gata6

Summary

Gene Symbol: gata6
Description: GATA binding protein 6
Alias: GATA-5, cb603, transcription factor GATA-6
Species: zebrafish

Top Publications

  1. doi Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis
    Honghui Huang
    Laboratory of Functional Genomics, Institute of Molecular and Cell Biology, Proteos, Singapore
    Development 135:3209-18. 2008
  2. pmc A protein disulfide isomerase expressed in the embryonic midline is required for left/right asymmetries
    Kazuyuki Hoshijima
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 16:2518-29. 2002
  3. pmc GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation
    Tessa Peterkin
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    EMBO J 22:4260-73. 2003
  4. pmc DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish
    Shunya Hozumi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan
    PLoS ONE 7:e33675. 2012
  5. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
  6. pmc Redundancy and evolution of GATA factor requirements in development of the myocardium
    Tessa Peterkin
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Dev Biol 311:623-35. 2007
  7. ncbi Exocrine pancreas development in zebrafish
    Nelson S Yee
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Biol 284:84-101. 2005
  8. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007
  9. pmc Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development
    Kunal Rai
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    Mol Cell Biol 26:7077-85. 2006
  10. ncbi Gata4 regulates the formation of multiple organs
    Audrey Holtzinger
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 132:4005-14. 2005

Scientific Experts

  • Yunhan Hong
  • Gianfranco Matrone
  • Hisako Miyagi
  • Yaniv Hinits
  • Hyon J Kim
  • Isabelle Manfroid
  • Zhen Li
  • William Q Gillis
  • Niccolò Bolli
  • Todd Evans
  • Tessa Peterkin
  • Kunal Rai
  • Jinrong Peng
  • Lei Zeng
  • Donghun Shin
  • Roger Patient
  • Stephanie Chidester
  • David A Jones
  • Audrey Holtzinger
  • Changqing Chang
  • Ao Yin
  • Vladimir Korzh
  • Svitlana Korzh
  • Alice Heicklen-Klein
  • Smitha R James
  • Adam R Karpf
  • Bradley R Cairns
  • Ashish R Deshwar
  • Minho Won
  • Abigail Gibson
  • Mollie L Kelly
  • Wei Qin
  • Andrew J Latimer
  • Nian Liu
  • Lincoln D Nadauld
  • Natasha Novikov
  • Maarit Hölttä-Vuori
  • Shunya Hozumi
  • Shuo Lin
  • XuBo Niu
  • Cong Xu
  • Nelson S Yee
  • Dong Liang
  • Erin L Cadwalader
  • Tracy E Dohn
  • Sarah A Hutchinson
  • Maximilian Schuff
  • Li Jan Lo
  • Filipa Costa Simões
  • Ioannis Serafimidis
  • Shu Lan Yang
  • Zhiyuan Gong
  • Sarah J Childs
  • Nikolaus S Trede
  • Sung Kook Hong
  • Yi Chung Chen
  • Amir Rikin
  • Leif C Lindeman
  • Chuan Gao
  • Fei Qi
  • Svetlana Korzh
  • Chang Jen Huang
  • Jae Sun Park
  • Julio D Amigo
  • Cheng Ying Chu
  • Kenneth D Poss
  • Tzu Min Chan
  • Didier Y R Stainier
  • H Joseph Yost
  • Yutaka Kikuchi
  • Pei Yi Cheng
  • Honghui Huang
  • Vanesa Muncan
  • Elizabeth J Manos
  • Bruce Appel
  • Bhaskarjyoti Sarmah
  • Kimiko Fukuda
  • John W Lin
  • Xuefei Yuan
  • Ian C Scott
  • Martin Gering
  • John C Onderisin
  • Anastasiia Aleksandrova
  • Hugo Lavoie
  • Jeffrey T A Burrows
  • Hyunju Ro
  • Igor B Dawid
  • Kazuyuki Hoshijima
  • Yihan Zhang
  • Song Li

