Jessica Tiedke
  • Linsen Du
  • Martin In Shing Chung
  • Atsuo Iida
  • Rasoul Nourizadeh-Lillabadi
  • Cristian Soza-Ried
  • Milton A English
  • Christiane L Belele

Detail Information

Publications70

  1. doi SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish
    Xiuling Li
    State Key Laboratory of Molecular Neuroscience, Center of Systems Biology and Human Health, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P R China
    Development 139:4321-9. 2012
    ..Our findings demonstrate that sae1 is essential for the maintenance of HSPCs during fetal hematopoiesis in zebrafish...
  2. doi C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis
    Jie Mei
    State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
    Dev Biol 319:273-84. 2008
    ..of several apoptosis regulators such as p53, mdm2, p21, Bax and caspase 3, and down-regulation expression of hbae1 in the C1q-like morphant embryos...
  3. doi Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
    Blood 112:5228-37. 2008
    ..Ribosomal stress syndromes represent a broader spectrum of human congenital diseases caused by genotoxic stress; therefore, imbalance of p53 family members may become a new target for therapeutics...
  4. pmc Hematopoiesis
    Madhumita Jagannathan-Bogdan
    HHMI Children s Hospital Boston, Boston, MA 02115, USA
    Development 140:2463-7. 2013
    ..Here, we provide a broad overview of vertebrate hematopoiesis. We also highlight the benefits of using zebrafish as a model...
  5. pmc Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs
    Yong Zhang
    Blood Cell Development and Cancer Keystone, Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Cell 24:411-25. 2013
    ..Accordingly, circumstances that tip the balance of these paralogs in favor of Rpl22 (e.g., Rpl22l1 knockdown or Rpl22 overexpression) result in repression of Smad1 and blockade of HSC emergence...
  6. doi Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
    Chang Bin Jing
    Key Laboratory of Stem Cell Biology, Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, People s Republic of China
    Dev Biol 374:24-31. 2013
    ..These results suggested that plcg1 functioned specifically in zebrafish ICM granulopoiesis for the first time. Our studies suggest that specific pathways regulate the differentiation of the hematopoietic lineages...
  7. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
    ..1 in the bloodless mutant cloche resulted in myelopoietic rescue, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis...
  8. pmc Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR
    Jared J Ganis
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, and Harvard Stem Cell Institute, Harvard Medical School, 1 Blackfan Cir, Karp 7, Boston, MA 02115, USA
    Dev Biol 366:185-94. 2012
    ..Our studies provide a comprehensive characterization of the zebrafish globin loci and clarify the regulation of globin switching...
  9. ncbi Characterization of embryonic globin genes of the zebrafish
    Alison Brownlie
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 255:48-61. 2003
    ..Our studies are the first to systematically evaluate the embryonic globins in the zebrafish and will ultimately be useful in evaluating zebrafish mutants with defects in hemoglobin production and switching...
  10. ncbi Myelopoiesis in the zebrafish, Danio rerio
    C M Bennett
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:643-51. 2001
    ..The morphologic and molecular genetic evidence presented here supports the zebrafish as an informative model system for the study of normal and aberrant human myelopoiesis. (Blood. 2001;98:643-651)..
  11. pmc Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation
    Alison M Taylor
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Mass, USA
    Exp Hematol 40:228-237.e5. 2012
    ..Together, our studies demonstrate a role of p53 in mediating the cellular defects associated with rps29 and establish a role for rps29 and p53 in hematopoietic stem cells and red blood cell development...
  12. doi Dominant-negative C/ebpα and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis
    Ting Zhou
    Key Laboratory of Stem Cell Biology and State Key Laboratory of Medical Genomics and Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Blood 118:3842-52. 2011
    ..The results indicate that Bmi1 acts immediately downstream of C/ebpαDN to regulate the survival and self-renewal of HSPCs and contribute to the erythropoietic dysplasia...
  13. doi Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish
    Hao Yuan
    Centre National de la Recherche Scientifique LIA124, Sino French Research Center for Life Sciences and Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, China
    Blood 117:7014-20. 2011
    ..Our results therefore implicate sumoylation in early lineage determination and reveal the possible molecular mechanism underlying the puzzling biased primitive hematopoiesis in vertebrates...
  14. doi PDCD2 controls hematopoietic stem cell differentiation during development
    Joseph Kramer
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Stem Cells Dev 22:58-72. 2013
    ..Furthermore, the effects of pdcd2 in regulating mitotic cell death may contribute to its role(s) in directing hematopoietic differentiation during development...
