gli1

Summary

Gene Symbol: gli1
Description: GLI family zinc finger 1
Alias: zinc finger protein GLI1, GLI-Kruppel family member 1, detour, dtr
Species: zebrafish

Top Publications

  1. pmc Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway
    Bhaskarjyoti Sarmah
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 8240, USA
    Proc Natl Acad Sci U S A 107:19921-6. 2010
  2. ncbi Zebrafish mutations affecting retinotectal axon pathfinding
    R O Karlstrom
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:427-38. 1996
  3. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
  4. pmc Converse conformational control of smoothened activity by structurally related small molecules
    Hongbo Yang
    College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 284:20876-84. 2009
  5. doi A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary
    Christine A Devine
    Department of Biology, University of Massachusetts, Amherst, MA, USA
    Dev Biol 326:143-54. 2009
  6. pmc Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway
    Marco J Koudijs
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
    BMC Dev Biol 8:15. 2008
  7. pmc Gli function is essential for motor neuron induction in zebrafish
    Gary Vanderlaan
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Dev Biol 282:550-70. 2005
  8. ncbi A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
    Shang Yew Tay
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Development 132:625-34. 2005
  9. ncbi Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
    Oksana V Tyurina
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Dev Biol 277:537-56. 2005
  10. ncbi Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    Rolf O Karlstrom
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 130:1549-64. 2003

Research Grants

  1. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
  2. Development of Cranial Motor Neurons
    Anand Chandrasekhar; Fiscal Year: 2007
  3. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
  4. Molecular Control of Pituitary Development and Tumorigenesis
    Rolf O Karlstrom; Fiscal Year: 2010

Scientific Experts

  • H Baier
  • John K Mich
  • Ichiro Masai
  • Hiroki Teraoka
  • KATHLEEN WHITLOCK
  • ROLF KARLSTROM
  • Yau Hung Chen
  • Peng Huang
  • Yin Xiong Li
  • Marco J Koudijs
  • Robert D Knight
  • Veronica Gonzalez-Nunez
  • Anand Chandrasekhar
  • Burcu Guner
  • Meng Chieh Shen
  • Tyler Schwend
  • Evyn J Loucks
  • Nicolas Chassaing
  • Sandeep Paul
  • Laura I Hudish
  • Iskra A Signore
  • Tom Stiff
  • Jinhu Wang
  • Zizhang Zhou
  • Davalyn R Powell
  • Hao Lu
  • Mylarappa Ningappa
  • Lei Sun
  • Gang Zhai
  • Paul G Rack
  • Anthony M Recidoro
  • Shotaro Saita
  • B Ju
  • Susana Pascoal
  • Yike Yuan
  • Chengjin Zhang
  • Ashish Kumar Maurya
  • Jennifer L Sbrogna
  • Oksana V Tyurina
  • Malgorzata I Wiweger
  • Yun Zhao
  • Tom Stückemann
  • Evyn Loucks
  • Tyler R Huycke
  • Jin Jiang
  • James K Chen
  • Patricia A Gongal
  • Jonathan Bibliowicz
  • Song Li
  • Shuo Lin
  • Kavita Chalasani
  • Zhanying Hu
  • Marcey Osgood
  • Carmen G Feijóo
  • A Tuba Ozacar
  • Sudipto Roy
  • Bhaskarjyoti Sarmah
  • Keith P Gates
  • Jhumku D Kohtz
  • Christine A Devine
  • Hongbo Yang
  • Shannon C Lunt
  • Sara C Ahlgren
  • Seung Woo Park
  • Jovica Ninkovic
  • Matthias Schafer
  • Jeremiah D Paulus
  • Gary Vanderlaan
  • Shang Yew Tay
  • Jochen A Stadler
  • Domenico F Galati
  • Andrew M Ravanelli
  • Stephanie Albert
  • Simone Schindler
  • Sophie Lamarre
  • José Suazo
  • Christine Coubes
  • Jean Louis Dufier
  • J Gage Crump
  • Annaïck Desmaison
  • Dion Giovannone
  • Catherine Vincent-Delorme
  • Laurent Pasquier
  • Oscar Cerda
  • Massimiliano Rossi
  • Stanislas Faguer
  • Carolina Jerez
  • Mark O'Driscoll
  • Alicia Colombo Flores
  • Erica E Davis

