gdf6a

Summary

Gene Symbol: gdf6a
Description: growth differentiation factor 6a
Alias: rdr, sb:cb278, growth/differentiation factor 6-A, GDF-6-A, cb278, darl, growth differentiation factor 6, out, protein radar, radar
Species: zebrafish

Top Publications

  1. doi Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies
    Mika Asai-Coakwell
    Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada
    Hum Mol Genet 22:1432-42. 2013
  2. doi Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development
    Curtis R French
    Department of Biological Sciences, University of Alberta, CW405, Biological Sciences Bldg, Edmonton T6G 2E9, Canada
    Dev Biol 333:37-47. 2009
  3. pmc An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina
    Nathan J Gosse
    Department of Physiology, Program in Developmental Biology, Genetics, University of California, 1550 Fourth Street, San Francisco, CA 94158 2722, USA
    Proc Natl Acad Sci U S A 106:2236-41. 2009
  4. doi Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes
    Mika Asai-Coakwell
    Department of Ophthalmology, University of Alberta, Edmonton, Canada
    Hum Mol Genet 18:1110-21. 2009
  5. pmc Pbx homeodomain proteins pattern both the zebrafish retina and tectum
    Curtis R French
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    BMC Dev Biol 7:85. 2007
  6. pmc GDF6, a novel locus for a spectrum of ocular developmental anomalies
    Mika Asai-Coakwell
    Department of Ophthalmology and Medical Genetics, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Am J Hum Genet 80:306-15. 2007
  7. pmc Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomalies
    Anneke I den Hollander
    Division of Craniofacial and Molecular Genetics, Tufts University, 136 Harrison Ave, Boston MA 02111, USA
    BMC Genet 11:102. 2010
  8. pmc Morphogenesis and cell fate determination within the adaxial cell equivalence group of the zebrafish myotome
    Mai E Nguyen-Chi
    Australian Regenerative Medicine Institute, Monash University, Clayton, Australia
    PLoS Genet 8:e1003014. 2012
  9. ncbi The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling
    Atsushi Kawakami
    Department of Biological Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Curr Biol 15:480-8. 2005
  10. pmc Maternal induction of ventral fate by zebrafish radar
    Samuel Sidi
    Institut National de la Santé et de la Recherche Médicale U368, Ecole Normale Superieure, 75005 Paris, France
    Proc Natl Acad Sci U S A 100:3315-20. 2003

Scientific Experts

  • J H Postlethwait
  • Phil Crosier
  • Michael Schebesta
  • Curtis R French
  • Atsushi Kawakami
  • Mika Asai-Coakwell
  • Andrew J Waskiewicz
  • Ordan J Lehmann
  • Leonardo E Valdivia
  • Vanessa L Holly
  • Michèle G Duval
  • W Ted Allison
  • Marie Christine Ramel
  • Caroline S Hill
  • Sabine Reichert
  • Mai E Nguyen-Chi
  • Hideomi Tanaka
  • Renee Kruse-Bend
  • Yves Sauve
  • Periasamy Sundaresan
  • Richard I Dorsky
  • Anneke I den Hollander
  • Natalie Chaplin
  • Nykolaus P Reed
  • Timothy Erickson
  • Eric S Veien
  • Hideaki Nojima
  • Nathan J Gosse
  • Daniel Maurus
  • Solei Cermenati
  • Veronica van Heyningen
  • Jennifer Bonner
  • Gina E Elsen
  • Ming Ye
  • Thomas F Schilling
  • Genevieve Kinna
  • Graham J Lieschke
  • Andrew J Latimer
  • Benjamin M Hogan
  • Linxi Qian
  • C Goutel
  • Wilson Horner
  • Stephen W Wilson
  • Rodrigo M Young
  • Samuel Sidi
  • McKenzie Givens
  • Quenten P Schwarz
  • Anna M Krasnow
  • Heather L Stickney
  • Lisa M Lawrence
  • Florencia Cavodeassi
  • Terra S Vleeshouwer-Neumann
  • Claudia Wierzbicki
  • Audrey M Williams
  • Thomas A Hawkins
  • Thomas P Wilm
  • Amanuel Tafessu
  • Gaia Gestri
  • Dayna B Lamb
  • Kara L Cerveny
  • Frederic M Rosa
  • Aneta Ringholm
  • Jakub K Famulski
  • Nicolas B David
  • A Phillip Oel
  • Sonya A Widen
  • Christopher J Hall
  • Rebecca A Randall
  • Peter J Francis
  • Irma Lopez
  • Elfride De Baere
  • E Delot
  • Lindsey March
  • Xiao hua Dai
  • Robert K Koenekoop
  • Jakub Famulski
  • Michele Duval
  • Fred B Berry
  • Sabine Fuhrmann
  • Tyler S Quist
  • Robert Bryson-Richardson
  • Abigail Gibson
  • Thomas E Hall
  • Rii Morimura
  • Chi Bin Chien
  • Peter D Currie
  • Wendy Chua
  • Toshio Ohshima
  • Carmen Sonntag
  • Jude Rosenthal