Detail Information

Publications66

  1. doi Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis
    Honghui Huang
    Laboratory of Functional Genomics, Institute of Molecular and Cell Biology, Proteos, Singapore
    Development 135:3209-18. 2008
    ....
  2. pmc A protein disulfide isomerase expressed in the embryonic midline is required for left/right asymmetries
    Kazuyuki Hoshijima
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 16:2518-29. 2002
    ....
  3. pmc GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation
    Tessa Peterkin
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    EMBO J 22:4260-73. 2003
    ..We therefore conclude that proper maturation of cardiac mesoderm requires GATA-6, which functions to maintain BMP-4 and Nkx2 expression...
  4. pmc DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish
    Shunya Hozumi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan
    PLoS ONE 7:e33675. 2012
    ..Therefore, our results suggest a model in which zebrafish Ddx46 is required for the development of the digestive organs and brain, possibly through the control of pre-mRNA splicing...
  5. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells...
  6. pmc Redundancy and evolution of GATA factor requirements in development of the myocardium
    Tessa Peterkin
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Dev Biol 311:623-35. 2007
    ..show that GATA4 knockdown, for example, only affects cardiac marker expression in the absence of either GATA5 or GATA6. A similar situation pertains for GATA5 in Xenopus whereas, in zebrafish, GATA5 (faust) plays a major role in ..
  7. ncbi Exocrine pancreas development in zebrafish
    Nelson S Yee
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Biol 284:84-101. 2005
    ..By contrast, analyses of mind bomb mutants and jagged morpholino-injected larvae suggest that Notch signaling principally regulates ductal differentiation of bipotential exocrine progenitors...
  8. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007
    ..Furthermore, zebrafish Dnmt2 methylates an RNA species of approximately 80 bases, consistent with tRNA methylation. Thus, Dnmt2 promotes zebrafish development, likely through cytoplasmic RNA methylation...
  9. pmc Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development
    Kunal Rai
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    Mol Cell Biol 26:7077-85. 2006
    ..Our results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues...
  10. ncbi Gata4 regulates the formation of multiple organs
    Audrey Holtzinger
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 132:4005-14. 2005
    ..Therefore, a single transcription factor regulates the formation of many organs. Gata6 is a closely related transcription factor with an overlapping expression pattern...
  11. ncbi casanova plays an early and essential role in endoderm formation in zebrafish
    J Alexander
    Programs in Developmental Biology and Human Genetics, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 0448, USA
    Dev Biol 215:343-57. 1999
    ....
  12. doi Mespaa can potently induce cardiac fates in zebrafish
    Ashish R Deshwar
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 0A4 Department of Molecular Genetics, University of Toronto, Canada
    Dev Biol 418:17-27. 2016
    ..Furthermore, the late activation of migration and cardiac gene transcription in mespaa over-expressing cells challenges previous studies on the timing of these events and provides intriguing questions for future study. ..
  13. pmc Characterization of Danio rerio Nanog and functional comparison to Xenopus Vents
    Maximilian Schuff
    Institute of Biochemistry, University of Ulm, Ulm, Germany
    Stem Cells Dev 21:1225-38. 2012
    ..Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog...
  14. pmc The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish
    Julio D Amigo
    Department of Medicine, Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 114:4654-63. 2009
    ..One of these enhancers contains functional GATA-binding sites, indicating the potential for a regulatory loop in which GATA factors control the expression of their partner protein FOG-1...
  15. pmc Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling
    Natasha Novikov
    Department of Surgery, Weill Cornell Medical College, Cornell University, 1300 York Ave, LC 708, New York, NY, USA
    Development 140:3787-98. 2013
    ..We identified genes expressed in lateral mesoderm that are dysregulated in zebrafish when both gata5 and gata6 are depleted, causing a block to cardiomyocyte specification...
  16. doi Zfyve9a regulates the proliferation of hepatic cells during zebrafish embryogenesis
    Nian Liu
    Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou, China
    Int J Dev Biol 57:773-8. 2013
    ..Thus, our results reveal the liver-specific function of zfyve9a during early embryogenesis and indicate that the zfyve9a mediated signal is essential for the proliferation of hepatic cells during the expansion of liver bud. ..
  17. pmc A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish
    Mollie L Kelly
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA Department of Biochemistry and Molecular Biology, Drexel University, Philadelphia, PA 19102, USA
    Dev Cell 29:350-9. 2014
    ..Furthermore, we show that activated Erk signals by phosphorylating the transcription factor Gata6 on a conserved serine residue to promote neural crest migration and proper formation of craniofacial structures, ..
