foxp2

Summary

Gene Symbol: foxp2
Description: forkhead box P2
Alias: forkhead box protein P2
Species: zebrafish

Top Publications

  1. ncbi Molecular cloning and developmental expression of foxP2 in zebrafish
    Joshua L Bonkowsky
    Department of Pediatric Neurology and Pediatrics, University of Utah Medical Center, Salt Lake City, Utah 84132, USA
    Dev Dyn 234:740-6. 2005
  2. ncbi Expression of FoxP2 during zebrafish development and in the adult brain
    Rina Shah
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Int J Dev Biol 50:435-8. 2006
  3. ncbi Molecular cloning, characterization, and developmental expression of foxp1 in zebrafish
    Lu Cheng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, People s Republic of China
    Dev Genes Evol 217:699-707. 2007
  4. pmc Domain-specific regulation of foxP2 CNS expression by lef1
    Joshua L Bonkowsky
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    BMC Dev Biol 8:103. 2008
  5. pmc Hypoxia disruption of vertebrate CNS pathfinding through ephrinB2 Is rescued by magnesium
    Tamara J Stevenson
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 8:e1002638. 2012
  6. pmc Suppression and epigenetic regulation of MiR-9 contributes to ethanol teratology: evidence from zebrafish and murine fetal neural stem cell models
    Dana L Pappalardo-Carter
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, College of Medicine, Bryan, Texas
    Alcohol Clin Exp Res 37:1657-67. 2013
  7. pmc Lamination Speeds the Functional Development of Visual Circuits
    Nikolas Nikolaou
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Hospital Campus, London, SE1 1UL, UK Electronic address
    Neuron 88:999-1013. 2015
  8. pmc Zebrafish foxP2 zinc finger nuclease mutant has normal axon pathfinding
    Lingyan Xing
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e43968. 2012
  9. pmc Discovery and assessment of conserved Pax6 target genes and enhancers
    Pedro Coutinho
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genome Res 21:1349-59. 2011

Scientific Experts

  • J L Bonkowsky
  • Nikolas Nikolaou
  • Pedro Coutinho
  • Tamara J Stevenson
  • Dana L Pappalardo-Carter
  • Esther Fujimoto
  • Lingyan Xing
  • Lu Cheng
  • Rina Shah
  • Eric S Carter
  • Wei Jung A Chen
  • Rajesh C Miranda
  • Pratheesh Sathyan
  • Sridevi Balaraman
  • Tatjana Piotrowski
  • Tony Trinh
  • Jacob Sneddon
  • Chi Bin Chien
  • David J Grunwald
  • Tyler S Quist
  • Kazuyuki Hoshijima
  • Cory Kogelschatz
  • Cameron J Brimley
  • Mark E Lush
  • Xiaofang Guo
  • Weiwei Fan
  • Xueyan Yang
  • Fan Liu
  • Yonghao Gui
  • Mei Chong
  • Wenjuan Zhang
  • Daru Lu
  • Li Fang Chu
  • Milan Jamrich
  • Rodney C Samaco
  • Olga Medina-Martinez

Detail Information

Publications9

  1. ncbi Molecular cloning and developmental expression of foxP2 in zebrafish
    Joshua L Bonkowsky
    Department of Pediatric Neurology and Pediatrics, University of Utah Medical Center, Salt Lake City, Utah 84132, USA
    Dev Dyn 234:740-6. 2005
    Forkhead domain transcription factors are a large gene family with multiple roles in development. FOXP2, a recently identified member of this family, has been shown to be critical for normal development of language in humans, but little ..
  2. ncbi Expression of FoxP2 during zebrafish development and in the adult brain
    Rina Shah
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Int J Dev Biol 50:435-8. 2006
    ..Mutations in the human FOXP2 gene cause abnormal speech development. Here we report the structure and expression pattern of zebrafish FoxP2...
  3. ncbi Molecular cloning, characterization, and developmental expression of foxp1 in zebrafish
    Lu Cheng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, People s Republic of China
    Dev Genes Evol 217:699-707. 2007
    ..These results provide evidence that foxp1 is likely to function as a very important transcription factor in the development of the central nervous system and many other organs in zebrafish...
  4. pmc Domain-specific regulation of foxP2 CNS expression by lef1
    Joshua L Bonkowsky
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    BMC Dev Biol 8:103. 2008
    b>FOXP2 is a forkhead transcription factor critical for normal development of language in humans, but little is known of its broader function and regulation during central nervous system (CNS) development...
  5. pmc Hypoxia disruption of vertebrate CNS pathfinding through ephrinB2 Is rescued by magnesium
    Tamara J Stevenson
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 8:e1002638. 2012
    ..These results demonstrate that evolutionarily conserved genetic pathways regulate connectivity changes in the CNS in response to hypoxia, and they support a potential neuroprotective role for magnesium...
  6. pmc Suppression and epigenetic regulation of MiR-9 contributes to ethanol teratology: evidence from zebrafish and murine fetal neural stem cell models
    Dana L Pappalardo-Carter
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, College of Medicine, Bryan, Texas
    Alcohol Clin Exp Res 37:1657-67. 2013
    ..However, recent evidence for ethanol (EtOH) sensitivity of the miRNA miR-9 suggests one mechanism, whereby EtOH broadly influences development. We hypothesized that loss of miR-9 function recapitulates aspects of EtOH teratology...
  7. pmc Lamination Speeds the Functional Development of Visual Circuits
    Nikolas Nikolaou
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Hospital Campus, London, SE1 1UL, UK Electronic address
    Neuron 88:999-1013. 2015
    ..Thus, the formation of synaptic laminae is ultimately dispensable for the correct wiring of direction-selective tectal circuits, but it is crucial for the rapid assembly of these networks...
  8. pmc Zebrafish foxP2 zinc finger nuclease mutant has normal axon pathfinding
    Lingyan Xing
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e43968. 2012
    b>foxP2, a forkhead-domain transcription factor, is critical for speech and language development in humans, but its role in the establishment of CNS connectivity is unclear...
  9. pmc Discovery and assessment of conserved Pax6 target genes and enhancers
    Pedro Coutinho
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genome Res 21:1349-59. 2011
    ..We have identified several novel direct targets, including some putative disease genes, among them Foxp2; these will allow further dissection of Pax6 function in development and disease.