Detail Information

Publications41

  1. doi Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies
    Mika Asai-Coakwell
    Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada
    Hum Mol Genet 22:1432-42. 2013
    ..Here we show that mutations in the transforming growth factor-β (TGF-β) ligand Growth Differentiation Factor 6, which specifies the dorso-ventral retinal axis, contribute to Leber congenital amaurosis...
  2. doi Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development
    Curtis R French
    Department of Biological Sciences, University of Alberta, CW405, Biological Sciences Bldg, Edmonton T6G 2E9, Canada
    Dev Biol 333:37-47. 2009
    ..In this study, we investigate the functions of two zebrafish Bmps, Gdf6a and Bmp4, during initiation of dorsal retinal identity, and subsequently during lens differentiation...
  3. pmc An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina
    Nathan J Gosse
    Department of Physiology, Program in Developmental Biology, Genetics, University of California, 1550 Fourth Street, San Francisco, CA 94158 2722, USA
    Proc Natl Acad Sci U S A 106:2236-41. 2009
    ..We have discovered that the diffusible TGFss-related factor Radar (Gdf6a) is necessary and sufficient for activation of dorsal markers, such as Bmp4, Tbx5, Tbx2b, and Ephrin-B2, ..
  4. doi Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes
    Mika Asai-Coakwell
    Department of Ophthalmology, University of Alberta, Edmonton, Canada
    Hum Mol Genet 18:1110-21. 2009
    ..We identified seven heterozygous mutations in growth differentiation factor 6 (GDF6), a member of the BMP family, in patients with both ocular and vertebral anomalies, ..
  5. pmc Pbx homeodomain proteins pattern both the zebrafish retina and tectum
    Curtis R French
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    BMC Dev Biol 7:85. 2007
    ..Although previous results have demonstrated that Pbx is required for proper eye size, functions in regulating retinal cell identity and patterning have not yet been examined...
  6. pmc GDF6, a novel locus for a spectrum of ocular developmental anomalies
    Mika Asai-Coakwell
    Department of Ophthalmology and Medical Genetics, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Am J Hum Genet 80:306-15. 2007
    ..deletion encompasses GDF6, encoding a member of the bone-morphogenetic protein family, and that inhibition of gdf6a in a model organism accurately recapitulates the proband's phenotype...
  7. pmc Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomalies
    Anneke I den Hollander
    Division of Craniofacial and Molecular Genetics, Tufts University, 136 Harrison Ave, Boston MA 02111, USA
    BMC Genet 11:102. 2010
    ..A mutation in the zebrafish out of sight (out) locus results in a particularly severe reduction of eye size...
  8. pmc Morphogenesis and cell fate determination within the adaxial cell equivalence group of the zebrafish myotome
    Mai E Nguyen-Chi
    Australian Regenerative Medicine Institute, Monash University, Clayton, Australia
    PLoS Genet 8:e1003014. 2012
    ..Thus our results reveal that the synergistic actions of HH, FGF, and BMP signaling independently create a three-dimensional (3D) signaling milieu that coordinates cell fate within the adaxial cell equivalence group...
  9. ncbi The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling
    Atsushi Kawakami
    Department of Biological Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Curr Biol 15:480-8. 2005
    ..We further show that Bmp activity can be attenuated by the coexpression of Scube2. Our data support the idea that Scube2 can modulate the long-range action of Bmp-dependent signaling in the neural tube and somites...
  10. pmc Maternal induction of ventral fate by zebrafish radar
    Samuel Sidi
    Institut National de la Santé et de la Recherche Médicale U368, Ecole Normale Superieure, 75005 Paris, France
    Proc Natl Acad Sci U S A 100:3315-20. 2003
    ..in the zebrafish embryo by the maternally encoded transforming growth factor beta (TGF-beta) signaling molecule, Radar. Loss-of-function experiments, together with epistasis analyses, identify maternal Radar as an upstream activator ..
  11. ncbi Pathways in blood and vessel development revealed through zebrafish genetics
    Philip S Crosier
    Division of Molecular Medicine, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Int J Dev Biol 46:493-502. 2002
    ..Gdf6a/radar, a member of the bone morphogenetic protein (BMP) family, is expressed in the zebrafish hypochord and primitive ..
  12. ncbi The BMP-related protein radar: a maintenance factor for dorsal neuroectoderm cells?
    E Delot
    Unité INSERM U368, Ecole Normale Superieure, 46 rud d Ulm, F 75005, Paris, France
    Mech Dev 85:15-25. 1999
    We have previously cloned several members of the TGF-beta superfamily of growth factors in zebrafish, one of which, Radar, belongs to the Dpp-Vg1-related (DVR) subgroup, with highest homology to GDF6...
  13. ncbi The ventralizing activity of Radar, a maternally expressed bone morphogenetic protein, reveals complex bone morphogenetic protein interactions controlling dorso-ventral patterning in zebrafish