  15. pmc Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia
    Bai Liang He
    Division of Haematology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Blood 123:2518-29. 2014
    ..This study provides novel insight into the role of flt3 during hematopoiesis and establishes a zebrafish model of FLT3-ITD(+) and FLT3-TKD(+) AML that may facilitate high-throughput screening of novel and personalized agents. ..
  16. pmc Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation
    Petra Haunhorst
    Institute for Clinical Cytobiology and Cytopathology, Faculty of Medicine, Philipps Universitat, 35037 Marburg, Germany
    Mol Biol Cell 24:1895-903. 2013
    ..These data suggest an evolutionarily conserved role of cytosolic monothiol multidomain glutaredoxins in cellular iron metabolism pathways, including the biogenesis of Fe/S proteins and hemoglobin maturation...
  17. pmc Ddx46 is required for multi-lineage differentiation of hematopoietic stem cells in zebrafish
    Ryo Hirabayashi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Hiroshima, Japan
    Stem Cells Dev 22:2532-42. 2013
    ..Taken together, our results provide the first genetic evidence that zebrafish Ddx46 is required for the multilineage differentiation of HSCs during development, through the regulation of specific gene expressions. ..
  18. pmc Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F
    Imelda T Sandoval
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Chem Biol 20:753-63. 2013
    ..Our data support this mechanism of action for kalihinol F and the utility of zebrafish as an effective system for identifying therapeutic and target pathways. ..
  19. pmc Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing
    Zhaojun Zhang
    CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
    BMC Genomics 14:896. 2013
    ..In this study, we analyzed the transcriptome using deep sequencing data from an Rpl11-deficient zebrafish model to identify Rpl11-mediated hematopoietic failure and investigate the underlying mechanisms...
  20. doi MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development
    Zhenhong Su
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio X Institute, Huazhong University of Science and Technology, Wuhan, PR China Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province, Key Discipline of Pharmacy of Hubei Department of Education, Medical College, Hubei Polytechnic University, Huangshi, Hubei, PR China
    Int J Biochem Cell Biol 49:53-63. 2014
    ..These findings establish miR-144 as a novel miRNA that regulates hematopoiesis and vascular development by repressing expression of meis1. ..
  21. doi Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis
    Martin In Shing Chung
    Division of Haematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Exp Hematol 39:986-998.e5. 2011
    ..In this study, we have characterized the sequence homology, gene expression, hematopoietic functions, and regulation of sox genes in F group (SoxF) in zebrafish embryos...
  22. doi Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish
    Li Ting Chen
    1 State Key Laboratory of Medical Genomics and Shanghai, Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University SITU School of Medicine, Shanghai, 200025, China 2 Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and SITU School of Medicine, Shanghai 200025, China 3
    Nat Commun 5:3811. 2014
    ....
  23. pmc Nom1 mediates pancreas development by regulating ribosome biogenesis in zebrafish
    Wei Qin
    Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
    PLoS ONE 9:e100796. 2014
    ..This suggests that targeting Pp1α into the nucleolus by Nom1 is important for pancreatic proliferation. Altogether, our studies revealed a new mechanism involving Nom1 in controlling vertebrate exocrine pancreas formation. ..
  24. doi Tissue factor pathway inhibitor-2 is critical in zebrafish cardiogenesis
    Yanli Zhang
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Institutes of Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China
    Biochem Biophys Res Commun 456:827-33. 2015
    ..Taken together, this study demonstrated a critical role of zTfpi-2 during embryonic cardiac development, as well as an important regulator of hematopoiesis. ..
  25. pmc A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing
    Evisa Gjini
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 35:789-804. 2015
    ..tet2(m/m) zebrafish are viable and fertile, providing an ideal model to dissect altered pathways in hematopoietic cells and, for small-molecule screens in embryos, to identify compounds with specific activity against tet2 mutant cells. ..
  26. pmc Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish
    Hao Yuan
    CNRS LIA124, Sino French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Sci Rep 5:9011. 2015
    ..While C/ebpα-dependent transcription is involved in myeloid differentiation, our studies here reveal that C/ebpα sumoylation is essential for HSPC development during definitive hematopoiesis. ..
  27. pmc The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation
    Sonia Mercurio
    Department of Molecular Biotechnology and Health Sciences and Molecular Biotechnology Center, University of Turin, Italy
    Haematologica 100:720-9. 2015
    ..Consistently, reduction or increase of the cytosolic heme rescued the erythroid defects in zebrafish deficient in Flvcr1a or Flvcr1b, respectively. Thus, heme export represents a tightly regulated process that controls erythropoiesis. ..