Detail Information

Publications66

  1. pmc Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway
    Bhaskarjyoti Sarmah
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 8240, USA
    Proc Natl Acad Sci U S A 107:19921-6. 2010
    ..Perturbations from IP6K2 depletion or TNP were reversed by overexpressing smoM2, gli1, or ip6k2. Moreover, the inhibitory effect of cyclopamine was reversed by overexpressing ip6k2...
  2. ncbi Zebrafish mutations affecting retinotectal axon pathfinding
    R O Karlstrom
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:427-38. 1996
    ..In Class I mutant larvae (belladonna, detour, you-too, iguana, umleitung, blowout) axons grow directly to the ipsilateral tectal lobe after leaving the eye...
  3. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
    ..This activity is largely due to gli1, the expression of which is fully dependent on Hh signaling in mouse but not in zebrafish...
  4. pmc Converse conformational control of smoothened activity by structurally related small molecules
    Hongbo Yang
    College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 284:20876-84. 2009
    ..Using Gli1-dependent GFP transgenic zebrafish and in vitro biochemical assays, we identified and characterized two potent Smo ..
  5. doi A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary
    Christine A Devine
    Department of Biology, University of Massachusetts, Amherst, MA, USA
    Dev Biol 326:143-54. 2009
    ..b>Gli1 is required for the differentiation of selected endocrine cell types and acts as the major activator of Hh-mediated ..
  6. pmc Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway
    Marco J Koudijs
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
    BMC Dev Biol 8:15. 2008
    ..We attempted to fully activate the Hh pathway by removing both receptors for the Hh proteins, called Patched1 and 2, which are functioning as negative regulators in this pathway...
  7. pmc Gli function is essential for motor neuron induction in zebrafish
    Gary Vanderlaan
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Dev Biol 282:550-70. 2005
    ..For instance, cranial motor neurons are essentially lost in zebrafish detour (gli1(-)) mutants, whereas motor neuron development is unaffected in mouse single gli and some double gli ..
  8. ncbi A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
    Shang Yew Tay
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Development 132:625-34. 2005
    ....
  9. ncbi Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
    Oksana V Tyurina
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Dev Biol 277:537-56. 2005
    ..In vertebrates, at least three Gli transcription factors (Gli1, Gli2, and Gli3) are involved in Hh signal transduction...
  10. ncbi Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    Rolf O Karlstrom
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 130:1549-64. 2003
    ..We report that detour (dtr) mutations encode loss-of-function alleles of gli1...
  11. ncbi Discontinuous organization and specification of the lateral floor plate in zebrafish
    Matthias Schafer
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Dev Biol 301:117-29. 2007
    ..We conclude that different levels of HH and Nkx2.2 activities are responsible for the alternating appearance of LFP and p3 neuronal progenitor cells in the zebrafish ventral neural tube...
  12. pmc Arhgap36-dependent activation of Gli transcription factors
    Paul G Rack
    Departments of Chemical and Systems Biology
    Proc Natl Acad Sci U S A 111:11061-6. 2014
    ..Our findings reveal a new mechanism of Gli transcription factor activation and implicate ARHGAP36 dysregulation in the onset and/or progression of GLI-dependent cancers. ..
  13. doi Inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase induces orofacial defects in zebrafish
    Iskra A Signore
    Programa de Anatomía y Biología del Desarrollo, Instituto de Ciencias Biomedicas ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Birth Defects Res A Clin Mol Teratol 106:814-830. 2016
    ..Our aim is to study whether defects of HMGCR function would produce orofacial malformation similar to those found in disorders of cholesterol synthesis...
  14. pmc N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube
    Kavita Chalasani
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Mol Biol Cell 22:1505-15. 2011
    ..In addition, these findings are the first to demonstrate a requirement for cadherins in synchronizing cell-cycle exit and differentiation and a reciprocal interaction between AJs and Hh signaling...
  15. pmc Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo
    Ashish Kumar Maurya
    ASTAR Institute of Molecular and Cell Biology, Proteos, Singapore Department of Biological Sciences, National University of Singapore, Singapore
    PLoS Genet 9:e1003955. 2013
    ..targeted mutagenesis, we show that in zebrafish, Kif7 acts principally to suppress the activity of the Gli1 transcription factor...
  16. ncbi Genetic dissection of the retinotectal projection
    H Baier
    Abteilung Physikalische Biologie, Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:415-25. 1996
    ..The results of this screen show that a large-scale genetic approach can be applied to relatively late and circumscribed developmental processes in the vertebrate brain...
  17. pmc miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling
    Laura I Hudish
    Departments of Pediatrics and Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Development 143:2292-304. 2016
    ..Thus, miR-219 appears to decrease progenitor cell sensitivity to Shh signaling, thereby driving these cells towards differentiation. ..
  18. pmc Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development
    Gang Zhai
    Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Science, Wuhan, Hubei, People s Republic of China
    Mol Cell Biol 34:1310-21. 2014
    ..Our study reveals a novel role of sept6 in ciliogenesis during early embryonic development in zebrafish. ..
  19. pmc Transcription of the SCL/TAL1 interrupting Locus (Stil) is required for cell proliferation in adult Zebrafish Retinas
    Lei Sun
    From the Department of Biological Sciences and
    J Biol Chem 289:6934-40. 2014
    ..The latter data suggest that Stil play a role in cell proliferation through the Shh signal transduction pathway. ..
  20. pmc Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway
    B Ju
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, TN, USA
    Oncogenesis 3:e96. 2014
    ..upregulated expression of genes involved in the cell cycle, cancer signaling and Shh downstream targets ptc1, gli1 and gli2a...
  21. pmc Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish
    Anthony M Recidoro
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA, USA
    J Bone Miner Res 29:2346-56. 2014
    ....
  22. pmc Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration
    Sandeep Paul
    Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Development 143:2066-76. 2016
    ....
  23. pmc The Role of ARF6 in Biliary Atresia
    Mylarappa Ningappa
    Hillman Center for Pediatric Transplantation of the Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center UPMC, Pittsburgh, PA, 15224, United States of America
    PLoS ONE 10:e0138381. 2015
    ..Altered extrahepatic bile ducts, gut, and cardiovascular anomalies constitute the variable phenotype of biliary atresia (BA)...
  24. pmc Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway
    Shotaro Saita
    From the Division of Cell Biology and
    J Biol Chem 289:25639-54. 2014
    ..Our findings thus indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo. ..
  25. doi A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation
    Hao Lu
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
    Dev Biol 397:225-36. 2015
    ..Taken together, our findings identify Arl13b as an important effector of ciliary membrane biogenesis and ciliary length regulation, and provide insights into possible mechanisms of dysfunction of the protein in Joubert syndrome. ..
  26. pmc Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling
    Jinhu Wang
    Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 522:226-30. 2015
    ..These findings extend our understanding of tissue interactions during regeneration and have implications for mobilizing epicardial cells for therapeutic heart repair. ..
  27. pmc ATR promotes cilia signalling: links to developmental impacts
    Tom Stiff
    Double Strand Break Repair Laboratory and
    Hum Mol Genet 25:1574-87. 2016
    ..Our findings reveal a novel role for ATR in cilia signalling distinct from its canonical function during replication and strengthen emerging links between cilia function and development...
  28. pmc Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling
    Zizhang Zhou
    State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center of Nanjing University, Nanjing 210061, China
    Dev Cell 34:58-72. 2015
    ..Our findings reveal a conserved mechanism by which Ci/Gli is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers...
  29. pmc Cdon promotes neural crest migration by regulating N-cadherin localization
    Davalyn R Powell