  18. pmc Nom1 mediates pancreas development by regulating ribosome biogenesis in zebrafish
    Wei Qin
    Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
    PLoS ONE 9:e100796. 2014
    ..This suggests that targeting Pp1α into the nucleolus by Nom1 is important for pancreatic proliferation. Altogether, our studies revealed a new mechanism involving Nom1 in controlling vertebrate exocrine pancreas formation. ..
  19. doi Temporal cohesion of the structural, functional and molecular characteristics of the developing zebrafish heart
    Gianfranco Matrone
    University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom Electronic address
    Differentiation 89:117-27. 2015
    ..This study provides important insights into the complex temporal relationship between structure and function of the developing zebrafish heart...
  20. pmc Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreas
    Minho Won
    Section on Developmental Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892 2790
    Proc Natl Acad Sci U S A 112:12426-31. 2015
    ..Further, the complex relationships among genotype, phenotype, and morpholino effect in this case may be instructive in the ongoing consideration of morpholino use. ..
  21. pmc CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart
    Gianfranco Matrone
    British Heart Foundation Centre for Cardiovascular Science, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Methodist Hospital Research Institute, Houston, TX 77030, USA
    J Cell Sci 128:4560-71. 2015
    ..The balance of Cdk9 and Larp7 plays a key role in cardiomyocyte proliferation and response to injury. Larp7 represents a potentially novel therapeutic target to promote cardiomyocyte proliferation and recovery from injury. ..
  22. doi Characterization of the zebrafish cx36.7 gene promoter: Its regulation of cardiac-specific expression and skeletal muscle-specific repression
    Hisako Miyagi
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 B13 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan Electronic address
    Gene 577:265-74. 2016
    ..When gata4, gata5 and gata6 were simultaneously knocked down, the promoter activity was significantly decreased...
  23. doi The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development
    Svitlana Korzh
    Department of Biological Sciences, National University of Singapore
    Dev Biol 359:262-76. 2011
    ..These findings contribute to the understanding of epithelial-mesenchymal interactions and highlight an interaction between Hh and Fgf signaling pathways during esophagus and swimbladder development...
  24. doi Depletion of Bhmt elevates sonic hedgehog transcript level and increases β-cell number in zebrafish
    Shu Lan Yang
    Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research A STAR, Proteos, Singapore
    Endocrinology 152:4706-17. 2011
    ..Therefore, although there are still many intriguing questions to be answered, our finding may identify a novel function for Bhmt involving modulation of Shh signaling to control β-cell development...
  25. pmc Distinct phases of Wnt/β-catenin signaling direct cardiomyocyte formation in zebrafish
    Tracy E Dohn
    Molecular and Developmental Biology Graduate Program, University of Cincinnati, USA
    Dev Biol 361:364-76. 2012
    ....
  26. pmc cpsf1 is required for definitive HSC survival in zebrafish
    Niccolò Bolli
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 117:3996-4007. 2011
    ..These studies show that cpsf1 is essential for HSC survival and differentiation in caudal hematopoietic tissue...
  27. pmc 2-O-sulfotransferase regulates Wnt signaling, cell adhesion and cell cycle during zebrafish epiboly
    Erin L Cadwalader
    Department of Neurobiology and Anatomy, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 139:1296-305. 2012
    ..Together, these results indicate that 2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3β and β-catenin intracellular localization and function...
  28. pmc Retinoic acid signaling plays a restrictive role in zebrafish primitive myelopoiesis
    Dong Liang
    Model Animal Research Center, MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    PLoS ONE 7:e30865. 2012
    ..Taken together, our results demonstrate that RA signaling restricts zebrafish primitive myelopoiesis through acting downstream of gata4/5/6, upstream of, or parallel to, cloche, and upstream of scl...
  29. pmc Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway
    Cong Xu
    Howard Hughes Medical Institute, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 22:625-38. 2012
    ..Our study identifies a Nanog-like-Mxtx2-Nodal pathway and establishes a role for Nanog-like in regulating the formation of the extraembryonic tissue required for endoderm induction...
  30. doi Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish
    XuBo Niu
    Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China
    Dev Biol 367:197-207. 2012
    ..Our data provide the first direct genetic evidence that COPII function is essential for the organogenesis of the digestive system...
  31. doi The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism
    Lei Zeng
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 367:178-86. 2012
    ..We show that expression of bmp4 is modulated by the miR-145 direct target gata6 but not a second potential direct target, klf5a...
  32. pmc Tbl3 regulates cell cycle length during zebrafish development
    Sarah A Hutchinson
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 368:261-72. 2012
    ..These data suggest that tbl3 plays a tissue-specific role regulating cell cycle rate during development...