    C Goutel
    INSERM U 368, Ecole Normale Superieure, 46 rue d Ulm, 75005, Paris, France
    Mech Dev 99:15-27. 2000
    ..We provide evidence here that a maternally expressed bone morphogenetic protein (BMP), Radar, may control early ventral specification in zebrafish...
  14. ncbi Radar is required for the establishment of vascular integrity in the zebrafish
    Christopher J Hall
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Dev Biol 251:105-17. 2002
    ..Here, we propose a role for Radar, one of the zebrafish orthologues of gdf6, in establishing integrity of the trunk vasculature in zebrafish embryos...
  15. pmc Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
    Leonardo E Valdivia
    Department of Cell and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Development 143:1087-98. 2016
    ..These mutants carry lesions in gdf6a, a gene encoding a BMP family member previously implicated in dorsoventral patterning of the eye...
  16. pmc gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate
    Michèle G Duval
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 9:e92991. 2014
    ..using nocturnal murine models, we instead utilize cone-rich zebrafish and herein investigate relationships between gdf6a and tbx2b in cone photoreceptor development...
  17. doi Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development
    Vanessa L Holly
    Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada
    Dev Biol 388:192-204. 2014
    ..Overexpression of a low dose of sfrp5 mRNA causes an increase in dorsal retina marker gene expression. We propose a model in which Sfrp proteins function as facilitators of both BMP and Wnt signaling within the dorsal retina. ..
  18. doi A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border
    Sabine Reichert
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Development 140:4435-44. 2013
    ..Taken together, our data define a BMP regulatory network that controls cell fate decisions at the neural plate border. ..
  19. doi Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish
    Hideomi Tanaka
    Department of Life Science and Medical Bio Science, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Dev Biol 370:223-36. 2012
    ..These results suggest that the phosphorylation of Dpysl2 and Dpysl3 by Cdk5 and DYRK2 is required for the proper positioning of RB neurons and NCCs during neurulation in zebrafish embryos...
  20. pmc Extraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafish
    Renee Kruse-Bend
    Department of Neurobiology and Anatomy, 20 North 1900 East, Room 401 MREB, University of Utah, Salt Lake City, UT 84132, USA
    Dev Biol 371:57-65. 2012
    ..We identified gdf6a as a dorsal initiation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination...
  21. ncbi Requirement for endoderm and FGF3 in ventral head skeleton formation
    Nicolas B David
    U 368 INSERM, Ecole Normale Superieure, 46 rue d Ulm, F 75230 Paris cedex 05, France
    Development 129:4457-68. 2002
    ..Together, our results reveal for the first time that the endoderm provides differential cues along the anteroposterior axis to control ventral head skeleton development and demonstrate that this function is mediated in part by Fgf3...
  22. pmc The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands
    Marie Christine Ramel
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, United Kingdom
    Dev Biol 378:170-82. 2013
    ....
  23. pmc Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system
    Timothy Erickson
    Department of Biological Sciences, University of Alberta, CW405, Biological Sciences Bldg, Edmonton T6G 2E9, Canada
    Neural Dev 5:22. 2010
    ..Meis1 is a TALE-class homeodomain transcription factor known to specify anterior-posterior identity in the hindbrain, but its role in visual system patterning has not been investigated...
  24. pmc Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar
    Nykolaus P Reed
    Department of Microbial Pathogenesis and Immune Response, School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee, USA
    Dev Dyn 239:1047-60. 2010
    ..radar/gdf6a is a zebrafish ortholog of Gdf6 and has an essential role in embryonic patterning...
  25. pmc Absence of an external germinal layer in zebrafish and shark reveals a distinct, anamniote ground plan of cerebellum development
    Natalie Chaplin
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    J Neurosci 30:3048-57. 2010
    ..We show that these anamniotes share a common ground plan of granule cell production that does not include an external germinal layer...
  26. pmc Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling
    Jennifer Bonner
    Department of Neurobiology and Anatomy University, Utah School of Medicine, Salt Lake City, UT 84132, USA
    Dev Biol 313:398-407. 2008
    ..Together, our work demonstrates that proliferation and patterning in the developing spinal cord are separable events that are regulated independently by Wnt signaling...
  27. doi Syntabulin, a motor protein linker, controls dorsal determination