    Department of Craniofacial Biology, School of Dental Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA Cell Biology, Stem Cells, and Development Graduate Program, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
    Dev Biol 407:289-99. 2015
    ..Our results reveal a novel role for cdon in zebrafish neural crest migration, and suggest a mechanism by which Cdon is required to localize N-cadherin to the cell membrane in migratory NCCs for directed migration. ..
  30. pmc Targeted resequencing identifies PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network
    Nicolas Chassaing
    CHU Toulouse, Service de Genetique Medicale, Hopital Purpan, 31059 Toulouse, France Université Paul Sabatier Toulouse III, EA 4555, 31000 Toulouse, France INSERM U1056, 31000 Toulouse, France
    Genome Res 26:474-85. 2016
    ....
  31. ncbi Zebrafish bashful/laminin-alpha 1 mutants exhibit multiple axon guidance defects
    Jeremiah D Paulus
    Department of Zoology, Cell and Molecular Biology Training Program, University of Wisconsin, Madison, Wisconsin, USA
    Dev Dyn 235:213-24. 2006
    ..In contrast to CNS axons, most peripheral axons appear normal in bal mutants. Our results, thus, reveal important and diverse functions for laminin-alpha1 in guiding developing axons in vivo...
  32. pmc A novel PEGylated liposome-encapsulated SANT75 suppresses tumor growth through inhibiting hedgehog signaling pathway
    Yike Yuan
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, PR China
    PLoS ONE 8:e60266. 2013
    ..Our findings suggest that liposomal formulated SANT75 has improved solubility and bioavailability and should be further developed as a drug candidate for treating tumors with abnormally high Hh activity...
  33. doi Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish
    John K Mich
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 138:5113-9. 2011
    ..We also provide evidence that RA pathway activation can modulate Gli function in a Hh ligand-independent manner. These findings support a model in which Hh and RA signaling cooperate to promote PMN cell fates in zebrafish...
  34. doi Heat-shock-mediated conditional regulation of hedgehog/gli signaling in zebrafish
    Meng Chieh Shen
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Dev Dyn 242:539-49. 2013
    ..Systems for conditional regulation of Hh signaling facilitate the study of these postembryonic Hh functions...
  35. pmc Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function
    Chengjin Zhang
    Julius L Chambers Biomedical Biotechnology Research Institute, Durham, NC 27707, USA
    Birth Defects Res A Clin Mol Teratol 97:8-27. 2013
    ..The present study was conducted to test the hypothesis that ethanol affects GABAergic and glutamatergic neuron development by disrupting Fgf, Shh, and agrin function...
  36. doi Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling
    Tom Stückemann
    Institute of Molecular Biology, University of Innsbruck, Technikerstrasse 25, Innsbruck, Austria
    Development 139:2711-20. 2012
    ..of Hh signalling, and propose that Cxcr4a enhances Hh-dependent proliferation by promoting the activity of Gli1. Our results indicate that Cxcr4a is required for Hh-dependent cell proliferation but not for Hh-dependent ..
  37. pmc Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Genet 8:e1002762. 2012
    ....
  38. pmc Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone
    Tyler R Huycke
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 139:2371-80. 2012
    ..Hence, patterning within a module may include adjacent regions of functionally related bones and might require that signaling pathways function over an extended period of development...
  39. pmc Assessing teratogenic changes in a zebrafish model of fetal alcohol exposure
    Evyn Loucks
    Program in Developmental Biology, Children s Memorial Research Center, Northwestern University, USA
    J Vis Exp . 2012
    ..Described here are the basic techniques used to study and manipulate the zebrafish FAS model...
  40. pmc HSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas
    Malgorzata I Wiweger
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS ONE 7:e29734. 2012
    ..The presence of the malformed and/or displaced teeth with abnormal enamel was declared by half of the respondents indicating that MO might indeed be also associated with dental problems...
  41. pmc Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis
    Zhanying Hu
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Autophagy 7:1514-27. 2011
    ..morphogenesis of brain regionalization and body plan as well as for expression regulation of neural gene markers: gli1, huC, nkx2.2, pink1, β-synuclein, xb51 and zic1...