  33. pmc Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation
    Yaniv Hinits
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, King s College London, UK
    Dev Biol 369:199-210. 2012
    ..Mef2cb single mutants have a functional heart and are viable adults. Our results show that the key role of Mef2c in myocardial differentiation is conserved throughout the vertebrate heart...
  34. doi Alleviation of seipinopathy-related ER stress by triglyceride storage
    Maarit Hölttä-Vuori
    Institute of Biomedicine, Anatomy, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 22:1157-66. 2013
    ..We propose that the decreased TG content contributes to the pathology induced by seipin N88S, and that rescuing TG levels may provide a novel therapeutic strategy in seipinopathy...
  35. pmc G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis
    Ioannis Serafimidis
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou 4, Athens 11527, Greece
    Mol Cell Biol 31:4442-53. 2011
    ..Finally, we identified sphingosine-1-phosphate (S1P) as a ligand mediating islet cell aggregation in both species acting through distinct but closely related receptors...
  36. pmc liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in zebrafish
    Changqing Chang
    College of Animal Sciences, Zhejiang University, Hangzhou, People s Republic of China
    PLoS ONE 6:e22910. 2011
    ..Finally, we proved that Leg1 is a secretory protein. This intrigued us to propose that Leg1 might act as a novel secreted regulator that is essential for liver and other digestive organ development in zebrafish...
  37. pmc Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators
    Filipa Costa Simões
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington OX3 9DS, UK
    Development 138:3235-45. 2011
    ..We propose that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart...
  38. pmc Wnt signaling is required for early development of zebrafish swimbladder
    Ao Yin
    Department of Biological Sciences, National University of Singapore, Singapore, Singapore
    PLoS ONE 6:e18431. 2011
    ..To investigate the potential conservation of signaling events in early development of the lung and swimbladder, we wish to address the question whether Wnt signaling plays a role in swimbladder development...
  39. pmc The tbx/bHLH transcription factor mga regulates gata4 and organogenesis
    Amir Rikin
    Department of Surgery, Weill Cornell Medical College, New York, New York, USA
    Dev Dyn 239:535-47. 2010
    ..Transcript profiling experiments show that mga functions early to influence key regulators of mesendoderm, including tbx6, cas, and sox17...
  40. pmc Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development
    Zhen Li
    Department of Biological Sciences, National University of Singapore, Singapore
    BMC Dev Biol 7:117. 2007
    ....
  41. ncbi Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar)
    F Reifers
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 127:225-35. 2000
    ..Fgf8 is required for the earliest stages of nkx2.5 and gata4, but not gata6, expression in cardiac precursors...
  42. ncbi Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains
    Hugo Lavoie
    Laboratoire de Neurogénétique, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Hum Mol Genet 12:2967-79. 2003
    ....
  43. ncbi T-box binding sites are required for activity of a cardiac GATA-4 enhancer
    Alice Heicklen-Klein
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 267:490-504. 2004
    ..Thus, GATA-4 regulatory elements control gene expression differentially along the rostro-caudal axis, and T-box binding elements in the GATA-4 promoter contribute to heart-specific expression...
  44. ncbi Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    John W Lin
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Dev Biol 270:474-86. 2004
    ..Together, these findings suggest the presence of distinct ptf1a-dependent and ptf1a-independent precursor populations in developing zebrafish pancreas...
  45. ncbi Using the zebrafish model to study GATA transcription factors
    Alice Heicklen-Klein
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin Room 501, Bronx, NY 10461, USA
    Semin Cell Dev Biol 16:95-106. 2005
    ....
  46. ncbi The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli
    Lincoln D Nadauld
    Department of Oncological Sciences, University of Utah, Salt Lake City 84112, USA
    J Biol Chem 280:30490-5. 2005
    ....
  47. ncbi Inositol polyphosphates regulate zebrafish left-right asymmetry
    Bhaskarjyoti Sarmah
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U 3209 MRBIII, 465 21 st Avenue South, Nashville, Tennessee 37232, USA
    Dev Cell 9:133-45. 2005
    ..Our data suggest that the pathway for inositol hexakisphosphate production is a key regulator of asymmetric Ca(2+) flux during LR specification...
  48. ncbi Endoderm development in vertebrates: fate mapping, induction and regional specification
    Kimiko Fukuda
    Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minamiohsawa, Hachioji, Tokyo 192 0397, Japan
    Dev Growth Differ 47:343-55. 2005
    ..We discuss the classical fate mapping of the endoderm and the more recent progress in characterizing its induction, segregation and regional specification...
  49. pmc Wnt5 signaling in vertebrate pancreas development
    Hyon J Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Biol 3:23. 2005
    ..Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development...