  28. doi Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish
    Hai Wang
    CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China China National Committee for Terms in Sciences and Technologies, Beijing 100717, China
    Biochem Biophys Res Commun 460:923-30. 2015
    ..In zebrafish, injection of foxo3b-specific morpholinos (foxo3b MO) resulted in reduced globin (hbae1 and hbbe2) and gata1 gene expression...
  29. pmc DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish
    Xiaohui Liu
    CNRS LIA124, Sino French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
    J Hematol Oncol 8:15. 2015
    ..However, the precise molecular mechanism of how Dnmt1 is involved in HSPC maintenance remains unexplored...
  30. pmc TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis
    Lei Gao
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS Genet 11:e1005346. 2015
    ..Collectively, this study demonstrates a novel and vital role of TopBP1 in the maintenance of HSPCs genome integrity and survival during hematopoietic progenitor expansion. ..
  31. pmc Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress
    Alberto Rissone
    Disorders of Immunity Section, Genetics and Molecular Biology Branch Zebrafish Core and Oncogenesis and Development Section, Translational and Functional Genomics Branch Genomics Core, Cancer Genetics and Comparative Genomics Branch Division of Intramural Research Flow Cytometry Core and Cytogenetics and Microscopy Core, Genetic Disease Research Branch National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892
    J Exp Med 212:1185-202. 2015
    ..Our results link hematopoietic cell fate in AK2 deficiency to cellular energy depletion and increased oxidative stress. This points to the potential use of antioxidants as a supportive therapeutic modality for patients with RD. ..
  32. pmc Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish
    Christoph Seiler
    Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 10:e0131908. 2015
    ..Morpholino-mediated knockdown of these genes mimicked the T cell defects in the corresponding mutant embryos, demonstrating the previously unrecognized, essential roles of agtpbp1 and eps15L1 in T cell development. ..
  33. doi Computational and functional analysis of biopharmaceutical drugs in zebrafish: Erythropoietin as a test model
    Michela Guarienti
    Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy Electronic address
    Pharmacol Res 102:12-21. 2015
    ....
  34. doi Ontogeny of globin expression in zebrafish (Danio rerio)
    Jessica Tiedke
    Institute of Zoology and Zoological Museum, Biozentrum Grindel, University of Hamburg, Martin Luther King Platz 3, 20146, Hamburg, Germany
    J Comp Physiol B 181:1011-21. 2011
    ..Globin X mRNA level was highest in oocytes, but low in later stages. Together, these data suggest a specific role for each globin, which are also associated with certain events in fish development...
  35. pmc csrnp1a is necessary for the development of primitive hematopoiesis progenitors in zebrafish
    Jaime Espina
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    PLoS ONE 8:e53858. 2013
    ..These and previous observations suggest an important role of Csnrps transcription factors in progenitor biology, both in the neural and hematopoietic linages...
  36. doi Metalloprotease-dependent onset of blood circulation in zebrafish
    Atsuo Iida
    Department of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Kawahara cho 53, Shogo in, Kyoto 606 8507, Japan
    Curr Biol 20:1110-6. 2010
    ..Based on these findings, we propose that the first erythroid cells require both flow-dependent passive and proteolysis-dependent active processes to enter the circulation...
  37. pmc Novel evolutionary-conserved role for the activity-dependent neuroprotective protein (ADNP) family that is important for erythropoiesis
    Efrat Dresner
    Adams Super Center for Brain Studies, Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Department of Human Molecular Genetics and Biochemistry, Sagol School of Neuroscience, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 287:40173-85. 2012
    ..ADNP is vital for embryonic development. Is this function conserved for the homologous protein ADNP2?..
  38. pmc Activated N-Ras signaling regulates arterial-venous specification in zebrafish
    Chun Guang Ren
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Hematol Oncol 6:34. 2013
    ..So far the pathological roles of activated Ras signaling in hematopoiesis and vasculogenesis are largely unknown...
  39. doi Widespread occurrence of N-terminal acylation in animal globins and possible origin of respiratory globins from a membrane-bound ancestor
    Miriam Blank
    Institute of Zoology and Zoological Museum, Department of Biology, University of Hamburg, Hamburg, Germany
    Mol Biol Evol 29:3553-61. 2012
    ....
  40. pmc Tbl3 regulates cell cycle length during zebrafish development
    Sarah A Hutchinson
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 368:261-72. 2012
    ..These data suggest that tbl3 plays a tissue-specific role regulating cell cycle rate during development...