  42. pmc Ectopic proliferation contributes to retinal dysplasia in the juvenile zebrafish patched2 mutant eye
    Jonathan Bibliowicz
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, Texas, USA
    Invest Ophthalmol Vis Sci 52:8868-77. 2011
    ..This study extends the analysis of retinal structure and homeostasis in ptc2-/- mutants to juvenile stages, to determine whether Patched 2 function is essential in the postembryonic eye...
  43. doi Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning
    Patricia A Gongal
    Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada
    Dev Biol 355:55-64. 2011
    ..We propose that Hmx4 is a critical regulator of retinoic acid synthesis in a developing embryo, and that this regulation is essential for controlling Shh signaling and forebrain development...
  44. pmc Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish
    Susana Pascoal
    Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 8:e68021. 2013
    ..Accurate regulation of Notch signalling is central for developmental processes in a variety of tissues, but its function in pectoral fin development in zebrafish is still unknown...
  45. ncbi Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling
    Yin Xiong Li
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lab Invest 87:231-40. 2007
    ..This insight into FASD pathogenesis may suggest novel strategies for preventing these common congenital defects...
  46. ncbi The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturation
    Ichiro Masai
    Masai Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, Hirosawa, Saitama, Japan
    Development 132:1539-53. 2005
    ..This dual requirement of Hh signalling in RGC differentiation implies that the regulation of a neurogenic wave is more complex in the zebrafish retina than in the Drosophila eye...
  47. ncbi The role of hedgehog signaling in the development of the zebrafish visual system
    Jochen A Stadler
    EMBL, Developmental Biology Programme, Meyerhofstrasse 1, DE 69117 Heidelberg, Germany
    Dev Neurosci 26:346-51. 2004
    ....
  48. ncbi Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression
    Hiroki Teraoka
    Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    Aquat Toxicol 78:103-13. 2006
    ..b (shhb) and their receptors, patched1 (ptc1) and patched2 (ptc2), as well as the downstream transcription factors, gli1 and gli2a...
  49. ncbi The zebrafish detour gene is essential for cranial but not spinal motor neuron induction
    A Chandrasekhar
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Development 126:2727-37. 1999
    The zebrafish detour (dtr) mutation generates a novel neuronal phenotype. In dtr mutants, most cranial motor neurons, especially the branchiomotor, are missing. However, spinal motor neurons are generated normally...
  50. ncbi Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons
    Josette M Ungos
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420 USA
    Development 130:5351-62. 2003
    ..These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors...
  51. ncbi Gonadotropin-releasing hormone (GnRH) cells arise from cranial neural crest and adenohypophyseal regions of the neural plate in the zebrafish, Danio rerio
    K E Whitlock
    Field of Genetics and Development Neurobiology and Behavior, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 257:140-52. 2003
    ..Thus, the GnRH cells arise from tissue closely associated with the developing olfactory placode, and their different developmental origins reflect their different functional roles in the adult animal...
  52. ncbi Multiple roles for Hedgehog signaling in zebrafish pituitary development
    Jennifer L Sbrogna
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Dev Biol 254:19-35. 2003
    ..from a complete loss of the adenohypophysis (smu/smo and yot/gli2 mutants) to more subtle patterning defects (dtr/gli1 mutants), may correlate to human Hh signaling mutant phenotypes seen in Holoprosencephaly and other congenital ..
  53. ncbi Cyclops-independent floor plate differentiation in zebrafish embryos
    Stephanie Albert
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
    Dev Dyn 226:59-66. 2003
    ..This finding suggests that the correct temporal development of the MFP is required for the distinction of LFP and MFP cells in wild-type embryos...
  54. ncbi Making the connection: retinal axon guidance in the zebrafish
    James Culverwell
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Semin Cell Dev Biol 13:497-506. 2002
    ..The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain...