    Hideaki Nojima
    Laboratory for Vertebrate Axis Formation, RIKEN Center for Developmental Biology, Hyogo 650 0047, Japan
    Development 137:923-33. 2010
    ..Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation...
  28. pmc Zic-associated holoprosencephaly: zebrafish Zic1 controls midline formation and forebrain patterning by regulating Nodal, Hedgehog, and retinoic acid signaling
    Daniel Maurus
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Genes Dev 23:1461-73. 2009
    ..Repression of BMP signaling in dorsal forebrain has been implicated in causing MIH HPE. This work provides a mechanistical explanation at the molecular level of why Zic factors are associated with both major forms of HPE...
  29. pmc Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis
    Gina E Elsen
    The Committee on Neurobiology, University of Chicago, 947 East 58th Street, Chicago, IL 60637, USA
    Dev Biol 314:376-92. 2008
    ..In summary, we conclude that Zic1 and Zic4 control zebrafish 4th ventricle morphogenesis by regulating multiple mechanisms including cell proliferation and fate specification in the dorsal hindbrain...
  30. ncbi Sox18 and Sox7 play redundant roles in vascular development
    Solei Cermenati
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, Milan, Italy
    Blood 111:2657-66. 2008
    ..Our data suggest that a defect in arteriovenous identity could be responsible for the formation of telangiectases in patients with HLT...
  31. ncbi Zebrafish Radar: a new member of the TGF-beta superfamily defines dorsal regions of the neural plate and the embryonic retina
    M Rissi
    Department of Cell Biology, Biozentrum der Universitat, Basel, Switzerland
    Mech Dev 49:223-34. 1995
    ..new members of this superfamily involved in the control of early zebrafish embryogenesis, we have isolated a gene, Radar, which appears to be conserved throughout vertebrate evolution and defines a new subfamily within the superfamily...
  32. ncbi Transcriptional profiling of caudal fin regeneration in zebrafish
    Michael Schebesta
    Howard Hughes Medical Institute, Department of Cardiology, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA
    ScientificWorldJournal 6:38-54. 2006
    ..Taken together, we provide a comprehensive database of fin regeneration that will serve as an important tool for understanding the molecular mechanisms of regeneration...
  33. ncbi Notch signaling regulates midline cell specification and proliferation in zebrafish
    Andrew J Latimer
    Department of Biological Sciences, Vanderbilt University, U7211 BSB MRBIII, 465 21st Avenue South, Nashville, TN 37232, USA
    Dev Biol 298:392-402. 2006
    ..Together, our results indicate that Notch signaling regulates allocation of appropriate numbers of different midline cells by different mechanisms...
  34. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
    ..1 expression, but the role of alk8 was independent of the scl-dependent cell-fate pathway. Furthermore, the role of Alk8 in myelopoiesis was genetically separable from its earlier role in dorsal-ventral embryonic patterning...
  35. ncbi Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development
    Genevieve Kinna
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Mech Dev 123:277-87. 2006
    ..Hence, the primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development...
  36. ncbi Ethanol disrupts the formation of hypochord and dorsal aorta during the development of embryonic zebrafish
    Linxi Qian
    Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai Medical School of Fudan University, Shanghai 200032, China
    Sci China C Life Sci 48:608-15. 2005
    ..The consequent lack of vasculogenic factors including Radar and Ang-1 partly explains the defects in formation and integrity of dorsal aorta...
  37. pmc Radar breaks the fog: insights into dorsoventral patterning in zebrafish
    Thomas P Wilm
    Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Proc Natl Acad Sci U S A 100:4363-5. 2003
  38. ncbi One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology
    Aneta Ringholm
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, BMC, 75 124 Uppsala, Sweden
    J Neurochem 82:6-18. 2002
    ....
  39. ncbi Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily
    A J Davidson
    Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
    Genome Res 9:121-9. 1999
    ..In zebrafish, there are three genes that belong to the Gdf5, 6, 7 subgroup that have been named radar, dynamo, and contact. The genes radar and dynamo both encode proteins most similar to mouse GDF6...
  40. ncbi Conversion of zebrafish blastomeres to an endodermal fate by TGF-beta-related signaling
    N Peyrieras
    INSERM U368, Ecole Normale Superieure, Paris, France
    Curr Biol 8:783-6. 1998
    ....
  41. ncbi Vertebrate genome evolution and the zebrafish gene map
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Nat Genet 18:345-9. 1998
    ..This zebrafish gene map will facilitate molecular identification of mutated zebrafish genes, which can suggest functions for human genes known only by sequence...