  50. ncbi Notch signaling regulates midline cell specification and proliferation in zebrafish
    Andrew J Latimer
    Department of Biological Sciences, Vanderbilt University, U7211 BSB MRBIII, 465 21st Avenue South, Nashville, TN 37232, USA
    Dev Biol 298:392-402. 2006
    ..Together, our results indicate that Notch signaling regulates allocation of appropriate numbers of different midline cells by different mechanisms...
  51. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  52. pmc T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine
    Vanesa Muncan
    Netherlands Institute for Developmental Biology, Center for Biomedical Research, Hubrecht Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    EMBO Rep 8:966-73. 2007
    ..This study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life...
  53. ncbi Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development
    Isabelle Manfroid
    GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
    Development 134:4011-21. 2007
    ....
  54. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
    ..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
  55. pmc Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes
    Audrey Holtzinger
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 312:613-22. 2007
    ..Here we show that in zebrafish the gata5 and gata6 genes are redundant for specification of cardiomyocytes. Embryos depleted of these two gene products are heartless...
  56. doi Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation
    Pei Yi Cheng
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
    Development 135:941-52. 2008
    ..This study underscores a novel role of zebrafish cdx1b in the development of different digestive organs compared with its mammalian homologs...
  57. doi Functional analysis of the evolutionarily conserved cis-regulatory elements on the sox17 gene in zebrafish
    Tzu Min Chan
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan, ROC
    Dev Biol 326:456-70. 2009
    ..This information provides new insight into the complexity of endoderm formation and serves as a valuable resource for the establishment of a complete endoderm gene regulatory network...
  58. doi Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development
    Jae Sun Park
    Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Seoul, Korea
    Dev Dyn 238:1574-81. 2009
    ..In addition, the vmhc promoter and the transgenic zebrafish (vmhc:gfp) are useful tools to study the formation and function of the ventricle. Developmental Dynamics 238:1574-1581, 2009. (c) 2009 Wiley-Liss, Inc...
  59. pmc Whole genome duplications and expansion of the vertebrate GATA transcription factor gene family
    William Q Gillis
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    BMC Evol Biol 9:207. 2009
    ..All bilaterian animal genomes have at least one member each of two classes, GATA123 and GATA456...
  60. pmc miR-145 directs intestinal maturation in zebrafish
    Lei Zeng
    Biochemistry and Molecular Biology, and Smooth Muscle Research Group, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 106:17793-8. 2009
    ..Loss or gain of miR-145 function phenocopies defects observed with altered gata6 expression and accordingly, we show that miR-145 directly represses gata6, and that gata6 is a major miR-145 ..
  61. pmc Dnmt3 and G9a cooperate for tissue-specific development in zebrafish
    Kunal Rai
    Department of Oncological Sciences, oward Hughes Medical Institute, and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 285:4110-21. 2010
    ..We propose a model wherein specific DNMT-histone methyltransferase networks are utilized to silence critical regulators of cell fate in a tissue-specific manner...
  62. pmc Identification and characterization of alternative promoters of zebrafish Rtn-4/Nogo genes in cultured cells and zebrafish embryos
    Yi Chung Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Nucleic Acids Res 38:4635-50. 2010
    ..Using morpholino knockdown experiments, GATA4 and GATA6 were involved in the control of P1 promoter activity in the liver and intestine, while Myf5 and MyoD for the ..
  63. pmc Mmp23b promotes liver development and hepatocyte proliferation through the tumor necrosis factor pathway in zebrafish
    Fei Qi
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing, China
    Hepatology 52:2158-66. 2010
    ..Because mmp23b/MMP23B is highly conserved, our findings in zebrafish warrant further investigation of its role in regulating liver development in mammals...
  64. pmc Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays
    Leif C Lindeman
    Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, and Norwegian Center for Stem Cell Research, Oslo, Norway
    PLoS ONE 5:e15651. 2010
    ..Many studies have been carried out in mice and humans; however limited high-resolution information exists to date for non-mammalian vertebrate species...
  65. pmc Common genetic control of haemangioblast and cardiac development in zebrafish
    Tessa Peterkin
    Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK
    Development 136:1465-74. 2009
    ..We demonstrate that gata4, gata5 and gata6 are essential for anterior haemangioblast specification, and for subsequent myelopoiesis, acting as early as ..
  66. pmc Pre-gastrula expression of zebrafish extraembryonic genes
    Sung Kook Hong
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Dev Biol 10:42. 2010
    ..The yolk syncytial layer initially forms below the margin, in a domain called the external yolk syncytial layer (E-YSL)...