  55. pmc Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling
    Shannon C Lunt
    Department of Biology, Texas A and M University, College Station, Texas 77843, USA
    Dev Dyn 238:1744-59. 2009
    ..Thus, our data indicate the requirement for cilia in the Hh signal transduction pathway may not represent a universal mechanism in vertebrates...
  56. ncbi Molecular changes associated with teratogen-induced cyclopia
    Evyn J Loucks
    Children s Memorial Research Center Program in Developmental Biology, Chicago, Illinois, USA
    Birth Defects Res A Clin Mol Teratol 79:642-51. 2007
    ..Exposure of zebrafish embryos to a number of teratogens results in cyclopia, but little is known about the underlying molecular changes...
  57. doi Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development
    Robert D Knight
    MRC Centre for Developmental Neurobiology, Kings College London, London, UK
    J Exp Zool B Mol Dev Evol 310:355-69. 2008
    ..These data imply that dorsal mandibular arch muscle identity in fish, chick and mouse is specified by a highly conserved molecular process despite differing functions of these muscles in different lineages...
  58. pmc Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis
    Burcu Guner
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:4435-51. 2008
    ..These data suggest that there are distinct origins and signaling requirements for the PD and PI...
  59. pmc Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas
    Seung Woo Park
    Department of Surgery, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 134:2080-90. 2008
    ..To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish embryos...
  60. doi Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity
    Jovica Ninkovic
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Department of Zebrafish Neurogenetics, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Development 135:3137-48. 2008
    ..Furthermore, we identify the transcription factor Gli1, expressed in medial IZ cells, as an antagonist of E(Spl) and Gsk3beta/PKA, and demonstrate that the neurogenesis-..
  61. pmc Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent
    John K Mich
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 328:342-54. 2009
    ..These results demonstrate that Hh signaling is not required for zebrafish PGC migration, and underscore the importance of regulated cell-cell adhesion for cell migration in vivo...
  62. doi Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds
    Yau Hung Chen
    Graduate Institute of Life Sciences, Tamkang University, No 151 Ying chuan Road, Tamsui, Taipei County, 251, Taiwan
    Transgenic Res 18:855-64. 2009
    ..In conclusion, this unique Tg(k18:shh:RFP) fish line, should be an excellent experimental animal for screening for a lower toxicity level of the new Hh-inhibitor and can even be used as a new anti-cancer drug-screening platform...
  63. doi Sonic hedgehog (Shh)-Gli signaling controls neural progenitor cell division in the developing tectum in zebrafish
    Carmen G Feijóo
    Center for Genomics of the Cell, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Eur J Neurosci 33:589-98. 2011
    ....
  64. pmc Visualization of Gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish
    Tyler Schwend
    Integrated Graduate Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e14396. 2010
    ..Understanding the requirements for Hh-signaling in organisms can be gained by assessing Gli activity in a spatial and temporal fashion...
  65. doi Characterization of drCol 15a1b: a novel component of the stem cell niche in the zebrafish retina
    Veronica Gonzalez-Nunez
    Developmental Biology Unit, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    Stem Cells 28:1399-411. 2010
    ....
  66. pmc The transcriptional repressor REST/NRSF modulates hedgehog signaling
    Keith P Gates
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Dev Biol 340:293-305. 2010
    ..The role of Rest as a regulator of Hh signaling has broad implications for many developmental contexts where REST and Hh signaling act...

Research Grants4

  1. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  2. Development of Cranial Motor Neurons
    Anand Chandrasekhar; Fiscal Year: 2007
    ..Together, these experiments will generate novel insight into neuronal migration mechanisms in the vertebrate hindbrain. ..
  3. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ....
  4. Molecular Control of Pituitary Development and Tumorigenesis
    Rolf O Karlstrom; Fiscal Year: 2010
    ..Comment [MB1]: I assume that stat is in the US? I would insert US here, given that you are applying for PHS money. ..