  41. ncbi The pu.1 promoter drives myeloid gene expression in zebrafish
    Karl Hsu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 104:1291-7. 2004
    ..These transgenic lines will be useful to dissect the cellular and molecular control of myeloid cell differentiation, and this promoter fragment may prove useful in the development of zebrafish models of acute myeloid leukemia...
  42. doi Antagonism of microRNA function in zebrafish embryos by using locked nucleic acid enzymes (LNAzymes)
    Hemant Suryawanshi
    CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India
    Chembiochem 13:584-9. 2012
    ..We demonstrate that LNAzyme can efficiently knockdown miRNAs with minimal toxicity to the zebrafish embryos...
  43. pmc Methionine aminopeptidase 2 is required for HSC initiation and proliferation
    Alvin C H Ma
    Department of Medicine, LKS Faculty of Medicine, Queen Mary Hospital, Pok Fu Lam Road, Hong Kong
    Blood 118:5448-57. 2011
    ..This study demonstrated a hitherto-undescribed role of MetAP2 in definitive hematopoiesis and a possible link to noncanonical Wnt and ERK signaling...
  44. doi cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis
    Yiyue Zhang
    State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, People s Republic of China
    Blood 118:4093-101. 2011
    ..Our study reveals that cMyb plays a hitherto unidentified role in dictating physiologic HSPC migration by modulating Sdf1a signaling...
  45. pmc Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish
    Ting Xi Liu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Exp Hematol 35:230-9. 2007
    ..We investigated the role of CCAAT enhancer-binding protein-alpha (C/EBPalpha) during zebrafish embryonic blood development...
  46. ncbi A global role for zebrafish klf4 in embryonic erythropoiesis
    M R Gardiner
    Institute for Molecular Bioscience, University of Queensland, Australia
    Mech Dev 124:762-74. 2007
    ..In addition, we show klf4 preferentially binds CACCC box elements in the primitive zebrafish beta-like globin gene promoters. These results have global implications for primitive erythroid gene regulation by KLF-CACCC box interactions...
  47. ncbi Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia
    A Brownlie
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 20:244-50. 1998
    ..As mutations in ALAS2 cause congenital sideroblastic anaemia (CSA) in humans, sau represents the first animal model of this disease...
  48. pmc Zebrafish promoter microarrays identify actively transcribed embryonic genes
    Fiona C Wardle
    Wellcome Trust Cancer Research UK Gurdon Institute and Department of Zoology, Cambridge University, Cambridge, UK
    Genome Biol 7:R71. 2006
    ..This approach will allow investigators to determine the genomic binding locations of DNA interacting proteins during development and expedite the assembly of the genetic networks that regulate embryogenesis...
  49. ncbi Heme regulates exocrine peptidase precursor genes in zebrafish
    Han Wang
    Department of Zoology and Stephenson Research and Technology Center, University of Oklahoma, Norman, Oklahoma 73019, USA
    Exp Biol Med (Maywood) 232:1170-80. 2007
    ..Our findings provide a better understanding of heme deficiency pathogenesis and enhance our ability to diagnose and treat patients with porphyria or pancreatic diseases...
  50. ncbi Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis
    Ryuki Hanaoka
    Laboratory of Developmental Molecular Genetics, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto, 606 8501, Japan
    Genes Cells 11:293-303. 2006
    ....
  51. pmc Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants
    Saulius Sumanas
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 621 C Young Dr South, Los Angeles, CA 90095, USA
    Blood 106:534-41. 2005
    ..Further functional studies of these novel genes should help to elucidate critical early steps leading to the formation of vertebrate blood vessels...
  52. ncbi Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome
    Sarah E Craven
    DNA Way, South San Francisco, CA 94080, USA
    Blood 105:3528-34. 2005
    ..Thus, we identify an essential role for Hspa9b in hematopoiesis and implicate both loss of HSPA9B specifically and mitochondrial dysfunction generally in the pathogenesis of the MDS...
  53. pmc A crucial interaction between embryonic red blood cell progenitors and paraxial mesoderm revealed in spadetail embryos
    Laurel A Rohde
    Department of Organismal Biology and Anatomy, University of Chicago, IL 60637 USA
    Dev Cell 7:251-62. 2004
    ..Importantly, our data identify a hematopoietic microenvironment that allows embryonic RBC production in the zebrafish...
  54. ncbi Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis
    A C Oates
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Blood 94:2622-36. 1999
    ..Taken together with recent gene knockout data in the mouse, we suggest that jak2a may be functionally equivalent to mammalian Jak2, with a role in early erythropoiesis...
  55. ncbi Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line
    A C Oates
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Dev Dyn 215:352-70. 1999
    ..dev dyn 1999;215:352-370...
  56. pmc CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Biol Chem 286:12483-94. 2011
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis...
  57. doi A role for the transcription intermediary factor 2 in zebrafish myelopoiesis
    Julia Zhuravleva
    INSERM, University of Burgundy, Dijon, France
    Exp Hematol 36:559-67. 2008
    ..Therefore, we decided to choose the zebrafish model to study TIF2. The aim of this study was to characterize the role of this HAT during embryonic development...
  58. doi The role of survivin2 in primitive hematopoiesis during zebrafish development
    A C H Ma
    Division of Haematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Leukemia 23:712-20. 2009
    ..In conclusion, sur2 is important in maintaining hematopoietic stem and lineage committed cells during zebrafish development, by virtue of its antiapoptotic activity in a caspase dependent and cell autonomous fashion...
  59. pmc Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI
    Hao Jin
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, People s Republic of China
    Development 136:647-54. 2009
    ..Our results highlight the importance of niche in shaping the differentiation output of developing HSPCs...
  60. pmc Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression
    Jennifer Rhodes
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Mol Cell Biol 29:5911-22. 2009
    ..Our results cast Emi1 as a critical regulator of genomic fidelity during embryogenesis and suggest that the factor may act as a tumor suppressor...
  61. doi A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera
    Alvin C H Ma
    Department of Medicine, The University of Hong Kong, Hong Kong
    Exp Hematol 37:1379-1386.e4. 2009
    ..In this study, we generated a zebrafish ortholog of human JAK2(V617F) (referred herewith jak2a(V581F)) by site-directed mutagenesis and examined its relevance as a model of human PV...
  62. pmc Selective interaction between Trf3 and Taf3 required for early development and hematopoiesis
    Daniel O Hart
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Dyn 238:2540-9. 2009
    ..Thus, a selective interaction between Trf3 and Taf3 is required for early zebrafish development and initiation of hematopoiesis. Finally, we provide evidence that TRF3 and TAF3 are also required for hematopoiesis initiation in the mouse...
  63. pmc Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish
    Christiane L Belele
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 114:5162-72. 2009
    ..Our findings suggest that the impact of Gata1 on hematopoiesis correlates with its DNA-binding ability and that primitive hematopoiesis is more sensitive to reduction in Gata1 function than definitive hematopoiesis...
  64. pmc A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production
    Laxminarayana R Devireddy
    Case Comprehensive Cancer Center and Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell 141:1006-17. 2010
    ..Siderophore-depleted mammalian cells and zebrafish embryos fail to synthesize heme, an iron-dependent mitochondrial process. Our results reveal features of intracellular iron homeostasis that are conserved from bacteria through humans...
  65. pmc Mtmr8 is essential for vasculature development in zebrafish embryos
    Jie Mei
    State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
    BMC Dev Biol 10:96. 2010
    ..Here, we attempt to explore the function of Mtmr8 in vasculature development parallel to its function in muscle development...
  66. pmc Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved
    Cristian Soza-Ried
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 107:17304-8. 2010
    ..Our results, therefore, suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution...
  67. pmc Early embryonic gene expression profiling of zebrafish prion protein (Prp2) morphants
    Rasoul Nourizadeh-Lillabadi
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    PLoS ONE 5:e13573. 2010
    ..Notwithstanding the importance in human and animal disease, fundamental aspects of PRNP/Prp function and transmission remains unaccounted for...
  68. doi Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis
    Linsen Du
    State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
    Development 138:619-29. 2011
    ..Our study identifies Rumba and Haus3 as two essential regulators of HSPC maintenance during zebrafish fetal hematopoiesis...
  69. pmc Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates
    C Kwok
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Nucleic Acids Res 26:3562-6. 1998
    ..Such successes are providing the basis for a new era of mapping tools, in the form of whole genome radiation hybrid panels, and are opening new possibilities for systematic genome analysis in the animal genetics community...
  70. pmc Functional analysis of human hematopoietic stem cell gene expression using zebrafish
    Craig E Eckfeldt
    Division of Hematology, Oncology, and Transplantation, Department of Medicine, Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA
    PLoS Biol 3:e254. 2005
    ..cells at 30 and 48 h postfertilization and subsequently confirmed by quantitative RT-PCR for erythroid-specific hbae1 and myeloid-specific lcp1 transcripts...